LOCUS       NM_025824               3877 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus basic leucine zipper and W2 domains 1 (Bzw1), mRNA.
ACCESSION   NM_025824 XM_986817
VERSION     NM_025824.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3877)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3877)
  AUTHORS   Qi,H., Zheng,Z. and Liu,Q.
  TITLE     Activation of BZW1 by CEBPB in macrophages promotes eIF2alpha
            phosphorylation-mediated metabolic reprogramming and endoplasmic
            reticulum stress in MRL/lpr lupus-prone mice
  JOURNAL   Cell Mol Biol Lett 28 (1), 79 (2023)
   PUBMED   37828427
  REMARK    GeneRIF: Activation of BZW1 by CEBPB in macrophages promotes
            eIF2alpha phosphorylation-mediated metabolic reprogramming and
            endoplasmic reticulum stress in MRL/lpr lupus-prone mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3877)
  AUTHORS   Zhang,J., Pi,S.B., Zhang,N., Guo,J., Zheng,W., Leng,L., Lin,G. and
            Fan,H.Y.
  TITLE     Translation regulatory factor BZW1 regulates preimplantation embryo
            development and compaction by restricting global non-AUG Initiation
  JOURNAL   Nat Commun 13 (1), 6621 (2022)
   PUBMED   36333315
  REMARK    GeneRIF: Translation regulatory factor BZW1 regulates
            preimplantation embryo development and compaction by restricting
            global non-AUG Initiation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3877)
  AUTHORS   Shen,Z.J., Hu,J., O'Neal,M.A. and Malter,J.S.
  TITLE     Pin1 Regulates IL-5 Induced Eosinophil Polarization and Migration
  JOURNAL   Cells 10 (2), 211 (2021)
   PUBMED   33494375
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3877)
  AUTHORS   Yu,M., Sha,H., Gao,Y., Zeng,H., Zhu,M. and Gao,X.
  TITLE     Alternative 3' UTR polyadenylation of Bzw1 transcripts display
            differential translation efficiency and tissue-specific expression
  JOURNAL   Biochem Biophys Res Commun 345 (1), 479-485 (2006)
   PUBMED   16690031
REFERENCE   6  (bases 1 to 3877)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3877)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3877)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ085444.1, AC121091.10, AK076560.1 and AK161192.1.
            
            On Feb 1, 2019 this sequence version replaced NM_025824.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167074.1, AK151919.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               CJ085444.1         3-175
            174-174             AC121091.10        73455-73455
            175-238             CJ085444.1         177-240
            239-1782            AK076560.1         2-1545
            1783-2733           AK161192.1         1543-2493
            2734-3050           AK076560.1         2500-2816
            3051-3877           AC121091.10        86912-87738
FEATURES             Location/Qualifiers
     source          1..3877
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 29.09 cM"
     gene            1..3877
                     /gene="Bzw1"
                     /gene_synonym="1200015E15Rik; mKIAA0005"
                     /note="basic leucine zipper and W2 domains 1"
                     /db_xref="GeneID:66882"
                     /db_xref="MGI:MGI:1914132"
     exon            1..319
                     /gene="Bzw1"
                     /gene_synonym="1200015E15Rik; mKIAA0005"
                     /inference="alignment:Splign:2.1.0"
     exon            320..393
                     /gene="Bzw1"
                     /gene_synonym="1200015E15Rik; mKIAA0005"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..1589
                     /gene="Bzw1"
                     /gene_synonym="1200015E15Rik; mKIAA0005"
                     /note="basic leucine zipper and W2 domain-containing
                     protein 1"
                     /codon_start=1
                     /product="eIF5-mimic protein 2"
                     /protein_id="NP_080100.1"
