LOCUS       NM_001037719            3235 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus B and T lymphocyte associated (Btla), transcript
            variant 1, mRNA.
ACCESSION   NM_001037719 XM_489565
VERSION     NM_001037719.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3235)
  AUTHORS   Mkhikian,H., Zhou,R.W., Saryan,H., Sanchez,C.D., Balakrishnan,A.,
            Dang,J., Mortales,C.L. and Demetriou,M.
  TITLE     N-Glycan Branching Regulates BTLA Opposite to PD-1 to Limit T Cell
            Hyperactivity Induced by Branching Deficiency
  JOURNAL   J Immunol 213 (9), 1329-1337 (2024)
   PUBMED   39269653
  REMARK    GeneRIF: N-Glycan Branching Regulates BTLA Opposite to PD-1 to
            Limit T Cell Hyperactivity Induced by Branching Deficiency.
REFERENCE   2  (bases 1 to 3235)
  AUTHORS   Shen,X., Mai,R., Han,X., Wang,Q., Wang,Y., Ji,T., Tong,Y., Chen,P.,
            Zhao,J., He,X., Wen,T., Liang,R., Lin,Y., Luo,X. and Cai,X.
  TITLE     BTLA deficiency promotes HSC activation and protects against
            hepatic ischemia-reperfusion injury
  JOURNAL   Hepatol Commun 8 (6), e0449 (2024)
   PUBMED   38840336
  REMARK    GeneRIF: BTLA deficiency promotes HSC activation and protects
            against hepatic ischemia-reperfusion injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3235)
  AUTHORS   Guruprasad,P., Carturan,A., Zhang,Y., Cho,J.H., Kumashie,K.G.,
            Patel,R.P., Kim,K.H., Lee,J.S., Lee,Y., Kim,J.H., Chung,J.,
            Joshi,A., Cohen,I., Shestov,M., Ghilardi,G., Harris,J.,
            Pajarillo,R., Angelos,M., Lee,Y.G., Liu,S., Rodriguez,J., Wang,M.,
            Ballard,H.J., Gupta,A., Ugwuanyi,O.H., Hong,S.J.A.,
            Bochi-Layec,A.C., Sauter,C.T., Chen,L., Paruzzo,L., Kammerman,S.,
            Shestova,O., Liu,D., Vella,L.A., Schuster,S.J., Svoboda,J.,
            Porazzi,P. and Ruella,M.
  TITLE     The BTLA-HVEM axis restricts CAR T cell efficacy in cancer
  JOURNAL   Nat Immunol 25 (6), 1020-1032 (2024)
   PUBMED   38831106
  REMARK    GeneRIF: The BTLA-HVEM axis restricts CAR T cell efficacy in
            cancer.
REFERENCE   4  (bases 1 to 3235)
  AUTHORS   Yu,X., Yang,F., Shen,Z., Zhang,Y., Sun,J., Qiu,C., Zheng,Y.,
            Zhao,W., Yuan,S., Zeng,D., Zhang,S., Long,J., Zhu,M., Zhang,X.,
            Wu,J., Ma,Z., Zhu,H., Su,M., Xu,J., Li,B., Mao,R., Su,Z. and
            Zhang,J.
  TITLE     BTLA contributes to acute-on-chronic liver failure infection and
            mortality through CD4+ T-cell exhaustion
  JOURNAL   Nat Commun 15 (1), 1835 (2024)
   PUBMED   38418488
  REMARK    GeneRIF: BTLA contributes to acute-on-chronic liver failure
            infection and mortality through CD4[+] T-cell exhaustion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3235)
  AUTHORS   Seo,G.Y., Takahashi,D., Wang,Q., Mikulski,Z., Chen,A., Chou,T.F.,
            Marcovecchio,P., McArdle,S., Sethi,A., Shui,J.W., Takahashi,M.,
            Surh,C.D., Cheroutre,H. and Kronenberg,M.
