LOCUS       NM_052993               2084 bp    mRNA    linear   ROD 21-MAY-2024
DEFINITION  Mus musculus core 1 synthase, glycoprotein-N-acetylgalactosamine
            3-beta-galactosyltransferase, 1 (C1galt1), mRNA.
ACCESSION   NM_052993
VERSION     NM_052993.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2084)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2084)
  AUTHORS   Faber,J.E., Zhang,H., Xenakis,J.G., Bell,T.A., Hock,P.,
            Pardo-Manuel de Villena,F., Ferris,M.T. and Rzechorzek,W.
  TITLE     Large differences in collateral blood vessel abundance among
            individuals arise from multiple genetic variants
  JOURNAL   J Cereb Blood Flow Metab 43 (11), 1983-2004 (2023)
   PUBMED   37572089
REFERENCE   3  (bases 1 to 2084)
  AUTHORS   Sheikh,S., Lo,B.K.M., Kaune,H., Bansal,J., Deleva,A. and
            Williams,S.A.
  TITLE     Rescue of follicle development after oocyte-induced ovary
            dysfunction and infertility in a model of POI
  JOURNAL   Front Cell Dev Biol 11, 1202411 (2023)
   PUBMED   37614224
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2084)
  AUTHORS   Suzuki,R., Nakamura,Y., Koiwai,R., Fuseya,S., Murakami,Y.,
            Hagiwara,K., Sato,T., Takahashi,S. and Kudo,T.
  TITLE     Global Loss of Core 1-Derived O-Glycans in Mice Leads to High
            Mortality Due to Acute Kidney Failure and Gastric Ulcers
  JOURNAL   Int J Mol Sci 23 (3), 1273 (2022)
   PUBMED   35163200
  REMARK    GeneRIF: Global Loss of Core 1-Derived O-Glycans in Mice Leads to
            High Mortality Due to Acute Kidney Failure and Gastric Ulcers.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2084)
  AUTHORS   Bergstrom,K., Shan,X., Casero,D., Batushansky,A., Lagishetty,V.,
            Jacobs,J.P., Hoover,C., Kondo,Y., Shao,B., Gao,L., Zandberg,W.,
            Noyovitz,B., McDaniel,J.M., Gibson,D.L., Pakpour,S., Kazemian,N.,
            McGee,S., Houchen,C.W., Rao,C.V., Griffin,T.M., Sonnenburg,J.L.,
            McEver,R.P., Braun,J. and Xia,L.
  TITLE     Proximal colon-derived O-glycosylated mucus encapsulates and
            modulates the microbiota
  JOURNAL   Science 370 (6515), 467-472 (2020)
   PUBMED   33093110
REFERENCE   6  (bases 1 to 2084)
  AUTHORS   Williams,S.A., Xia,L., Cummings,R.D., McEver,R.P. and Stanley,P.
  TITLE     Fertilization in mouse does not require terminal galactose or
            N-acetylglucosamine on the zona pellucida glycans
  JOURNAL   J Cell Sci 120 (Pt 8), 1341-1349 (2007)
   PUBMED   17374637
REFERENCE   7  (bases 1 to 2084)
  AUTHORS   Alexander,W.S., Viney,E.M., Zhang,J.G., Metcalf,D., Kauppi,M.,
            Hyland,C.D., Carpinelli,M.R., Stevenson,W., Croker,B.A.,
            Hilton,A.A., Ellis,S., Selan,C., Nandurkar,H.H., Goodnow,C.C.,
            Kile,B.T., Nicola,N.A., Roberts,A.W. and Hilton,D.J.
  TITLE     Thrombocytopenia and kidney disease in mice with a mutation in the
            C1galt1 gene
  JOURNAL   Proc Natl Acad Sci U S A 103 (44), 16442-16447 (2006)
   PUBMED   17062753
  REMARK    GeneRIF: disease in plt1/plt1 mice suggests that, in addition to
            immune-mediated effects, intrinsic C1Gal-T1 deficiency in
            megakaryocytes and the kidney may contribute to pathology
REFERENCE   8  (bases 1 to 2084)
  AUTHORS   Xia,L. and McEver,R.P.
