LOCUS       NM_001401092            1634 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus BTG anti-proliferation factor 4 (Btg4), transcript
            variant 2, mRNA.
ACCESSION   NM_001401092
VERSION     NM_001401092.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1634)
  AUTHORS   Zheng,H.C., Xue,H., Zhang,C.Y. and Zhang,R.
  TITLE     Bioinformatic analysis of the clinicopathological and prognostic
            significance of oocyte-arresting BTG4 mRNA expression in
            gynecological cancers
  JOURNAL   J Obstet Gynaecol 43 (1), 2182672 (2023)
   PUBMED   36880525
  REMARK    GeneRIF: Bioinformatic analysis of the clinicopathological and
            prognostic significance of oocyte-arresting BTG4 mRNA expression in
            gynecological cancers.
REFERENCE   2  (bases 1 to 1634)
  AUTHORS   Wan,Y., Yang,S., Li,T., Cai,Y., Wu,X., Zhang,M., Muhammad,T.,
            Huang,T., Lv,Y., Chan,W.Y., Lu,G., Li,J., Sha,Q.Q., Chen,Z.J. and
            Liu,H.
  TITLE     LSM14B is essential for oocyte meiotic maturation by regulating
            maternal mRNA storage and clearance
  JOURNAL   Nucleic Acids Res 51 (21), 11652-11667 (2023)
   PUBMED   37889087
REFERENCE   3  (bases 1 to 1634)
  AUTHORS   Jiang,X., Cheng,Y., Zhu,Y., Xu,C., Li,Q., Xing,X., Li,W., Zou,J.,
            Meng,L., Azhar,M., Cao,Y., Tong,X., Qin,W., Zhu,X. and Bao,J.
  TITLE     Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression
            and maturation in mice
  JOURNAL   Nat Commun 14 (1), 3729 (2023)
   PUBMED   37349316
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1634)
  AUTHORS   Rong,Y., Zhu,Y.Z., Yu,J.L., Wu,Y.W., Ji,S.Y., Zhou,Y., Jiang,Y.,
            Jin,J., Fan,H.Y., Shen,L. and Sha,Q.Q.
  TITLE     USP16-mediated histone H2A lysine-119 deubiquitination during
            oocyte maturation is a prerequisite for zygotic genome activation
  JOURNAL   Nucleic Acids Res 50 (10), 5599-5616 (2022)
   PUBMED   35640597
REFERENCE   5  (bases 1 to 1634)
  AUTHORS   He,Y., Chen,Q., Dai,J., Cui,Y., Zhang,C., Wen,X., Li,J., Xiao,Y.,
            Peng,X., Liu,M., Shen,B., Sha,J., Hu,Z., Li,J. and Shu,W.
  TITLE     Single-cell RNA-Seq reveals a highly coordinated transcriptional
            program in mouse germ cells during primordial follicle formation
  JOURNAL   Aging Cell 20 (7), e13424 (2021)
   PUBMED   34174788
REFERENCE   6  (bases 1 to 1634)
  AUTHORS   Evsikov,A.V., de Vries,W.N., Peaston,A.E., Radford,E.E.,
            Fancher,K.S., Chen,F.H., Blake,J.A., Bult,C.J., Latham,K.E.,
            Solter,D. and Knowles,B.B.
  TITLE     Systems biology of the 2-cell mouse embryo
  JOURNAL   Cytogenet Genome Res 105 (2-4), 240-250 (2004)
   PUBMED   15237213
REFERENCE   7  (bases 1 to 1634)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 1634)
  AUTHORS   Matsuda,S., Rouault,J., Magaud,J. and Berthet,C.
  TITLE     In search of a function for the TIS21/PC3/BTG1/TOB family
  JOURNAL   FEBS Lett 497 (2-3), 67-72 (2001)
   PUBMED   11377414
  REMARK    Review article
REFERENCE   9  (bases 1 to 1634)
  AUTHORS   Tirone,F.
  TITLE     The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB
            family: regulator in control of cell growth, differentiation, and
            DNA repair?
  JOURNAL   J Cell Physiol 187 (2), 155-165 (2001)
   PUBMED   11267995
  REMARK    Review article
REFERENCE   10 (bases 1 to 1634)
  AUTHORS   Buanne,P., Corrente,G., Micheli,L., Palena,A., Lavia,P.,
            Spadafora,C., Lakshmana,M.K., Rinaldi,A., Banfi,S., Quarto,M.,
            Bulfone,A. and Tirone,F.
