LOCUS       NM_007573               1177 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus complement component 1, q subcomponent binding protein
            (C1qbp), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_007573
VERSION     NM_007573.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1177)
  AUTHORS   Gutierrez-Aguilar,M., Klutho,P.J., Aguayo-Ortiz,R., Song,L. and
            Baines,C.P.
  TITLE     Endogenous complement 1q binding protein (C1qbp) regulates
            mitochondrial permeability transition and post-myocardial
            infarction remodeling and dysfunction
  JOURNAL   J Mol Cell Cardiol 196, 1-11 (2024)
   PUBMED   39209214
REFERENCE   2  (bases 1 to 1177)
  AUTHORS   Kim,J.M., Kim,H.K., Cho,H.J., Moon,S.A., Kim,Y., Hong,J.Y.,
            Lee,S.H., Kim,K. and Koh,J.M.
  TITLE     Extracellular C1qbp inhibits myogenesis by suppressing NFATc1
  JOURNAL   Sci Rep 14 (1), 15678 (2024)
   PUBMED   38977785
  REMARK    GeneRIF: Extracellular C1qbp inhibits myogenesis by suppressing
            NFATc1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1177)
  AUTHORS   Zhang,C., Liu,Y., Jiang,J., Chen,C., Duan,Z., Su,H., Wang,S.,
            Tian,B., Shi,Y., Xiang,R. and Luo,Y.
  TITLE     Targeting tumor cell-to-macrophage communication by blocking
            Vtn-C1qbp interaction inhibits tumor progression via enhancing
            macrophage phagocytosis
  JOURNAL   Theranostics 14 (7), 2757-2776 (2024)
   PUBMED   38773982
  REMARK    GeneRIF: Targeting tumor cell-to-macrophage communication by
            blocking Vtn-C1qbp interaction inhibits tumor progression via
            enhancing macrophage phagocytosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1177)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1177)
  AUTHORS   Yagi,M., Do,Y., Hirai,H., Miki,K., Toshima,T., Fukahori,Y.,
            Setoyama,D., Abe,C., Nabeshima,Y.I., Kang,D. and Uchiumi,T.
  TITLE     Improving lysosomal ferroptosis with NMN administration protects
            against heart failure
  JOURNAL   Life Sci Alliance 6 (12), e202302116 (2023)
   PUBMED   37793777
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1177)
  AUTHORS   Nicholson-Weller,A. and Klickstein,L.B.
  TITLE     C1q-binding proteins and C1q receptors
  JOURNAL   Curr Opin Immunol 11 (1), 42-46 (1999)
   PUBMED   10047536
  REMARK    Review article
REFERENCE   7  (bases 1 to 1177)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   8  (bases 1 to 1177)
  AUTHORS   Lim,B.L., White,R.A., Hummel,G.S., Schwaeble,W., Lynch,N.J.,
            Peerschke,E.I., Reid,K.B. and Ghebrehiwet,B.
  TITLE     Characterization of the murine gene of gC1qBP, a novel cell protein
            that binds the globular heads of C1q, vitronectin, high molecular
            weight kininogen and factor XII
  JOURNAL   Gene 209 (1-2), 229-237 (1998)
   PUBMED   9524273
REFERENCE   9  (bases 1 to 1177)
  AUTHORS   Lynch,N.J., Reid,K.B., van den Berg,R.H., Daha,M.R., Leigh,L.A.,
            Ghebrehiwet,B., Lim,W.B. and Schwaeble,W.J.
  TITLE     Characterisation of the rat and mouse homologues of gC1qBP, a 33
            kDa glycoprotein that binds to the globular 'heads' of C1q
  JOURNAL   FEBS Lett 418 (1-2), 111-114 (1997)
   PUBMED   9414106
REFERENCE   10 (bases 1 to 1177)
  AUTHORS   Caubin,J., Iglesias,T., Bernal,J., Munoz,A., Marquez,G.,
            Barbero,J.L. and Zaballos,A.
  TITLE     Isolation of genomic DNA fragments corresponding to genes modulated
            in vivo by a transcription factor
  JOURNAL   Nucleic Acids Res 22 (20), 4132-4138 (1994)
   PUBMED   7937138
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY275303.1, AK010601.1 and CF381952.1.
