LOCUS       NM_025375               1809 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus BUD23, rRNA methyltransferase and ribosome maturation
            factor (Bud23), transcript variant 1, mRNA.
ACCESSION   NM_025375
VERSION     NM_025375.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1809)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1809)
  AUTHORS   Baxter,M., Voronkov,M., Poolman,T., Galli,G., Pinali,C., Goosey,L.,
            Knight,A., Krakowiak,K., Maidstone,R., Iqbal,M., Zi,M., Prehar,S.,
            Cartwright,E.J., Gibbs,J., Matthews,L.C., Adamson,A.D.,
            Humphreys,N.E., Rebelo-Guiomar,P., Minczuk,M., Bechtold,D.A.,
            Loudon,A. and Ray,D.
  TITLE     Cardiac mitochondrial function depends on BUD23 mediated ribosome
            programming
  JOURNAL   Elife 9, e50705 (2020)
   PUBMED   31939735
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1809)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   4  (bases 1 to 1809)
  AUTHORS   Merla,G., Ucla,C., Guipponi,M. and Reymond,A.
  TITLE     Identification of additional transcripts in the Williams-Beuren
            syndrome critical region
  JOURNAL   Hum Genet 110 (5), 429-438 (2002)
   PUBMED   12073013
REFERENCE   5  (bases 1 to 1809)
  AUTHORS   DeSilva,U., Elnitski,L., Idol,J.R., Doyle,J.L., Gan,W.,
            Thomas,J.W., Schwartz,S., Dietrich,N.L., Beckstrom-Sternberg,S.M.,
            McDowell,J.C., Blakesley,R.W., Bouffard,G.G., Thomas,P.J.,
            Touchman,J.W., Miller,W. and Green,E.D.
  TITLE     Generation and comparative analysis of approximately 3.3 Mb of
            mouse genomic sequence orthologous to the region of human
            chromosome 7q11.23 implicated in Williams syndrome
  JOURNAL   Genome Res 12 (1), 3-15 (2002)
   PUBMED   11779826
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084109.2.
            
            On May 17, 2018 this sequence version replaced NM_025375.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC117987.1, SRR13422600.1594721.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-436               AC084109.2         111526-111961       c
            437-598             AC084109.2         111016-111177       c
            599-636             AC084109.2         110886-110923       c
            637-732             AC084109.2         108251-108346       c
            733-815             AC084109.2         108075-108157       c
            816-912             AC084109.2         107736-107832       c
            913-1009            AC084109.2         106109-106205       c
            1010-1060           AC084109.2         104622-104672       c
            1061-1146           AC084109.2         103844-103929       c
            1147-1192           AC084109.2         103341-103386       c
            1193-1251           AC084109.2         103030-103088       c
            1252-1341           AC084109.2         100551-100640       c
            1342-1809           AC084109.2         99959-100426        c
FEATURES             Location/Qualifiers
     source          1..1809
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 74.97 cM"
     gene            1..1809
                     /gene="Bud23"
                     /gene_synonym="1110003N24Rik; Wbscr22"
                     /note="BUD23, rRNA methyltransferase and ribosome
                     maturation factor"
                     /db_xref="GeneID:66138"
                     /db_xref="MGI:MGI:1913388"
     exon            1..436
                     /gene="Bud23"
                     /gene_synonym="1110003N24Rik; Wbscr22"
                     /inference="alignment:Splign:2.1.0"
     exon            437..598
                     /gene="Bud23"
                     /gene_synonym="1110003N24Rik; Wbscr22"
                     /inference="alignment:Splign:2.1.0"
     CDS             551..1396
                     /gene="Bud23"
                     /gene_synonym="1110003N24Rik; Wbscr22"
                     /EC_number="2.1.1.309"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Williams-Beuren syndrome chromosomal region 22 protein
                     homolog; ribosome biogenesis methyltransferase WBSCR22;
                     bud site selection protein 23 homolog; probable 18S rRNA
                     (guanine-N(7))-methyltransferase; rRNA methyltransferase
                     and ribosome maturation factor; Williams Beuren syndrome
                     chromosome region 22"
                     /codon_start=1
                     /product="18S rRNA (guanine-N(7))-methyltransferase
                     isoform 1"
                     /protein_id="NP_079651.2"
                     /db_xref="CCDS:CCDS19732.2"
                     /db_xref="GeneID:66138"
                     /db_xref="MGI:MGI:1913388"
