LOCUS       NM_007570               3083 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus BTG anti-proliferation factor 2 (Btg2), mRNA.
ACCESSION   NM_007570
VERSION     NM_007570.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3083)
  AUTHORS   Ceccarelli,M., Rossi,S., Bonaventura,F., Massari,R., D'Elia,A.,
            Soluri,A., Micheli,L., D'Andrea,G., Mancini,B., Raspa,M.,
            Scavizzi,F., Alaggio,R., Del Bufalo,F., Miele,E., Carai,A.,
            Mastronuzzi,A. and Tirone,F.
  TITLE     Intracerebellar administration of the chemokine Cxcl3 reduces the
            volume of medulloblastoma lesions at an advanced stage by promoting
            the migration and differentiation of preneoplastic precursor cells
  JOURNAL   Brain Pathol 35 (1), e13283 (2025)
   PUBMED   38946128
REFERENCE   2  (bases 1 to 3083)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3083)
  AUTHORS   Bestepe,F., Ghanem,G.F., Fritsche,C.M., Weston,J., Sahay,S.,
            Mauro,A.K., Sahu,P., Tas,S.M., Ruemmele,B., Persing,S., Good,M.E.,
            Chatterjee,A., Huggins,G.S., Salehi,P. and Icli,B.
  TITLE     MicroRNA-409-3p/BTG2 signaling axis improves impaired angiogenesis
            and wound healing in obese mice
  JOURNAL   FASEB J 38 (3), e23459 (2024)
   PUBMED   38329343
  REMARK    GeneRIF: MicroRNA-409-3p/BTG2 signaling axis improves impaired
            angiogenesis and wound healing in obese mice.
REFERENCE   4  (bases 1 to 3083)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   5  (bases 1 to 3083)
  AUTHORS   Dan Hu,Q., Wang,H.L., Liu,J., He,T., Tan,R.Z., Zhang,Q., Su,H.W.,
            Kantawong,F., Lan,H.Y. and Wang,L.
  TITLE     Btg2 Promotes Focal Segmental Glomerulosclerosis via
            Smad3-Dependent Podocyte-Mesenchymal Transition
  JOURNAL   Adv Sci (Weinh) 10 (32), e2304360 (2023)
   PUBMED   37749872
  REMARK    GeneRIF: Btg2 Promotes Focal Segmental Glomerulosclerosis via
            Smad3-Dependent Podocyte-Mesenchymal Transition.
REFERENCE   6  (bases 1 to 3083)
  AUTHORS   Guehenneux,F., Duret,L., Callanan,M.B., Bouhas,R., Hayette,S.,
            Berthet,C., Samarut,C., Rimokh,R., Birot,A.M., Wang,Q., Magaud,J.P.
            and Rouault,J.P.
  TITLE     Cloning of the mouse BTG3 gene and definition of a new gene family
            (the BTG family) involved in the negative control of the cell cycle
  JOURNAL   Leukemia 11 (3), 370-375 (1997)
   PUBMED   9067576
REFERENCE   7  (bases 1 to 3083)
  AUTHORS   Lin,W.J., Gary,J.D., Yang,M.C., Clarke,S. and Herschman,H.R.
  TITLE     The mammalian immediate-early TIS21 protein and the
            leukemia-associated BTG1 protein interact with a protein-arginine
            N-methyltransferase
  JOURNAL   J Biol Chem 271 (25), 15034-15044 (1996)
   PUBMED   8663146
REFERENCE   8  (bases 1 to 3083)
  AUTHORS   Lim,I.K., Lee,M.S., Lee,S.H., Kim,N.K., Jou,I., Seo,J.S. and
            Park,S.C.
  TITLE     Differential expression of TIS21 and TIS1 genes in the various
            organs of Balb/c mice, thymic carcinoma tissues and human cancer
            cell lines
  JOURNAL   J Cancer Res Clin Oncol 121 (5), 279-284 (1995)
   PUBMED   7768965
REFERENCE   9  (bases 1 to 3083)
  AUTHORS   Fletcher,B.S., Lim,R.W., Varnum,B.C., Kujubu,D.A., Koski,R.A. and
            Herschman,H.R.
  TITLE     Structure and expression of TIS21, a primary response gene induced
            by growth factors and tumor promoters
  JOURNAL   J Biol Chem 266 (22), 14511-14518 (1991)
   PUBMED   1713584
REFERENCE   10 (bases 1 to 3083)
  AUTHORS   Tippetts,M.T., Varnum,B.C., Lim,R.W. and Herschman,H.R.