  TITLE     Epithelial HVEM maintains intraepithelial T cell survival and
            contributes to host protection
  JOURNAL   Sci Immunol 7 (73), eabm6931 (2022)
   PUBMED   35905286
REFERENCE   6  (bases 1 to 3235)
  AUTHORS   Han,P., Goularte,O.D., Rufner,K., Wilkinson,B. and Kaye,J.
  TITLE     An inhibitory Ig superfamily protein expressed by lymphocytes and
            APCs is also an early marker of thymocyte positive selection
  JOURNAL   J Immunol 172 (10), 5931-5939 (2004)
   PUBMED   15128774
  REMARK    GeneRIF: BTLA is expressed by all mature lymphocytes, splenic
            macrophages, and mature, but not immature bone marrow-derived
            dendritic cells. BTLA is implicated as a negative regulator of the
            activation and/or function of various hemopoietic cell types.
REFERENCE   7  (bases 1 to 3235)
  AUTHORS   Gavrieli,M., Watanabe,N., Loftin,S.K., Murphy,T.L. and Murphy,K.M.
  TITLE     Characterization of phosphotyrosine binding motifs in the
            cytoplasmic domain of B and T lymphocyte attenuator required for
            association with protein tyrosine phosphatases SHP-1 and SHP-2
  JOURNAL   Biochem Biophys Res Commun 312 (4), 1236-1243 (2003)
   PUBMED   14652006
REFERENCE   8  (bases 1 to 3235)
  AUTHORS   Zang,X., Loke,P., Kim,J., Murphy,K., Waitz,R. and Allison,J.P.
  TITLE     B7x: a widely expressed B7 family member that inhibits T cell
            activation
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10388-10392 (2003)
   PUBMED   12920180
REFERENCE   9  (bases 1 to 3235)
  AUTHORS   Watanabe,N., Gavrieli,M., Sedy,J.R., Yang,J., Fallarino,F.,
            Loftin,S.K., Hurchla,M.A., Zimmerman,N., Sim,J., Zang,X.,
            Murphy,T.L., Russell,J.H., Allison,J.P. and Murphy,K.M.
  TITLE     BTLA is a lymphocyte inhibitory receptor with similarities to
            CTLA-4 and PD-1
  JOURNAL   Nat Immunol 4 (7), 670-679 (2003)
   PUBMED   12796776
  REMARK    GeneRIF: BTLA is a third inhibitory receptor on T lymphocytes with
            similarities to cytotoxic T lymphocyte-associated antigen 4
            (CTLA-4) and programmed death 1 (PD-1).
REFERENCE   10 (bases 1 to 3235)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK041334.1, BC108964.1 and BB123968.1.
            
            On Dec 16, 2005 this sequence version replaced NM_001037719.1.
            
            Transcript Variant: This variant (1) encodes the longer transcript
            and it encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC108964.1, AY293285.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-482               AK041334.1         3-484
            483-688             BC108964.1         485-690
            689-3230            AK041334.1         688-3229
            3231-3235           BB123968.1         299-303
FEATURES             Location/Qualifiers
     source          1..3235
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 29.52 cM"
     gene            1..3235
                     /gene="Btla"
                     /gene_synonym="A630002H24"
                     /note="B and T lymphocyte associated"
                     /db_xref="GeneID:208154"
                     /db_xref="MGI:MGI:2658978"
     exon            1..125
                     /gene="Btla"
