LOCUS       NM_013483               3454 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus butyrophilin, subfamily 1, member A1 (Btn1a1), mRNA.
ACCESSION   NM_013483
VERSION     NM_013483.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3454)
  AUTHORS   Jeong,J., Kadegowda,A.K.G., Meyer,T.J., Jenkins,L.M., Dinan,J.C.,
            Wysolmerski,J.J., Weigert,R. and Mather,I.H.
  TITLE     The butyrophilin 1a1 knockout mouse revisited: Ablation of Btn1a1
            leads to concurrent cell death and renewal in the mammary
            epithelium during lactation
  JOURNAL   FASEB Bioadv 3 (12), 971-997 (2021)
   PUBMED   34938960
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3454)
  AUTHORS   Garside,V.C., Cullum,R., Alder,O., Lu,D.Y., Vander Werff,R.,
            Bilenky,M., Zhao,Y., Jones,S.J., Marra,M.A., Underhill,T.M. and
            Hoodless,P.A.
  TITLE     SOX9 modulates the expression of key transcription factors required
            for heart valve development
  JOURNAL   Development 142 (24), 4340-4350 (2015)
   PUBMED   26525672
REFERENCE   3  (bases 1 to 3454)
  AUTHORS   Lee,F.Y., Faivre,E.J., Suzawa,M., Lontok,E., Ebert,D., Cai,F.,
            Belsham,D.D. and Ingraham,H.A.
  TITLE     Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic
            hedgehog signaling and disruption of endocrine development
  JOURNAL   Dev Cell 21 (2), 315-327 (2011)
   PUBMED   21820362
REFERENCE   4  (bases 1 to 3454)
  AUTHORS   LaRocca,J., Pietruska,J. and Hixon,M.
  TITLE     Akt1 is essential for postnatal mammary gland development,
            function, and the expression of Btn1a1
  JOURNAL   PLoS One 6 (9), e24432 (2011)
   PUBMED   21915327
  REMARK    GeneRIF: Data illustrated the importance of Akt1 in mammary
            epithelial cell proliferation, as well as in the regulation of
            Btn1a1 and subsequent expression of ss-casein.
REFERENCE   5  (bases 1 to 3454)
  AUTHORS   Smith,I.A., Knezevic,B.R., Ammann,J.U., Rhodes,D.A., Aw,D.,
            Palmer,D.B., Mather,I.H. and Trowsdale,J.
  TITLE     BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both
            inhibitors of T cell activation
  JOURNAL   J Immunol 184 (7), 3514-3525 (2010)
   PUBMED   20208008
  REMARK    GeneRIF: These data are consistent with a coinhibitory role for
            mouse Butyrophilins
REFERENCE   6  (bases 1 to 3454)
  AUTHORS   Ogg,S.L., Komaragiri,M.V. and Mather,I.H.
  TITLE     Structural organization and mammary-specific expression of the
            butyrophilin gene
  JOURNAL   Mamm Genome 7 (12), 900-905 (1996)
   PUBMED   8995761
REFERENCE   7  (bases 1 to 3454)
  AUTHORS   Taylor,C., Everest,M. and Smith,C.
  TITLE     Restriction fragment length polymorphism in amplification products
            of the bovine butyrophilin gene: assignment of bovine butyrophilin
            to bovine chromosome 23
  JOURNAL   Anim Genet 27 (3), 183-185 (1996)
   PUBMED   8759118
REFERENCE   8  (bases 1 to 3454)
  AUTHORS   Ishii,T., Aoki,N., Noda,A., Adachi,T., Nakamura,R. and Matsuda,T.
  TITLE     Carboxy-terminal cytoplasmic domain of mouse butyrophilin
            specifically associates with a 150-kDa protein of mammary
            epithelial cells and milk fat globule membrane
  JOURNAL   Biochim Biophys Acta 1245 (3), 285-292 (1995)
   PUBMED   8541302
REFERENCE   9  (bases 1 to 3454)
  AUTHORS   Jenkins,N.A., Gilbert,D.J., Yamamoto,R., Kilimann,M.W. and
            Copeland,N.G.
  TITLE     Amphiphysin (Amph) maps to the proximal region of mouse chromosome
            13
  JOURNAL   Genomics 28 (2), 363-365 (1995)
   PUBMED   8530056
REFERENCE   10 (bases 1 to 3454)
  AUTHORS   Amadou,C., Ribouchon,M.T., Mattei,M.G., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G., Avoustin,P. and Pontarotti,P.