                     /translation="MASRSRRPEHSGPPELFYDQNEARKYVRNSRMIDIQTKMTERAL
                     ELLCLPEGQPSYLLDIGCGSGLSGDYISEEGHYWVGIDISPAMLDAALDRDTEGDLLL
                     GDMGQGVPFRPGSFDGCISISAVQWLCNANKKSDVPARRLYCFFSSLYSALVRGARAV
                     LQLYPENSEQLELITTQATRAGFTGGVVVDFPNSAKAKKFYLCLFSGPSTSLPKGLTE
                     SQDADQASESMFTSERAPHKKARRDLVKKSREWVLEKKERRRRQGKEVRPDTQYTGRK
                     RKPRF"
     exon            599..636
                     /gene="Bud23"
                     /gene_synonym="1110003N24Rik; Wbscr22"
                     /inference="alignment:Splign:2.1.0"
     exon            637..732
                     /gene="Bud23"
                     /gene_synonym="1110003N24Rik; Wbscr22"
                     /inference="alignment:Splign:2.1.0"
     exon            733..815
                     /gene="Bud23"
                     /gene_synonym="1110003N24Rik; Wbscr22"
                     /inference="alignment:Splign:2.1.0"
     exon            816..912
                     /gene="Bud23"
                     /gene_synonym="1110003N24Rik; Wbscr22"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1009
                     /gene="Bud23"
                     /gene_synonym="1110003N24Rik; Wbscr22"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1060
                     /gene="Bud23"
                     /gene_synonym="1110003N24Rik; Wbscr22"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1146
                     /gene="Bud23"
                     /gene_synonym="1110003N24Rik; Wbscr22"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1192
                     /gene="Bud23"
                     /gene_synonym="1110003N24Rik; Wbscr22"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1251
                     /gene="Bud23"
                     /gene_synonym="1110003N24Rik; Wbscr22"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1341
                     /gene="Bud23"
                     /gene_synonym="1110003N24Rik; Wbscr22"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1809
                     /gene="Bud23"
                     /gene_synonym="1110003N24Rik; Wbscr22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1789..1794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bud23"
                     /gene_synonym="1110003N24Rik; Wbscr22"
                     /note="hexamer: ATTAAA"
     polyA_site      1809
                     /gene="Bud23"
                     /gene_synonym="1110003N24Rik; Wbscr22"
                     /note="major polyA site"
ORIGIN      
        1 tagaaaggaa ggttgcttgg gctggatccc ttcccctcct tttctccgat taaatacgaa
       61 agccaacaaa gacgaagata aggaaaagga cgacaaagaa agtggcgtct cgtgtatcgt
      121 cccagctggt ccccttgttg gcctggttct cctgcttttt gcgaagggct tccctccggg
      181 cgcgcaaacg ccgttctctc tctagctgct ctccgtagtg cgcctggtag aaggcgtcaa
      241 agtcgaacat ggtgcgaccg tcgccgggag aagccctaga gccaccggga gcccgagggg
      301 tgtagggagg agggcgagga ggagcgggat cggccacggg cgtcttagag ggcttgacgc
      361 caggtccgcg caggtcctgg tcgctgagca aacctcggtc atacttgcgc cggaggatgg
      421 tgctgcccaa gaccagccaa tcaaataaaa ggaaaggcgg gggaaaaggt ccgcctgagg
      481 cgggcgcaga ttgatgacgt caaagcgtcg cgctagtgct cgccggtccc agcgttgcca
      541 taccatcgag atggcatctc gtagccggag acccgaacac agcggaccgc cggagctgtt
      601 ttatgaccag aatgaagccc ggaaatacgt tcgcaactca cggatgattg acatccagac
      661 caagatgact gagcgagcgc tggagctcct ctgtttacca gagggtcagc cttcttacct
      721 gttagacatt ggctgcggtt ctgggctgag tggagattat atctcagaag agggacacta
      781 ctgggtgggc attgacatca gccctgccat gttggatgcc gccttggacc gagatacaga
      841 gggggacctg ctgctagggg acatgggcca gggcgtccct ttcagaccgg gctcttttga
      901 tggctgcatc agcatctctg ctgtgcagtg gctctgcaac gccaacaaga agtcggacgt
      961 ccctgccagg cgcctgtact gcttcttttc ttccttgtac tctgcccttg tccgtggggc
     1021 ccgagctgtc ctgcagctgt accctgagaa ctcggagcag ctggagctga tcacaaccca
     1081 ggccacgagg gcaggcttca ctggcggcgt ggtggtagac ttccccaaca gtgccaaagc
     1141 aaagaagttc tacctctgtc tgttttctgg gccttccacc tccctgccaa aggggctgac
     1201 tgaaagtcag gatgcagacc aggcctccga gtccatgttc accagtgagc gggccccaca
     1261 caagaaggca cggagggacc tggtgaagaa gagccgggaa tgggtcctag agaagaagga
     1321 gaggcgcagg cgccagggca aggaggtcag acctgacacc cagtacaccg gccgaaagcg
     1381 caagccccgc ttctgagtgc gctgtatcta atcaattgga gatagagcct ggccacccac
     1441 acctgcagcc agtcctgcag ccgtcctggc cacccactct gttcagagag tgggagctgc
     1501 ccagcccggg acctgcctct ggggaattct ctggactgaa ctgtttacct cagcagctag
     1561 caacatagta ttttagaaaa gttgggaggc tctcaaaata ttttttcact aaaagagttc
     1621 cagggatctg ggtttggcag ctcagatcct gtaatcccaa caccctcctg ggagtctgag
     1681 acaagaagat ggaaagttcc aggccagtct gggcaacaca gcaaaaacct gtcttacaaa
     1741 aacaaaaaga aaagaatttc taaggatgct ttattttgtc ctaaatgcat taaatgactt
     1801 tctaagtaa
//
