LOCUS       NM_024285               4410 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Mus musculus popeye domain cAMP effector 1 (Popdc1), transcript
            variant 2, mRNA.
ACCESSION   NM_024285
VERSION     NM_024285.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4410)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4410)
  AUTHORS   Li,H., Wang,P., Zhang,C., Zuo,Y., Zhou,Y. and Han,R.
  TITLE     Defective BVES-mediated feedback control of cAMP in muscular
            dystrophy
  JOURNAL   Nat Commun 14 (1), 1785 (2023)
   PUBMED   36997581
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4410)
  AUTHORS   Li,H., Wang,P., Hsu,E., Pinckard,K.M., Stanford,K.I. and Han,R.
  TITLE     Systemic AAV9.BVES delivery ameliorates muscular dystrophy in a
            mouse model of LGMDR25
  JOURNAL   Mol Ther 31 (2), 398-408 (2023)
   PUBMED   36433649
REFERENCE   4  (bases 1 to 4410)
  AUTHORS   Swan,A.H., Schindler,R.F.R., Savarese,M., Mayer,I., Rinne,S.,
            Bleser,F., Schanzer,A., Hahn,A., Sabatelli,M., Perna,F.,
            Chapman,K., Pfuhl,M., Spivey,A.C., Decher,N., Udd,B., Tasca,G. and
            Brand,T.
  TITLE     Differential effects of mutations of POPDC proteins on heteromeric
            interaction and membrane trafficking
  JOURNAL   Acta Neuropathol Commun 11 (1), 4 (2023)
   PUBMED   36624536
  REMARK    Erratum:[Acta Neuropathol Commun. 2023 Jul 11;11(1):114. doi:
            10.1186/s40478-023-01591-0.. PMID: 37434226]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4410)
  AUTHORS   Baldwin,T.A., Li,Y., Marsden,A.N., Rinne,S., Garza-Carbajal,A.,
            Schindler,R.F.R., Zhang,M., Garcia,M.A., Venna,V.R., Decher,N.,
            Brand,T. and Dessauer,C.W.
  TITLE     POPDC1 scaffolds a complex of adenylyl cyclase 9 and the potassium
            channel TREK-1 in heart
  JOURNAL   EMBO Rep 23 (12), e55208 (2022)
   PUBMED   36254885
REFERENCE   6  (bases 1 to 4410)
  AUTHORS   Andree,B., Fleige,A., Arnold,H.H. and Brand,T.
  TITLE     Mouse Pop1 is required for muscle regeneration in adult skeletal
            muscle
  JOURNAL   Mol Cell Biol 22 (5), 1504-1512 (2002)
   PUBMED   11839816
REFERENCE   7  (bases 1 to 4410)
  AUTHORS   Chalhoub,N., Benachenhou,N. and Vacher,J.
  TITLE     Physical and transcriptional map of the mouse Chromosome 10
            proximal region syntenic to human 6q16-q21
  JOURNAL   Mamm Genome 12 (12), 887-892 (2001)
   PUBMED   11707774
REFERENCE   8  (bases 1 to 4410)
  AUTHORS   Andree,B., Hillemann,T., Kessler-Icekson,G., Schmitt-John,T.,
            Jockusch,H., Arnold,H.H. and Brand,T.
  TITLE     Isolation and characterization of the novel popeye gene family
            expressed in skeletal muscle and heart
  JOURNAL   Dev Biol 223 (2), 371-382 (2000)
   PUBMED   10882522
REFERENCE   9  (bases 1 to 4410)
  AUTHORS   Reese,D.E. and Bader,D.M.
  TITLE     Cloning and expression of hbves, a novel and highly conserved mRNA
            expressed in the developing and adult heart and skeletal muscle in
            the human
  JOURNAL   Mamm Genome 10 (9), 913-915 (1999)
   PUBMED   10441744
REFERENCE   10 (bases 1 to 4410)
  AUTHORS   Reese,D.E., Zavaljevski,M., Streiff,N.L. and Bader,D.
  TITLE     bves: A novel gene expressed during coronary blood vessel
            development
  JOURNAL   Dev Biol 209 (1), 159-171 (1999)
   PUBMED   10208750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155715.24.
