LOCUS       NM_001360127            6280 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus beta-transducin repeat containing protein (Btrc),
            transcript variant 9, mRNA.
ACCESSION   NM_001360127 XM_006526608
VERSION     NM_001360127.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6280)
  AUTHORS   McCallum-Loudeac,J., Moody,E., Williams,J., Johnstone,G.,
            Sircombe,K.J., Clarkson,A.N. and Wilson,M.J.
  TITLE     Deletion of a conserved genomic region associated with adolescent
            idiopathic scoliosis leads to vertebral rotation in mice
  JOURNAL   Hum Mol Genet 33 (9), 787-801 (2024)
   PUBMED   38280229
REFERENCE   2  (bases 1 to 6280)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6280)
  AUTHORS   Joo,H.J., D'Alessandro,M., Oh,G., Han,S., Kim,W.J., Chung,G.E.,
            Jang,Y., Lee,J.B., Lee,C. and Yang,Y.
  TITLE     Novel targets of beta-TrCP cooperatively accelerate carbohydrate
            and fatty acid consumption
  JOURNAL   J Cell Physiol 239 (3), e31095 (2024)
   PUBMED   37584358
  REMARK    GeneRIF: Novel targets of beta-TrCP cooperatively accelerate
            carbohydrate and fatty acid consumption.
REFERENCE   4  (bases 1 to 6280)
  AUTHORS   Fernandez-Gines,R., Encinar,J.A., Escoll,M., Carnicero-Senabre,D.,
            Jimenez-Villegas,J., Garcia-Yague,A.J., Gonzalez-Rodriguez,A.,
            Garcia-Martinez,I., Valverde,A.M., Rojo,A.I. and Cuadrado,A.
  TITLE     Specific targeting of the NRF2/beta-TrCP axis promotes beneficial
            effects in NASH
  JOURNAL   Redox Biol 69, 103027 (2024)
   PUBMED   38184999
  REMARK    GeneRIF: Specific targeting of the NRF2/beta-TrCP axis promotes
            beneficial effects in NASH.
REFERENCE   5  (bases 1 to 6280)
  AUTHORS   Cui,M., Peng,J., Zhou,Y., Wang,X. and Cui,D.
  TITLE     Exosomal GPT2 derived from triple-negative breast cancer cells
            promotes metastasis by activating BTRC
  JOURNAL   Thorac Cancer 14 (21), 2018-2025 (2023)
   PUBMED   37287397
  REMARK    GeneRIF: Exosomal GPT2 derived from triple-negative breast cancer
            cells promotes metastasis by activating BTRC.
REFERENCE   6  (bases 1 to 6280)
  AUTHORS   Hatakeyama,S., Kitagawa,M., Nakayama,K., Shirane,M., Matsumoto,M.,
            Hattori,K., Higashi,H., Nakano,H., Okumura,K., Onoe,K., Good,R.A.
            and Nakayama,K.
  TITLE     Ubiquitin-dependent degradation of IkappaBalpha is mediated by a
            ubiquitin ligase Skp1/Cul 1/F-box protein FWD1
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3859-3863 (1999)
   PUBMED   10097128
REFERENCE   7  (bases 1 to 6280)
  AUTHORS   Maniatis,T.
  TITLE     A ubiquitin ligase complex essential for the NF-kappaB,
            Wnt/Wingless, and Hedgehog signaling pathways
  JOURNAL   Genes Dev 13 (5), 505-510 (1999)
   PUBMED   10072378
  REMARK    Review article
REFERENCE   8  (bases 1 to 6280)
  AUTHORS   Spencer,E., Jiang,J. and Chen,Z.J.
  TITLE     Signal-induced ubiquitination of IkappaBalpha by the F-box protein
            Slimb/beta-TrCP
  JOURNAL   Genes Dev 13 (3), 284-294 (1999)
   PUBMED   9990853
REFERENCE   9  (bases 1 to 6280)
  AUTHORS   Winston,J.T., Strack,P., Beer-Romero,P., Chu,C.Y., Elledge,S.J. and
            Harper,J.W.