  TITLE     Tumor promoter-inducible genes are differentially expressed in the
            developing mouse
  JOURNAL   Mol Cell Biol 8 (10), 4570-4572 (1988)
   PUBMED   3185562
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY766758.1, AK133796.1, AK171400.1 and BQ561887.1.
            
            On Jan 14, 2006 this sequence version replaced NM_007570.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132259.1, AK133796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BY766758.1         6-40
            36-2626             AK133796.1         1-2591
            2627-2994           AK171400.1         1282-1649
            2995-3083           BQ561887.1         349-437
FEATURES             Location/Qualifiers
     source          1..3083
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.1 cM"
     gene            1..3083
                     /gene="Btg2"
                     /gene_synonym="APRO1; Pc3; TIS21"
                     /note="BTG anti-proliferation factor 2"
                     /db_xref="GeneID:12227"
                     /db_xref="MGI:MGI:108384"
     exon            1..244
                     /gene="Btg2"
                     /gene_synonym="APRO1; Pc3; TIS21"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..579
                     /gene="Btg2"
                     /gene_synonym="APRO1; Pc3; TIS21"
                     /note="BTG family member 2; NGF-inducible protein TIS21; B
                     cell translocation gene 2, anti-proliferative"
                     /codon_start=1
                     /product="protein BTG2"
                     /protein_id="NP_031596.1"
                     /db_xref="CCDS:CCDS15302.1"
                     /db_xref="GeneID:12227"
                     /db_xref="MGI:MGI:108384"
                     /translation="MSHGKRTDMLPEIAAAVGFLSSLLRTRGCVSEQRLKVFSRALQD
                     ALTDHYKHHWFPEKPSKGSGYRCIRINHKMDPIISKVASQIGLSQPQLHRLLPSELTL
                     WVDPYEVSYRIGEDGSICVLYEEAPVAASYGLLTCKNQMMLGRSSPSKNYVMAVSS"
     exon            245..3083
                     /gene="Btg2"
                     /gene_synonym="APRO1; Pc3; TIS21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2597..2602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btg2"
                     /gene_synonym="APRO1; Pc3; TIS21"
                     /note="hexamer: AATAAA"
     polyA_site      2621
                     /gene="Btg2"
                     /gene_synonym="APRO1; Pc3; TIS21"
                     /note="major polyA site"
     regulatory      2735..2740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btg2"
                     /gene_synonym="APRO1; Pc3; TIS21"
                     /note="hexamer: TATAAA"
     polyA_site      2759
                     /gene="Btg2"
                     /gene_synonym="APRO1; Pc3; TIS21"
ORIGIN      
        1 gagtggtatg aaaggcgcag cccggggaaa gtccgggcag agcccgagag gtggccagac
       61 cgtcatcatc gttctaatac agctacttcc tcagccaccg gtatgagcca cgggaagaga
      121 accgacatgc tcccggagat cgccgccgcc gtgggtttcc tctccagtct cctgaggact
      181 cggggctgcg tgagcgagca gagactcaag gttttcagta gggcgctcca ggacgcactg
      241 accgatcatt acaaacacca ctggtttcca gaaaaaccat ccaaaggttc tggctatcgc
      301 tgtatccgta tcaaccacaa gatggacccc atcatcagca aggtggccag ccagattgga
      361 ctcagccagc cccagctgca ccggctgctg cccagtgagc tgaccctgtg ggttgatccc
