LOCUS       NM_013482               2535 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus Bruton agammaglobulinemia tyrosine kinase (Btk), mRNA.
ACCESSION   NM_013482
VERSION     NM_013482.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2535)
  AUTHORS   Benoit,R.Y., Zagrodnik,J.L., Carew,S.J. and Moore,C.S.
  TITLE     Bruton Tyrosine Kinase Inhibition Decreases Inflammation and
            Differentially Impacts Phagocytosis and Cellular Metabolism in
            Mouse- and Human-derived Myeloid Cells
  JOURNAL   Immunohorizons 8 (9), 652-667 (2024)
   PUBMED   39259208
  REMARK    GeneRIF: Bruton Tyrosine Kinase Inhibition Decreases Inflammation
            and Differentially Impacts Phagocytosis and Cellular Metabolism in
            Mouse- and Human-derived Myeloid Cells.
REFERENCE   2  (bases 1 to 2535)
  AUTHORS   Desai,J.V., Zarakas,M.A., Wishart,A.L., Roschewski,M.,
            Aufiero,M.A., Donko,A., Wigerblad,G., Shlezinger,N., Plate,M.,
            James,M.R., Lim,J.K., Uzel,G., Bergerson,J.R., Fuss,I.,
            Cramer,R.A., Franco,L.M., Clark,E.S., Khan,W.N., Yamanaka,D.,
            Chamilos,G., El-Benna,J., Kaplan,M.J., Staudt,L.M., Leto,T.L.,
            Holland,S.M., Wilson,W.H., Hohl,T.M. and Lionakis,M.S.
  TITLE     BTK drives neutrophil activation for sterilizing antifungal
            immunity
  JOURNAL   J Clin Invest 134 (12) (2024) In press
   PUBMED   38696257
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 2535)
  AUTHORS   Estupinan,H.Y., Bouderlique,T., He,C., Berglof,A., Cappelleri,A.,
            Frengen,N., Zain,R., Karlsson,M.C.I., Mansson,R. and Smith,C.I.E.
  TITLE     In BTK, phosphorylated Y223 in the SH3 domain mirrors catalytic
            activity, but does not influence biological function
  JOURNAL   Blood Adv 8 (8), 1981-1990 (2024)
   PUBMED   38507738
  REMARK    GeneRIF: In BTK, phosphorylated Y223 in the SH3 domain mirrors
            catalytic activity, but does not influence biological function.
REFERENCE   4  (bases 1 to 2535)
  AUTHORS   Han,F., Shi,X., Liao,T., Zhang,W., Ma,M., Leng,Q., Jiang,W., Na,N.,
            Miao,Y. and Huang,Z.
  TITLE     Bruton's tyrosine kinase ablation inhibits B cell responses and
            antibody production for the prevention of chronic rejection in
            cardiac transplantation
  JOURNAL   Clin Immunol 261, 109941 (2024)
   PUBMED   38365047
  REMARK    GeneRIF: Bruton's tyrosine kinase ablation inhibits B cell
            responses and antibody production for the prevention of chronic
            rejection in cardiac transplantation.
REFERENCE   5  (bases 1 to 2535)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 2535)
  AUTHORS   Chung,H.Y., Dong,Z. and Wortis,H.H.
  TITLE     B cell deficiency progresses with lineage maturation in
            nude.X-linked immunodeficient mice B cell deficiency progresses
            with lineage maturation
  JOURNAL   J Immunol 149 (11), 3456-3462 (1992)
   PUBMED   1385525
REFERENCE   7  (bases 1 to 2535)
  AUTHORS   Perlmutter,R.M., Nahm,M., Stein,K.E., Slack,J., Zitron,I.,
            Paul,W.E. and Davie,J.M.
  TITLE     Immunoglobulin subclass-specific immunodeficiency in mice with an
            X-linked B-lymphocyte defect
  JOURNAL   J Exp Med 149 (4), 993-998 (1979)
   PUBMED   311819
REFERENCE   8  (bases 1 to 2535)
  AUTHORS   Volf,D., Sensenbrenner,L.L., Sharkis,S.J., Elfenbein,G.J. and
            Scher,I.
