LOCUS       NM_016859               3854 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus bystin-like (Bysl), mRNA.
ACCESSION   NM_016859
VERSION     NM_016859.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3854)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3854)
  AUTHORS   Lin,R., Flerova,E., Wamsley,C.E., McCue,P.A., Lallas,C.D.,
            Jiang,W., Huang,J., Wang,Z.X. and Li,L.
  TITLE     Sarcomatoid renal cell tumor harboring a novel BYSL::TFEB fusion
            with concurrent TFEB amplification
  JOURNAL   Genes Chromosomes Cancer 62 (6), 353-360 (2023)
   PUBMED   36704911
  REMARK    GeneRIF: Sarcomatoid renal cell tumor harboring a novel BYSL::TFEB
            fusion with concurrent TFEB amplification.
REFERENCE   3  (bases 1 to 3854)
  AUTHORS   Adachi,K., Soeta-Saneyoshi,C., Sagara,H. and Iwakura,Y.
  TITLE     Crucial role of Bysl in mammalian preimplantation development as an
            integral factor for 40S ribosome biogenesis
  JOURNAL   Mol Cell Biol 27 (6), 2202-2214 (2007)
   PUBMED   17242206
  REMARK    GeneRIF: findings provide evidence for a crucial role of Bysl as an
            integral factor for ribosome biogenesis and suggest a critical
            dependence of blastocyst formation on active translation machinery
REFERENCE   4  (bases 1 to 3854)
  AUTHORS   Aoki,R., Suzuki,N., Paria,B.C., Sugihara,K., Akama,T.O., Raab,G.,
            Miyoshi,M., Nadano,D. and Fukuda,M.N.
  TITLE     The Bysl gene product, bystin, is essential for survival of mouse
            embryos
  JOURNAL   FEBS Lett 580 (26), 6062-6068 (2006)
   PUBMED   17055491
  REMARK    GeneRIF: Bystin is expressed in luminal and glandular epithelia in
            the mouse uterus at peri-implantation stages. Targeted disruption
            of the moBysl resulted in embryonic lethality shortly after
            implantation.
REFERENCE   5  (bases 1 to 3854)
  AUTHORS   Chen,W., Bucaria,J., Band,D.A., Sutton,A. and Sternglanz,R.
  TITLE     Enp1, a yeast protein associated with U3 and U14 snoRNAs, is
            required for pre-rRNA processing and 40S subunit synthesis
  JOURNAL   Nucleic Acids Res 31 (2), 690-699 (2003)
   PUBMED   12527778
REFERENCE   6  (bases 1 to 3854)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3854)
  AUTHORS   Trachtulec,Z. and Forejt,J.
  TITLE     Synteny of orthologous genes conserved in mammals, snake, fly,
            nematode, and fission yeast
  JOURNAL   Mamm Genome 12 (3), 227-231 (2001)
   PUBMED   11252172
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143027.1 and AC139214.12.
            
            On Jan 15, 2008 this sequence version replaced NM_016859.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143027.1, AK083033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1794              AK143027.1         2-1795
            1795-1795           AC139214.12        191766-191766       c
            1796-3854           AK143027.1         1797-3855
FEATURES             Location/Qualifiers
     source          1..3854
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.63 cM"
     gene            1..3854
                     /gene="Bysl"
                     /gene_synonym="Bys; Enp1"
                     /note="bystin-like"
                     /db_xref="GeneID:53414"
                     /db_xref="MGI:MGI:1858419"
     exon            1..586
                     /gene="Bysl"
                     /gene_synonym="Bys; Enp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1632