  TITLE     Localization of new genes and markers to the distal part of the
            human major histocompatibility complex (MHC) region and comparison
            with the mouse: new insights into the evolution of mammalian
            genomes
  JOURNAL   Genomics 26 (1), 9-20 (1995)
   PUBMED   7782091
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145168.1, AL714025.12, AK142596.1 and BE199598.1.
            
            On Nov 2, 2007 this sequence version replaced NM_013483.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011497.1, AK142596.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AK145168.1         2-92
            92-94               AL714025.12        69733-69735         c
            95-3442             AK142596.1         2-3349
            3443-3454           BE199598.1         1-12                c
FEATURES             Location/Qualifiers
     source          1..3454
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 9.72 cM"
     gene            1..3454
                     /gene="Btn1a1"
                     /gene_synonym="Btn"
                     /note="butyrophilin, subfamily 1, member A1"
                     /db_xref="GeneID:12231"
                     /db_xref="MGI:MGI:103118"
     exon            1..120
                     /gene="Btn1a1"
                     /gene_synonym="Btn"
                     /inference="alignment:Splign:2.1.0"
     exon            121..242
                     /gene="Btn1a1"
                     /gene_synonym="Btn"
                     /inference="alignment:Splign:2.1.0"
     exon            243..593
                     /gene="Btn1a1"
                     /gene_synonym="Btn"
                     /inference="alignment:Splign:2.1.0"
     exon            594..875
                     /gene="Btn1a1"
                     /gene_synonym="Btn"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1025
                     /gene="Btn1a1"
                     /gene_synonym="Btn"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1046
                     /gene="Btn1a1"
                     /gene_synonym="Btn"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1073
                     /gene="Btn1a1"
                     /gene_synonym="Btn"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..3449
                     /gene="Btn1a1"
                     /gene_synonym="Btn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3430..3435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btn1a1"
                     /gene_synonym="Btn"
                     /note="hexamer: AATAAA"
     polyA_site      3449
                     /gene="Btn1a1"
                     /gene_synonym="Btn"
                     /note="major polyA site"
ORIGIN      
        1 aacagcacac agccttcttc cttctgaaga gctctctctt tggccccggg gtgacaagca
       61 gcccttttca cttgatcact gtggctctgg ctcccttttc ctctgggtct gtcgaaatcg
      121 cctgaagctc ttggcgggct tcattgcccc agttagctca gagatggcag ttcccaccaa
      181 ctcctgcctc ctggtctgtc tgctcaccct cactgtccta cagctgccca cgctggattc
      241 ggcagctccc ttcgatgtga ccgcacctca ggagccagtg ttggccctag tgggctcaga
      301 tgccgagctg acctgtggct tttccccaaa cgcgagctca gaatacatgg agctgctgtg
      361 gtttcgacag acgaggtcga cagcggtact tctataccgg gatggccagg agcaggaggg
      421 ccagcagatg acggagtacc gcgggagggc gacgctggcg acagccgggc ttctagacgg
      481 ccgcgctact ctgctgatcc gagatgtcag ggtctcagac cagggggagt accggtgcct
      541 tttcaaagac aacgacgact tcgaggaggc cgccgtatac ctcaaagtgg ctgctgtggg
      601 ttcagatcct caaatcagta tgacggttca agagaatgga gaaatggagc tggagtgcac
