LOCUS       NM_009777               1104 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus complement component 1, q subcomponent, beta
            polypeptide (C1qb), mRNA.
ACCESSION   NM_009777
VERSION     NM_009777.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1104)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1104)
  AUTHORS   Cobo,I., Paliwal,S., Bodas,C., Felipe,I., Melia-Aloma,J.,
            Torres,A., Martinez-Villarreal,J., Malumbres,M., Garcia,F.,
            Millan,I., Del Pozo,N., Park,J.C., MacDonald,R.J., Munoz,J.,
            Mendez,R. and Real,F.X.
  TITLE     NFIC regulates ribosomal biology and ER stress in pancreatic acinar
            cells and restrains PDAC initiation
  JOURNAL   Nat Commun 14 (1), 3761 (2023)
   PUBMED   37353485
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1104)
  AUTHORS   Anderson,S.R., Zhang,J., Steele,M.R., Romero,C.O., Kautzman,A.G.,
            Schafer,D.P. and Vetter,M.L.
  TITLE     Complement Targets Newborn Retinal Ganglion Cells for Phagocytic
            Elimination by Microglia
  JOURNAL   J Neurosci 39 (11), 2025-2040 (2019)
   PUBMED   30647151
REFERENCE   4  (bases 1 to 1104)
  AUTHORS   Mortensen,S.A., Sander,B., Jensen,R.K., Pedersen,J.S., Golas,M.M.,
            Jensenius,J.C., Hansen,A.G., Thiel,S. and Andersen,G.R.
  TITLE     Structure and activation of C1, the complex initiating the
            classical pathway of the complement cascade
  JOURNAL   Proc Natl Acad Sci U S A 114 (5), 986-991 (2017)
   PUBMED   28104818
REFERENCE   5  (bases 1 to 1104)
  AUTHORS   Hong,S., Beja-Glasser,V.F., Nfonoyim,B.M., Frouin,A., Li,S.,
            Ramakrishnan,S., Merry,K.M., Shi,Q., Rosenthal,A., Barres,B.A.,
            Lemere,C.A., Selkoe,D.J. and Stevens,B.
  TITLE     Complement and microglia mediate early synapse loss in Alzheimer
            mouse models
  JOURNAL   Science 352 (6286), 712-716 (2016)
   PUBMED   27033548
REFERENCE   6  (bases 1 to 1104)
  AUTHORS   McClive,P.J. and Morahan,G.
  TITLE     Assignment of the mouse homologues of 6 loci from HSA1p to
            chromosomes 3 and 4
  JOURNAL   Genomics 23 (1), 243-246 (1994)
   PUBMED   7829080
REFERENCE   7  (bases 1 to 1104)
  AUTHORS   Petry,F., Reid,K.B. and Loos,M.
  TITLE     Gene expression of the A- and B-chain of mouse C1q in different
            tissues and the characterization of the recombinant A-chain
  JOURNAL   J Immunol 147 (11), 3988-3993 (1991)
   PUBMED   1940381
REFERENCE   8  (bases 1 to 1104)
  AUTHORS   Petry,F., Reid,K.B. and Loos,M.
  TITLE     Molecular cloning and characterization of the complementary DNA
            coding for the B-chain of murine Clq
  JOURNAL   FEBS Lett 258 (1), 89-93 (1989)
   PUBMED   2591537
REFERENCE   9  (bases 1 to 1104)
  AUTHORS   Wood,L., Pulaski,S. and Vogeli,G.
  TITLE     cDNA clones coding for the complete murine B chain of complement
            C1q: nucleotide and derived amino acid sequences
  JOURNAL   Immunol Lett 17 (2), 115-119 (1988)
   PUBMED   3258843
REFERENCE   10 (bases 1 to 1104)
  AUTHORS   Wood,L., Pulaski,S. and Vogeli,G.
  TITLE     cDNA clones coding for the complete murine B chain of complement
            Clq: nucleotide and derived amino acid sequences
  JOURNAL   Immunol Lett 17 (1), 59-62 (1988)
   PUBMED   3258283
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627214.15.
            
            On Apr 27, 2018 this sequence version replaced NM_009777.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152764.1, BC067001.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AL627214.15        77486-77643         c
            159-360             AL627214.15        73570-73771         c
            361-1104            AL627214.15        71569-72312         c
FEATURES             Location/Qualifiers
     source          1..1104
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 69.05 cM"
     gene            1..1104
                     /gene="C1qb"
                     /gene_synonym="Adia"
                     /note="complement component 1, q subcomponent, beta
                     polypeptide"
                     /db_xref="GeneID:12260"
                     /db_xref="MGI:MGI:88224"
     exon            1..158
                     /gene="C1qb"
                     /gene_synonym="Adia"
                     /inference="alignment:Splign:2.1.0"
     exon            159..360
                     /gene="C1qb"
                     /gene_synonym="Adia"
                     /inference="alignment:Splign:2.1.0"
     exon            361..1104
                     /gene="C1qb"
                     /gene_synonym="Adia"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1080..1085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1qb"
                     /gene_synonym="Adia"
                     /note="hexamer: AATAAA"
     polyA_site      1101
                     /gene="C1qb"
                     /gene_synonym="Adia"
                     /note="major polyA site"
ORIGIN      
        1 agcctgttgg gccttgggag gggacagcaa gggaaggttc ttcctgcctc tagggaccca
       61 gacttccgct ttctgaggac agcagcaggc tctgggctct gggaatccac tgctgtccgg
      121 cctagaagca tcacagaaca ccaggattcc atacacagga agcccctgag gctgagctga
      181 tgaagacaca gtggggtgag gtctggacac acctgttact gctgcttcta ggttttctcc
      241 atgtgtcctg ggcccaaagc agctgcaccg ggccccctgg catccctggc atccctgggg
      301 tccctggggt tcctggctct gatggccaac caggcactcc agggataaag ggggagaaag
      361 ggctccctgg actggctgga gaccttggtg agtttggaga gaaaggggac ccagggatcc
      421 ctgggactcc aggcaaagtt ggccctaagg gtcccgtcgg ccctaagggt actccaggcc
      481 cctctggacc ccgcggtccc aaaggcgatt ctggggacta cggggctaca cagaaagtcg
      541 ccttctctgc cctgaggacc atcaacagcc ccttgcgacc gaaccaggtc attcgcttcg
      601 aaaaggtgat caccaacgcg aacgagaact atgagccacg caacggcaag ttcacctgca
      661 aggtgcctgg cctctactac ttcacctatc atgccagctc ccggggcaac ctgtgtgtga
      721 atctcgttcg tggccgcgat cgggacagca tgcagaaagt agtcaccttc tgtgactatg
      781 cccagaacac cttccaggtg accacaggtg gggtagtctt gaagctagag caagaggagg
      841 ttgttcacct gcaggccaca gacaagaact ccctcctggg cattgagggt gccaacagca
      901 tcttcactgg ctttctgctt ttccctgaca tggatgcgta atcacggggt caaattacac
      961 ctatccaaca ccatcttcct gcctccctgc cagcaatcct ccctggaccc ctgacatcac
     1021 ccccttgact gcctgaaacc cagaccagag ccctgtagat gttacagaac gaatgggtca
     1081 ataaactctt caaggccaaa agac
//
