LOCUS       NM_009773               3669 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus BUB1B, mitotic checkpoint serine/threonine kinase
            (Bub1b), mRNA.
ACCESSION   NM_009773
VERSION     NM_009773.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3669)
  AUTHORS   Zeng,Q., Zhang,S., He,L., Fu,Q., Liao,L., Chen,L. and Ding,X.
  TITLE     Knockdown of BUB1B Inhibits the Proliferation, Migration, and
            Invasion of Colorectal Cancer by Regulating the JNK/c-Jun Signaling
            Pathway
  JOURNAL   Cancer Biother Radiopharm 39 (3), 236-246 (2024)
   PUBMED   37782908
  REMARK    GeneRIF: Knockdown of BUB1B Inhibits the Proliferation, Migration,
            and Invasion of Colorectal Cancer by Regulating the JNK/c-Jun
            Signaling Pathway.
REFERENCE   2  (bases 1 to 3669)
  AUTHORS   Sterling,N.A., Terry,B.K., McDonnell,J.M. and Kim,S.
  TITLE     P53 independent pathogenic mechanisms contribute to BubR1
            microcephaly
  JOURNAL   Front Cell Dev Biol 11, 1282182 (2023)
   PUBMED   37900274
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3669)
  AUTHORS   Mora-Bermudez,F., Kanis,P., Macak,D., Peters,J., Naumann,R.,
            Xing,L., Sarov,M., Winkler,S., Oegema,C.E., Haffner,C.,
            Wimberger,P., Riesenberg,S., Maricic,T., Huttner,W.B. and Paabo,S.
  TITLE     Longer metaphase and fewer chromosome segregation errors in modern
            human than Neanderthal brain development
  JOURNAL   Sci Adv 8 (30), eabn7702 (2022)
   PUBMED   35905187
REFERENCE   4  (bases 1 to 3669)
  AUTHORS   Yue,W., Wang,Y., Meng,T.G., Zhang,H.Y., Zhang,X.R., Ouyang,Y.C.,
            Hou,Y., Schatten,H., Wang,Z.B. and Sun,Q.Y.
  TITLE     Kinetochore scaffold 1 regulates SAC function during mouse oocyte
            meiotic maturation
  JOURNAL   FASEB J 36 (3), e22210 (2022)
   PUBMED   35167144
REFERENCE   5  (bases 1 to 3669)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3669)
  AUTHORS   Orelio,C. and Dzierzak,E.
  TITLE     Identification of 2 novel genes developmentally regulated in the
            mouse aorta-gonad-mesonephros region
  JOURNAL   Blood 101 (6), 2246-2249 (2003)
   PUBMED   12433684
REFERENCE   7  (bases 1 to 3669)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3669)
  AUTHORS   Sudakin,V., Chan,G.K. and Yen,T.J.
  TITLE     Checkpoint inhibition of the APC/C in HeLa cells is mediated by a
            complex of BUBR1, BUB3, CDC20, and MAD2
  JOURNAL   J Cell Biol 154 (5), 925-936 (2001)
   PUBMED   11535616
REFERENCE   9  (bases 1 to 3669)
  AUTHORS   Wang,X., Babu,J.R., Harden,J.M., Jablonski,S.A., Gazi,M.H.,
            Lingle,W.L., de Groen,P.C., Yen,T.J. and van Deursen,J.M.
  TITLE     The mitotic checkpoint protein hBUB3 and the mRNA export factor
            hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing
            proteins
  JOURNAL   J Biol Chem 276 (28), 26559-26567 (2001)
   PUBMED   11352911
REFERENCE   10 (bases 1 to 3669)
  AUTHORS   Davenport,J.W., Fernandes,E.R., Harris,L.D., Neale,G.A. and
            Goorha,R.
  TITLE     The mouse mitotic checkpoint gene bub1b, a novel bub1 family
            member, is expressed in a cell cycle-dependent manner
  JOURNAL   Genomics 55 (1), 113-117 (1999)
   PUBMED   9889005
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY013487.1, AK133909.1, BU054510.1 and AV315589.1.
