LOCUS       NP_080116                419 aa            linear   ROD 30-APR-2024
DEFINITION  eIF5-mimic protein 1 [Mus musculus].
ACCESSION   NP_080116
VERSION     NP_080116.2
DBSOURCE    REFSEQ: accession NM_025840.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 419)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 419)
  AUTHORS   Wang,M., He,T., Meng,D., Lv,W., Ye,J., Cheng,L. and Hu,J.
  TITLE     BZW2 Modulates Lung Adenocarcinoma Progression through
            Glycolysis-Mediated IDH3G Lactylation Modification
  JOURNAL   J Proteome Res 22 (12), 3854-3865 (2023)
   PUBMED   37955350
  REMARK    GeneRIF: BZW2 Modulates Lung Adenocarcinoma Progression through
            Glycolysis-Mediated IDH3G Lactylation Modification.
REFERENCE   3  (residues 1 to 419)
  AUTHORS   Zhang,J., Pi,S.B., Zhang,N., Guo,J., Zheng,W., Leng,L., Lin,G. and
            Fan,H.Y.
  TITLE     Translation regulatory factor BZW1 regulates preimplantation embryo
            development and compaction by restricting global non-AUG Initiation
  JOURNAL   Nat Commun 13 (1), 6621 (2022)
   PUBMED   36333315
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 419)
  AUTHORS   Shen,Z.J., Hu,J., O'Neal,M.A. and Malter,J.S.
  TITLE     Pin1 Regulates IL-5 Induced Eosinophil Polarization and Migration
  JOURNAL   Cells 10 (2), 211 (2021)
   PUBMED   33494375
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 419)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 419)
  AUTHORS   Tachikawa,K., Sasaki,S., Maeda,T. and Nakajima,K.
  TITLE     Identification of molecules preferentially expressed beneath the
            marginal zone in the developing cerebral cortex
  JOURNAL   Neurosci Res 60 (2), 135-146 (2008)
   PUBMED   18055048
REFERENCE   7  (residues 1 to 419)
  AUTHORS   Gallardo,T.D., John,G.B., Shirley,L., Contreras,C.M., Akbay,E.A.,
            Haynie,J.M., Ward,S.E., Shidler,M.J. and Castrillon,D.H.
  TITLE     Genomewide discovery and classification of candidate ovarian
            fertility genes in the mouse
  JOURNAL   Genetics 177 (1), 179-194 (2007)
   PUBMED   17660561
  REMARK    GeneRIF: Transcripts highly enriched in ovary; gene identified as
            candidate female fertility factor.
REFERENCE   8  (residues 1 to 419)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   9  (residues 1 to 419)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   10 (residues 1 to 419)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY009345.1, AK160544.1 and BQ032572.1.
            
            On Jun 19, 2003 this sequence version replaced NP_080116.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003229.1, BC013060.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 16.42 cM"
     Protein         1..419
                     /product="eIF5-mimic protein 1"
                     /note="basic leucine zipper and W2 domain-containing
                     protein 2; brain development-related molecule 2"
                     /calculated_mol_wt=47932
     Region          1..22
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VK1.1)"
     Site            117
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y6E2; propagated from
                     UniProtKB/Swiss-Prot (Q91VK1.1)"
     Region          218..408
                     /region_name="W2_eIF5C_like"
                     /note="C-terminal W2 domain of the eukaryotic translation
                     initiation factor 5C and similar proteins; cd11560"
                     /db_xref="CDD:211398"
     Site            412
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q91VK1.1)"
     Site            414
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y6E2; propagated from
                     UniProtKB/Swiss-Prot (Q91VK1.1)"
     Site            419
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9WTT7; propagated from
                     UniProtKB/Swiss-Prot (Q91VK1.1)"
     CDS             1..419
                     /gene="Bzw2"
                     /gene_synonym="1110001I24Rik; 5mp1; Bdm2; HSPC028"
                     /coded_by="NM_025840.3:166..1425"
                     /db_xref="CCDS:CCDS25884.1"
                     /db_xref="GeneID:66912"
                     /db_xref="MGI:MGI:1914162"
ORIGIN      
        1 mnkhqkpvlt gqrfktrkrd ekekfeptvf rdtlvqglne agddleavak fldstgsrld
       61 yrryadtlfd ilvagsmlap ggtriddgdk tkmtnhcvfs anedhetirn yaqvfnklir
      121 rykylekafe demkklllfl kafseaeqtk lamlsgillg ngtlpatilt slftdslvke
      181 giaasfavkl fkawmaekda nsvtsslrka nldkrllelf pvnrqsvdhf akyftdaglk
      241 elsdflrvqq slgtrkelqk elqerlsqec pikevvlyvk eemkrndlpe tavigllwtc
      301 imnavewnkk eelvaeqalk hlkqyaplla vfssqgqsel vllqkvqeyc ydnihfmkaf
      361 qkivvlfyka dvlseeailk wykeahaakg ksvfldqmkk fvewlqnaee esesegees
//
