LOCUS       NM_021550               1507 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus C1GALT1-specific chaperone 1 (C1galt1c1), mRNA.
ACCESSION   NM_021550
VERSION     NM_021550.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1507)
  AUTHORS   Suzuki,R., Nakamura,Y., Koiwai,R., Fuseya,S., Murakami,Y.,
            Hagiwara,K., Sato,T., Takahashi,S. and Kudo,T.
  TITLE     Global Loss of Core 1-Derived O-Glycans in Mice Leads to High
            Mortality Due to Acute Kidney Failure and Gastric Ulcers
  JOURNAL   Int J Mol Sci 23 (3), 1273 (2022)
   PUBMED   35163200
  REMARK    GeneRIF: Global Loss of Core 1-Derived O-Glycans in Mice Leads to
            High Mortality Due to Acute Kidney Failure and Gastric Ulcers.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1507)
  AUTHORS   Zeng,J., Eljalby,M., Aryal,R.P., Lehoux,S., Stavenhagen,K.,
            Kudelka,M.R., Wang,Y., Wang,J., Ju,T., von Andrian,U.H. and
            Cummings,R.D.
  TITLE     Cosmc controls B cell homing
  JOURNAL   Nat Commun 11 (1), 3990 (2020)
   PUBMED   32778659
  REMARK    GeneRIF: Cosmc controls B cell homing.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1507)
  AUTHORS   Fuseya,S., Suzuki,R., Okada,R., Hagiwara,K., Sato,T., Narimatsu,H.,
            Yokoi,H., Kasahara,M., Usui,T., Morito,N., Yamagata,K., Kudo,T. and
            Takahashi,S.
  TITLE     Mice lacking core 1-derived O-glycan in podocytes develop transient
            proteinuria, resulting in focal segmental glomerulosclerosis
  JOURNAL   Biochem Biophys Res Commun 523 (4), 1007-1013 (2020)
   PUBMED   31973821
REFERENCE   4  (bases 1 to 1507)
  AUTHORS   Stotter,B.R., Talbot,B.E., Capen,D.E., Artelt,N., Zeng,J.,
            Matsumoto,Y., Endlich,N., Cummings,R.D. and Schlondorff,J.S.
  TITLE     Cosmc-dependent mucin-type O-linked glycosylation is essential for
            podocyte function
  JOURNAL   Am J Physiol Renal Physiol 318 (2), F518-F530 (2020)
   PUBMED   31904283
  REMARK    GeneRIF: Cosmc-dependent mucin-type O-linked glycosylation has an
            essential and likely cell nonautonomous role for podocyte function.
REFERENCE   5  (bases 1 to 1507)
  AUTHORS   Cutler,C.E., Jones,M.B., Cutler,A.A., Mener,A., Arthur,C.M.,
            Stowell,S.R. and Cummings,R.D.
  TITLE     Cosmc is required for T cell persistence in the periphery
  JOURNAL   Glycobiology 29 (11), 776-788 (2019)
   PUBMED   31317176
  REMARK    GeneRIF: Loss of Cosmc is highly deleterious to T cell persistence,
            with near-complete elimination of Cosmc-null T cells from spleen
            and lymph nodes.
REFERENCE   6  (bases 1 to 1507)
  AUTHORS   Fu,J., Wei,B., Wen,T., Johansson,M.E., Liu,X., Bradford,E.,
            Thomsson,K.A., McGee,S., Mansour,L., Tong,M., McDaniel,J.M.,
            Sferra,T.J., Turner,J.R., Chen,H., Hansson,G.C., Braun,J. and
            Xia,L.
  TITLE     Loss of intestinal core 1-derived O-glycans causes spontaneous
            colitis in mice
  JOURNAL   J Clin Invest 121 (4), 1657-1666 (2011)
   PUBMED   21383503
REFERENCE   7  (bases 1 to 1507)
  AUTHORS   Wang,Y., Ju,T., Ding,X., Xia,B., Wang,W., Xia,L., He,M. and
            Cummings,R.D.
