LOCUS       NM_001037758            6358 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus beta-transducin repeat containing protein (Btrc),
            transcript variant 1, mRNA.
ACCESSION   NM_001037758
VERSION     NM_001037758.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6358)
  AUTHORS   McCallum-Loudeac,J., Moody,E., Williams,J., Johnstone,G.,
            Sircombe,K.J., Clarkson,A.N. and Wilson,M.J.
  TITLE     Deletion of a conserved genomic region associated with adolescent
            idiopathic scoliosis leads to vertebral rotation in mice
  JOURNAL   Hum Mol Genet 33 (9), 787-801 (2024)
   PUBMED   38280229
REFERENCE   2  (bases 1 to 6358)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6358)
  AUTHORS   Joo,H.J., D'Alessandro,M., Oh,G., Han,S., Kim,W.J., Chung,G.E.,
            Jang,Y., Lee,J.B., Lee,C. and Yang,Y.
  TITLE     Novel targets of beta-TrCP cooperatively accelerate carbohydrate
            and fatty acid consumption
  JOURNAL   J Cell Physiol 239 (3), e31095 (2024)
   PUBMED   37584358
  REMARK    GeneRIF: Novel targets of beta-TrCP cooperatively accelerate
            carbohydrate and fatty acid consumption.
REFERENCE   4  (bases 1 to 6358)
  AUTHORS   Fernandez-Gines,R., Encinar,J.A., Escoll,M., Carnicero-Senabre,D.,
            Jimenez-Villegas,J., Garcia-Yague,A.J., Gonzalez-Rodriguez,A.,
            Garcia-Martinez,I., Valverde,A.M., Rojo,A.I. and Cuadrado,A.
  TITLE     Specific targeting of the NRF2/beta-TrCP axis promotes beneficial
            effects in NASH
  JOURNAL   Redox Biol 69, 103027 (2024)
   PUBMED   38184999
  REMARK    GeneRIF: Specific targeting of the NRF2/beta-TrCP axis promotes
            beneficial effects in NASH.
REFERENCE   5  (bases 1 to 6358)
  AUTHORS   Cui,M., Peng,J., Zhou,Y., Wang,X. and Cui,D.
  TITLE     Exosomal GPT2 derived from triple-negative breast cancer cells
            promotes metastasis by activating BTRC
  JOURNAL   Thorac Cancer 14 (21), 2018-2025 (2023)
   PUBMED   37287397
  REMARK    GeneRIF: Exosomal GPT2 derived from triple-negative breast cancer
            cells promotes metastasis by activating BTRC.
REFERENCE   6  (bases 1 to 6358)
  AUTHORS   Hatakeyama,S., Kitagawa,M., Nakayama,K., Shirane,M., Matsumoto,M.,
            Hattori,K., Higashi,H., Nakano,H., Okumura,K., Onoe,K., Good,R.A.
            and Nakayama,K.
  TITLE     Ubiquitin-dependent degradation of IkappaBalpha is mediated by a
            ubiquitin ligase Skp1/Cul 1/F-box protein FWD1
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3859-3863 (1999)
   PUBMED   10097128
REFERENCE   7  (bases 1 to 6358)
  AUTHORS   Maniatis,T.
  TITLE     A ubiquitin ligase complex essential for the NF-kappaB,
            Wnt/Wingless, and Hedgehog signaling pathways
  JOURNAL   Genes Dev 13 (5), 505-510 (1999)
   PUBMED   10072378
  REMARK    Review article
REFERENCE   8  (bases 1 to 6358)
  AUTHORS   Spencer,E., Jiang,J. and Chen,Z.J.
  TITLE     Signal-induced ubiquitination of IkappaBalpha by the F-box protein
            Slimb/beta-TrCP
  JOURNAL   Genes Dev 13 (3), 284-294 (1999)
   PUBMED   9990853
REFERENCE   9  (bases 1 to 6358)
  AUTHORS   Winston,J.T., Strack,P., Beer-Romero,P., Chu,C.Y., Elledge,S.J. and
            Harper,J.W.