  TITLE     Induction of partial chimerism in nonirradiated
            B-lymphocyte-deficient CBA/N mice
  JOURNAL   J Exp Med 147 (3), 940-945 (1978)
   PUBMED   305463
REFERENCE   9  (bases 1 to 2535)
  AUTHORS   Scher,I., Steinberg,A.D., Berning,A.K. and Paul,W.E.
  TITLE     X-linked B-lymphocyte immune defect in CBA/N mice. II. Studies of
            the mechanisms underlying the immune defect
  JOURNAL   J Exp Med 142 (3), 637-650 (1975)
   PUBMED   1080788
REFERENCE   10 (bases 1 to 2535)
  AUTHORS   Scher,I., Ahmed,A., Strong,D.M., Steinberg,A.D. and Paul,W.E.
  TITLE     X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of
            the function and composition of spleen cells
  JOURNAL   J Exp Med 141 (4), 788-803 (1975)
   PUBMED   805203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ044967.1, L29788.1, DT921900.1 and BY596531.1.
            
            On Nov 24, 2007 this sequence version replaced NM_013482.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L08967.1, L29788.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                CJ044967.1         2-29
            29-904              L29788.1           1-876
            905-948             DT921900.1         429-472
            949-2222            L29788.1           921-2194
            2223-2535           BY596531.1         112-424
FEATURES             Location/Qualifiers
     source          1..2535
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 56.18 cM"
     gene            1..2535
                     /gene="Btk"
                     /gene_synonym="xid"
                     /note="Bruton agammaglobulinemia tyrosine kinase"
                     /db_xref="GeneID:12229"
                     /db_xref="MGI:MGI:88216"
     exon            1..130
                     /gene="Btk"
                     /gene_synonym="xid"
                     /inference="alignment:Splign:2.1.0"
     exon            131..301
                     /gene="Btk"
                     /gene_synonym="xid"
                     /inference="alignment:Splign:2.1.0"
     exon            302..400
                     /gene="Btk"
                     /gene_synonym="xid"
                     /inference="alignment:Splign:2.1.0"
     exon            401..469
                     /gene="Btk"
                     /gene_synonym="xid"
                     /inference="alignment:Splign:2.1.0"
     exon            470..551
                     /gene="Btk"
                     /gene_synonym="xid"
                     /inference="alignment:Splign:2.1.0"
     exon            552..680
                     /gene="Btk"
                     /gene_synonym="xid"
                     /inference="alignment:Splign:2.1.0"
     exon            681..748
                     /gene="Btk"
                     /gene_synonym="xid"
                     /inference="alignment:Splign:2.1.0"
     exon            749..936
                     /gene="Btk"
                     /gene_synonym="xid"
                     /inference="alignment:Splign:2.1.0"
     exon            937..999
                     /gene="Btk"
                     /gene_synonym="xid"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1054
                     /gene="Btk"
                     /gene_synonym="xid"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1134
                     /gene="Btk"
                     /gene_synonym="xid"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1262
                     /gene="Btk"
                     /gene_synonym="xid"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1337
                     /gene="Btk"
                     /gene_synonym="xid"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1509
                     /gene="Btk"
                     /gene_synonym="xid"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1726
                     /gene="Btk"
                     /gene_synonym="xid"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1791