      661 ctcctctgga tggtacccag agcctcaggt gcagtggaga acaggcaaca gagagatgct
      721 accatccacg tcagagtcca agaagcataa tgaggaaggc ctgttcactg tggcagtttc
      781 aatgatgatc agagacagct ccataaagaa catgtcctgc tgcatccaga atatcctcct
      841 tggccagggg aaggaagtag agatctcctt accagctccc ttcgtgccaa ggctgactcc
      901 ctggatagta gctgtggcta tcatcttact ggccttagga tttctcacca ttgggtccat
      961 atttttcact tggaaactat acaaggaaag atccagtctg cggaagaagg aatttggctc
     1021 taaagagaga cttctggaag aactcagatg caaaaagact gtactgcatg aagttgacgt
     1081 gactctggat ccagacacag cccaccccca cctcttcctg tatgaagatt caaagtcagt
     1141 tcgattggaa gattcacgtc agatcctgcc tgatagacca gagagatttg actcctggcc
     1201 ctgtgtgttg ggccgtgaga cctttacttc agggagacat tactgggagg tggaggtggg
     1261 agatagaact gactgggcca ttggtgtgtg tagggagaat gtggtgaaga aagggtttga
     1321 ccccatgact cctgataatg ggttctgggc tgtggagttg tatggaaatg ggtactgggc
     1381 cctcacccca ctcaggacct ctctccgatt agcagggccc cctcgcagag ttggggtttt
     1441 tctggactat gacgcaggag acatttcctt ctacaacatg agtaacggat ctcttatcta
     1501 tactttccct agcatctctt tctctggccc cctccgtccc ttcttttgtc tgtggtcctg
     1561 tggtaaaaag cccctgacca tctgttcaac tgccaatggg cctgagaaag tcacagtcat
     1621 tgctaatgtc caggacgaca ttcccttgtc cccgctgggg gaaggctgta cttctggaga
     1681 caaagacact ctccattcta aactgatccc gttctcacct agccaagcgg caccataaca
     1741 aatattccag cttcacgact ttgccttcct ttgactaatc cctcatgccc cgaagcttca
     1801 gctgttggct tcttgcagcc ctgcttcttc ctggtggatg gagattaatt cacattggga
     1861 aggttaggta tgttgctgcc agacaaggca ggaagaaagg ccatcctagt ttgtttctgt
     1921 actaacagtg gggaggaaga gagctgaatc ctaaactatt tccagtgctc atattccttc
     1981 aggccagagc ctatagagaa ggatttggta caatcactcg agggatcaag aggcaattag
     2041 gttggcatgg aattatggca gaaacatctg gaataggggt atgtggaatg acaggtttta
     2101 ggtaagggag aacaaaacca aaccatagga tgctgagaaa gaaagatctt ggactaaact
     2161 cctaaaaaag cacttagaga agatatgaca ggcaaatgaa gtgaatttgg tctaatttga
     2221 tacacttgcc ctgtccctag ggtttttcag ttatatctca atttttttgt tgttaattac
     2281 atttttgaca gcttcataca tgtatataat gcattctaat tactctcact ctcctctatt
     2341 ctgtcttatt tccctcccct cccctcatac cttccttctt gcttcaaacc tggcacactg
     2401 agtttaatgg gctatcatgg gaacatggat ttagagcttt cctctgagct caagagagca
     2461 ggtgtgactg aatacagtga tttcccctct cctacaatca atcagcagtc aatagctcag
     2521 ctgggagggg tagggcctca tgagacttcc cctatcaagg ctaaatgttg aaagggccag
     2581 tttttagcac ctgtgagatc atgattgcaa gagcccagaa gacagcattg ctcggtcatt
     2641 ctccctaccc tttggctttt ctggtctttt gtcctctctt tcaggatgtg tctgaactct
     2701 gtatcttaag ttttctatgt catgttctat aagatagagg agactggccc tgcttgtttg
     2761 agagcaatgt gagcaagcta gcaagagaca gaaaggagcg gagatgaata ggggtagaga
     2821 aaatttttaa acaaaccctc caggtgtgtg tgtgtgtgtg tgtgtcttcc tcttttttga
     2881 cctccctaaa ggtcaatcca acctcacatt attgactcca ctaggtgggg gttctgtgtg
     2941 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgttttaaga tagaggttta ctatgtagct
     3001 taggctggct ttgaattcct gatcctcctg cctctacctt ccaagtgctg gaaacatagc
     3061 cacatccacc acccctatcc agtccacctg gtttgattca gcaacgctca ggtagcatcg
     3121 ctgtttgatc tggagctgcc agctccctcg gcccccactg caatgcttaa ccccctcaca
     3181 ggcaccttcc cttgcctaac actgccatcc ttttccacac tgagccattt gctcaatgta
     3241 gcctacccag gtatcctgct ttctggtccc caaagttaca ccatgatgct cagcacagct
     3301 ggacagtttg tcccaatttg tgtgtgtcct cctgtttgta tgggacttct ttttgtcaat
     3361 ggcctgtgtg tgtatccaag ctcttccact tctattgtat ttttccggct tctaaaacag
     3421 atgttaccaa ataaagaaag agaaagaaaa aaaa
//