  TITLE     The SCFbeta-TRCP-ubiquitin ligase complex associates specifically
            with phosphorylated destruction motifs in IkappaBalpha and
            beta-catenin and stimulates IkappaBalpha ubiquitination in vitro
  JOURNAL   Genes Dev 13 (3), 270-283 (1999)
   PUBMED   9990852
  REMARK    Erratum:[Genes Dev 1999 Apr 15;13(8):1050]
REFERENCE   10 (bases 1 to 6358)
  AUTHORS   Yaron,A., Hatzubai,A., Davis,M., Lavon,I., Amit,S., Manning,A.M.,
            Andersen,J.S., Mann,M., Mercurio,F. and Ben-Neriah,Y.
  TITLE     Identification of the receptor component of the
            IkappaBalpha-ubiquitin ligase
  JOURNAL   Nature 396 (6711), 590-594 (1998)
   PUBMED   9859996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY290279.1, BY070850.1, AK145624.1, AK052317.1, AC126454.3 and
            BP768842.1.
            
            On Nov 27, 2007 this sequence version replaced NM_001037758.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145624.1, AK083257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BY290279.1         2-5
            5-17                BY070850.1         2-14
            18-551              AK145624.1         1-534
            552-995             AK052317.1         576-1019
            996-2995            AK145624.1         979-2978
            2996-5799           AC126454.3         130395-133198
            5800-6358           BP768842.1         25-583              c
FEATURES             Location/Qualifiers
     source          1..6358
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.75 cM"
     gene            1..6358
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /note="beta-transducin repeat containing protein"
                     /db_xref="GeneID:12234"
                     /db_xref="MGI:MGI:1338871"
     exon            1..153
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1923
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 1A isoform a"
                     /protein_id="NP_001032847.2"
                     /db_xref="CCDS:CCDS29860.1"
                     /db_xref="GeneID:12234"
                     /db_xref="MGI:MGI:1338871"
                     /translation="MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPG
                     TGALTAFQNSSEREDCNNGEPPRKIIPEKNSLRQTYNSCARLCINQETVCLTSTAMKT
                     ENCVAKAKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQM
                     CHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRV
                     TSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDENAPPNSFYRALYPKII
                     QDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKSTLE
                     CKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNAGEMLNTLIHHCEAVLHLRFN
                     NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKV
                     WNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEEL
                     VRCIRFDNKRIVSGAYDGKIKVWDLMAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEF
                     QIVSSSHDDTILIWDFLNDPAAHAEPPRSPSRTYTYISR"
     exon            154..261
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            262..339
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            340..429
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            430..661