                     /db_xref="CCDS:CCDS14971.1"
                     /db_xref="GeneID:66882"
                     /db_xref="MGI:MGI:1914132"
                     /translation="MNNQKQQKPTLSGQRFKTRKRDEKERFDPTQFQDCIIQGLTETG
                     TDLEAVAKFLDASGAKLDYRRYAETLFDILVAGGMLAPGGTLADDMMRTDVCVFAAQE
                     DLETMQAFAQVFNKLIRRYKYLEKGFEDEVKKLLLFLKGFSESERNKLAMLTGVLLAN
                     GTLNASILNSLYNENLVKEGVSAAFAVKLFKSWINEKDINAVAASLRKVSMDNRLMEL
                     FPANKQSVEHFTKYFTEAGLKELSEYVRNQQTIGARKELQKELQEQMSRGDPFKDIIL
                     YVKEEMKKNNIPEPVVIGIVWSSVMSTVEWNKKEELVAEQAIKHLKQYSPLLAAFTTQ
                     GQSELTLLLKIQEYCYDNIHFMKAFQKIVVLFYKAEVLSEEPILKWYKDAHVAKGKSV
                     FLEQMKKFVEWLKNAEEESESEAEEGD"
     exon            394..570
                     /gene="Bzw1"
                     /gene_synonym="1200015E15Rik; mKIAA0005"
                     /inference="alignment:Splign:2.1.0"
     exon            571..665
                     /gene="Bzw1"
                     /gene_synonym="1200015E15Rik; mKIAA0005"
                     /inference="alignment:Splign:2.1.0"
     exon            666..731
                     /gene="Bzw1"
                     /gene_synonym="1200015E15Rik; mKIAA0005"
                     /inference="alignment:Splign:2.1.0"
     exon            732..867
                     /gene="Bzw1"
                     /gene_synonym="1200015E15Rik; mKIAA0005"
                     /inference="alignment:Splign:2.1.0"
     exon            868..977
                     /gene="Bzw1"
                     /gene_synonym="1200015E15Rik; mKIAA0005"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1148
                     /gene="Bzw1"
                     /gene_synonym="1200015E15Rik; mKIAA0005"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1295
                     /gene="Bzw1"
                     /gene_synonym="1200015E15Rik; mKIAA0005"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1434
                     /gene="Bzw1"
                     /gene_synonym="1200015E15Rik; mKIAA0005"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1557
                     /gene="Bzw1"
                     /gene_synonym="1200015E15Rik; mKIAA0005"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..3877
                     /gene="Bzw1"
                     /gene_synonym="1200015E15Rik; mKIAA0005"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3054..3059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bzw1"
                     /gene_synonym="1200015E15Rik; mKIAA0005"
                     /note="hexamer: AATAAA"
     polyA_site      3076
                     /gene="Bzw1"
                     /gene_synonym="1200015E15Rik; mKIAA0005"
                     /note="major polyA site"
     regulatory      3853..3858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bzw1"
                     /gene_synonym="1200015E15Rik; mKIAA0005"
                     /note="hexamer: AATAAA"
     polyA_site      3877
                     /gene="Bzw1"
                     /gene_synonym="1200015E15Rik; mKIAA0005"
                     /note="major polyA site"
ORIGIN      
        1 ggaggccggc cgctgcggcg gaggaagggg gacgggctac cctggtacaa gagtcagggc
       61 agcctggggc tttagggtgg gacagagacg cctaccaccg cggtgttagc cggtgccccc
      121 gagctgcaac cccgcggcct tcggcagggg ggagtgcgaa ctggcgcagg gtagaaatct
      181 cgcgatagca ggcctccggg gcgggggtgg cgcctcttcc tcccctcctg ctcgcgttag
      241 ttccggtcgc agaggagaca gcgccgcagt tgccgccagc tcggggattt ctggctcttt
      301 tctcttcgcc ttaaattcgg gtgtctttta tgaataatca aaagcagcaa aaaccaacgc
      361 tatcaggcca gcgttttaaa accagaaaaa gagatgaaaa agagaggttt gaccctactc
      421 agtttcaaga ctgtattatt caaggcttaa ctgaaactgg tactgatttg gaagcagtag
      481 ctaagtttct tgatgcttct ggagcaaaac ttgactaccg ccgctatgca gaaacactct
      541 ttgacattct ggtggctggc ggaatgctgg ccccgggtgg tacactggca gatgacatga
      601 tgcgcacaga tgtctgtgtg ttcgcagcac aagaagacct agagaccatg caagcattcg
      661 ctcaggtttt taacaagcta atcaggcgct acaaatacct ggagaaaggt tttgaagatg