  TITLE     Targeted disruption of the gene encoding core 1
            beta1-3-galactosyltransferase (T-synthase) causes embryonic
            lethality and defective angiogenesis in mice
  JOURNAL   Methods Enzymol 416, 314-331 (2006)
   PUBMED   17113876
  REMARK    GeneRIF: It was found that targeted disruption of this gene causes
            embryonic lethality and defective angiogenesis in mice.
REFERENCE   9  (bases 1 to 2084)
  AUTHORS   Xia,L., Ju,T., Westmuckett,A., An,G., Ivanciu,L., McDaniel,J.M.,
            Lupu,F., Cummings,R.D. and McEver,R.P.
  TITLE     Defective angiogenesis and fatal embryonic hemorrhage in mice
            lacking core 1-derived O-glycans
  JOURNAL   J Cell Biol 164 (3), 451-459 (2004)
   PUBMED   14745002
REFERENCE   10 (bases 1 to 2084)
  AUTHORS   Ju,T., Brewer,K., D'Souza,A., Cummings,R.D. and Canfield,W.M.
  TITLE     Cloning and expression of human core 1
            beta1,3-galactosyltransferase
  JOURNAL   J Biol Chem 277 (1), 178-186 (2002)
   PUBMED   11677243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF471960.1, BC064767.1, BG077752.2, AI060759.1, BB625752.1 and
            AW824923.1.
            
            On Dec 30, 2009 this sequence version replaced NM_052993.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064767.1, AF157962.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               BF471960.1         485-593             c
            110-564             BC064767.1         1-455
            565-573             BF471960.1         22-30               c
            574-742             BC064767.1         465-633
            743-1167            BG077752.2         155-579
            1168-1478           AI060759.1         1-311               c
            1479-1809           BB625752.1         141-471
            1810-2084           AW824923.1         1-275               c
FEATURES             Location/Qualifiers
     source          1..2084
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 3.37 cM"
     gene            1..2084
                     /gene="C1galt1"
                     /gene_synonym="2210410E06Rik; T-synthase"
                     /note="core 1 synthase, glycoprotein-N-acetylgalactosamine
                     3-beta-galactosyltransferase, 1"
                     /db_xref="GeneID:94192"
                     /db_xref="MGI:MGI:2151071"
     exon            1..171
                     /gene="C1galt1"
                     /gene_synonym="2210410E06Rik; T-synthase"
                     /inference="alignment:Splign:2.1.0"
     exon            172..408
                     /gene="C1galt1"
                     /gene_synonym="2210410E06Rik; T-synthase"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1280
                     /gene="C1galt1"
                     /gene_synonym="2210410E06Rik; T-synthase"
                     /EC_number="2.4.1.122"
                     /note="core1 UDP-galactose:N-acetylgalactosamine-alpha-R
                     beta 1,3-galactosyltransferase 1; T-syn; core 1
                     beta3-Gal-T1; core 1 O-glycan T-synthase; core 1
                     beta1,3-galactosyltransferase 1; core 1
                     UDP-galactose:N-acetylgalactosamine-alpha-R beta
                     1,3-galactosyltransferase 1"
                     /codon_start=1
                     /product="glycoprotein-N-acetylgalactosamine
                     3-beta-galactosyltransferase 1"
                     /protein_id="NP_443719.3"
                     /db_xref="CCDS:CCDS19908.1"
                     /db_xref="GeneID:94192"
