LOCUS       NM_009770               1414 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus BTG anti-proliferation factor 3 (Btg3), transcript
            variant 1, mRNA.
ACCESSION   NM_009770 XM_358876
VERSION     NM_009770.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1414)
  AUTHORS   Cheng,Y.C., Acedera,J.D., Li,Y.J. and Shieh,S.Y.
  TITLE     A keratinocyte-adipocyte signaling loop is reprogrammed by loss of
            BTG3 to augment skin carcinogenesis
  JOURNAL   Cell Death Differ 31 (8), 970-982 (2024)
   PUBMED   38714880
  REMARK    GeneRIF: A keratinocyte-adipocyte signaling loop is reprogrammed by
            loss of BTG3 to augment skin carcinogenesis.
REFERENCE   2  (bases 1 to 1414)
  AUTHORS   Cheng,Y.C., Chiang,H.Y., Cheng,S.J., Chang,H.W., Li,Y.J. and
            Shieh,S.Y.
  TITLE     Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor
            microenvironment through HIF-1 activation
  JOURNAL   Cell Death Dis 11 (12), 1046 (2020)
   PUBMED   33311481
  REMARK    GeneRIF: Loss of the tumor suppressor BTG3 drives a pro-angiogenic
            tumor microenvironment through HIF-1 activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1414)
  AUTHORS   Simonson,L., Vold,S., Mowers,C., Massey,R.J., Ong,I.M.,
            Longley,B.J. and Chang,H.
  TITLE     Keratin 13 deficiency causes white sponge nevus in mice
  JOURNAL   Dev Biol 468 (1-2), 146-153 (2020)
   PUBMED   32758484
REFERENCE   4  (bases 1 to 1414)
  AUTHORS   Lorda-Diez,C.I., Garcia-Riart,B., Montero,J.A., Rodriguez-Leon,J.,
            Garcia-Porrero,J.A. and Hurle,J.M.
  TITLE     Apoptosis during embryonic tissue remodeling is accompanied by cell
            senescence
  JOURNAL   Aging (Albany NY) 7 (11), 974-985 (2015)
   PUBMED   26568417
REFERENCE   5  (bases 1 to 1414)
  AUTHORS   Winkler,G.S.
  TITLE     The mammalian anti-proliferative BTG/Tob protein family
  JOURNAL   J Cell Physiol 222 (1), 66-72 (2010)
   PUBMED   19746446
  REMARK    Review article
REFERENCE   6  (bases 1 to 1414)
  AUTHORS   Yoneda,M., Suzuki,T., Nakamura,T., Ajima,R., Yoshida,Y., Kakuta,S.,
            Katsuko,S., Iwakura,Y., Shibutani,M., Mitsumori,K., Yokota,J. and
            Yamamoto,T.
  TITLE     Deficiency of antiproliferative family protein Ana correlates with
            development of lung adenocarcinoma
  JOURNAL   Cancer Sci 100 (2), 225-232 (2009)
   PUBMED   19068083
  REMARK    GeneRIF: Deficiency of antiproliferative family protein Ana
            correlates with development of lung adenocarcinoma.
REFERENCE   7  (bases 1 to 1414)
  AUTHORS   Birot,A., Duret,L., Bartholin,L., Santalucia,B., Tigaud,I.,
            Magaud,J. and Rouault,J.
  TITLE     Identification and molecular analysis of BANP
  JOURNAL   Gene 253 (2), 189-196 (2000)
   PUBMED   10940556
REFERENCE   8  (bases 1 to 1414)
  AUTHORS   Seo,M.S., Lee,M.S. and Lim,I.K.
  TITLE     Expression of rat BTG(3) gene, Rbtg3, is regulated by redox changes
  JOURNAL   Gene 240 (1), 165-173 (1999)
   PUBMED   10564823
REFERENCE   9  (bases 1 to 1414)
  AUTHORS   Yoshida,Y., Matsuda,S., Ikematsu,N., Kawamura-Tsuzuku,J.,
            Inazawa,J., Umemori,H. and Yamamoto,T.
  TITLE     ANA, a novel member of Tob/BTG1 family, is expressed in the
            ventricular zone of the developing central nervous system
  JOURNAL   Oncogene 16 (20), 2687-2693 (1998)
   PUBMED   9632145
REFERENCE   10 (bases 1 to 1414)
  AUTHORS   Guehenneux,F., Duret,L., Callanan,M.B., Bouhas,R., Hayette,S.,
            Berthet,C., Samarut,C., Rimokh,R., Birot,A.M., Wang,Q., Magaud,J.P.
            and Rouault,J.P.
  TITLE     Cloning of the mouse BTG3 gene and definition of a new gene family
            (the BTG family) involved in the negative control of the cell cycle
  JOURNAL   Leukemia 11 (3), 370-375 (1997)
   PUBMED   9067576
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CK623612.1, AK144415.1 and
            AC130844.3.
            
            On Jul 10, 2014 this sequence version replaced NM_009770.2.
