LOCUS       NM_079835               2563 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus butyrophilin-like 2 (Btnl2), mRNA.
ACCESSION   NM_079835 XM_622989 XM_903355
VERSION     NM_079835.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2563)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2563)
  AUTHORS   Du,Y., Peng,Q., Cheng,D., Pan,T., Sun,W., Wang,H., Ma,X., He,R.,
            Zhang,H., Cui,Z., Feng,X., Liu,Z., Zhao,T., Hu,W., Shen,L.,
            Jiang,W., Gao,N., Martin,B.N., Zhang,C.J., Zhang,Z. and Wang,C.
  TITLE     Cancer cell-expressed BTNL2 facilitates tumour immune escape via
            engagement with IL-17A-producing gammadelta T cells
  JOURNAL   Nat Commun 13 (1), 231 (2022)
   PUBMED   35017553
  REMARK    GeneRIF: Cancer cell-expressed BTNL2 facilitates tumour immune
            escape via engagement with IL-17A-producing gammadelta T cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2563)
  AUTHORS   Panea,C., Zhang,R., VanValkenburgh,J., Ni,M., Adler,C., Wei,Y.,
            Ochoa,F., Schmahl,J., Tang,Y., Siao,C.J., Poueymirou,W., Espert,J.,
            Lim,W.K., Atwal,G.S., Murphy,A.J., Sleeman,M.A., Hovhannisyan,Z.
            and Haxhinasto,S.
  TITLE     Butyrophilin-like 2 regulates site-specific adaptations of
            intestinal gammadelta intraepithelial lymphocytes
  JOURNAL   Commun Biol 4 (1), 913 (2021)
   PUBMED   34312491
  REMARK    GeneRIF: Butyrophilin-like 2 regulates site-specific adaptations of
            intestinal gammadelta intraepithelial lymphocytes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2563)
  AUTHORS   Basak,A.J., Maiti,S., Hansda,A., Mahata,D., Duraivelan,K.,
            Kundapura,S.V., Lee,W., Mukherjee,G., De,S. and Samanta,D.
  TITLE     Structural Insights into N-terminal IgV Domain of BTNL2, a T Cell
            Inhibitory Molecule, Suggests a Non-canonical Binding Interface for
            Its Putative Receptors
  JOURNAL   J Mol Biol 432 (22), 5938-5950 (2020)
   PUBMED   32976909
  REMARK    GeneRIF: Structural Insights into N-terminal IgV Domain of BTNL2, a
            T Cell Inhibitory Molecule, Suggests a Non-canonical Binding
            Interface for Its Putative Receptors.
REFERENCE   5  (bases 1 to 2563)
  AUTHORS   Swanson,R.M., Gavin,M.A., Escobar,S.S., Rottman,J.B., Lipsky,B.P.,
            Dube,S., Li,L., Bigler,J., Wolfson,M., Arnett,H.A. and Viney,J.L.
  TITLE     Butyrophilin-like 2 modulates B7 costimulation to induce Foxp3
            expression and regulatory T cell development in mature T cells
  JOURNAL   J Immunol 190 (5), 2027-2035 (2013)
   PUBMED   23359506
  REMARK    GeneRIF: Butyrophilin-like 2 modulates B7 costimulation to induce
            Foxp3 expression and regulatory T cell development in mature T
            cells.
REFERENCE   6  (bases 1 to 2563)
  AUTHORS   Zhao,Y., Bian,G., Yu,C., Liu,F., Liu,L., Guo,H., Guo,J., Ju,G. and
            Wang,J.
  TITLE     Cross-reactivity of anti-programmed death ligand 2 polyclonal
            antibody in mouse tissues
  JOURNAL   Sci China Life Sci 55 (11), 940-947 (2012)
   PUBMED   23090063
REFERENCE   7  (bases 1 to 2563)
  AUTHORS   Arnett,H.A., Escobar,S.S., Gonzalez-Suarez,E., Budelsky,A.L.,
            Steffen,L.A., Boiani,N., Zhang,M., Siu,G., Brewer,A.W. and
            Viney,J.L.
  TITLE     BTNL2, a butyrophilin/B7-like molecule, is a negative costimulatory
            molecule modulated in intestinal inflammation
  JOURNAL   J Immunol 178 (3), 1523-1533 (2007)
   PUBMED   17237401
  REMARK    GeneRIF: BTNL2 is overexpressed during both the asymptomatic and
            symptomatic phase of the Mdr1a knockout model of spontaneous
            colitis. Soluble BTNL2-Fc protein inhibits proliferation of murine
            T4 cells from the spleen, mesenteric lymph node, and Peyer's patch.
