LOCUS       NM_146000               2208 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus BUD13 homolog (Bud13), mRNA.
ACCESSION   NM_146000
VERSION     NM_146000.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2208)
  AUTHORS   Zhuang,S., Lu,W., Shen,L., Huang,Z., Zhang,X. and Zhang,Y.
  TITLE     RNASEH1-AS1 induced by H3K27ac stabilizes ANXA2 mRNA to promote the
            progression of colorectal cancer through recruiting BUD13
  JOURNAL   Neoplasma 70 (5), 597-609 (2023)
   PUBMED   38053379
  REMARK    GeneRIF: RNASEH1-AS1 induced by H3K27ac stabilizes ANXA2 mRNA to
            promote the progression of colorectal cancer through recruiting
            BUD13.
REFERENCE   2  (bases 1 to 2208)
  AUTHORS   Liu,M., Ruan,X., Liu,X., Dong,W., Wang,D., Yang,C., Liu,L.,
            Wang,P., Zhang,M. and Xue,Y.
  TITLE     The mechanism of BUD13 m6A methylation mediated
            MBNL1-phosphorylation by CDK12 regulating the vasculogenic mimicry
            in glioblastoma cells
  JOURNAL   Cell Death Dis 13 (12), 1017 (2022)
   PUBMED   36463205
  REMARK    GeneRIF: The mechanism of BUD13 m6A methylation mediated
            MBNL1-phosphorylation by CDK12 regulating the vasculogenic mimicry
            in glioblastoma cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2208)
  AUTHORS   Frankiw,L., Majumdar,D., Burns,C., Vlach,L., Moradian,A.,
            Sweredoski,M.J. and Baltimore,D.
  TITLE     BUD13 Promotes a Type I Interferon Response by Countering Intron
            Retention in Irf7
  JOURNAL   Mol Cell 73 (4), 803-814 (2019)
   PUBMED   30639243
  REMARK    GeneRIF: BUD13 is a protein that has the ability to increase
            splicing of the Irf7 intron. BUD13 depletion compromises type I
            interferon response by countering intron retention in Irf7.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC164105.4.
            
            On Nov 17, 2006 this sequence version replaced NM_146000.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025490.1, AK038126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AC164105.4         161899-162060       c
            163-253             AC164105.4         158639-158729       c
            254-338             AC164105.4         157971-158055       c
            339-1112            AC164105.4         156637-157410       c
            1113-1330           AC164105.4         154729-154946       c
            1331-1433           AC164105.4         153662-153764       c
            1434-1572           AC164105.4         153239-153377       c
            1573-1757           AC164105.4         152822-153006       c
            1758-1839           AC164105.4         152543-152624       c
            1840-2208           AC164105.4         146289-146657       c
FEATURES             Location/Qualifiers
     source          1..2208
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 25.38 cM"
     gene            1..2208
                     /gene="Bud13"
                     /gene_synonym="D030060M11Rik"
                     /note="BUD13 homolog"
                     /db_xref="GeneID:215051"
                     /db_xref="MGI:MGI:2443443"
     exon            1..162
                     /gene="Bud13"
                     /gene_synonym="D030060M11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1933
                     /gene="Bud13"
                     /gene_synonym="D030060M11Rik"
                     /codon_start=1
                     /product="BUD13 homolog"
                     /protein_id="NP_666112.1"
                     /db_xref="CCDS:CCDS23145.1"
                     /db_xref="GeneID:215051"
                     /db_xref="MGI:MGI:2443443"
                     /translation="MAAAPPLTKAEYLKRYLSGTDAGLEGGPEAGRKRRKKRPKPGGA
                     GGKGMRIVDDDVGWAAISTAKPEKEEEEDGDLPVVAEFVDERPEEVKQMEAFRSSAKW
                     KLLGGHGEDGHFHHDDQDSSPPRRVRHDTPDTSPPRKARHDTPDPSPPRKARHDTPDT
                     SPPRKARHDTPDPSPPRKARHDTPDPSPPRRVRHDTPDLSPPRRVRHDTPDLSPPRRV
                     RHDTPDPSPPRRVRHDLDASPPRKSHRNSSAVSPRRGHHGSLGTSSPRQTHNHSPTAA
                     QHRRTLDSSGTQHLRRAHHESPDLELHKAKSSKAAERAPSKAASQSGLGPSHPSLSTN
                     SKYEHDSDLSPPRKRQAKAHFEAKKQLDSKGVYQKASDSDLSPPRKKKNSGHQDSDSD
                     LSPPRNRPRRQSSDSDLSPPRRRQRTKSSDSDLSPPRRSPRPGKKTAHMYSGAKTGLV
                     TDVQREHQELKKQDQDTTDLGAQFEFTETVFRDKSGRKRNLKLERLEQRRKAEKDSER
                     DELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQEREGDPMANF
                     IKKNKAKENKNKKVKPRYSGPAPPPNRFNIWPGYRWDGVDRSNGFEQKRFARLASKKA
                     VEELAYKWSVEDM"
     exon            163..253
                     /gene="Bud13"
                     /gene_synonym="D030060M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            254..338
                     /gene="Bud13"
                     /gene_synonym="D030060M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            339..1112
                     /gene="Bud13"
                     /gene_synonym="D030060M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1330
                     /gene="Bud13"
                     /gene_synonym="D030060M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1433
                     /gene="Bud13"
                     /gene_synonym="D030060M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1572
                     /gene="Bud13"
                     /gene_synonym="D030060M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1757
                     /gene="Bud13"
                     /gene_synonym="D030060M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1839
                     /gene="Bud13"
                     /gene_synonym="D030060M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..2208
                     /gene="Bud13"
                     /gene_synonym="D030060M11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2182..2187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bud13"
                     /gene_synonym="D030060M11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2208
                     /gene="Bud13"
                     /gene_synonym="D030060M11Rik"
                     /note="major polyA site"
ORIGIN      
        1 ccccgccctc gccgctgcca tggcggcagc tccgccactc accaaagctg agtatctgaa
       61 gcgttacttg tctgggacag atgctggctt ggaaggaggt cccgaggccg gtcgcaagcg
      121 gcgcaaaaaa cggccgaagc ctggaggcgc tggcggcaag ggaatgcgga ttgttgatga
      181 tgatgtgggc tgggcggcta tctctactgc taagccggaa aaggaggagg aagaggatgg
      241 agatttgcct gtggtggctg agtttgtgga tgagcgtcca gaagaggtaa agcagatgga
      301 ggccttccgc tccagtgcca agtggaagct tctgggaggc cacggtgaag atggacattt
      361 tcatcacgat gaccaagatt catctcctcc taggagggtc cgtcatgaca ccccagacac
      421 atctcctccc agaaaggccc gtcatgacac cccagaccca tctcctccca ggaaggcccg
      481 tcatgacacc ccagacacat ctcctcccag aaaggcccgt catgacaccc cagacccatc
      541 tcctcccagg aaggcccgtc atgacacccc agacccatct cctcccagga gagttcgtca
      601 tgacaccccg gatctatctc ccccaaggag agttcgtcat gacaccccgg atctatctcc
      661 tcccaggaga gtccgccatg acaccccgga tccatctcct cccaggagag tccgccatga
      721 cttagatgct tctcccccca ggaagtctca tcgtaattct tcagccgtat ctcctaggag
      781 aggccatcat ggttccttag gtacctcttc tccgagacag acccataacc actcccctac
      841 tgcagcccag catagaagga ctcttgactc ttcaggtaca cagcatctca ggagggccca
      901 tcatgagtcc cctgatttgg aactgcacaa agccaaaagt agtaaagctg cagaaagagc
      961 ccctagcaag gctgcatccc agagtgggct aggaccctct cacccatcac tctccaccaa
     1021 cagcaagtac gagcacgact ctgacctctc tcctccacgg aaacggcaag caaaggctca
     1081 ttttgaagct aagaaacagc ttgattctaa aggtgtctac caaaaagcct ctgattcaga
     1141 tctttctcct ccacggaaaa aaaaaaattc ggggcaccag gattctgatt cagatctgtc
     1201 accaccacgg aacagaccaa ggcggcagag ctctgactcc gacctctctc caccccggag
     1261 aagacagagg accaaatcct ctgattctga cctctctcca cctcgaagga gtccccgtcc
     1321 tggcaagaag actgcacaca tgtattccgg agcaaaaact gggttggtca ctgatgttca
     1381 gcgggagcac caggaactca agaaacaaga ccaggacacc acagacctcg gagcacagtt
     1441 tgaattcact gaaactgtat ttcgagacaa gtctggtcgg aagaggaatt tgaagctaga
     1501 gcgcttggaa cagaggagaa aagcagagaa agactcagag cgagatgagc tatatgccca
     1561 gtgggggaaa gggcttgccc agagccggca gcagcaacag aatgtagaag atgcaatgaa
     1621 ggagatgcag aagcctctgg cccgctacat agatgatgaa gatctggatc ggatgctgag
     1681 agaacaagaa agagaagggg acccgatggc caactttatt aagaagaata aagctaagga
     1741 gaacaagaat aagaaagtga agccccgcta cagtggtcct gctcctcctc ccaatagatt
     1801 caacatttgg cctgggtatc gctgggatgg agtggacaga tccaatggct ttgaacagaa
     1861 gcgctttgcc aggctcgcca gcaagaaggc tgtggaggag cttgcctaca agtggagtgt
     1921 ggaggatatg tgacaccacc ccccccccag gccatgtgac ccctgaggcc atgtgatgct
     1981 gtggtgctgt tagcaccagc tcacatccag ctctaaagga gtcctgctaa gagacgcaga
     2041 ccagcaagtt gctgtcagcc tgacctttgg acaggcacct aacctggctg tgccctcact
     2101 gtctgtggct ggcttgggca ggacacggtg acttctttat cccagggttt gttcttggcc
     2161 agtgttttcc tttttcttaa aaataaacac atatttattt ttttataa
//