  TITLE     Cosmc is an essential chaperone for correct protein O-glycosylation
  JOURNAL   Proc Natl Acad Sci U S A 107 (20), 9228-9233 (2010)
   PUBMED   20439703
  REMARK    GeneRIF: Cosmc is an essential chaperone for correct protein
            O-glycosylation.
REFERENCE   8  (bases 1 to 1507)
  AUTHORS   Schietinger,A., Philip,M., Yoshida,B.A., Azadi,P., Liu,H.,
            Meredith,S.C. and Schreiber,H.
  TITLE     A mutant chaperone converts a wild-type protein into a
            tumor-specific antigen
  JOURNAL   Science 314 (5797), 304-308 (2006)
   PUBMED   17038624
  REMARK    GeneRIF: a somatic mutation in the chaperone gene Cosmc abolished
            function of a glycosyltransferase, disrupting O-glycan Core 1
            synthesis & creating a tumor-specific glycopeptidic neo-epitope
            consisting of a monosaccharide and a specific wild-type protein
            sequence
REFERENCE   9  (bases 1 to 1507)
  AUTHORS   Ju,T. and Cummings,R.D.
  TITLE     A unique molecular chaperone Cosmc required for activity of the
            mammalian core 1 beta 3-galactosyltransferase
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16613-16618 (2002)
   PUBMED   12464682
REFERENCE   10 (bases 1 to 1507)
  AUTHORS   Inoue,S., Sano,H. and Ohta,M.
  TITLE     Growth suppression of Escherichia coli by induction of expression
            of mammalian genes with transmembrane or ATPase domains
  JOURNAL   Biochem Biophys Res Commun 268 (2), 553-561 (2000)
   PUBMED   10679242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590633.9, AK008040.1 and AL845279.4.
            
            On Dec 3, 2009 this sequence version replaced NM_021550.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments. An in-frame
            AUG is located 46 codons upstream of the annotated translation
            start site but is not being annotated as a start site since it is
            not conserved and is in a weak Kozak sequence context.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029909.1, AY159320.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AL590633.9         6162-6217           c
            57-1329             AK008040.1         4-1276
            1330-1363           AL590633.9         2001-2034           c
            1364-1507           AL845279.4         29809-29952         c
FEATURES             Location/Qualifiers
     source          1..1507
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 22.91 cM"
     gene            1..1507
                     /gene="C1galt1c1"
                     /gene_synonym="1500002I11Rik; C1GalT2; Cosmc"
                     /note="C1GALT1-specific chaperone 1"
                     /db_xref="GeneID:59048"
                     /db_xref="MGI:MGI:1913493"
     exon            1..166
                     /gene="C1galt1c1"
                     /gene_synonym="1500002I11Rik; C1GalT2; Cosmc"
                     /inference="alignment:Splign:2.1.0"
     exon            167..1507
                     /gene="C1galt1c1"
                     /gene_synonym="1500002I11Rik; C1GalT2; Cosmc"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1123
                     /gene="C1galt1c1"
                     /gene_synonym="1500002I11Rik; C1GalT2; Cosmc"
                     /note="core 1 beta3-galactosyltransferase-specific