            
            On Oct 6, 2007 this sequence version replaced NM_009773.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF107296.1, BC031577.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                BY013487.1         2-61
            61-1773             AK133909.1         2-1714
            1774-2130           BU054510.1         276-632
            2131-3663           AK133909.1         2072-3604
            3664-3669           AV315589.1         246-251
FEATURES             Location/Qualifiers
     source          1..3669
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.4 cM"
     gene            1..3669
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /note="BUB1B, mitotic checkpoint serine/threonine kinase"
                     /db_xref="GeneID:12236"
                     /db_xref="MGI:MGI:1333889"
     exon            1..251
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            252..398
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..458
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..603
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            604..800
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            801..967
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1182
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1274
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1504
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1617
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1733
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1783
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1841
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1950
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2213
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2347
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2488
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2589
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2739
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2882
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3057
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3164
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3669
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3648..3653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /note="hexamer: AATAAA"
     polyA_site      3668
                     /gene="Bub1b"
                     /gene_synonym="BUBR1"
                     /note="major polyA site"
ORIGIN      
        1 ggggagcggc gaggctacgt ctgcgtcaag agacgttaaa tttgaaactt ggcggcccgt
       61 gcgtgatggg ggcgtgagga ggctattctg agaaggaatc gggtgcgtgg ttttgtttag
      121 gagcacgggg tgacgatctt cgcagctcca gagccagctg aaggttgagg gagactcagt
      181 tagcactcgg aggataaagg tctgcggaag ggcgagagca agtattggga atgcaggatg
      241 gcggaggcga gtgaagccat gtgcctggag ggagcagagt gggagctgag taaagaaaac
      301 atacagccct tacggcacgg gcgggtcatg tccacacttc agggagcttt ggcaaagcaa
      361 gagtcagccg gccacactgc tctgcagcag cagaaacggg catttgaatc tgaaatccgc
      421 ttttactctg gagatgaccc tctggatgtg tgggacagat atattaattg gacagaacag
      481 aactaccctc aaggggggaa agagagtaac atgtcagcgt tagtggagag agcgatagaa
      541 gcactccaag gagagacgcg ctattataat gacccccgct ttctcagtct ctggatcaaa
      601 ttgggacatt tgtgcaatga acctttggat atgtacagct atttacaaag ccaaggaatt
      661 ggcgtttccc ttgcccagtt ctatatttca tgggctgaag aatacgaagc tagagaaaat
      721 ttcaagaaag cggacataat attccaggaa gggattgaac gcaaggctga gcccctggac
      781 agactgcagt cccagcacag acagttccag tctcgagtgt cgcgacaagc tttcttggcc