                     /gene_synonym="A630002H24"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..937
                     /gene="Btla"
                     /gene_synonym="A630002H24"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; B- and T-lymphocyte attenuator; B- and
                     T-lymphocyte-associated protein"
                     /codon_start=1
                     /product="B- and T-lymphocyte attenuator isoform 1
                     precursor"
                     /protein_id="NP_001032808.2"
                     /db_xref="CCDS:CCDS28195.1"
                     /db_xref="GeneID:208154"
                     /db_xref="MGI:MGI:2658978"
                     /translation="MKTVPAMLGTPRLFREFFILHLGLWSILCEKATKRNDEECPVQL
                     TITRNSKQSARTGELFKIQCPVKYCVHRPNVTWCKHNGTICVPLEVSPQLYTSWEENQ
                     SVPVFVLHFKPIHLSDNGSYSCSTNFNSQVINSHSVTIHVTERTQNSSEHPLITVSDI
                     PDATNASGPSTMEERPGRTWLLYTLLPLGALLLLLACVCLLCFLKRIQGKEKKPSDLA
                     GRDTNLVDIPASSRTNHQALPSGTGIYDNDPWSSMQDESELTISLQSERNNQGIVYAS
                     LNHCVIGRNPRQENNMQEAPTEYASICVRS"
     exon            126..446
                     /gene="Btla"
                     /gene_synonym="A630002H24"
                     /inference="alignment:Splign:2.1.0"
     exon            447..482
                     /gene="Btla"
                     /gene_synonym="A630002H24"
                     /inference="alignment:Splign:2.1.0"
     exon            483..641
                     /gene="Btla"
                     /gene_synonym="A630002H24"
                     /inference="alignment:Splign:2.1.0"
     exon            642..688
                     /gene="Btla"
                     /gene_synonym="A630002H24"
                     /inference="alignment:Splign:2.1.0"
     exon            689..3235
                     /gene="Btla"
                     /gene_synonym="A630002H24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2395..2400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btla"
                     /gene_synonym="A630002H24"
                     /note="hexamer: AATAAA"
     polyA_site      2416
                     /gene="Btla"
                     /gene_synonym="A630002H24"
     regulatory      3195..3200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btla"
                     /gene_synonym="A630002H24"
                     /note="hexamer: AATAAA"
     polyA_site      3215
                     /gene="Btla"
                     /gene_synonym="A630002H24"
                     /note="major polyA site"
ORIGIN      
        1 ctgacacgtg ctgggaatga agacagtgcc tgccatgctt gggactcctc ggttatttag
       61 ggaattcttc atcctccatc tgggcctctg gagcatcctt tgtgagaaag ctactaagag
      121 gaatgatgaa gagtgtccag tgcaacttac tattacgagg aattccaaac agtctgccag
      181 gacaggagag ttatttaaaa ttcaatgtcc tgtgaaatac tgtgttcata gacctaatgt
      241 gacttggtgt aagcacaatg gaacaatctg tgtacccctt gaggttagcc ctcagctata
      301 cactagttgg gaagaaaatc aatcagttcc ggtttttgtt ctccacttta aaccaataca
      361 tctcagtgat aatgggtcgt atagctgttc tacaaacttc aattctcaag ttattaatag
      421 ccattcagta accatccatg tgacagaaag gactcaaaac tcttcagaac acccactaat
      481 aacagtatct gacatcccag atgccaccaa tgcctcagga ccatccacca tggaagagag
      541 gccaggcagg acttggctgc tttacacctt gcttcctttg ggggcattgc ttctgctcct
