LOCUS       NM_001111094            2113 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus butyrophilin-like 1 (Btnl1), mRNA.
ACCESSION   NM_001111094 XM_001471910 XM_001471911
VERSION     NM_001111094.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2113)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2113)
  AUTHORS   Suzuki,T., Kilbey,A., Casa-Rodriguez,N., Lawlor,A.,
            Georgakopoulou,A., Hayman,H., Yin Swe,K.L., Nordin,A., Cantu,C.,
            Vantourout,P., Ridgway,R.A., Byrne,R.M., Chen,L., Verzi,M.P.,
            Gay,D.M., Gil Vazquez,E., Belnoue-Davis,H.L., Gilroy,K.,
            Kostner,A.H., Kersten,C., Thuwajit,C., Andersen,D.K., Wiesheu,R.,
            Jandke,A., Blyth,K., Roseweir,A.K., Leedham,S.J., Dunne,P.D.,
            Edwards,J., Hayday,A., Sansom,O.J. and Coffelt,S.B.
  TITLE     beta-Catenin Drives Butyrophilin-like Molecule Loss and gammadelta
            T-cell Exclusion in Colon Cancer
  JOURNAL   Cancer Immunol Res 11 (8), 1137-1155 (2023)
   PUBMED   37309673
REFERENCE   3  (bases 1 to 2113)
  AUTHORS   Jandke,A., Melandri,D., Monin,L., Ushakov,D.S., Laing,A.G.,
            Vantourout,P., East,P., Nitta,T., Narita,T., Takayanagi,H.,
            Feederle,R. and Hayday,A.
  TITLE     Butyrophilin-like proteins display combinatorial diversity in
            selecting and maintaining signature intraepithelial gammadelta T
            cell compartments
  JOURNAL   Nat Commun 11 (1), 3769 (2020)
   PUBMED   32724083
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2113)
  AUTHORS   Di Marco Barros,R., Roberts,N.A., Dart,R.J., Vantourout,P.,
            Jandke,A., Nussbaumer,O., Deban,L., Cipolat,S., Hart,R.,
            Iannitto,M.L., Laing,A., Spencer-Dene,B., East,P., Gibbons,D.,
            Irving,P.M., Pereira,P., Steinhoff,U. and Hayday,A.
  TITLE     Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific
            gammadelta T Cell Compartments
  JOURNAL   Cell 167 (1), 203-218 (2016)
   PUBMED   27641500
REFERENCE   5  (bases 1 to 2113)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 2113)
  AUTHORS   Lebrero-Fernandez,C. and Bas-Forsberg,A.
  TITLE     The ontogeny of Butyrophilin-like (Btnl) 1 and Btnl6 in murine
            small intestine
  JOURNAL   Sci Rep 6, 31524 (2016)
   PUBMED   27528202
  REMARK    GeneRIF: data show that the expression of Btnl1 and Btnl6 is
            delayed in the murine neonatal gut and that the appearance of the
            Btnl1 and Btnl6 proteins in the intestinal mucosa associates with
            the expansion of Vgamma7Vdelta4 TCR IELs
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2113)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 2113)
  AUTHORS   Bas,A., Swamy,M., Abeler-Dorner,L., Williams,G., Pang,D.J.,
            Barbee,S.D. and Hayday,A.C.
  TITLE     Butyrophilin-like 1 encodes an enterocyte protein that selectively
            regulates functional interactions with T lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 108 (11), 4376-4381 (2011)
   PUBMED   21368163
  REMARK    GeneRIF: Enforced epithelial cell expression of Btnl1 attenuated
            the cells' response to activated intraepithelial lymphocyte, as
            evidenced by suppression of IL-6 and other inflammatory mediators.
REFERENCE   9  (bases 1 to 2113)
  AUTHORS   Yamazaki,T., Goya,I., Graf,D., Craig,S., Martin-Orozco,N. and
            Dong,C.
  TITLE     A butyrophilin family member critically inhibits T cell activation
  JOURNAL   J Immunol 185 (10), 5907-5914 (2010)
   PUBMED   20944003
  REMARK    GeneRIF: BTNL1 is a critical inhibitory molecule for T cell
            activation and immune diseases.
REFERENCE   10 (bases 1 to 2113)
  AUTHORS   Stammers,M., Rowen,L., Rhodes,D., Trowsdale,J. and Beck,S.
  TITLE     BTL-II: a polymorphic locus with homology to the butyrophilin gene
            family, located at the border of the major histocompatibility
            complex class II and class III regions in human and mouse
  JOURNAL   Immunogenetics 51 (4-5), 373-382 (2000)
   PUBMED   10803852
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CR974457.17.