                     molecular chaperone; beta1,3-galactosyltransferase 2;
                     C1Gal-T2; mC1Gal-T2; core 1 beta3-Gal-T2; core 1
                     beta1,3-galactosyltransferase 2"
                     /codon_start=1
                     /product="C1GALT1-specific chaperone 1"
                     /protein_id="NP_067525.1"
                     /db_xref="CCDS:CCDS30095.1"
                     /db_xref="GeneID:59048"
                     /db_xref="MGI:MGI:1913493"
                     /translation="MLSESSSFLKGVMLGSIFCALITMLGHIRIGNRMHHHEHHHLQA
                     PNKDDISKISEAERMELSKSFRVYCIVLVKPKDVSLWAAVKETWTKHCDKAEFFSSEN
                     VKVFESINMDTNDMWLMMRKAYKYAYDQYRDQYNWFFLARPTTFAVIENLKYFLLKKD
                     QSQPFYLGHTVKSGDLEYVSVDGGIVLSIESMKRLNSLLSVPEKCPEQGGMIWKISED
                     KQLAVCLKYAGVFAENAEDADGKDVFNTKSVGLFIKEAMTNQPNQVVEGCCSDMAVTF
                     NGLTPNQMHVMMYGVYRLRAFGHVFNDALVFLPPNGSEND"
     regulatory      1483..1488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1galt1c1"
                     /gene_synonym="1500002I11Rik; C1GalT2; Cosmc"
                     /note="hexamer: ATTAAA"
     polyA_site      1499
                     /gene="C1galt1c1"
                     /gene_synonym="1500002I11Rik; C1GalT2; Cosmc"
                     /note="major polyA site"
ORIGIN      
        1 accctcgtca gcttcctctg ttgctccgtc attaatgaca ccaacgagag gataccgcct
       61 gcgtctagag cagcctggtt ccgagcgtaa cagagtgggc cttggacctc tcacgtccaa
      121 gcctcgtgag gcagcgcttt cctgccctgg agccgttcta gatgcggaaa aaatgctttc
      181 agaaagcagt tcctttttga agggtgtgat gcttggaagc atcttctgtg ccttgatcac
      241 tatgctaggc cacattagga ttggaaacag aatgcaccac catgagcatc accatctgca
      301 agcccctaac aaagacgata tctcgaaaat ttcagaggct gaacgcatgg agctcagtaa
      361 gagtttccgg gtatactgta tagttcttgt aaaacccaaa gatgtgagtc tttgggctgc
      421 agtgaaggag acttggacca aacactgtga caaagcagaa ttcttcagtt ctgaaaatgt
      481 taaagtgttt gagtcaatta atatggacac aaatgacatg tggttgatga tgaggaaagc
      541 ttacaaatat gcttatgatc aatacaggga ccaatacaac tggttcttcc ttgcacgccc
      601 cactactttc gctgttattg aaaacctcaa atattttttg ttaaaaaagg atcaatccca
      661 acctttctat ctcggacaca ctgtaaaatc tggagacctt gaatatgtga gtgtggatgg
      721 aggaattgtc ttaagcatag aatcaatgaa aagactcaac agtcttctca gtgttcctga
      781 aaagtgtcct gaacaaggag gaatgatttg gaagatatct gaagataaac agctggcggt
      841 ctgcctgaaa tacgccggag tatttgcaga aaatgccgaa gatgccgatg gaaaagatgt
      901 gtttaatacc aaatccgttg gccttttcat taaagaggca atgactaacc aaccaaacca
      961 ggtagtagaa ggctgttgct ctgatatggc tgttactttc aatggactga ctcctaatca
     1021 gatgcacgtg atgatgtatg gggtgtaccg gcttagggca tttggacatg ttttcaatga
     1081 tgcattggtt ttcttacctc caaatggttc tgagaatgac tgacagaaag caagagcatg
     1141 catttagtaa ctatattacg acatggtatc atttttaatt gatgacagat ctaacatagt
     1201 aatatgattc tttttcttat cttttaccca ttgaagtctg cttgtacaat gtcaaatgga
     1261 atgctgtttt tcccttatat cattcctgag aaatttaaat gtattaaaaa taaatgtttt
     1321 aaaaatagca atttttcaaa cacatattta taagtatatt tatgtgataa agactaaatt
     1381 atagacattg taatctgtgg tgtatctttg cttattggtt ttaaacttat gtatcatttt
     1441 agctttgtaa tatatgtaaa tgagacctct agagaatttg tgattaaaga atactcgtag
     1501 ccctgtg
//