      421 tatgaagtgt cttaccgcat cggggaggat ggctccatct gtgtcctgta tgaggaggcc
      481 ccggtggctg cctcctatgg gctcctcacc tgcaagaacc agatgatgct gggcaggagc
      541 agcccctcga agaactatgt gatggccgtc tccagctaga taggagccac ccgaccctgg
      601 cactctactg ttctcatgct gccctgacaa caggccaccg tatacctcaa cctggggaac
      661 tgtattttta aaatgaagag ctatttatac atgttttttt tttttttttt taagaaaaga
      721 ggaaaaaaac caaaagattt tttttaaaaa aaaaagaaaa agaaaaacaa ttctttaaag
      781 ggagctgctt ggaagtggcc tccccaggtg cctttggaga gaactgttct tgattgcatc
      841 tgtgagccag tgtttgccta ggggaatggg ttggggattg gcctagccaa ggtaaaaggg
      901 gattcttggc tgatcccccc aggaggtggt ggaagggagc aaggttagca actgtgaatg
      961 agaggggtca gggtctgctc tgggttaccg tcccagctgg gatgcctgta tgcctggtcc
     1021 ctctcttact caggggcatt caagcctgat cttaaataat actacattgc ctaatcttct
     1081 cttttgtttt tcggctgaga tcaggggcag actgaaaggc ctctcctgtc ccttctgttc
     1141 taagcagtct cttgaagccg tgtctcgttt ctgagtctac ccttgggggc ctgaagagct
     1201 tgcttcccag cccggaatct gtctaaacat tttttggagg gtgggatgta aggcaggcgc
     1261 gcaaagactt tggggctaag atggagagga cctgcacaaa acctttgctt tgctctgtgc
     1321 tgctttgtat gggtggatag tgaataattt agggatgatt tgcaatggaa ttttgggacc
     1381 caaagagtat ccaatggggg taggtctttt ggacccagtc cttccttttg ggaaccacac
     1441 gacagtctga atgctgctac cactattcct ttgagaggtg gctcaaagct ccagggaact
     1501 ccaagtcctt tcttactgcc ttctcttcaa gagcaacctt ccccattttt tctttcccct
     1561 ttcctgcggt tgggtcctgg agggccctat ttcctaggac aagcgttctc agtcactgtg
     1621 caatagtccc aggatgctct gagaccggac ctcccagccc ctcctgatgc cctggtaggt
     1681 tttagggacc cattcttccc attcttctag gggttctgac tggctggtgg gccttgcgga
     1741 gatcttcctg ggccacaggg agggcacctg tgcactgcag gactacctgg tattcttgta
     1801 gggctgccat gaagagtcaa accttgggca cagctttagc tccttggtgc tcagagcacc
     1861 tgtgggggag gttacctctc tctctctctt agtaaaatcc aaatttattt gtagatgtgt
     1921 gcaatattta ctgttctggg ttggagaaaa ttgggaaaca ctgggaagaa atggctttcc
     1981 ttcaggttca gtgacactga tgagggcttc ttagaaggcc tcaagtctct caaactgaag
     2041 gacagagcta gagctagccc gtcacccctt ggtgaggatt cccttccccg tttctctcca
     2101 ccgccatggc atcctgtgtc ctagatttct cagctcctca gtttctgctc aaaggtgcta
     2161 tttaccaaac tctctgcctg cccgggcaga caggccccag cttcgcacag ccttcccagg
     2221 tggcttcgtc tctcttgctt taaccttaac tctgggccca cagacctgag agctgtggcc
     2281 tacaacaaag ctgtgaattg ttccagatgg ttcttgtgtt ttgtccgcac acaggtgcct
     2341 gccgtttaga agctgcctcc tggtctcatg cttaaatctt caattcttta ctgtccttgt
     2401 tcactttaga aatgacaaac cctagagctg gactgttgag caggcctgtc tctcttatta
     2461 agtaaaaata agaaatagtg gtaagtttgt aagctattct gacagaaaag acaaaggtta
     2521 ctaattgtat aatagcgctt ttatatggaa gactgtacag ctttatggac aaatgtaaac
     2581 tttctttttt gtttttaata aaaatgtagc agatcgtgta atgtgtagag aaggtggaat
     2641 tccatagcgc tgactggccc tcttagatac aaaccccttc gtgtttcgtg gacttcatca
     2701 gttgtcctga gctccgtctg cagcatgcag acgttataaa agatacccta ggtttgtgac
     2761 gaggttgctt ccattgcatc ccctctcctt gggaggcggc tccatacttc tgtccttgtg
     2821 aatattgtca caggtctctt aaaaaacaaa caaacaaaaa agcccaaaaa ccaatatgtt
     2881 atctgcacac tctgcagcca gttccatagt tttgctcttg gccattcagc acattgaaga
     2941 gctggccagc tgtgtccaca tctgcgcaag caagccacca cggctggaaa ctatataaag
     3001 aaaagaaacc atccagaaag ttccaaagac acaagacttg ggtttggcac acactaagca
     3061 caccagtgca ctcgatgcga ctg
//