                     /gene="Bysl"
                     /gene_synonym="Bys; Enp1"
                     /codon_start=1
                     /product="bystin"
                     /protein_id="NP_058555.3"
                     /db_xref="CCDS:CCDS50132.1"
                     /db_xref="GeneID:53414"
                     /db_xref="MGI:MGI:1858419"
                     /translation="MPKFKVTRGASNREKHAPLAEQILAGNAVRAGTREKRRGREVEE
                     EEEYVGPRLSRRILQQARQQQEELETDHGAGDRSAPPRERATRLGPGLPQDGSDEEDE
                     EWPTLEKAAKMAGVDHQAEVIVDPEDERAIEMFMNKNPPVRRTLADIIMEKLTEKQTE
                     VETVMSEVSGFPMPQLDPRVLEVYRGVREVLCKYRSGKLPKAFKVIPALSNWEQILYV
                     TEPEAWTAAAMYQATRIFASNLKERMAQRFYNLVLLPRVRDDIAEYKRLNFHLYMALK
                     KALFKPGAWFKGILIPLCESGTCTLREAIIVGSIITKCSIPVLHSSAAMLKIAEMEYS
                     GANSIFLRLLLDKKYALPYRVLDALVFHFLAFRTEKRQLPVLWHQCLLTLAQRYKADL
                     ATEQKEALLELLRLQPHPQLSPEIRRELQSAVPRDVEDGGVTME"
     exon            587..749
                     /gene="Bysl"
                     /gene_synonym="Bys; Enp1"
                     /inference="alignment:Splign:2.1.0"
     exon            750..888
                     /gene="Bysl"
                     /gene_synonym="Bys; Enp1"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1022
                     /gene="Bysl"
                     /gene_synonym="Bys; Enp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1183
                     /gene="Bysl"
                     /gene_synonym="Bys; Enp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1286
                     /gene="Bysl"
                     /gene_synonym="Bys; Enp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..3854
                     /gene="Bysl"
                     /gene_synonym="Bys; Enp1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1949
                     /gene="Bysl"
                     /gene_synonym="Bys; Enp1"
                     /note="major polyA site"
     polyA_site      2806
                     /gene="Bysl"
                     /gene_synonym="Bys; Enp1"
ORIGIN      
        1 agaacgtcat cgactcggct ccgcccccaa ggcgtccaac gggttgacag gacgccctag
       61 gctactttca tgaattctgg aaaagggtga cttggacatc cacctttcta atgagattac
      121 ctgagaattt gggggctcct gctataggtc ccgaagctct tcctgagagt aatagatgag
      181 gaacttccgg cctcctaacg ctggggggca ctgtgatctc tcagtggcct cttggcgatc
      241 ggaacacaca gcgcaagcgc agtatcggct ttttagccgg cttcacacgt gtgaacctgg
      301 tgggcaattt tttcggccaa aatgcccaaa ttcaaggtga cacgtggggc cagcaatcgg
      361 gagaagcatg cacctctggc cgagcagatc ctggctggga acgcagtgcg cgcggggacc
      421 cgagaaaaac ggcgggggcg tgaggtcgaa gaggaggaag agtatgtggg accccggcta
      481 agcagacgga ttttgcagca agccagacaa cagcaggagg agctcgaaac tgaccatggg
      541 gctggtgatc ggtcagcacc accgcgagag cgcgccacgc ggctggggcc gggattgcca
      601 caggatggat cagatgagga ggatgaggag tggcctaccc tggagaaggc agccaaaatg
      661 gccggggtgg accaccaggc agaggtgatc gtggaccctg aagatgagcg tgccattgaa
      721 atgttcatga acaagaatcc tcccgtgagg cgcaccctgg ctgatatcat catggagaag
      781 ttgacggaga agcagacaga ggtggagact gtcatgtcag aggtatcggg cttccctatg
      841 cctcagctgg atccccgggt cctggaagtt taccgaggag tccgggaggt gttatgtaag
      901 taccgcagtg ggaaactgcc caaggctttt aaggtcatcc ctgcactgtc caactgggag
      961 cagatcctct atgtcactga gcctgaggcc tggactgcag ccgccatgta tcaagccacc
     1021 aggatttttg cctctaactt gaaggagcgc atggctcagc gcttctacaa ccttgtcctg