      841 cttgggaatg aagaggagga ggctttggag ccttctgaac cacagagaag ctcgctagct
      901 gagctgaaga gcagagggaa gaagatggcc agagcgccca tcagccgtgt cggaggtgct
      961 ctgaaagctc caggtcagag cagagggttc ctaaatgcag ttccccagcc agtacacggt
     1021 aatcgcagga tcaccgtttt tgatgaaaat gccgataccg cgtctagaac ggagttatct
     1081 aagcctgtag cccagccatg gatggcaccc cctgtgccca gggccaaaga gaacgaactt
     1141 cagccaggcc catggagcac agacaggccg gcgggacgca ggcctcatga caatccagcc
     1201 tctgtgacgt cgattcccag cgtgcttccc agctttacgc cgtacgtgga agagagcgcc
     1261 cagcagacag tcatgacacc atgcaagatt gagcctagta tcaaccatgt tctcagcacc
     1321 aggaagccag ggagagaaga aggagacccc ttgcagagag ttcagagtca tcagcaaggc
     1381 tgtgaggaga agaaggagaa gatgatgtac tgtaaggaga agatctatgc cggagttggg
     1441 gagttctcct ttgaggagat ccgagctgaa gtgttccgaa agaagctgaa agaacgaagg
     1501 gaagccgagc tgttgaccag tgcaaagaag agggaggaga tgcagaagca gatcgaagag
     1561 atggagagga ggctgaaggc aatgcaggct gttcagcaag aaggagctgg gggccagcaa
     1621 gaagagaaga tgcctacaga ggacccagcc agattgcaga ttgcttcggg gcctcaggaa
     1681 atgtcgggag ttcctctgtc ctgttccatc tgtccactaa gctcgaatcc tagggaaatt
     1741 tcacctgctg agaacatttt gcaagaacag cctgattcta aaggttccag tatgcctttc
     1801 tccatttttg atgagtctct ttcagacaaa aaggacaaaa gtcctgctac aggtggtcca
     1861 caggttctca atgcccagag aagacccctt tcagttctca aaactacaga agtgggcacc
     1921 acaaatgagg atgtgtctcc cgatatttgt gatgaactca cagaacttga gcctctgagt
     1981 gaagacgcca tcatcactgg tttcaggaac gtcactctct gtcccaaccc tgaggacact
     2041 tgtgactttg ctagagcagc tcgtttggca tctactcctt tccatgagat actgtcctcg
     2101 aagggcatcg ctgctgatcc cgagggactg ttgcaggaag aggatctgga tgggaaggcc
     2161 gccgaggctc atcacactgt tcatcaccag gccctcatca taaagaaact gagcccaatt
     2221 attgaagaga gccgtgaggc cacccactca tctggcttct ccaggtcttc ttcctcagct
     2281 cccagtacat cctccatcaa aggctttcag cttctggaaa agctggagct gactaatgac
     2341 ggggcagaag atgctattca gtcaccctgg tgttcacagt atcgcctaca actgttaaaa
     2401 tccctactag aattaagtgc ttttgcggag ttttctgtgg aagaccgacc gatgcctgtg
     2461 ctggaaatag ggaaggagat tgagttaggt cctgaggatt acgtcatcaa gcaagagcac
     2521 ctaacatgtg acgattacag gttattctgg gtggcaccaa gaagctctgc agagctaacc
     2581 atgataaagg catcatctca gcctatcccg tgggattttt atatcaacct caagttgaag
     2641 gagcgtctga atgaggacta tgaccagctt tgcagctgct gtcagtacca agatggccat
     2701 gttgtttggt accagtatat aaactgctcc acccttcaga atcttctcca acacagcgaa
     2761 tttgttactc atgaaataat agtgttgatt atttacaacc tcttgacaat cgtggagaag
     2821 ctacacagag ctgaaatagt acacggagac ttgagtccac ggagtctgat cctacgaaac
     2881 agaatccacg acccctatga ctatgtaaat aaggacgatc acgctgtgag gatcatggac
     2941 ttctcctaca gtgttgacct gagggtgcag ctggatgcgt ttgcctatag tggctttcgg
     3001 actgcacaga tcctggaagg acaaaagatc ctggctaact gttcttctcc ctaccatgta
     3061 gatctgttgg gtatagcaga cctagcgcac ttactcctgt tcaaggagca cctccatgtc
     3121 ttctgggatg gactcctctg gaaacttagc cagagcacct ctgagctaaa agacagtgaa
     3181 ttgtggaata aattctttgt gcggattctg aatgccagtg acaagtccac agtgtctgtt
     3241 ctgggggagc tggcagcaga aatgggtggg gcttttgatg ccacattcca tagccacctg
     3301 aacagagccc tgtggaagct ggggaagaca atcagcccgg aagctttgct cactcagcaa
     3361 gacaagcagc caggcggctc ccagagccct gcctaagcca tgggtatggt gaagaactgg
     3421 tctggggctg ctgtgatttg tttagagcac acttagacac atcagcagtc cttcactagg
     3481 ggtcactctc agtagcacag ctttcagcca ggtggctgtg ccctggcagc ctcatctggt
     3541 ttattcaaaa ggtttctgtg cagacagctg ctttttagcc ctctggcttc tgccttctct
     3601 cttttgtaat tttataacat gtactctcct ttcactgtgt attttataat aaaatagttt
     3661 ttgttacat
//
