LOCUS       NM_025840               1889 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus basic leucine zipper and W2 domains 2 (Bzw2), mRNA.
ACCESSION   NM_025840
VERSION     NM_025840.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1889)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1889)
  AUTHORS   Wang,M., He,T., Meng,D., Lv,W., Ye,J., Cheng,L. and Hu,J.
  TITLE     BZW2 Modulates Lung Adenocarcinoma Progression through
            Glycolysis-Mediated IDH3G Lactylation Modification
  JOURNAL   J Proteome Res 22 (12), 3854-3865 (2023)
   PUBMED   37955350
  REMARK    GeneRIF: BZW2 Modulates Lung Adenocarcinoma Progression through
            Glycolysis-Mediated IDH3G Lactylation Modification.
REFERENCE   3  (bases 1 to 1889)
  AUTHORS   Zhang,J., Pi,S.B., Zhang,N., Guo,J., Zheng,W., Leng,L., Lin,G. and
            Fan,H.Y.
  TITLE     Translation regulatory factor BZW1 regulates preimplantation embryo
            development and compaction by restricting global non-AUG Initiation
  JOURNAL   Nat Commun 13 (1), 6621 (2022)
   PUBMED   36333315
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1889)
  AUTHORS   Shen,Z.J., Hu,J., O'Neal,M.A. and Malter,J.S.
  TITLE     Pin1 Regulates IL-5 Induced Eosinophil Polarization and Migration
  JOURNAL   Cells 10 (2), 211 (2021)
   PUBMED   33494375
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1889)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1889)
  AUTHORS   Tachikawa,K., Sasaki,S., Maeda,T. and Nakajima,K.
  TITLE     Identification of molecules preferentially expressed beneath the
            marginal zone in the developing cerebral cortex
  JOURNAL   Neurosci Res 60 (2), 135-146 (2008)
   PUBMED   18055048
REFERENCE   7  (bases 1 to 1889)
  AUTHORS   Gallardo,T.D., John,G.B., Shirley,L., Contreras,C.M., Akbay,E.A.,
            Haynie,J.M., Ward,S.E., Shidler,M.J. and Castrillon,D.H.
  TITLE     Genomewide discovery and classification of candidate ovarian
            fertility genes in the mouse
  JOURNAL   Genetics 177 (1), 179-194 (2007)
   PUBMED   17660561
  REMARK    GeneRIF: Transcripts highly enriched in ovary; gene identified as
            candidate female fertility factor.
REFERENCE   8  (bases 1 to 1889)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   9  (bases 1 to 1889)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   10 (bases 1 to 1889)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY009345.1, AK160544.1 and BQ032572.1.
            
            On Aug 15, 2009 this sequence version replaced NM_025840.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003229.1, BC013060.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BY009345.1         2-30
            30-1444             AK160544.1         3-1417
            1445-1889           BQ032572.1         1-445               c
FEATURES             Location/Qualifiers
     source          1..1889
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 16.42 cM"
     gene            1..1889
                     /gene="Bzw2"
                     /gene_synonym="1110001I24Rik; 5mp1; Bdm2; HSPC028"
                     /note="basic leucine zipper and W2 domains 2"
                     /db_xref="GeneID:66912"
                     /db_xref="MGI:MGI:1914162"
     exon            1..158
                     /gene="Bzw2"
                     /gene_synonym="1110001I24Rik; 5mp1; Bdm2; HSPC028"
                     /inference="alignment:Splign:2.1.0"
     exon            159..223
                     /gene="Bzw2"
                     /gene_synonym="1110001I24Rik; 5mp1; Bdm2; HSPC028"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1425
                     /gene="Bzw2"
                     /gene_synonym="1110001I24Rik; 5mp1; Bdm2; HSPC028"
                     /note="basic leucine zipper and W2 domain-containing
                     protein 2; brain development-related molecule 2"
                     /codon_start=1
                     /product="eIF5-mimic protein 1"
                     /protein_id="NP_080116.2"
                     /db_xref="CCDS:CCDS25884.1"
                     /db_xref="GeneID:66912"
                     /db_xref="MGI:MGI:1914162"
                     /translation="MNKHQKPVLTGQRFKTRKRDEKEKFEPTVFRDTLVQGLNEAGDD
                     LEAVAKFLDSTGSRLDYRRYADTLFDILVAGSMLAPGGTRIDDGDKTKMTNHCVFSAN
                     EDHETIRNYAQVFNKLIRRYKYLEKAFEDEMKKLLLFLKAFSEAEQTKLAMLSGILLG
                     NGTLPATILTSLFTDSLVKEGIAASFAVKLFKAWMAEKDANSVTSSLRKANLDKRLLE
                     LFPVNRQSVDHFAKYFTDAGLKELSDFLRVQQSLGTRKELQKELQERLSQECPIKEVV
                     LYVKEEMKRNDLPETAVIGLLWTCIMNAVEWNKKEELVAEQALKHLKQYAPLLAVFSS
