LOCUS       NM_007572               1082 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus complement component 1, q subcomponent, alpha
            polypeptide (C1qa), mRNA.
ACCESSION   NM_007572
VERSION     NM_007572.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1082)
  AUTHORS   Fu,X., Ye,F., Wan,Y., Xi,G., Hua,Y. and Keep,R.F.
  TITLE     The Role of Complement C1qa in Experimental Intracerebral
            Hemorrhage
  JOURNAL   Transl Stroke Res (2024) In press
   PUBMED   39370487
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1082)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   3  (bases 1 to 1082)
  AUTHORS   Mao,A., Li,Z., Shi,X., Zhang,K., Kan,H., Geng,L. and He,D.
  TITLE     Complement Factor C1q Mediates Vascular Endothelial Dysfunction in
            STZ-Induced Diabetic Mice
  JOURNAL   Diabetes 73 (9), 1527-1536 (2024)
   PUBMED   38869460
  REMARK    GeneRIF: Complement Factor C1q Mediates Vascular Endothelial
            Dysfunction in STZ-Induced Diabetic Mice.
REFERENCE   4  (bases 1 to 1082)
  AUTHORS   Renz,P., Steinfort,M., Haesler,V., Tscherrig,V., Huang,E.J.,
            Chavali,M., Liddelow,S., Rowitch,D.H., Surbek,D., Schoeberlein,A.
            and Brosius Lutz,A.
  TITLE     Neuroinflammatory reactive astrocyte formation correlates with
            adverse outcomes in perinatal white matter injury
  JOURNAL   Glia 72 (9), 1663-1673 (2024)
   PUBMED   38924630
REFERENCE   5  (bases 1 to 1082)
  AUTHORS   Scott-Hewitt,N., Mahoney,M., Huang,Y., Korte,N., Yvanka de
            Soysa,T., Wilton,D.K., Knorr,E., Mastro,K., Chang,A., Zhang,A.,
            Melville,D., Schenone,M., Hartigan,C. and Stevens,B.
  TITLE     Microglial-derived C1q integrates into neuronal ribonucleoprotein
            complexes and impacts protein homeostasis in the aging brain
  JOURNAL   Cell 187 (16), 4193-4212 (2024)
   PUBMED   38942014
REFERENCE   6  (bases 1 to 1082)
  AUTHORS   Cutler,A.J., Botto,M., van Essen,D., Rivi,R., Davies,K.A., Gray,D.
            and Walport,M.J.
  TITLE     T cell-dependent immune response in C1q-deficient mice: defective
            interferon gamma production by antigen-specific T cells
  JOURNAL   J Exp Med 187 (11), 1789-1797 (1998)
   PUBMED   9607920
REFERENCE   7  (bases 1 to 1082)
  AUTHORS   Botto,M., Dell'Agnola,C., Bygrave,A.E., Thompson,E.M., Cook,H.T.,
            Petry,F., Loos,M., Pandolfi,P.P. and Walport,M.J.
  TITLE     Homozygous C1q deficiency causes glomerulonephritis associated with
            multiple apoptotic bodies
  JOURNAL   Nat Genet 19 (1), 56-59 (1998)
   PUBMED   9590289
REFERENCE   8  (bases 1 to 1082)
  AUTHORS   Vyse,T.J., Drake,C.G., Rozzo,S.J., Roper,E., Izui,S. and
            Kotzin,B.L.
  TITLE     Genetic linkage of IgG autoantibody production in relation to lupus
            nephritis in New Zealand hybrid mice
  JOURNAL   J Clin Invest 98 (8), 1762-1772 (1996)
   PUBMED   8878426
REFERENCE   9  (bases 1 to 1082)
  AUTHORS   Petry,F., McClive,P.J., Botto,M., Morley,B.J., Morahan,G. and
            Loos,M.
  TITLE     The mouse C1q genes are clustered on chromosome 4 and show
            conservation of gene organization
  JOURNAL   Immunogenetics 43 (6), 370-376 (1996)
   PUBMED   8606057
REFERENCE   10 (bases 1 to 1082)
  AUTHORS   Petry,F., Reid,K.B. and Loos,M.
  TITLE     Gene expression of the A- and B-chain of mouse C1q in different
            tissues and the characterization of the recombinant A-chain
  JOURNAL   J Immunol 147 (11), 3988-3993 (1991)
   PUBMED   1940381
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY318890.1, AK002655.1 and BY698724.1.