  TITLE     Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth
            inhibitory genes, highly expressed in the olfactory epithelium
  JOURNAL   Genomics 68 (3), 253-263 (2000)
   PUBMED   10995567
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119831.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161379.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AC119831.6         100689-100795
            108-228             AC119831.6         108151-108271
            229-285             AC119831.6         110952-111008
            286-484             AC119831.6         111328-111526
            485-622             AC119831.6         111970-112107
            623-821             AC119831.6         112650-112848
            822-1634            AC119831.6         113934-114746
FEATURES             Location/Qualifiers
     source          1..1634
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 27.84 cM"
     gene            1..1634
                     /gene="Btg4"
                     /gene_synonym="PC3B"
                     /note="BTG anti-proliferation factor 4"
                     /db_xref="GeneID:56057"
                     /db_xref="MGI:MGI:1860140"
     exon            1..107
                     /gene="Btg4"
                     /gene_synonym="PC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            108..228
                     /gene="Btg4"
                     /gene_synonym="PC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            229..285
                     /gene="Btg4"
                     /gene_synonym="PC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            286..484
                     /gene="Btg4"
                     /gene_synonym="PC3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..1064
                     /gene="Btg4"
                     /gene_synonym="PC3B"
                     /note="protein PC3b; B cell translocation gene 4; BTG
                     family member 4"
                     /codon_start=1
                     /product="protein BTG4"
                     /protein_id="NP_001388021.1"
                     /db_xref="GeneID:56057"
                     /db_xref="MGI:MGI:1860140"
                     /translation="MRDEIATAVFFVTRLVKKHEKLSTQQIETFALKLMTILFEKYRG
                     HWHPDCPSKGQAFRCIRINNNENKDPVLERACAESNVNFFHLGLPKEMTIWVDPYEVC
                     CRYGEKKHPFTIASFKGRWENWELAQHVSCAVNRATGDCSSGTSSDEESCSREAQIIP
                     KVNNPKSVYQVENFKQSLQPWFCLPRRKHLADGRGFLPGAACHPVPKSSKWCRPASRR
                     VDRYHWVNAQLFSGQTAPGEPGEEALSSLKQK"
     exon            485..622
                     /gene="Btg4"
                     /gene_synonym="PC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            623..821
                     /gene="Btg4"
                     /gene_synonym="PC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1634
                     /gene="Btg4"
                     /gene_synonym="PC3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1269..1274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btg4"
                     /gene_synonym="PC3B"
                     /note="hexamer: AATGAA"
     polyA_site      1287
                     /gene="Btg4"
                     /gene_synonym="PC3B"
                     /note="major polyA site"
     regulatory      1295..1300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btg4"
                     /gene_synonym="PC3B"
                     /note="hexamer: AATAAA"
     polyA_site      1321
                     /gene="Btg4"
                     /gene_synonym="PC3B"
                     /note="major polyA site"
     regulatory      1607..1612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btg4"
                     /gene_synonym="PC3B"
                     /note="hexamer: AATAAA"
     polyA_site      1625
                     /gene="Btg4"
                     /gene_synonym="PC3B"
ORIGIN      
        1 ctgttgatcc tgcccacagt tactagagaa actccaagga tcttattgca tctgctggtc
       61 atgcctaggc atgtctagag accagggaga ctcatgtttt aatctaaatt aagaaaacct
      121 tgatggattt gaaaaataac tggtgagatc ttcattttac tgccgactct ttacactgta
      181 tatgactgga tcggttgctt gaagagaaag aaacagcaat tgcaagagtt ttgtaagcca
      241 cattttccaa cggcggtcct ctgaagcctg aatatttgac tctatgtctc tacacagact
      301 gctttggaat catgagagac gaaattgcaa cagcagtttt ttttgtcaca agattggtga
      361 aaaagcatga gaaactgagt actcaacaga tagaaacctt tgcactaaag ctgatgacca
      421 tcttgtttga aaagtacaga ggtcactggc accctgactg cccttccaag gggcaggctt
      481 ttaggtgtat caggataaac aacaatgaga ataaagaccc tgttttagaa agggcttgtg
      541 ctgagagtaa tgtgaatttt tttcatctgg gacttccaaa ggagatgacc atatgggtcg
      601 atccctatga ggtgtgctgt aggtatggtg agaaaaagca tccctttaca attgcttctt
      661 ttaaaggtag atgggagaac tgggagttgg ctcagcatgt cagctgtgca gttaacagag
      721 ccacgggaga ctgctcctct ggcacatctt ctgatgaaga aagctgcagc agggaggccc
      781 agatcatccc caaagtgaac aacccaaaga gcgtctacca ggttgaaaat ttcaaacagt
      841 cattgcagcc gtggttctgc ctcccccgta gaaagcattt ggcagatggt cgtgggttcc
      901 tcccgggggc tgcttgccac ccagtgccca agagctctaa gtggtgccgg ccagcttcgc
      961 gcagggtgga cagatatcac tgggtcaacg cacaactgtt cagtggtcag acagcaccag
     1021 gagagcctgg agaagaggcc ttgtcttccc taaagcaaaa atgaggctaa agccaagaaa
     1081 tgcccccagt agaaaaaaat gcctgcttca ggaatgtgag cacagaaggc tgtccttgca
     1141 cacagaccag cacttgactt ttagctactt ttaattctta tttaacttta tgtaaaattt
     1201 tatgaacact agtgaatata ggtgcctaga aaagtgatag aacagagatg ttgccggtga
     1261 taaaataaaa tgaattatag gaaggaagac ttgaaataaa tactcttgtg tttttaacaa
     1321 acttctagtt cagtttgttg caagacagtt ttaagtcttg ttttaatcat tgttttaaaa
     1381 gtaggttttc aactaaggaa gattgatcct gacaaaatcc cctctggact tgtctttttt
     1441 tttttttttt tttccttgta accagtctat tttataaatc tgttaaaagc ttggtggaaa
     1501 atttaaagat aaatcccttt ttatgtcttt ttaaaagttt gatttacaac tgaaagtgag
     1561 tagatttact gatatcatct attttataaa agtggtactt gcttctaata aagtattcaa
     1621 actaagccaa gaaa
//