            
            On or before Jun 6, 2008 this sequence version replaced
            XM_001471910.1, XM_001471911.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849377,
                              SAMN00849378 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               CR974457.17        57198-57458
            262-413             CR974457.17        57891-58042
            414-767             CR974457.17        59560-59913
            768-1049            CR974457.17        61027-61308
            1050-1250           CR974457.17        61416-61616
            1251-1271           CR974457.17        62172-62192
            1272-1298           CR974457.17        62307-62333
            1299-1325           CR974457.17        62528-62554
            1326-1352           CR974457.17        64427-64453
            1353-2113           CR974457.17        65334-66094
FEATURES             Location/Qualifiers
     source          1..2113
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..2113
                     /gene="Btnl1"
                     /gene_synonym="Btnl3; Gm316; Gm33"
                     /note="butyrophilin-like 1"
                     /db_xref="GeneID:100038862"
                     /db_xref="MGI:MGI:1932027"
     exon            1..261
                     /gene="Btnl1"
                     /gene_synonym="Btnl3; Gm316; Gm33"
                     /inference="alignment:Splign:2.1.0"
     exon            262..413
                     /gene="Btnl1"
                     /gene_synonym="Btnl3; Gm316; Gm33"
                     /inference="alignment:Splign:2.1.0"
     exon            414..767
                     /gene="Btnl1"
                     /gene_synonym="Btnl3; Gm316; Gm33"
                     /inference="alignment:Splign:2.1.0"
     exon            768..1049
                     /gene="Btnl1"
                     /gene_synonym="Btnl3; Gm316; Gm33"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1250
                     /gene="Btnl1"
                     /gene_synonym="Btnl3; Gm316; Gm33"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1271
                     /gene="Btnl1"
                     /gene_synonym="Btnl3; Gm316; Gm33"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1298
                     /gene="Btnl1"
                     /gene_synonym="Btnl3; Gm316; Gm33"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1325
                     /gene="Btnl1"
                     /gene_synonym="Btnl3; Gm316; Gm33"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1352
                     /gene="Btnl1"
                     /gene_synonym="Btnl3; Gm316; Gm33"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..2113
                     /gene="Btnl1"
                     /gene_synonym="Btnl3; Gm316; Gm33"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccttaaat aagagctgaa gatggctgca gctttctcct agactcctcc aggagaaact
       61 ctaaagccag agcctggggg cagcattgtg tgtccacctt gccactgaga acatctacgg
      121 aaattggaca ctctggcccc agcatccaca cgcttgactg ttggccacag taacacaggt
      181 gtggatggtc cccagagcca gggtccagga gtgcactgag gatccctggg gcttcaagga
      241 acccacagct ctgtccagac gggaattttt ttcctgagaa ctttcacctg ttgccctcct
      301 atggtgaacc tggacttgac cttccactct gatgatgaag ggctccccct ccgtccctcc
      361 agctggttgt ctcctccctc tgctcctcct gctgtttacc ggagtctctg gagaagtgtc
      421 ttggttttct gtgaagggac cagctgagcc catcactgtc ctgctgggga ctgaagccac
      481 cctgccctgc cagctgtctc ctgaacagag tgcagctcgc atgcacatcc gatggtaccg
      541 tgcccagccc acccctgctg tgctggtgtt ccacaacgga caggagcagg gagaggtgca
      601 gatgccggaa tacaggggca ggacccagat ggtgagacaa gccattgaca tgggaagtgt
      661 ggctctgcag atacagcagg tccaggcctc tgatgatggc ctgtaccact gtcagtttac
      721 agatggcttc acctcccaag aggtctccat ggagcttcga gtcataggtt taggctctgc
      781 ccctcttgtt cacatgacag gacctgagaa tgatgggatc cgagtgttgt gctcctcaag
      841 tggctggttc ccaaaaccca aagtgcaatg gagagacacc tccgggaaca tgctactgtc
      901 ctcctctgag ttgcagaccc aagacagaga agggctcttc caggtggaag tgtctctttt
      961 ggtcacagat agagctattg gcaatgtgat ctgctccatc caaaatccca tgtatgacca
     1021 ggagaaatcg aaggccatcc tcctcccaga gcccttcttc cccaagacgt gtccatggaa
     1081 agtagccctg gtttgttctg tcctcatact attggtcctg ctcggtggga tcagccttgg
     1141 aatctggaaa gaacatcaag tcaaaaggag agaaattaaa aaatggtcaa aggaacatga
     1201 agaaatgctt ctgttgaaga aggggacaaa atctgtactg aagatcagag atgacctcca
     1261 ggccgaccta gatcggagga aggcgctgta caaagaagac tggaagaagg ccttgctgta
     1321 ccctgactgg aggaaggagc tgttccagga ggctcctgtg aggataaatt atgaaatgcc
     1381 tgaccaggac aagacagact caaggacaga agagaacaga ggtgaggaga ctgtcagcag
     1441 ctcacaagta gaccacaacc tcatcacact ctcccaggaa ggcttcatgt tgggaagata
     1501 ctactgggag gtggatgtca aggacacaga ggagtggaca ctaggagttt atgagctgtg
     1561 cactcaggat gcatcactta cagacccctt gaggaaattc agagtcctgg aaaagaatgg
     1621 agatggatac agggctcttg acttctgttc ccaaaacatt aattcggaag aacctctgca
     1681 actgaagaca cgtccgctga agatcgccat cttcttggat caggaagaca atgacctctc
     1741 tttctacaac atgaccgatg agacacacat cttttccttt gcccaggtcc ctttcttggg
     1801 atcaccctat ccttacttca cacgtaattc catggggctc tctgcaacag cacagcccta
     1861 agtgatgtgc acagggaatt caatgggtgg gtgctgcagc gtgctacccg taaggccctc
     1921 ttaggcaggc acagggggcc tctgaccaag aggcctctta acctgagact ccatgagcct
     1981 cggggatcag atcctggaca agattctcgg accatctgtg tcgtgcatgg tgttatagtt
     2041 attaatagcc ttccttcttt tgacaaaaat gtgtttaatc attcctaaga taaatgaatc
     2101 catggctttc tga
//