  TITLE     The SCFbeta-TRCP-ubiquitin ligase complex associates specifically
            with phosphorylated destruction motifs in IkappaBalpha and
            beta-catenin and stimulates IkappaBalpha ubiquitination in vitro
  JOURNAL   Genes Dev 13 (3), 270-283 (1999)
   PUBMED   9990852
  REMARK    Erratum:[Genes Dev 1999 Apr 15;13(8):1050]
REFERENCE   10 (bases 1 to 6280)
  AUTHORS   Yaron,A., Hatzubai,A., Davis,M., Lavon,I., Amit,S., Manning,A.M.,
            Andersen,J.S., Mann,M., Mercurio,F. and Ben-Neriah,Y.
  TITLE     Identification of the receptor component of the
            IkappaBalpha-ubiquitin ligase
  JOURNAL   Nature 396 (6711), 590-594 (1998)
   PUBMED   9859996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123058.3, AC126454.3 and BP768842.1.
            
            On Jan 27, 2018 this sequence version replaced XM_006526608.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.228745.1,
                                           SRR9219381.174852.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC123058.3         149780-149932
            154-261             AC126454.3         23514-23621
            262-351             AC126454.3         71396-71485
            352-583             AC126454.3         103313-103544
            584-770             AC126454.3         108065-108251
            771-867             AC126454.3         113026-113122
            868-1005            AC126454.3         113768-113905
            1006-1124           AC126454.3         114389-114507
            1125-1374           AC126454.3         116239-116488
            1375-1493           AC126454.3         117396-117514
            1494-1604           AC126454.3         119190-119300
            1605-1683           AC126454.3         119823-119901
            1684-1876           AC126454.3         127645-127837
            1877-6246           AC126454.3         129354-133723
            6247-6280           BP768842.1         25-58               c
FEATURES             Location/Qualifiers
     source          1..6280
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.75 cM"
     gene            1..6280
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /note="beta-transducin repeat containing protein"
                     /db_xref="GeneID:12234"
                     /db_xref="MGI:MGI:1338871"
     exon            1..153
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1845
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /note="isoform h is encoded by transcript variant 9"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 1A isoform h"
                     /protein_id="NP_001347056.1"
                     /db_xref="GeneID:12234"
                     /db_xref="MGI:MGI:1338871"
                     /translation="MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPG
                     TGALTAFQTYNSCARLCINQETVCLTSTAMKTENCVAKAKLANGTSSMIVPKQRKLSA
                     SYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPA
                     RGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAE
                     RRGWGQYLFKNKPPDENAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSET
                     SKGVYCLQYDDQKIVSGLRDNTIKIWDKSTLECKRILTGHTGSVLCLQYDERVIITGS
                     SDSTVRVWDVNAGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITL
                     RRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD
                     RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLM
                     AALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAHAEP
                     PRSPSRTYTYISR"
     exon            154..261
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            262..351
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            352..583
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            584..770
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            771..867
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1005
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1124
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1374
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1493
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1604
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1683
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1876
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..6247
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2178..2183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /note="hexamer: AATATA"
     polyA_site      2201
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /note="major polyA site"
     regulatory      2831..2836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /note="hexamer: AATAAA"
     polyA_site      2858
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
     regulatory      4900..4905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /note="hexamer: AATAAA"
     polyA_site      4940
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
     regulatory      6221..6226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /note="hexamer: AATACA"
     polyA_site      6222
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
     regulatory      6229..6234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /note="hexamer: ATTAAA"
     polyA_site      6239
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
     polyA_site      6247
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
ORIGIN      
        1 gggcggggga aggaagagga ggcgggatcc ggacgctgcg ttggctgcgg cctggcacga
       61 aaggggcggc cccggcggag agcagaccca gtagtccggg cgattatgga cccggcagag
      121 gcggtgctgc aggagaaagc gcttaagttt atgtgctcta tgcccaggtc tctgtggctg
      181 ggctgctcca gcctggcgga cagcatgcct tcgctgcgat gcctgtataa cccagggact
      241 ggcgcactca cagctttcca gacttacaac agctgtgcca ggctttgcat aaaccaagag
      301 acagtatgtc taacaagcac tgctatgaag actgaaaatt gtgtggccaa agccaaactt
      361 gccaatggca cttccagcat gattgtgccc aagcagcgga aactctcagc aagctatgag
      421 aaggaaaagg agctgtgtgt caagtatttt gagcagtggt cagagtctga tcaagtggaa
      481 tttgtagaac accttatatc ccaaatgtgt cactaccagc atgggcacat caactcctac
      541 ctaaaaccta tgctgcagag ggatttcata actgcactgc cagcacgggg tctggaccac
      601 atcgctgaga acattctgtc atacttggac gccaagtcac tgtgtgctgc tgagctcgtg
      661 tgcaaggaat ggtaccgcgt gacgtcggac ggcatgctgt ggaaaaagct catcgagagg
      721 atggtcagga cggactctct gtggcgaggc ctggcagagc gcagaggctg gggacagtac
      781 ttattcaaaa acaaacctcc tgatgagaac gctcctccca actcctttta tagagcgctt
      841 tatcctaaaa tcatacaaga cattgagaca atagagtcca attggagatg tgggcgacat
      901 agtttacaga gaatccactg ccggagtgaa acaagtaaag gggtttactg tttacagtac