                     /db_xref="MGI:MGI:2151071"
                     /translation="MASKSWLNFLVFLCGSAIGFFLCSQLLSILLREEAAIQPNMLHN
                     DPHARHSDDNGHSHLKGQMNFNADSSQHKDENIDVAENLYQKVKILCWVMTSPQNLEK
                     KAKHVKATWAQRCNKVLFMSSEENQDFPTVGLKTKEGREQLYWKTIKAFQYVHDHYLE
                     DADWFMKADDDTYVIVDNLRWLLSKYNPEQPIYFGRRFKPYVKQGYMSGGAGYVLSKE
                     ALRRFVNAFKTEKCTHSSSIEDLALGRCMEIINVEAGDSRDTIGKETFHPFVPEHHLI
                     KGYLPKTFWYWNYNYYPPIEGPGCCSDIAVSFHYVDGTTMYELEYLVYHLRPYGYLYR
                     YQPALPENILKEINQVNRKEDTKIKLGNP"
     exon            409..1076
                     /gene="C1galt1"
                     /gene_synonym="2210410E06Rik; T-synthase"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..2065
                     /gene="C1galt1"
                     /gene_synonym="2210410E06Rik; T-synthase"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgggcctc cgcgcgcccg gcgcccgcca gctgtgtgca ctcaggtgcg ggcaccttcc
       61 ggccgcaaca gtcccgagtg cccgccgccg ttggaccgtc agctttgtct ggagctggtc
      121 ggttatggtt ggaactttcc ctgcccttcg ttgactgagt gaaccagcca gaaatacatt
      181 cccaggaaat ggcctctaaa tcttggctga attttttagt cttcctctgt ggatcagcaa
      241 tagggttttt tttatgttct caactcttga gtattttgtt gcgagaagag gctgccattc
      301 agcctaacat gcttcacaat gaccctcatg caaggcattc agatgacaat ggacacagtc
      361 acctcaaagg acagatgaac ttcaatgcag attccagcca acataaagat gagaacatag
      421 acgttgctga gaacctctat cagaaagtta aaattctttg ttgggttatg acaagtcctc
      481 aaaatctaga gaaaaaggcc aaacatgtca aagctacgtg ggcccagcgt tgtaataaag
      541 tgttatttat gagttcggaa gaaaatcaag acttccctac tgtgggattg aaaaccaaag
      601 aaggcagaga gcaactatat tggaaaacaa ttaaagcttt ccagtatgta catgaccatt
      661 atttagaaga tgctgactgg tttatgaaag cagatgacga cacatacgtc attgtggaca
      721 acctgagatg gcttctatca aagtataacc ctgaacaacc catttacttt gggcgaagat
      781 ttaagcccta tgtgaagcag ggatacatga gcggaggagc gggctatgtc ctaagcaagg
      841 aagccttgag aagatttgtt aatgcattta aaacagaaaa gtgtacacat agttcctcca
      901 tcgaagactt agctctggga aggtgcatgg aaattataaa tgtagaagct ggagattcca
      961 gagataccat tgggaaagaa accttccatc catttgtacc agaacaccac ttaatcaaag
     1021 gttatctacc aaaaacattt tggtactgga attacaacta ttatcctccc atagagggtc
     1081 ctggatgctg ttctgatatt gcagtttctt ttcactatgt tgatgggaca actatgtatg
     1141 aattagaata cctcgtttat catcttcgtc catatggtta tttatataga tatcaacctg
     1201 ccttacctga gaatatactg aaagaaatta atcaagtaaa cagaaaggaa gatacaaaaa
     1261 taaaattagg caacccctga aagcagaaca taagtggtct acattgcact gaaggactct
     1321 tgcctttcta cggaaccctg aaatcccagt gaggaactca cctgaagtga acattccata
     1381 tagaaatctt tcaaatggat gactataaac tgaagcattt aaagagctgt gaagtttgct
     1441 aaaacgtgtt ttgatacagt aatatataaa tataaataaa tatatatgaa gaatttgtgt
     1501 ttttaaatgg tgacagaaga gctagaaaga ctctgtttct gactgttccc aacagtgtat
     1561 gttgttatca ctacagttgg agtggttagt ttataatcac cttctgcacc acaccagtta
     1621 gaacacaatg ctgaacagat ctgccttaaa gaaagaaaga aagaactgtt gctcagtgtt
     1681 gtttctcagc tgatatgtgt atgctacaaa ccagccttcc agttgccgaa tgaaaacttt
     1741 cctgtgatta tattatttat aattggcagt gtttcctcaa gaagaataag aagggcactt
     1801 accccaaagt gcagtaatta accacatttc caattattcc gagccttgac tccattagat
     1861 acttagttct aaagataatc aacccgatac caagtcccca ttgtcccctt tccaaatgtt
     1921 tgaccctgaa taccattttt cactattaat gctaatttac tcaaagcatt ggcagcattc
     1981 tgtaaatcat gcattttcaa atatgttgtt ccccgattca cccattgtta attgtaggta
     2041 acaattaaat ttaatgctgt ttggaaaaaa aaaaaaaaaa aaaa
//