            
            On Feb 7, 2019 this sequence version replaced NM_024285.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF204174.1, BC132044.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AC155715.24        109738-109884       c
            148-384             AC155715.24        106163-106399       c
            385-509             AC155715.24        102461-102585       c
            510-697             AC155715.24        99305-99492         c
            698-806             AC155715.24        97726-97834         c
            807-974             AC155715.24        91702-91869         c
            975-1116            AC155715.24        90727-90868         c
            1117-4410           AC155715.24        73135-76428         c
FEATURES             Location/Qualifiers
     source          1..4410
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 23.47 cM"
     gene            1..4410
                     /gene="Popdc1"
                     /gene_synonym="Bves; mBVES; Pop1"
                     /note="popeye domain cAMP effector 1"
                     /db_xref="GeneID:23828"
                     /db_xref="MGI:MGI:1346013"
     exon            1..147
                     /gene="Popdc1"
                     /gene_synonym="Bves; mBVES; Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            148..384
                     /gene="Popdc1"
                     /gene_synonym="Bves; mBVES; Pop1"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1235
                     /gene="Popdc1"
                     /gene_synonym="Bves; mBVES; Pop1"
                     /note="isoform a is encoded by transcript variant 2;
                     popeye protein 1; popeye domain-containing protein 1;
                     popeye 1; blood vessel epicardial substance"
                     /codon_start=1
                     /product="popeye domain-containing protein 1 isoform a"
                     /protein_id="NP_077247.1"
                     /db_xref="CCDS:CCDS23828.1"
                     /db_xref="GeneID:23828"
                     /db_xref="MGI:MGI:1346013"
                     /translation="MNSTESIPLAQSTVAGFTSELESLTPVPSNETTCENWREIHHLV
                     FHVANVCFAVGLLIPTTLHLHMILLRVMLSLGCTLYVVWATLYRCALDVMIWNSVFLG
                     INILHLSYLLYKKRPVKIEKELGGVYHRLFEPLRVPPDLFRRLTGQFCMIQTLKRGQV
                     YATEDKTSVDDRLSILLKGRMKVSYRGHFLHNIYPCAFIDSPEFRSTQMHKGEKFQVT
                     IVADDNCRFLCWSRERLTYFLESEPFLYEIFRYLIGKDITNKLYSLNDPTLNDKKVKK
                     LEPQMSLCTQISMLEMRNSITSSSDGEDGLHHFLRGSSSTASLPMSSPQQRASAKMKP
                     IEEGVEDDDEVFVSPDALKVHQLP"
     exon            385..509
                     /gene="Popdc1"
                     /gene_synonym="Bves; mBVES; Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..697
                     /gene="Popdc1"
                     /gene_synonym="Bves; mBVES; Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..806
                     /gene="Popdc1"
                     /gene_synonym="Bves; mBVES; Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..974
                     /gene="Popdc1"
                     /gene_synonym="Bves; mBVES; Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1116
                     /gene="Popdc1"
                     /gene_synonym="Bves; mBVES; Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..4410