      961 gacgaccaga agatagtcag cggccttcga gacaacacca tcaagatctg ggataaaagc
     1021 acactggaat gcaagcggat tctcacgggc cacacgggct ccgtcctgtg tctgcagtac
     1081 gatgagaggg tgatcatcac aggctcctca gactccaccg tcagagtgtg ggatgtaaat
     1141 gcaggtgaga tgctaaacac attgattcac cactgtgaag ccgttctgca cctgcgcttc
     1201 aataatggca tgatggtgac ctgttccaaa gaccgttcca tcgctgtgtg ggatatggct
     1261 tccccaactg acatcaccct caggagggtg ctggtgggac accgagctgc ggtcaatgtt
     1321 gtagactttg atgacaagta catcgtttct gcctctggag atagaaccat aaaggtgtgg
     1381 aacacaagta cctgtgaatt cgtaaggacc ctaaatgggc acaagcgtgg catcgcctgt
     1441 ttgcagtaca gagacaggct ggtggtgagc ggctcctctg acaacaccat caggctgtgg
     1501 gacatagagt gtggagcatg cctgcgagtg ttggagggcc atgaggagtt ggtacgctgc
     1561 attcgatttg ataacaaaag gatagtgagc ggagcctatg atgggaaaat taaagtgtgg
     1621 gatcttatgg ctgctttgga cccgcgtgct ccagcaggga ctctctgtct gcggacactt
     1681 gtggagcatt ctggaagagt tttccgcctc cagtttgatg aattccagat tgtcagtagt
     1741 tcacatgatg acacaattct catctgggac ttcctgaatg atccagctgc tcacgctgaa
     1801 ccgccccgct ccccttctcg gacatacacc tacatctcca gataaataac ccaacactgg
     1861 cctcataatt gcccaggact cgttaatgtt gcagtattta acagacctgc caagaccagg
     1921 atgaacaaca atcaaactcc tacccggatt cccggacgga tgagcgagga gcagggcttt
     1981 gagactcctg ttgggacaca gtcggtcagc agccgaccag gacggcctgc tcggcaccgg
     2041 ctgcctcagt gctgctatca gaagatgtct ttatcttgtg tgaatgattg gaacttccaa
     2101 gcctccctcc ccttcccttc cccttcctcc ctgcacctgt ttccctccca ttgggttcca
     2161 gacaaagatg acttataaat atatttagtg ttttgccaga atctctcttg ctttgccgtt
     2221 aagcagaaga actagtttcc ccacctggcc cacttctagg ggacaggggc tgcagcttcc
     2281 aggcagagac tgcctggcct cctcctgtta actgcaggag tgtccagcat ctggccagag
     2341 cagtcccagc cactgcgtgg gaggagacag ctgcctacac atcttggagg ggagagagag
     2401 agagagagag aggagaggcg cacacacact ggaagatctg cactgctgcc tccctccatt
     2461 gtctgggtgt ctgtccctct tccctgctcc catactccat cttgagcctg agaaggtgtg
     2521 caaagagagt cctcagctag catgaggcgg atcacctaga caatgtgaca cttgcaagag
     2581 ttgagttcgt ccttatttcc agcccaggct tttgctgcaa gtgaccaacc tggggcacca
     2641 gtggatttgt gaccatgaca ttggtcagtc acatttgcag ctttctcctt ccctgtgccc
     2701 tggggaaggg caggaatgtc ctgggcacca tcagtgctgt gtctgcttcg gactcagcgg
     2761 tcttcctcgg tcccatgtag agtggagagg agctgctgat tgcattcctc tcattaacaa
     2821 ttagatgtgt aataaaaagc attgtgcttc atcttaaatc actggcgagg cttggcctgc
     2881 acaaaggctt ggaatagcca gcaccaggca ccactgcact ctgctctgtg gctcgaattt
     2941 gttcctcgac tgagctggaa agcacccagg gacctgtaac tgcccaccaa gagcatagta
     3001 gcctaagaga tggtcaggag agaaacagat tctgggttag gccagtaaat gtcagcatct
     3061 cagccttcca ctgcaggtcc ttatgccgag tgcttgcaga aaggcgaggc tgccagaggg
     3121 gatcagggtg aagcttggca cacagggttt actgataagc aaaagctgcc ttctctttct
     3181 ttccttctcc cagccttatt tgctgtccac tttccccagc cagttagctg gcagtcagtg
     3241 atgacataag cggctgcact tccacaaggg cagagctaag caggtcgtgt acacggctgc
     3301 actgggcccc tgccagtagg ctccagatgc agacactcat ggccaaacct ggaagtactt
     3361 gaactgaaaa ccaacttagt taccccacag catgcacagg gcctgccaag gggtgactta
     3421 ggccacagtg cagcctcggt ttcacttgga agccaagcag tcagactgtc atgctgttcc
     3481 taaccgtgca tttgagttga agaaaaccaa ctgaacaagc tgcttaaaat agaacggggc
     3541 ccatcacatg tggtcacaga cagaccacct tcacctgagc aggaagtggg gccctttcac
     3601 aactggccct cagatagacc accttcactt cactggtttg caagttaccc cttgcccaac