REFERENCE   8  (bases 1 to 2563)
  AUTHORS   Nguyen,T., Liu,X.K., Zhang,Y. and Dong,C.
  TITLE     BTNL2, a butyrophilin-like molecule that functions to inhibit T
            cell activation
  JOURNAL   J Immunol 176 (12), 7354-7360 (2006)
   PUBMED   16751379
REFERENCE   9  (bases 1 to 2563)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   10 (bases 1 to 2563)
  AUTHORS   Stammers,M., Rowen,L., Rhodes,D., Trowsdale,J. and Beck,S.
  TITLE     BTL-II: a polymorphic locus with homology to the butyrophilin gene
            family, located at the border of the major histocompatibility
            complex class II and class III regions in human and mouse
  JOURNAL   Immunogenetics 51 (4-5), 373-382 (2000)
   PUBMED   10803852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK136521.1.
            
            On Apr 19, 2007 this sequence version replaced NM_079835.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136521.1, BC141103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2563              AK136521.1         3-2565
FEATURES             Location/Qualifiers
     source          1..2563
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..2563
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Btl2; BTLN2; Gm315; NG9"
                     /note="butyrophilin-like 2"
                     /db_xref="GeneID:547431"
                     /db_xref="MGI:MGI:1859549"
     exon            1..249
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Btl2; BTLN2; Gm315; NG9"
                     /inference="alignment:Splign:2.1.0"
     exon            250..333
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Btl2; BTLN2; Gm315; NG9"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1799
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Btl2; BTLN2; Gm315; NG9"
                     /note="butyrophylin-like MHC class II associated"
                     /codon_start=1
                     /product="butyrophilin-like protein 2"
                     /protein_id="NP_524574.1"
                     /db_xref="CCDS:CCDS37585.1"
                     /db_xref="GeneID:547431"
                     /db_xref="MGI:MGI:1859549"
                     /translation="MVDCPRYSLSGVAASFLFVLLTIKHPDDFRVVGPNLPILAKVGE
                     DALLTCQLLPKRTTAHMEVRWYRSDPDMPVIMYRDGAEVTGLPMEGYGGRAEWMEDST
                     EEGSVALKIRQVQPSDDGQYWCRFQEGDYWRETSVLLQVAALGSSPNIHVEGLGEGEV
                     QLVCTSRGWFPEPEVHWEGIWGEKLMSFSENHVPGEDGLFYVEDTLMVRNDSVETISC
                     FIYSHGLRETQEATIALSERLQTELASVSVIGHSQPSPVQVGENIELTCHLSPQTDAQ
                     NLEVRWLRSRYYPAVHVYANGTHVAGEQMVEYKGRTSLVTDAIHEGKLTLQIHNARTS
                     DEGQYRCLFGKDGVYQEARVDVQVMAVGSTPRITREVLKDGGMQLRCTSDGWFPRPHV
                     QWRDRDGKTMPSFSEAFQQGSQELFQVETLLLVTNGSMVNVTCSISLPLGQEKTARFP
                     LSDSKIALLWMTLPVVVLPLAMAIDLIKVKRWRRTNEQTHSSNQENNKNDENHRRRLP
                     SDERLR"
     exon            334..681
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Btl2; BTLN2; Gm315; NG9"
                     /inference="alignment:Splign:2.1.0"
     exon            682..963
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Btl2; BTLN2; Gm315; NG9"
                     /inference="alignment:Splign:2.1.0"
     exon            964..984
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Btl2; BTLN2; Gm315; NG9"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1332
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Btl2; BTLN2; Gm315; NG9"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1611
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Btl2; BTLN2; Gm315; NG9"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1713