            
            On Aug 12, 2006 this sequence version replaced NM_007573.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038075.1, AK169764.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                BY275303.1         2-75
            75-117              AK010601.1         14-56
            118-438             BY275303.1         119-439
            439-1111            AK010601.1         377-1049
            1112-1177           CF381952.1         105-170
FEATURES             Location/Qualifiers
     source          1..1177
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 43.21 cM"
     gene            1..1177
                     /gene="C1qbp"
                     /gene_synonym="D11Wsu182e; gC1qBP; HABP1; P32"
                     /note="complement component 1, q subcomponent binding
                     protein"
                     /db_xref="GeneID:12261"
                     /db_xref="MGI:MGI:1194505"
     exon            1..302
                     /gene="C1qbp"
                     /gene_synonym="D11Wsu182e; gC1qBP; HABP1; P32"
                     /inference="alignment:Splign:2.1.0"
     exon            303..453
                     /gene="C1qbp"
                     /gene_synonym="D11Wsu182e; gC1qBP; HABP1; P32"
                     /inference="alignment:Splign:2.1.0"
     exon            454..547
                     /gene="C1qbp"
                     /gene_synonym="D11Wsu182e; gC1qBP; HABP1; P32"
                     /inference="alignment:Splign:2.1.0"
     exon            548..643
                     /gene="C1qbp"
                     /gene_synonym="D11Wsu182e; gC1qBP; HABP1; P32"
                     /inference="alignment:Splign:2.1.0"
     exon            644..766
                     /gene="C1qbp"
                     /gene_synonym="D11Wsu182e; gC1qBP; HABP1; P32"
                     /inference="alignment:Splign:2.1.0"
     exon            767..1165
                     /gene="C1qbp"
                     /gene_synonym="D11Wsu182e; gC1qBP; HABP1; P32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1139..1144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1qbp"
                     /gene_synonym="D11Wsu182e; gC1qBP; HABP1; P32"
                     /note="hexamer: AATAAA"
     polyA_site      1159
                     /gene="C1qbp"
                     /gene_synonym="D11Wsu182e; gC1qBP; HABP1; P32"
                     /note="major polyA site"
ORIGIN      
        1 ggggcttccg gcagcgcgcg aggtcacacg gtgccttggc ccggtcgtcc ttccctctgc
       61 acgtgtccgc cccgcgatgc tccctctgct gcgttgcgtg ccccgcgccc tcggcgccgc
      121 cgcctccggc ctccgaaccg ccatcccggc ccagccgctt cggcatctcc tgcagcccgc
      181 gccccggcca tgcctccggc ccttcggttt gctcagcgta cgggccggct cggctcggcg
      241 ctctggcctc ctgcagcccc cggttccctg cgcgtgcggc tgtggcgctc tgcacacgga
      301 aggagacaag gccttcgttg aattcttgac tgatgaaatt aaggaagaaa agaagatcca
      361 gaaacacaag tcccttccca agatgtctgg agattgggag ctggaggtga acggcacgga
      421 ggctaaatta ttgcgcaaag ttgccggaga aaagatcacg gtcactttca acatcaacaa
      481 cagcatccct ccaacatttg atggtgagga ggagccctca caggggcaga aggctgaaga
      541 acaggagcca gaactgacat caactcccaa ctttgtggtt gaagttacca agactgatgg
      601 caagaagacc cttgtactgg actgtcacta tcctgaggat gagattggac acgaagatga
      661 ggccgagagt gatattttct ctatcaagga agttagcttt caggccactg gtgactctga
      721 gtggagggat acaaactata cactcaacac agattccctg gactgggcct tgtatgacca
      781 cctaatggat ttccttgcgg accgaggggt ggataacact tttgcggatg agttggtgga
      841 gctcagcaca gccctggagc accaggaata tatcaccttt cttgaggacc tcaaaagctt
      901 tgtcaagaac cagtagaact cagagactgc gggccttaat ttaaatggca agctttggcc
      961 agtgaacaaa agctcccttg gcatcagaat tatgcttcaa aaatggctgt catcctaata
     1021 tatcgggggg aagcaagttt aaattactgc tgttacacct ccattcgcta ttcctttggg
     1081 ctttttttct ctgtacaaat ttattatttg tagatttttg tataacatga tgatggacaa
     1141 taaatctgac tccaataaat ctccaaaaaa aaaaaaa
//