      721 aagttaaaaa gttactgctc ttcctaaagg ggttttcaga gtcggagagg aacaagcttg
      781 ccatgttgac tggtgtcctt ctggctaatg gaacccttaa tgcatccatt cttaacagcc
      841 tttataatga gaatttggtt aaagaagggg tttcagcagc ttttgctgta aagctcttta
      901 aatcatggat aaatgaaaaa gacatcaatg cagttgctgc gagtcttcgg aaagtcagca
      961 tggacaacag actgatggag ctgttccctg ccaataaaca aagtgttgag catttcacta
     1021 agtatttcac tgaggcgggc ttgaaggagc tttcagagta tgtccgtaac cagcagacca
     1081 ttggggcacg gaaggagctc caaaaggagc tgcaggagca gatgtcccgt ggggacccat
     1141 tcaaggacat aattttatat gtcaaggagg agatgaaaaa aaataacatt ccagaaccag
     1201 tggtcattgg gatagtctgg tccagtgtga tgagcaccgt ggagtggaac aaaaaagagg
     1261 agcttgtagc agagcaagcc atcaagcact tgaagcaata cagccctctc cttgctgcct
     1321 tcactactca aggtcagtct gagctgaccc tgctactgaa gatccaggag tattgctatg
     1381 acaacattca cttcatgaag gccttccaga aaatagtggt gcttttttat aaagctgagg
     1441 tcctgagtga agagcccatt ctgaagtggt ataaagacgc acatgttgca aagggcaaaa
     1501 gtgtcttcct tgagcaaatg aagaagtttg tagaatggct caaaaatgct gaggaggaat
     1561 ctgagtctga agctgaagaa ggtgactgaa ttttgaaaca acatcctcag taaagcaaac
     1621 aggagttgta gataaaatgt catgtctcat gtgtcctggt tcttacatct tcctacctcc
     1681 ctatatcaag catgatataa gggctttcat ggcaattttt attttaactg tttttatggt
     1741 tactggaaat gttggctttg gtttctgaaa ccacgtgtga ggagcaagct gcaggagccg
     1801 tagaattgaa tctgatgttg cattggtttt cagttacctt ctacctcctg tattttctac
     1861 tgtaataatg tgatgtaagg ccttccgcaa tgagcagttc actttattcc ctgggttttc
     1921 tatataaaca gttttcaaga tatgatttgg ttaaaaataa tttgttacaa aaagattctg
     1981 tttgcaaatt aaactgtaaa agtattcaaa gtctcaaagg gcaatgattt gtgtgataac
     2041 ttagtgtgtc cagagccctg ttcatcagtg aaaatcctgt agatgattga atccataaca
     2101 tgaaccctga cgttggttat atgtgagcat tttcttatat tcttaacccc agatgtttga
     2161 tttctgggta tcatccttag taaagccatg gagagcaaac ttgagtttga gaactacatg
     2221 tggcagaggt aggaagaagg aagctgagtc tttttctgga aacttctagg ttcatttgta
     2281 tctttccagg tagaacaggt tgataactcc tcacacaaac gttctacccc aggatacagc
     2341 tagactgtta taagagttcc cacaaggact gaatcaagga aatgtcttgt cactaaacca
     2401 tacgattgtt gagtgttttg ggtgagcgtg ttctaacagg atctctgtac gactccattt
     2461 tcctttgtga aggtgaagga cagtcattcg cggtctgcca ttcagttgtc tgggcctggc
     2521 ctcattctac tatagtcaag cacctagtaa ctcaccctag ttgccatttt cttaaattgc
     2581 catgagccaa atacttcaat tgattaatcc atttatttta acggctgcct tcgttgcttt
     2641 tctttttgct atccatttat agttagtagt ggaagatgta gccacctttt ttgggaaagg
     2701 ctaaaagtga acattttgaa agtttttttt tttaattggt aaaaaaaaaa tagtaagaga
     2761 ataatgccac cagagacttt agtggacatt gcccattttg aaggtgccat tcttagaagc
     2821 caagaatttg gtatttaaag tttatcttga gagaataacc tgtaatataa tttgaaataa
     2881 aggtatagta accttaagag cactgtagca aaaacattgg tgggtggggt gaatttgtaa
     2941 aatgaatgac tttgataaag ttttatgcac aggcaaatgt attcattaga ttctgtgtag
     3001 tgatctgctt tccctttgta atttgtagtc ctaaaaagat tttttttttt taaaataaag
     3061 tccatccttg catttaggtt ttatagatca gtctttttat tcccacccct cccccagtcg
     3121 cattgatccc taatggtgtg ctgtatgtcc tgctttcaga tgtcaactgt gtataaacat
     3181 tagtaacaat ttgtccatag aacttgcaga ctaaacacct cacagattcc aatgtagcta
     3241 aaactacatt gccatttcta caaccagatc cttgcatgtt aaccgtcgtt caaaacgcac
     3301 cgtttattat atactgtgta tagtgaaaga gtgtgtagtc ttccagaact acattatgat
     3361 ctttgatcat tgatctttcc cccccccttt atacacagta gtgtttaatt agtatagtag
     3421 cacacgagta aggcacctgt gagtacaatg taaagaaagg gatttatgaa attattctca
     3481 ttttaagttt aaatgccaac ctatcgcctc caatatgtaa ttcttaatgg agatgttaaa
     3541 actgtactct gaatcatgat tggataactg ttgattgaat tcctaacttg gtgtcagttt
     3601 ctaaggcctt tagtgtcttg gatattctac tgtgtgttta gaactgttaa gtgtcacctt
     3661 attctgggat tattgtccta gaaatattct gttcttataa aattttcaga taccaaaatg
     3721 ccacatactt tactcagcat aatgattgat ggtgagggga aatgcatgtg accaagtaat
     3781 taacttataa cagtgttcaa gctttttcca ttatccaaac cccccagaaa ccttttcccc
     3841 taatagcacc ccaataaatt ttaatataga tatacta
//