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Btl2; BTLN2; Gm315; NG9"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..2563
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Btl2; BTLN2; Gm315; NG9"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2563
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Btl2; BTLN2; Gm315; NG9"
                     /note="putative"
ORIGIN      
        1 gaaggtaaat gtgctgctct gactggagcc tcattttaga ctgaccctcg gggactcaac
       61 tctgcctaca gattgacacc attcaaatct tccttcacgc aaactggtga cgcttccact
      121 ttccttgcct gctccatcac cagtcactat gctctcctgt ccttagacac ctgctatgtg
      181 aatgaaggac acacttgtga ctgggtgaga ccaacagcct ccatttcacc ctaaaggaaa
      241 gagcaacagg gaggatggtg gattgcccac ggtatagtct atctggcgtg gctgcctcct
      301 tcctcttcgt cctgctgact ataaagcacc cagatgactt cagagtggtc ggtcctaacc
      361 tcccaatctt ggctaaagtc ggggaagatg ccctgctaac gtgtcagctc ctccccaaga
      421 ggaccacggc acacatggag gtgaggtggt accgctccga ccctgacatg ccagtgatta
      481 tgtaccggga tggagctgag gtgactgggc taccgatgga ggggtacgga ggccgggcag
      541 agtggatgga ggacagcact gaagagggca gtgtggctct gaagattcgc caggtccagc
      601 caagtgacga tggccagtac tggtgccgct tccaggaggg ggactactgg agagagacaa
      661 gcgtgctact ccaagtggct gctctaggat cttccccaaa tatccatgtg gagggactcg
      721 gagaaggaga ggtccagctt gtatgcacgt cccgaggctg gttccctgag cctgaggtgc
      781 actgggaagg catctgggga gaaaagttga tgagtttctc tgagaatcat gtgccaggtg
      841 aagatgggct attctatgtg gaagacacac tgatggtcag gaatgacagt gtagagacca
      901 tttcctgctt catctacagc catggcctca gagagaccca ggaggccacc atcgctctgt
      961 cagagaggct ccagaccgaa ctggcttccg ttagcgtaat cggacattcc cagcccagcc
     1021 ctgttcaagt cggagagaac atagaattaa cttgtcacct ctcacctcaa acggatgctc
     1081 agaacttaga ggtgaggtgg ctccgatccc gctattaccc tgcagtccac gtgtatgcaa
     1141 atggcaccca cgtggctgga gagcagatgg tagaatacaa agggaggact tcattggtga
     1201 ctgatgccat ccacgaggga aaactgaccc tgcaaattca caatgccaga acttcggatg
     1261 aagggcagta ccggtgcctt tttggaaaag atggtgtcta ccaggaggcc cgtgtggatg
     1321 tgcaggtgat ggcggtgggt tccaccccac ggatcaccag ggaggtcttg aaagatggag
     1381 gcatgcagct gaggtgtacg tctgatgggt ggttcccacg gccccatgtg cagtggaggg
     1441 acagagatgg aaagacaatg ccatcgtttt ccgaggcctt tcagcaaggg agccaggagc
     1501 tgttccaggt ggagacactt ctgctggtca caaacggctc catggtgaat gtgacctgct
     1561 ccatcagcct ccctctgggc caggagaaaa cagcccgttt ccctctctca gactccaaga
     1621 tagctttgct atggatgacc ctgcctgttg tggtgctgcc tctggccatg gctatcgacc
     1681 tgatcaaggt gaaacggtgg cggcggacca atgaacaaac acacagcagc aatcaggaaa
     1741 ataacaagaa tgacgaaaac cacaggcggc gacttccttc tgatgagagg ctcagatgaa
     1801 aatgcacccc gcaagcccaa cgcaccccat ttcctgaaca ccccatccct cctcccatct
     1861 tttcccctca ataagctgca ctgacatagg agtgctttca cttgctgctc tccaaaggtt
     1921 cttcatggac cctgtccgta cctgatgcaa ccatcacgca cagttgggag cacctcgacc
     1981 tgagccaacc cataatagtc ttgatccctc tctcacagtg atggcatctt ctctcccttt
     2041 gtctctttct gctatccctc aatctaggga ctatcccttg cctgtgcaca gcatctttat
     2101 ctcatcacct tctggaccca ccgtgaggat ggaagaactt agacctgcag agaaatgtca
     2161 ctcatctgag tcctggatgg gtttttctag aaatgcccaa tccagtagca ctagagggac
     2221 aaagcaggtg ggaggagagg gtttctttcc tccgtcctca agagaaagga ctaactgtga
     2281 ttcatggtta caaaagactt gacacttgca ctacaaatca gaccgggggt gggggaattg
     2341 tagaaataac taagggggta aaagcacttg ctgttcttgc agaggacctg agtttcattc
     2401 ctagcaccca tatggcaggt cataaccatc tataactcca gttctagggg gtcagatgcc
     2461 cttttctagc ctctgagggc accaggcaca catgtggtac acagacatag atgtaggcaa
     2521 aacacccata catctaaaat aaaaataatt tttataaaga att
//