      601 tgcctgtgtc tgcctgctct gctttctgaa aaggatccaa gggaaagaaa agaagccttc
      661 tgacttggca ggaagggaca ctaacctggt tgatattcca gccagttcca ggacaaatca
      721 ccaagcactg ccatcaggaa ctggaattta tgataatgat ccctggtcta gcatgcagga
      781 tgaatctgaa ttgacaatta gcttgcaatc agagagaaac aaccagggca ttgtttatgc
      841 ttctttgaac cattgtgtta ttggaaggaa tccaagacag gaaaacaaca tgcaggaggc
      901 acccacagaa tatgcatcca tttgtgtgag aagttaaacc tgccactgag ccaggcagcc
      961 tacactgcat gagtgcctgt caatacctct gtctggacct tcagtttcaa ataaccttca
     1021 acctggaaag tttcaattaa gatgctctgt gctggtgctg cgtcttaaag gtccatgaag
     1081 tatttagtta aaatttctcc tgaaaacttt gggagagttt tgtacaagac agactcttcc
     1141 ctgggaaaac tcatattacg aatagcagaa taatagggct tttaaaattg accatgtcgc
     1201 accatgtcgt acccaatgtg tgaattcaat attttctttg gaactaccaa acagacttac
     1261 aggggagaaa gaagcgtgtt atttggatct gctcactaca cattctagaa aaagaatggc
     1321 ccagtttgac taactagtca taaatatagt aatgattgta tgctctcagt cagtcatgat
     1381 aagacaatta cccatgtcaa tctatataga taatgcttta ttattttttt taatgtgaaa
     1441 gaaaaattat cttggactca attcagaaaa agattagaaa gggtaattgg tataatacag
     1501 atatagcata tgccagatag atgtggtgcc aacgatcctt atccccacca gtgagatgct
     1561 caccttcagc tggcttgatt gagaaagtaa ggtaggtagt aaagggctca tccacatata
     1621 gtgagtggat ttgcaatcag cgtggtagtg tttggatcaa gattaacgca catgaatgtg
     1681 attcaatgct gctggattaa tatacatatg gtacgtatgg gcctatgaac aagtgtccat
     1741 gggaatggat atattatcaa tctagagcga acttttagcc caccttttgc tttacgtgag
     1801 agcaagctca aagggcaatt tatgaaagga gaatcttgaa tattgagttg atccgtaggg
     1861 actggcatgc attcattaat gcctgtttct tgattctgag gaagtgaatc agaaaaaatc
     1921 atatgtaatg aagtagggcc tatggagatc actcaggttt aaattctgac attgcagctg
     1981 ttcaagaaga tgattatcag gtgttctgaa tttccggatt gagtctaatt acttaaaaat
     2041 agctcataat tttattcatc agcttgaggc ttgagttctc agaccctaaa actgaataat
     2101 ggcatagtct tagtatacag cagattgggc ctgagttaga agccactgga gcaaacacat
     2161 aaactgtcta tgtaattgca tgcatatatg tgggtgtgcc tgtgcatgtg tgtgctagca
     2221 tgcaaatgca agatgtgacg cctggaaata agacaagaga aaccagtcct tttgctgtgc
     2281 tttttttagt ttgcttagaa ggtgcaaagt actagagaaa atgagtcatt tatagaaaat
     2341 aacacgtaga ctggtgagaa tggaagggag ttgagaatgt atccataaac agtgaataaa
     2401 gaggccttac tacacagctt ttctcaccta ctgctcacct cgggttccag ttccctgaat
     2461 ctagaacaac aaacaatgtt ttcagacatg ttacaaccac ttctagttaa gcttgttcag
     2521 gcaggtgcat ttgtgggaat ttatgcaaaa aagaccttag aatagctgct catcttcaaa
     2581 atagaaacag gaaggatggg agggggatga gtactgcact ctgtctctct tatcagatca
     2641 acaggcaact taagcaaatc tttcagaatt gtctccggct ttaaaaggaa aatacttcgc
     2701 tctactctgt ttaaaacaat cttttaaaaa cgttgtgtgt acatgtatat ttgggtatgc
     2761 atgtatgtgt gtatatggtg tatgtgcgtg gtgtacacac atgtgtatgc aggagccaga
     2821 agagaaagtc aggcaccctt ttctattgca ctccacttta ttctgttaag ggaaggtctc
     2881 tcattgaacc tggagctctg ctagcaagca gcaagccagc gatggatcct cccatccctg
     2941 acccccacat tgctagacta tatttgctca tgcccagctt tttacaagga tgtggagaac
     3001 tgaaattcag gtcctcatga ttgcataaca agcactctca cttactaagc atgttctaat
     3061 atgttttaca atgaaagacg ctgctcaaga tttcacctca atgaatgatc aattctgttt
     3121 gtaccttgtt tgccaatcac atagcattta tgctcttatt cctacttagt aaatatgtat
     3181 gttgtagctc ctcaaataaa tttgttccag cattattttc atggttacct aactc
//