            
            Summary: This gene encodes B cell translocation gene 3, a member of
            the BTG gene family. This family is defined by a conserved
            N-terminal domain, known to bind transcription factors, and a less
            conserved C-terminal domain. This protein is thought to have
            anti-proliferative properties, and may be involved in regulating
            the G1-S transition to suppress cell cycle progression. Mice
            deficient for this gene display an increased incidence of lung
            cancers, and many human lung cancer cells exhibit decreased levels
            of B cell translocation gene 3. Alternate splicing results in
            multiple transcript variants. A pseudogene of this gene is found on
            chromosome 17. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z72000.1, AK144415.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                CK623612.1         1-50
            51-1407             AK144415.1         2-1358
            1408-1414           AC130844.3         134215-134221       c
FEATURES             Location/Qualifiers
     source          1..1414
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 45.36 cM"
     gene            1..1414
                     /gene="Btg3"
                     /gene_synonym="ANA; tob5"
                     /note="BTG anti-proliferation factor 3"
                     /db_xref="GeneID:12228"
                     /db_xref="MGI:MGI:109532"
     exon            1..210
                     /gene="Btg3"
                     /gene_synonym="ANA; tob5"
                     /inference="alignment:Splign:2.1.0"
     exon            211..389
                     /gene="Btg3"
                     /gene_synonym="ANA; tob5"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..975
                     /gene="Btg3"
                     /gene_synonym="ANA; tob5"
                     /note="B cell translocation gene 3; abundant in
                     neuroepithelium area protein; BTG family member 3"
                     /codon_start=1
                     /product="protein BTG3"
                     /protein_id="NP_033900.1"
                     /db_xref="CCDS:CCDS28277.1"
                     /db_xref="GeneID:12228"
                     /db_xref="MGI:MGI:109532"
                     /translation="MKNEIAAVVFFFTRLVRKHDKLKKEAVERFAEKLTQILQEKYKN
                     HWYPEKPSKGQAYRCIRVNKFQRVDPDVLKACENSCILYSDLGLPKELTLWVDPCEVC
                     CRYGEKNNAFIVASFENEDENKDEISKKVSRALDKVTSDYHSGSSSSDEDTSKEVDVK
                     PSSVAATPSPVYQISELIFPPLPMWHPLPRKKPGMYRGSGHQTHYPPPVPFAYPNPGR
                     KNKPFRPIPVTWVPPPGMHCDRNHWINPHMLAPH"
     exon            390..527
                     /gene="Btg3"
                     /gene_synonym="ANA; tob5"
                     /inference="alignment:Splign:2.1.0"
     exon            528..735
                     /gene="Btg3"
                     /gene_synonym="ANA; tob5"
                     /inference="alignment:Splign:2.1.0"
     exon            736..1414
                     /gene="Btg3"
                     /gene_synonym="ANA; tob5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1388..1393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btg3"
                     /gene_synonym="ANA; tob5"
                     /note="hexamer: AATAAA"
     polyA_site      1414
                     /gene="Btg3"
                     /gene_synonym="ANA; tob5"
                     /note="major polyA site"
ORIGIN      
        1 cttccgggcc tcgagccccc cgtgggccgc gtcgggactg cgttcgccct gtcggccgcg
       61 cgctccgccg cccgccagtc tggtcggcgc gcgctcagcg gcggcggcgg cggcccgacg
      121 acgcagcagc ggcgctcgcg ctcggctccc cggccacggg acgcggtcgc acccggcgag
      181 ggtgcagccc ccggagcggc ggcggcggcg ggaaaaatga agaacgaaat tgcggctgtt
      241 gtcttctttt tcacaaggct agttcgaaag catgacaagt tgaaaaaaga agcagttgag
      301 aggtttgctg agaaattaac tcaaatactt caagagaaat ataaaaatca ctggtatcca
      361 gaaaaaccat ccaaaggtca ggcctacaga tgcattcgtg tcaataagtt tcagagagtt
      421 gatcccgatg tcctgaaagc ctgtgagaac agctgcatct tgtacagcga cctgggcttg
      481 cctaaggagc ttacactctg ggtggatccg tgtgaggtgt gctgccggta tggagagaaa
      541 aacaatgcgt tcattgttgc cagctttgaa aatgaggacg agaacaagga tgaaatctcc
      601 aagaaagtta gcagggctct ggataaggtg acctctgatt atcactcagg gtcctcttcc
      661 tcagatgaag acacaagcaa ggaagtggac gtgaaaccca gctcagtggc ggcaacacca
      721 agccccgtgt accagatttc agaactgata ttcccacctc ttccaatgtg gcaccctttg
      781 cccagaaaaa agccaggaat gtatcgaggg agcggccatc agactcacta ccctcctcct
      841 gttccatttg cttatccaaa tccaggaagg aagaataaac cattccgccc aattccagtg
      901 acatgggtac ctcctcctgg aatgcattgt gaccgaaatc actggattaa tcctcacatg
      961 ttagcacctc actagctcct ttcattgtgt tgatgtcatg ttgctagaaa ggaagacata
     1021 ccttcctata tactaagagt tcatacttgt agtgaagtta gatgggcaaa accatcagac
     1081 ttatttttat agaaaagcta ttgagaataa tctttcttaa agtatatata tatatgcact
     1141 ttagatatat tgatatagtt tgagaaactt tattaaagtt agtcaagtgc ctgagttttt
     1201 aatattggac ttgagtattt atatattgtg cattgactct gttggataca aaaacactgt
     1261 aggagcgggc gatgtgttct agcacctttg agcatttact ttatggagag tatataagtt
     1321 atttatacag aaggacatct attttatgtc attatttaga agaattgtgt gaaatcatgt
     1381 agttgcaaat aaaaagtagt ttgaggcatg acaa
//