                     /gene="Popdc1"
                     /gene_synonym="Bves; mBVES; Pop1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1610..1615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Popdc1"
                     /gene_synonym="Bves; mBVES; Pop1"
                     /note="hexamer: ATTAAA"
     polyA_site      1634
                     /gene="Popdc1"
                     /gene_synonym="Bves; mBVES; Pop1"
                     /note="major polyA site"
     regulatory      1945..1950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Popdc1"
                     /gene_synonym="Bves; mBVES; Pop1"
                     /note="hexamer: AAGAAA"
     polyA_site      1965
                     /gene="Popdc1"
                     /gene_synonym="Bves; mBVES; Pop1"
     regulatory      4389..4394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Popdc1"
                     /gene_synonym="Bves; mBVES; Pop1"
                     /note="hexamer: AATAAA"
     polyA_site      4410
                     /gene="Popdc1"
                     /gene_synonym="Bves; mBVES; Pop1"
ORIGIN      
        1 agtcaaagcc tccgcgaacg gggagcgggc cggggccgcg ctgcctgggg acccgccgcg
       61 agcccgtcca gccaccgccg ctcgccgccg ccgccgccgt cgcaaacttt gcgcgcgccg
      121 ccgcccccgg gccccgggac gcgcaaggac ttttcaacat gaattccacg gagtccatcc
      181 cgctggcaca gtcaactgta gcaggtttta catctgagtt agaaagtctc acacccgtgc
      241 cttctaatga gaccacttgt gagaactggc gagagattca ccatctggtt tttcatgtag
      301 caaacgtttg ctttgcagtt ggtttgctaa ttcccaccac tcttcacctc catatgatac
      361 tgctcagagt gatgttgtct ctaggatgta ccctttatgt ggtctgggcc actctctacc
      421 gctgtgcctt ggatgtgatg atctggaact cggtgttctt gggtatcaat attttgcatc
      481 tttcatatct tttgtacaag aaaagaccgg tcaaaattga aaaggagctg ggtggtgtct
      541 accatcggtt gtttgaacca ctccgagtcc ctccggattt gtttagaagg ttaaccggac
      601 agttttgtat gatccagacc ttgaaaaggg gccaggttta cgccacagag gacaaaacct
      661 cagttgatga tcgtcttagt attctcctaa aaggaagaat gaaggtctcc tatcgaggac
      721 attttctgca taacatttac ccgtgtgcct ttatagattc tcccgaattc agatcaacgc
      781 agatgcacaa aggcgaaaaa ttccaggtca ccattgttgc agatgataac tgcaggttct
      841 tatgctggtc aagagaaaga ctgacttact ttctggagtc agagcctttt ctgtatgaaa
      901 tttttaggta ccttatagga aaagacatta caaataagct gtactcactg aatgacccta
      961 ctttaaatga taagaaagtt aagaagctgg agccccagat gagcctctgc acacagatct
     1021 ccatgctgga gatgaggaac agtatcacca gctccagcga cggcgaggac ggcctgcacc
     1081 actttctgcg gggctcctcc agcacggcgt ctctccccat gtcctccccg cagcagcgag
     1141 cctctgccaa gatgaagcca atcgaggaag gggtagaaga tgacgatgag gtctttgtgt
     1201 ctccagacgc actcaaagtc catcagttgc cttgagcggc atctggtgac cacgatggag
     1261 ctgccctgat gagtgagcag gagaagtccc acactctgtt gtgacctttg ggtggtttgc
     1321 ttcagtccct ccagaaggga agtgagggag ggccacagac actagctgtg tgctacctgt
     1381 cctgtcagcc agctccttgt gttagccaag ccttctgact agaccttgct ctatttttgc
     1441 agtagatata ttaatattat tttagttaat cttaaagcta tcaacacaaa caccttttcg
     1501 cttatttttc taagttgtgg cccatttctc atctctgtca tgggaattta gaacgagttg
     1561 ttcttctgat cattttaatg atgtaagttg aaatcgaggc tgacataaca ttaaaaagtt
     1621 taccttttgt tcaattgact ttttttatgg cacattttag acaaagactt gtctgttctt
     1681 gtttcccacc ccaagaccag aagtgattcc ctcactgggg ccactctcct tgttgggtgc