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            662..848
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            849..945
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1083
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1202
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1452
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1571
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1682
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1761
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1954
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..6325
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2256..2261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /note="hexamer: AATATA"
     polyA_site      2279
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /note="major polyA site"
     regulatory      2909..2914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /note="hexamer: AATAAA"
     polyA_site      2936
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
     regulatory      4978..4983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /note="hexamer: AATAAA"
     polyA_site      5018
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
     regulatory      6299..6304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /note="hexamer: AATACA"
     polyA_site      6300
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
     regulatory      6307..6312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
                     /note="hexamer: ATTAAA"
     polyA_site      6317
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
     polyA_site      6325
                     /gene="Btrc"
                     /gene_synonym="b-TrCP; beta-TrCP; Beta-Trcp1;
                     E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; SCF b-TRCP;
                     Slimb"
ORIGIN      
        1 gggcggggga aggaagagga ggcgggatcc ggacgctgcg ttggctgcgg cctggcacga
       61 aaggggcggc cccggcggag agcagaccca gtagtccggg cgattatgga cccggcagag
      121 gcggtgctgc aggagaaagc gcttaagttt atgtgctcta tgcccaggtc tctgtggctg
      181 ggctgctcca gcctggcgga cagcatgcct tcgctgcgat gcctgtataa cccagggact
      241 ggcgcactca cagctttcca gaattcctca gagagagaag actgtaataa tggcgaaccc
      301 cctaggaaga taataccaga gaagaattca cttagacaga cttacaacag ctgtgccagg
      361 ctttgcataa accaagagac agtatgtcta acaagcactg ctatgaagac tgaaaattgt
      421 gtggccaaag ccaaacttgc caatggcact tccagcatga ttgtgcccaa gcagcggaaa
      481 ctctcagcaa gctatgagaa ggaaaaggag ctgtgtgtca agtattttga gcagtggtca
      541 gagtctgatc aagtggaatt tgtagaacac cttatatccc aaatgtgtca ctaccagcat
      601 gggcacatca actcctacct aaaacctatg ctgcagaggg atttcataac tgcactgcca
      661 gcacggggtc tggaccacat cgctgagaac attctgtcat acttggacgc caagtcactg
      721 tgtgctgctg agctcgtgtg caaggaatgg taccgcgtga cgtcggacgg catgctgtgg
      781 aaaaagctca tcgagaggat ggtcaggacg gactctctgt ggcgaggcct ggcagagcgc
      841 agaggctggg gacagtactt attcaaaaac aaacctcctg atgagaacgc tcctcccaac
      901 tccttttata gagcgcttta tcctaaaatc atacaagaca ttgagacaat agagtccaat
      961 tggagatgtg ggcgacatag tttacagaga atccactgcc ggagtgaaac aagtaaaggg
     1021 gtttactgtt tacagtacga cgaccagaag atagtcagcg gccttcgaga caacaccatc
     1081 aagatctggg ataaaagcac actggaatgc aagcggattc tcacgggcca cacgggctcc