     1081 cttccccgag tgcgagatga cattgctgaa tacaaacgac tcaactttca cctctacatg
     1141 gcgctcaaga aggccctgtt caagcctgga gcctggttca aaggaatcct gatcccactg
     1201 tgtgagtccg gcacctgtac cctccgtgaa gccatcatcg tgggcagcat catcaccaag
     1261 tgctccatcc ccgtgctgca ctccagtgcg gccatgctga agatcgcaga aatggaatac
     1321 agcggtgcca acagcatctt cctgcgcctg ctgctggata agaagtacgc attgccctac
     1381 cgcgtgctcg acgctctggt cttccacttt ctggccttcc ggacggaaaa gcgccagctg
     1441 cctgtcctct ggcaccagtg cctgctgaca ctagcgcagc gctataaggc tgacctggcc
     1501 acagagcaga aggaggccct cctggagctg cttcggctgc agccccaccc gcagctgtcc
     1561 cctgagatca ggcgtgagct tcagagcgct gtccccagag acgtggagga tggtggtgtc
     1621 accatggaat gagaacagtc acctgtgttg gcccaggggg cgcaggacca ccccaggacc
     1681 ccagctggta tagttaaaga cctaggtcaa gacactgaag ggctactatg gctgccgtgg
     1741 cctaatcctg ggcagggagg actgcatctg gttggctttc tctgccattt taggctttgg
     1801 tccctgctca cttctggaag ctaaccggag ttacctcagt tcggttcagc gaccccacaa
     1861 cccacctggc agttggtata aggtctgctc tctccagata ctgtgtaagc tcgctggggt
     1921 gcggagaaaa caggcattta tttatcgcag ctcttgtgtt ttggtccctg gaggtccctg
     1981 cctctctccc ctgtcaccca cgggagaggt gggagtcact gctggctcct ccctgtcccc
     2041 agctcagaag agcgggttct tacttcccac agaaacctca ccccacctta ttcttcaaag
     2101 ttgtgtctct agactcttgc ttcctttgtt cttcacagga aatgtatgca cacgcgcccc
     2161 tgactcctac catgacgtac agtcagggcc gactctaggg atgccagatt ctgctgccat
     2221 gttggaaagg tgtctgttgg aaaagtggca gtggttcact gtcagggaag actatattgc
     2281 aggcccttgc taggggacag tgacacaaca gaatcaggaa aaaatgggat ttcttcctag
     2341 ctatcaagca accagagctt taggctggct gagacgccag gtcaggttcc tgtgtctgca
     2401 taactaatga gcaaagaata ctgtctggtt tggttttggt tttggttttg gttttttaag
     2461 acagggtttc cctgtgtatc cctgcctgtc ctggaactca ctctgtagac caggctgacc
     2521 ttgaacttgg ccacccacct gcctgatggt tcaacttttt gagggctagg cttacaatct
     2581 ttgtattatt ttaatggcct gagaaaatct gtatgaaatt ttagtagcag ccaaccatgg
     2641 atctgtaagt ttgaggccag ccactgctgt gaaacactac ctcaccaaaa acaacaacaa
     2701 aaacccttag accattgcat cacagctgac tgacttgaag tcaccttgct gtatcacgtt
     2761 cacttttgaa aacgtgtgtc tataacaatc cagtttgtat atctgagaag gtttggtctg
     2821 ttgagttcat atttgcttac acagtagatc atcttgtaaa cattagggaa aagcaaagag
     2881 aacaaaccta gcccaaccca accaaattac tccctgagct cactcaagct ctccctccct
     2941 tcctccctcc ctcttcctct cctctcctct cccatgcagg gctgctcctt tgcagcacca
     3001 ctgaggaagg gcctgcctcc ctgctagggg aagtgcttcc agccacaccc taaccccatt
     3061 catccggttt tgttttttta atacattctg agctttgtgc ctcagcatca gatccctgag
     3121 actggagttt aaaatggtta actgctggga attgagtcca ggctctcagg agtagccagt
     3181 gctgtcgctg agccaaagtt ctgcactatg tagcacaggc tagccctctt cctctgtctg
     3241 ccctgagtgt gctaaggaag caccatgcct gatgtcgtat gaatcttagg gttctgtgta
     3301 agggtccagc cctgtctccc gatgagccct ctgggtaatg ctggctgctc cttagcgctg
     3361 taattcgtcc acaaggaaag caggccatgc tgcctaggcg gcacctttct aacccttccc
     3421 aggaaaagtg ctctgcctaa gacagctgcc tggtgccccc cagctcccac aaccccaggg
     3481 atcacaagag ccacctttat tccgaaatct ttattaaggc agcatgatag aaatgggcca
     3541 ccagcccaaa ccttgtggcc cgaggaaaga cctgtgaccc tagggcttgc cctctctcca
     3601 gatagctctg tcacctccac ggcatcgatc catcccaacc taaccctgct ctgatgaaga
     3661 tgaggtggag gggtgaggag aggaaggcgt gacccccatc ccaggctgta gcagctcctg
     3721 ggccacaaag cagtagcaga ggggaagaag ggagggaaag agcaaccgcc agggttacca
     3781 ccacttgtgg ggtacaggcc tcactgtacc ctcttacagt tgtattcaaa gcaataaatt
     3841 aaaatgacca cggc
//