                     QGQSELVLLQKVQEYCYDNIHFMKAFQKIVVLFYKADVLSEEAILKWYKEAHAAKGKS
                     VFLDQMKKFVEWLQNAEEESESEGEES"
     exon            224..400
                     /gene="Bzw2"
                     /gene_synonym="1110001I24Rik; 5mp1; Bdm2; HSPC028"
                     /inference="alignment:Splign:2.1.0"
     exon            401..504
                     /gene="Bzw2"
                     /gene_synonym="1110001I24Rik; 5mp1; Bdm2; HSPC028"
                     /inference="alignment:Splign:2.1.0"
     exon            505..570
                     /gene="Bzw2"
                     /gene_synonym="1110001I24Rik; 5mp1; Bdm2; HSPC028"
                     /inference="alignment:Splign:2.1.0"
     exon            571..706
                     /gene="Bzw2"
                     /gene_synonym="1110001I24Rik; 5mp1; Bdm2; HSPC028"
                     /inference="alignment:Splign:2.1.0"
     exon            707..816
                     /gene="Bzw2"
                     /gene_synonym="1110001I24Rik; 5mp1; Bdm2; HSPC028"
                     /inference="alignment:Splign:2.1.0"
     exon            817..987
                     /gene="Bzw2"
                     /gene_synonym="1110001I24Rik; 5mp1; Bdm2; HSPC028"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1134
                     /gene="Bzw2"
                     /gene_synonym="1110001I24Rik; 5mp1; Bdm2; HSPC028"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1273
                     /gene="Bzw2"
                     /gene_synonym="1110001I24Rik; 5mp1; Bdm2; HSPC028"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1396
                     /gene="Bzw2"
                     /gene_synonym="1110001I24Rik; 5mp1; Bdm2; HSPC028"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1871
                     /gene="Bzw2"
                     /gene_synonym="1110001I24Rik; 5mp1; Bdm2; HSPC028"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1846..1851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bzw2"
                     /gene_synonym="1110001I24Rik; 5mp1; Bdm2; HSPC028"
                     /note="hexamer: AATAAA"
     polyA_site      1867
                     /gene="Bzw2"
                     /gene_synonym="1110001I24Rik; 5mp1; Bdm2; HSPC028"
                     /note="major polyA site"
ORIGIN      
        1 ggggcaggag gcggagctac accgggttct gtgtgtctgt gtcaatgtgt ctgtccttca
       61 ctcctccatt gtctgcctca gccactgccg ccgccactgc tgctgcagga tccgccgcag
      121 ccaccagtct cgcgcgtcgt cgctccctcc ttggacagta attttatgaa taagcatcag
      181 aagccagtac taacaggcca gcggttcaaa acccggaaaa gggatgaaaa agagaaattc
      241 gaacccacag ttttcaggga tacacttgtc caggggctta atgaagctgg tgatgacctt
      301 gaagctgtag ccaaattttt ggattctact ggctcacgat tagattaccg tcgctatgca
      361 gacacactct ttgatatcct ggtggctggc agtatgcttg cccctggagg aacacgcata
      421 gacgatggtg acaagaccaa gatgaccaac cactgtgtgt tttcagcaaa tgaagatcat
      481 gaaaccatcc gaaactatgc tcaggtcttc aataaactca tcaggagata caagtatttg
      541 gaaaaggcat ttgaagatga aatgaaaaag cttctcctct tccttaaagc attttctgaa
      601 gcagagcaga caaagttggc aatgctgtct gggatcctgc tgggcaatgg gaccctccca
      661 gccaccatcc tcaccagtct cttcacagac agcttagtca aagaaggcat cgcagcctca
      721 ttcgctgtca agcttttcaa agcctggatg gcagagaaag atgccaattc tgttacctct
      781 tcactgagaa aagccaactt agacaagagg ctgcttgaac tcttcccagt gaacagacag
      841 agtgtggatc atttcgctaa gtacttcact gacgcggggc tgaaggagct gtcggacttt
      901 ctccgagtcc agcagtcgct gggcaccagg aaagaactgc agaaggagct gcaagagcga
      961 ctgtctcagg aatgccccat caaggaggtg gtgctttacg tcaaagagga aatgaaaagg
     1021 aacgaccttc cggaaacagc tgtgatcggg ctgctgtgga cctgcatcat gaatgcggtg
     1081 gaatggaaca agaaggagga gctggttgcg gagcaggcac tgaagcacct aaagcaatac
     1141 gctccgctgc tggccgtgtt cagttcccaa ggccagtccg agctcgtcct cctgcagaag
     1201 gttcaggaat actgctacga caacatccac ttcatgaagg ccttccagaa gatcgtggtt
     1261 ctcttttata aagccgacgt tctgagcgaa gaggcgatac tgaagtggta taaagaagca
     1321 cacgccgcca aaggcaagag cgtctttctt gaccagatga agaaatttgt ggagtggtta
     1381 caaaatgcag aagaagaatc tgaatcagaa ggcgaagaaa gctaaatgtc tccagcacac
     1441 tgcctaaaaa agaaaaaaaa aattaaaacg ccacactttt cggttgggaa tgctgaagcg
     1501 tttggggagg gaaacttggc ttctgtttgc accaaggaaa taaatgatag gcgaggcctc
     1561 ccccgctccc cggggaaggc atttttttca tttctgtttt gtttcaatgg agccctgagg
     1621 cgtcggctac tacacttggg actctacctc tcactgtacg ctaactaaag ccattcaaca
     1681 agggggtcag gtaggaacct gaagctcaaa actcagtaca cccctttttt tagctgtatt
     1741 ttcaggtact gtgtgaacgc cccactggtg tctatgttac agggccactt caatagttgt
     1801 gtttcttctg ctcgtgtatg tgatttgaca aaccagtttt tttaaaataa acggcttttt
     1861 aaaaatcctt gaaaaaaaaa aaaaaaaaa
//