                     /gene="Btk"
                     /gene_synonym="xid"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1910
                     /gene="Btk"
                     /gene_synonym="xid"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2068
                     /gene="Btk"
                     /gene_synonym="xid"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2535
                     /gene="Btk"
                     /gene_synonym="xid"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2497..2502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btk"
                     /gene_synonym="xid"
                     /note="hexamer: ATTAAA"
     polyA_site      2532
                     /gene="Btk"
                     /gene_synonym="xid"
ORIGIN      
        1 agactgtcct tcctctctgg actgtaagaa tatgtctcca ggtccagagt cttcagagat
       61 caagtcccac cttccaagtc ctggcatctc acgacgtctg gggagctacc tgcattaagt
      121 cagaactgag tacacaaaca agttccagag agaggaagcc atggctgcag tgatactgga
      181 gagcatcttt ctgaagcgct cccagcagaa aaagaaaaca tcacctttaa acttcaagaa
      241 gcgcctgttt ctcttgactg tacacaaact ttcatactat gaatatgact ttgaacgtgg
      301 gagaagaggc agtaagaaag gttcaataga tgttgagaag atcacctgtg ttgaaacagt
      361 aattcctgaa aaaaatcccc caccagaaag acagattccg aggagaggtg aggagtctag
      421 tgaaatggaa cagatttcaa tcattgaaag gttcccgtac ccattccagg ttgtatatga
      481 tgaaggacct ctctatgttt tctccccaac tgaagagctg agaaagcgct ggattcacca
      541 gctcaaaaat gtaatccggt acaatagtga cctggtacag aaataccatc cttgcttctg
      601 gattgatgga cagtatctct gctgctctca gacagccaag aatgctatgg gctgccaaat
      661 tttggagaac aggaatggaa gcttaaaacc tgggagttct catcgaaaaa cgaaaaagcc
      721 tcttccccct accccagagg aagatcagat cttgaaaaaa ccgcttcccc cggagccaac
      781 agcagcacca atctccacaa ccgagctgaa aaaggtcgtg gccctttatg attacatgcc
      841 aatgaacgca aatgacttac aattgcgaaa gggcgaggag tattttatcc tggaggagag
      901 caacctaccg tggtggcgag cacgagataa aaatgggcag gaaggctaca tcccaagtaa
      961 ctatatcact gaagctgagg actccataga gatgtatgag tggtattcca agcacatgac
     1021 tcgaagtcaa gctgagcaac tgctaaagca agaggggaaa gaaggaggtt tcattgtcag
     1081 agactccagc aaagctggaa aatacaccgt gtctgtgttt gctaaatcta ctggggagcc
     1141 tcaaggggtg atccgccatt acgttgtgtg ttccacgcca cagagccagt attacctggc
     1201 tgagaaacac ctcttcagca ccatccctga gctcattaac taccatcaac acaactctgc
     1261 aggcctcata tccaggctga aatatcctgt gtctaaacaa aacaaaaacg cgccttctac
     1321 tgcaggcctg ggctatggat catgggaaat tgatccaaag gacctcacct tcttgaagga
     1381 gcttgggact ggacaattcg gtgtcgtgaa atatgggaag tggaggggcc aatatgatgt
     1441 ggccatcaag atgatcagag aaggttccat gtcggaggat gaattcattg aagaagccaa
     1501 agtcatgatg aatctttccc atgagaagct ggtgcagttg tatggcgtct gcaccaaaca
     1561 acgccccatc ttcatcatca ccgagtacat ggctaatggc tgcctcttga actacctgag
     1621 ggagatgcgg caccgcttcc agacacagca gctgcttgag atgtgcaaag atgtctgtga
     1681 agcaatggaa tacttggagt cgaagcagtt ccttcacaga gacctggcag ctcgaaactg
     1741 tttggtaaac gatcaaggag ttgtgaaagt atctgacttt ggcctgtcta ggtatgtcct
     1801 tgatgatgag tacaccagct ctgtaggctc caagtttcca gtccggtggt ctccaccaga
     1861 agtgcttatg tatagcaagt tcagcagcaa atctgacatc tgggcttttg gggttttaat
     1921 gtgggagatc tactccctgg ggaagatgcc gtatgagaga tttactaaca gtgagacagc
     1981 agaacacatt gctcaaggct tacgtctcta caggcctcat ctggcatcag agagggtata
     2041 taccatcatg tacagctgct ggcacgagaa agcagatgaa cgtcctagtt tcaaaattct
     2101 cttgagtaac attctagatg tgatggatga agaatcctga gctggctgct aagctccgtg
     2161 gatctcctcc tctctcctac aaaacctaat tccatgtttc ctgaggagtt ccctggctgc
     2221 agggctctag ccttccatgc gcctactgaa tgcatgaaga gccctggaca tctaggaatg
     2281 cctttcttct ctcgttccct ggcatactgc tctaagcaaa ggtcaaggga tttctgtgcc
     2341 tagtattacc cataacttca agactcctaa cagactgaat tggggatggg aacactttgg
     2401 gggagggaaa actgtaaata gctccactag ttgtccaaca gcttgttggt taagtgttaa
     2461 gagtggtggt ggtggtgggg gggtaggaat gttgccatta aaatgggttg ttttgttaca
     2521 ataaaattat tggaa
//