     3661 gtgtcccact agtgaatgcc attacgtgct gggtcaggtc acgtgtacag attgccttcc
     3721 ctgtgttagc cgcatttctc ctttcccaac caaccacgtg ttgcagactt gtctggttaa
     3781 ccccgccgag tcccttgtct gttatgttga ctgttaatag tgaaggactt tgctgcaaaa
     3841 cgggtcagac atgaagagac ctaagctgct tcaagaaatg gtctagtggc cacaagtcta
     3901 ccagcccttc ttcagttcca tgctgcttta agaagttagg agctggagga catctgccta
     3961 gcgtggatgc ccaggattag ggggcagtgt gggcactgct gcagactggt tggtgccagg
     4021 gctgtgctct cctcccaggt tcagctggag ggtgctgttc tgaagccagc cgggaagtgt
     4081 ggctgcccgt tgtctcaggc tggggtggac gctgctcact gaagcccata gagtggttaa
     4141 gctctttctg cagcttgccc tcgccactgc tgatggaaat gggaacaaag ttaagtggtc
     4201 tgagcacctg aattgctcgc atttctcagc tctgggggtc atttaccagt tcattgtaga
     4261 agaaacaatc aggtaagaag ttcatttcca gagaaggtga accccgctta ccatctctgc
     4321 atgatttcag tgggaattga ttatcactga tccccaactg ggcgagatgt aaagtttgac
     4381 ctttttaaaa agaaaagaga aacaaagaac atctccacac atttaaagga atagtagaca
     4441 agaagcttcg ggtgtcctgt ggctcggaga cgagaggaga gtctcgggtc aggcttggtt
     4501 ttttgtttgt ttgttttgtt ttgttttaac taaaatctac tttccaaaat aaaggctgca
     4561 agaccttccc tactgacagg ctgaggtcct taggcagctg agtaaagtgc acagggtgcc
     4621 tgctggagag catggcttct gtcacactga cagtgtctgg acaaggccaa cccatgcctt
     4681 gctgctcatg tgggagaggg agagagaggg agagagagag agagagagaa cgcgcgctgt
     4741 tttgcctctg ctgctaggga tgtcctttcc tttgaagtat agttagaaag tgggtgtgaa
     4801 ttatggatgg aaagcctttt acacttgtcc cttggctaaa ttctttctga tttgtcctaa
     4861 ctttagagac agaaactgtt tggaactctg ttgacaagta ataaagtctg gctctcagta
     4921 gcttgttttg gaactgaaaa tgacatcgag gctcctaaat cattctgtaa ggggaaaaaa
     4981 aaaaattttt tttaacaatc caaagctgca gagaaggctg tgtgcatcca tccagtccct
     5041 tgccttgcct tgccttgcct tgccttgcct tgccttgcct tgccttgcct tgccttgcct
     5101 tgccttgcct tgccttgcct tgccttgcct tgccggctcc tggtctgagt ggctgaggtt
     5161 gatctgcttg cttagcagtt gtccagagtg gagaatactg aaagtaatta gggctgtggt
     5221 ggtgttaatt gtcttagcat cttccctttg agctaaattg tgataccttc ctgtcctgaa
     5281 tctgaaggaa ggaggcccac tcagattagt gcaggcctgc gggctaggtg tgttctgaag
     5341 gatgccttca ggtggagatg aagcatgcag gtacccagcc ctgtggctgc accctttggt
     5401 gatggccagt ttacagtgga actgcaggcc acactaatct ctatccccgt ttggttacac
     5461 tcagcagttt cgaatgcacc agagacctcc aatagggtca atcctagact cacgcacatg
     5521 acctgtggca gtgtagagcc cacgtaacca cagtgagtgc agtcagtacg agagggagcc
     5581 atccccggaa taaaggtgag ctttgctgct ggctgtcttg aagcgttagt tcacggagga
     5641 tatcagaatc cttaaagcca aggagagaga ccaaagcagg gagacagtgg ctactggctt
     5701 gcgggaggga tggactgcgc tgccgcccag gaccctccat ggctagcaac cctgtctcaa
     5761 aacaaacgac actggcccag tgcctgtggc ctaaaattcc cagagacagt tgacttccca
     5821 aacactcgct tctctacaaa ctcagttatc tgacttagct tctaagtagg agggtgggga
     5881 tggtatgtgt ccctcagaca tttaaggaaa ggtccaatag gttcgatctc tgggtatcaa
     5941 ggaaaccgat accttcccaa agcggtgacc cttaaaccct agcaaactga ctgagggtgt
     6001 tcagtggacg ccagcatggg aacaggcctg gcaacaagtg tgagccaggg cttttgcttg
     6061 ttcgcttttt gttttctaga ttctccagtg ctgaccgctt taatttttgt gattatgttg
     6121 tagtggtgtg tagtcaatgt accaatatgt tcacaagtta ggatgatggt aatagtgtgt
     6181 tttggttttt taactgtttg gggaaaaaaa gtaaattaca aatacaagat taaagcgaat
     6241 tttctaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