     1741 agatctcttg ctagtgactg cctttatctg aatgggccgt gaatgacctc atcccatgcc
     1801 atttatcagt gactctggag cctggacctg cggtaaggtg tggaagcatt tctgagctca
     1861 gtgccaactc tcagctaaac cagactttct gtcttggaat ttggagccat cttcagatac
     1921 agttaagacc ttactttaga aataaagaaa gatgggctga gtgaatatca caggctgtgg
     1981 caccagcttt cccttcagtc ggcttctggg atcacagaag cagatgtact gagccagaca
     2041 ctgtggctta cacctgtaat gccagcactt gggaggctga ggtaggagca tgaagagttt
     2101 gaggtccacc tggggtcact tagtaagact ttgtctccaa acaacagaat atttatttaa
     2161 gggccagctg tttccagaac tgtggtcaag agcaaatcca cggggcagag ctttacctga
     2221 ggccagaggc atctaaccgg agtggtgatc tgagggcctt ggtatagatc tttcattcct
     2281 gctagtcacg ttttttaggg atgtgcgata tactaggttt tgcccaaatc atttgcttca
     2341 gctgacagtg gcgcacaggc cacccagcta aggccactga ttggctagtc acgtcattca
     2401 catttgcttc atctgctcaa accaactgga acatacaagc cacccctcct gcctcccatc
     2461 atgttccata gctaagaaaa attcacttaa cagttcttaa tcttgaaaca atgaaggcag
     2521 tggtgactta gccttggctt taaggttgga gtgaccaggg ggtcactttg tccattaatc
     2581 cacataagat gtgatagggt gagtctcaat ttccatgaaa ctacttagct cactcacaca
     2641 taaggctaat ttacagtcat tctgcaaata acaccccctg agaaggcagg aatatcggat
     2701 tccactgtga ccagtcttca tgtgtggtgc ttcagcggac ttggctaccc ctgatagtag
     2761 aaaagcttac ctctgctgat ctgccaggat ctagttgagg tatttgtagt gctgggaatg
     2821 gagttgtttt aaaggcacac agttaaaagt aggtaactta gaatcattta gaaatgtgtg
     2881 tgtatcagtg tcactgataa caaagatcag aatcttgtgg cgagggatct tcagagagcc
     2941 atttagtctg agtaagaaac atgaaactat ttttaaagac ctccaaggac gacaaagaga
     3001 cttggcgaac aggagctctg agccattgaa tagccctccc acatagacct gactgcaaag
     3061 gagcagaaaa gaacaggaaa atagttccaa gttaggccta cggacaactt tagattcatt
     3121 gccacagatg agcaagtgta tttttgtata aagcatacat taatagatta aaggatactt
     3181 cctctgattt tagcattcag ttagctccga gataatgttc agaaaatgct ctgcagaagt
     3241 tattctatct gtacccccga tctttgttta aatgtcccat caagtcagtt atatgactct
     3301 agagtataat atttacacca aaggaaaatt gtcatttaga atattttgaa agcccccaga
     3361 acatttatat ttataaaaca gatattatac atatgcacag ctatgtttat cttatgttag
     3421 tcgtaatggg tgctctgtta ccttattagt gctttctgag ttctctgtcc ccacccatca
     3481 ccctgttatg ctttaacagg caggtaccat ctgtcgtctg aggcttgatg tgggtcagag
     3541 gccaccacct taggatcagg ctcaacacct atgctcctga aggttttgtg ggggctgttg
     3601 ttttcctttt ggtttttgag tttgtttgtt ggtttatttt actcaaagcc acgcgtttcc
     3661 acttcctgcc cccgattgat gccctaaaca ctgagcactt gggtgctgga agaaatcttt
     3721 aggaaaagct gatgtgacct gcatacatct ttgtccccag cgcactcaag ttggggcacg
     3781 tcctccagga aatgtcccag ctagatggtg gtggcactta gccacccagt cctgccttta
     3841 aggcttagtg cacatctcct gcagactccc agggtgccac ccttagggct cactttttac
     3901 tgaaatccat ttctcctgag cctgctatct atgccagttt cctttcccct tcccttcctt
     3961 gcttcccagc atcctttgct actgcccact agagtgttgg aattcccacc cactcggctc
     4021 agtctcgagc aagcagttga cagctctgtg gaagctagat cgcgttcatg ccttggttct
     4081 gctatccacg ggataacaca cttttttttt ttttttaata tcacagcccc ttggaacacc
     4141 ctgggtatga tgacaccgtg tgcatactat aatttaaaga aactgatcgt aagtgctctt
     4201 tataggtttt ctcttatatt tgcaagctag ttttaagata acaaatttca caagtgcttt
     4261 ctgcagacct actataggaa gcctttcagg tgccgttcac atggataaca cactcacttt
     4321 atactaaagg tgtatgtctg agtataatgt tattgttcaa attcactcca tacgttgtca
     4381 tttgattaaa taaattttta cttagaaaaa
//