            
            On Jan 30, 2007 this sequence version replaced NM_007572.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002086.1, AK002655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                BY318890.1         4-78
            76-1080             AK002655.1         2-1006
            1081-1082           BY698724.1         392-393
FEATURES             Location/Qualifiers
     source          1..1082
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 69.05 cM"
     gene            1..1082
                     /gene="C1qa"
                     /gene_synonym="Adic; C1q"
                     /note="complement component 1, q subcomponent, alpha
                     polypeptide"
                     /db_xref="GeneID:12259"
                     /db_xref="MGI:MGI:88223"
     exon            1..99
                     /gene="C1qa"
                     /gene_synonym="Adic; C1q"
                     /inference="alignment:Splign:2.1.0"
     exon            100..269
                     /gene="C1qa"
                     /gene_synonym="Adic; C1q"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..844
                     /gene="C1qa"
                     /gene_synonym="Adic; C1q"
                     /note="complement C1q subcomponent subunit A; adiponectin
                     c"
                     /codon_start=1
                     /product="complement C1q subcomponent subunit A precursor"
                     /protein_id="NP_031598.2"
                     /db_xref="CCDS:CCDS18812.1"
                     /db_xref="GeneID:12259"
                     /db_xref="MGI:MGI:88223"
                     /translation="METSQGWLVACVLTMTLVWTVAEDVCRAPNGKDGAPGNPGRPGR
                     PGLKGERGEPGAAGIRTGIRGFKGDPGESGPPGKPGNVGLPGPSGPLGDSGPQGLKGV
                     KGNPGNIRDQPRPAFSAIRQNPMTLGNVVIFDKVLTNQESPYQNHTGRFICAVPGFYY
                     FNFQVISKWDLCLFIKSSSGGQPRDSLSFSNTNNKGLFQVLAGGTVLQLRRGDEVWIE
                     KDPAKGRIYQGTEADSIFSGFLIFPSA"
     exon            270..1082
                     /gene="C1qa"
                     /gene_synonym="Adic; C1q"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1054..1059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1qa"
                     /gene_synonym="Adic; C1q"
                     /note="hexamer: AATAAA"
     polyA_site      1081
                     /gene="C1qa"
                     /gene_synonym="Adic; C1q"
                     /note="major polyA site"
ORIGIN      
        1 atgaaacttg gcagtgtcct ggtgacacgc ctttgctgac gggtgtccca ccatcagcaa
       61 agggctggag catccagttt gatcggacca cggaggcagg gacaccatgg agacctctca
      121 gggatggctg gtggcctgtg tgctgaccat gaccctagta tggacagtgg ctgaagatgt
      181 ctgccgagca cccaacggga aggatggggc tccaggaaat cctggccgcc cggggaggcc
      241 gggtctcaaa ggagagagag gggagccagg agctgctggc atccggactg gtatccgagg
      301 ttttaaagga gacccagggg aatctggccc ccctggcaaa cctggcaatg tggggctccc
      361 aggtcccagt ggtcccctgg gggacagcgg cccccaagga ctgaagggcg tgaaaggcaa
      421 tccaggcaat atcagggacc agccccggcc agctttctca gccattcggc agaacccaat
      481 gacgcttggc aacgtggtta tctttgacaa ggtcctcacc aaccaggaga gtccatacca
      541 gaaccacacg ggtcgcttca tctgtgcagt gcccggcttc tattacttca acttccaagt
      601 gatctccaag tgggaccttt gtctgtttat caagtcttcc tccgggggcc agcccaggga
      661 ttccctgagt ttctctaaca ccaacaacaa ggggctcttt caggtgttag cagggggcac
      721 cgtgcttcag ctgcgacgag gggacgaggt gtggatcgaa aaggaccccg caaagggtcg
      781 catttaccag ggcactgaag ccgacagcat cttcagcgga ttcctcattt tcccctcggc
      841 ctgagctggg gatctgcccc tgcatcctgc catctcctgc gctccctgtt gtggaccacg
      901 cccccccctc cgtcctgcac ccctcccctc cgcactctgc aaagtgaagg ggctggggct
      961 ttagcaccct gggggagggg ctgtctcgga gggagggcac tgaggactga tgtttctgca
     1021 cactgcccag tggtttcttt aagcactttc tggaataaac gatccccgtc tgtgtctgtg
     1081 ac
//