     1141 gtcctgtgtc tgcagtacga tgagagggtg atcatcacag gctcctcaga ctccaccgtc
     1201 agagtgtggg atgtaaatgc aggtgagatg ctaaacacat tgattcacca ctgtgaagcc
     1261 gttctgcacc tgcgcttcaa taatggcatg atggtgacct gttccaaaga ccgttccatc
     1321 gctgtgtggg atatggcttc cccaactgac atcaccctca ggagggtgct ggtgggacac
     1381 cgagctgcgg tcaatgttgt agactttgat gacaagtaca tcgtttctgc ctctggagat
     1441 agaaccataa aggtgtggaa cacaagtacc tgtgaattcg taaggaccct aaatgggcac
     1501 aagcgtggca tcgcctgttt gcagtacaga gacaggctgg tggtgagcgg ctcctctgac
     1561 aacaccatca ggctgtggga catagagtgt ggagcatgcc tgcgagtgtt ggagggccat
     1621 gaggagttgg tacgctgcat tcgatttgat aacaaaagga tagtgagcgg agcctatgat
     1681 gggaaaatta aagtgtggga tcttatggct gctttggacc cgcgtgctcc agcagggact
     1741 ctctgtctgc ggacacttgt ggagcattct ggaagagttt tccgcctcca gtttgatgaa
     1801 ttccagattg tcagtagttc acatgatgac acaattctca tctgggactt cctgaatgat
     1861 ccagctgctc acgctgaacc gccccgctcc ccttctcgga catacaccta catctccaga
     1921 taaataaccc aacactggcc tcataattgc ccaggactcg ttaatgttgc agtatttaac
     1981 agacctgcca agaccaggat gaacaacaat caaactccta cccggattcc cggacggatg
     2041 agcgaggagc agggctttga gactcctgtt gggacacagt cggtcagcag ccgaccagga
     2101 cggcctgctc ggcaccggct gcctcagtgc tgctatcaga agatgtcttt atcttgtgtg
     2161 aatgattgga acttccaagc ctccctcccc ttcccttccc cttcctccct gcacctgttt
     2221 ccctcccatt gggttccaga caaagatgac ttataaatat atttagtgtt ttgccagaat
     2281 ctctcttgct ttgccgttaa gcagaagaac tagtttcccc acctggccca cttctagggg
     2341 acaggggctg cagcttccag gcagagactg cctggcctcc tcctgttaac tgcaggagtg
     2401 tccagcatct ggccagagca gtcccagcca ctgcgtggga ggagacagct gcctacacat
     2461 cttggagggg agagagagag agagagagag gagaggcgca cacacactgg aagatctgca
     2521 ctgctgcctc cctccattgt ctgggtgtct gtccctcttc cctgctccca tactccatct
     2581 tgagcctgag aaggtgtgca aagagagtcc tcagctagca tgaggcggat cacctagaca
     2641 atgtgacact tgcaagagtt gagttcgtcc ttatttccag cccaggcttt tgctgcaagt
     2701 gaccaacctg gggcaccagt ggatttgtga ccatgacatt ggtcagtcac atttgcagct
     2761 ttctccttcc ctgtgccctg gggaagggca ggaatgtcct gggcaccatc agtgctgtgt
     2821 ctgcttcgga ctcagcggtc ttcctcggtc ccatgtagag tggagaggag ctgctgattg
     2881 cattcctctc attaacaatt agatgtgtaa taaaaagcat tgtgcttcat cttaaatcac
     2941 tggcgaggct tggcctgcac aaaggcttgg aatagccagc accaggcacc actgcactct
     3001 gctctgtggc tcgaatttgt tcctcgactg agctggaaag cacccaggga cctgtaactg
     3061 cccaccaaga gcatagtagc ctaagagatg gtcaggagag aaacagattc tgggttaggc
     3121 cagtaaatgt cagcatctca gccttccact gcaggtcctt atgccgagtg cttgcagaaa
     3181 ggcgaggctg ccagagggga tcagggtgaa gcttggcaca cagggtttac tgataagcaa
     3241 aagctgcctt ctctttcttt ccttctccca gccttatttg ctgtccactt tccccagcca
     3301 gttagctggc agtcagtgat gacataagcg gctgcacttc cacaagggca gagctaagca
     3361 ggtcgtgtac acggctgcac tgggcccctg ccagtaggct ccagatgcag acactcatgg
     3421 ccaaacctgg aagtacttga actgaaaacc aacttagtta ccccacagca tgcacagggc
     3481 ctgccaaggg gtgacttagg ccacagtgca gcctcggttt cacttggaag ccaagcagtc
     3541 agactgtcat gctgttccta accgtgcatt tgagttgaag aaaaccaact gaacaagctg
     3601 cttaaaatag aacggggccc atcacatgtg gtcacagaca gaccaccttc acctgagcag
     3661 gaagtggggc cctttcacaa ctggccctca gatagaccac cttcacttca ctggtttgca
     3721 agttacccct tgcccaacgt gtcccactag tgaatgccat tacgtgctgg gtcaggtcac
     3781 gtgtacagat tgccttccct gtgttagccg catttctcct ttcccaacca accacgtgtt
     3841 gcagacttgt ctggttaacc ccgccgagtc ccttgtctgt tatgttgact gttaatagtg
     3901 aaggactttg ctgcaaaacg ggtcagacat gaagagacct aagctgcttc aagaaatggt
     3961 ctagtggcca caagtctacc agcccttctt cagttccatg ctgctttaag aagttaggag
     4021 ctggaggaca tctgcctagc gtggatgccc aggattaggg ggcagtgtgg gcactgctgc
     4081 agactggttg gtgccagggc tgtgctctcc tcccaggttc agctggaggg tgctgttctg
     4141 aagccagccg ggaagtgtgg ctgcccgttg tctcaggctg gggtggacgc tgctcactga
     4201 agcccataga gtggttaagc tctttctgca gcttgccctc gccactgctg atggaaatgg
     4261 gaacaaagtt aagtggtctg agcacctgaa ttgctcgcat ttctcagctc tgggggtcat
     4321 ttaccagttc attgtagaag aaacaatcag gtaagaagtt catttccaga gaaggtgaac
     4381 cccgcttacc atctctgcat gatttcagtg ggaattgatt atcactgatc cccaactggg
     4441 cgagatgtaa agtttgacct ttttaaaaag aaaagagaaa caaagaacat ctccacacat
     4501 ttaaaggaat agtagacaag aagcttcggg tgtcctgtgg ctcggagacg agaggagagt
     4561 ctcgggtcag gcttggtttt ttgtttgttt gttttgtttt gttttaacta aaatctactt
     4621 tccaaaataa aggctgcaag accttcccta ctgacaggct gaggtcctta ggcagctgag
     4681 taaagtgcac agggtgcctg ctggagagca tggcttctgt cacactgaca gtgtctggac
     4741 aaggccaacc catgccttgc tgctcatgtg ggagagggag agagagggag agagagagag
     4801 agagagaacg cgcgctgttt tgcctctgct gctagggatg tcctttcctt tgaagtatag
     4861 ttagaaagtg ggtgtgaatt atggatggaa agccttttac acttgtccct tggctaaatt
     4921 ctttctgatt tgtcctaact ttagagacag aaactgtttg gaactctgtt gacaagtaat
     4981 aaagtctggc tctcagtagc ttgttttgga actgaaaatg acatcgaggc tcctaaatca
     5041 ttctgtaagg ggaaaaaaaa aaattttttt taacaatcca aagctgcaga gaaggctgtg
     5101 tgcatccatc cagtcccttg ccttgccttg ccttgccttg ccttgccttg ccttgccttg
     5161 ccttgccttg ccttgccttg ccttgccttg ccttgccttg ccttgccttg ccggctcctg
     5221 gtctgagtgg ctgaggttga tctgcttgct tagcagttgt ccagagtgga gaatactgaa
     5281 agtaattagg gctgtggtgg tgttaattgt cttagcatct tccctttgag ctaaattgtg
     5341 ataccttcct gtcctgaatc tgaaggaagg aggcccactc agattagtgc aggcctgcgg
     5401 gctaggtgtg ttctgaagga tgccttcagg tggagatgaa gcatgcaggt acccagccct
     5461 gtggctgcac cctttggtga tggccagttt acagtggaac tgcaggccac actaatctct
     5521 atccccgttt ggttacactc agcagtttcg aatgcaccag agacctccaa tagggtcaat
     5581 cctagactca cgcacatgac ctgtggcagt gtagagccca cgtaaccaca gtgagtgcag
     5641 tcagtacgag agggagccat ccccggaata aaggtgagct ttgctgctgg ctgtcttgaa
     5701 gcgttagttc acggaggata tcagaatcct taaagccaag gagagagacc aaagcaggga
     5761 gacagtggct actggcttgc gggagggatg gactgcgctg ccgcccagga ccctccatgg
     5821 ctagcaaccc tgtctcaaaa caaacgacac tggcccagtg cctgtggcct aaaattccca
     5881 gagacagttg acttcccaaa cactcgcttc tctacaaact cagttatctg acttagcttc
     5941 taagtaggag ggtggggatg gtatgtgtcc ctcagacatt taaggaaagg tccaataggt
     6001 tcgatctctg ggtatcaagg aaaccgatac cttcccaaag cggtgaccct taaaccctag
     6061 caaactgact gagggtgttc agtggacgcc agcatgggaa caggcctggc aacaagtgtg
     6121 agccagggct tttgcttgtt cgctttttgt tttctagatt ctccagtgct gaccgcttta
     6181 atttttgtga ttatgttgta gtggtgtgta gtcaatgtac caatatgttc acaagttagg
     6241 atgatggtaa tagtgtgttt tggtttttta actgtttggg gaaaaaaagt aaattacaaa
     6301 tacaagatta aagcgaattt tctaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
