LOCUS       NM_007569               5010 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus BTG anti-proliferation factor 1 (Btg1), mRNA.
ACCESSION   NM_007569 XM_125842 XM_354562
VERSION     NM_007569.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5010)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5010)
  AUTHORS   Sulic,A.M., Das Roy,R., Papagno,V., Lan,Q., Saikkonen,R.,
            Jernvall,J., Thesleff,I. and Mikkola,M.L.
  TITLE     Transcriptomic landscape of early hair follicle and epidermal
            development
  JOURNAL   Cell Rep 42 (6), 112643 (2023)
   PUBMED   37318953
REFERENCE   3  (bases 1 to 5010)
  AUTHORS   Velayutham,N., Calderon,M.U., Alfieri,C.M., Padula,S.L., van
            Leeuwen,F.N., Scheijen,B. and Yutzey,K.E.
  TITLE     Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle arrest
  JOURNAL   J Mol Cell Cardiol 179, 30-41 (2023)
   PUBMED   37062247
  REMARK    GeneRIF: Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle
            arrest.
REFERENCE   4  (bases 1 to 5010)
  AUTHORS   Mlynarczyk,C., Teater,M., Pae,J., Chin,C.R., Wang,L., Arulraj,T.,
            Barisic,D., Papin,A., Hoehn,K.B., Kots,E., Ersching,J.,
            Bandyopadhyay,A., Barin,E., Poh,H.X., Evans,C.M., Chadburn,A.,
            Chen,Z., Shen,H., Isles,H.M., Pelzer,B., Tsialta,I., Doane,A.S.,
            Geng,H., Rehman,M.H., Melnick,J., Morgan,W., Nguyen,D.T.T.,
            Elemento,O., Kharas,M.G., Jaffrey,S.R., Scott,D.W., Khelashvili,G.,
            Meyer-Hermann,M., Victora,G.D. and Melnick,A.
  TITLE     BTG1 mutation yields supercompetitive B cells primed for malignant
            transformation
  JOURNAL   Science 379 (6629), eabj7412 (2023)
   PUBMED   36656933
  REMARK    GeneRIF: BTG1 mutation yields supercompetitive B cells primed for
            malignant transformation.
REFERENCE   5  (bases 1 to 5010)
  AUTHORS   Willemin,A., Lopez-Delisle,L., Bolt,C.C., Gadolini,M.L., Duboule,D.
            and Rodriguez-Carballo,E.
  TITLE     Induction of a chromatin boundary in vivo upon insertion of a TAD
            border
  JOURNAL   PLoS Genet 17 (7), e1009691 (2021)
   PUBMED   34292939
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5010)
  AUTHORS   Saka,Y., Tada,M. and Smith,J.C.
  TITLE     A screen for targets of the Xenopus T-box gene Xbra
  JOURNAL   Mech Dev 93 (1-2), 27-39 (2000)
   PUBMED   10781937
REFERENCE   7  (bases 1 to 5010)
  AUTHORS   Suk,K., Sipes,D.G. and Erickson,K.L.
  TITLE     Enhancement of B-cell translocation gene-1 expression by
            prostaglandin E2 in macrophages and the relationship to
            proliferation
  JOURNAL   Immunology 91 (1), 121-129 (1997)
   PUBMED   9203975
REFERENCE   8  (bases 1 to 5010)
  AUTHORS   Guehenneux,F., Duret,L., Callanan,M.B., Bouhas,R., Hayette,S.,
            Berthet,C., Samarut,C., Rimokh,R., Birot,A.M., Wang,Q., Magaud,J.P.
            and Rouault,J.P.
  TITLE     Cloning of the mouse BTG3 gene and definition of a new gene family
            (the BTG family) involved in the negative control of the cell cycle
  JOURNAL   Leukemia 11 (3), 370-375 (1997)
   PUBMED   9067576
REFERENCE   9  (bases 1 to 5010)
  AUTHORS   Lin,W.J., Gary,J.D., Yang,M.C., Clarke,S. and Herschman,H.R.
  TITLE     The mammalian immediate-early TIS21 protein and the
            leukemia-associated BTG1 protein interact with a protein-arginine
            N-methyltransferase
  JOURNAL   J Biol Chem 271 (25), 15034-15044 (1996)
   PUBMED   8663146
REFERENCE   10 (bases 1 to 5010)
  AUTHORS   Rouault,J.P., Samarut,C., Duret,L., Tessa,C., Samarut,J. and
            Magaud,J.P.
  TITLE     Sequence analysis reveals that the BTG1 anti-proliferative gene is
            conserved throughout evolution in its coding and 3' non-coding
            regions
  JOURNAL   Gene 129 (2), 303-306 (1993)
   PUBMED   8325512
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155936.7.
            
            On Oct 15, 2008 this sequence version replaced NM_007569.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149547.1, AK162764.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-472               AC155936.7         83141-83612         c
            473-5010            AC155936.7         77800-82337         c
FEATURES             Location/Qualifiers
     source          1..5010
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 49.89 cM"
     gene            1..5010
                     /gene="Btg1"
                     /note="BTG anti-proliferation factor 1"
                     /db_xref="GeneID:12226"
                     /db_xref="MGI:MGI:88215"
     exon            1..472
                     /gene="Btg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..840
                     /gene="Btg1"
                     /note="B-cell translocation gene 1 protein; B cell
                     translocation gene 1, anti-proliferative"
                     /codon_start=1
                     /product="protein BTG1"
                     /protein_id="NP_031595.1"
                     /db_xref="CCDS:CCDS24140.1"
                     /db_xref="GeneID:12226"
                     /db_xref="MGI:MGI:88215"
                     /translation="MHPFYTRAATMIGEIAAAVSFISKFLRTKGLTSERQLQTFSQSL
                     QELLAEHYKHHWFPEKPCKGSGYRCIRINHKMDPLIGQAAQRIGLSSQELFRLLPSEL
                     TLWVDPYEVSYRIGEDGSICVLYEASPAGGSTQNSTNVQMVDSRISCKEELLLGRTSP
                     SKNYNMMTVSG"
     exon            473..5010
                     /gene="Btg1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1795..1800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btg1"
                     /note="hexamer: AATAAA"
     polyA_site      1824
                     /gene="Btg1"
                     /note="major polyA site"
     regulatory      1841..1846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btg1"
                     /note="hexamer: ATTACA"
     polyA_site      1863
                     /gene="Btg1"
     regulatory      2284..2289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btg1"
                     /note="hexamer: AATAAA"
     polyA_site      2310
                     /gene="Btg1"
     regulatory      4189..4194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btg1"
                     /note="hexamer: ATTAAA"
     polyA_site      4208
                     /gene="Btg1"
ORIGIN      
        1 agctcttcgc ccctcggagc tggaaatgca actctcggga tcctcggagg ctaccgagct
       61 ggaggcggag gcggctgggg aggtccgagc gatgtgacca ggccgccatc gctcgtctct
      121 ctctgtctct cctgccgcct cctggcttga aaataacttt tttactctaa aggaaagaaa
      181 aaaaatcccc tagaaccagt agccgtccgc gcctcgcgcc ctcgcttcct ctcggccgtc
      241 gggtctgggc gagagcccgg ggtggccgct tcgccgtcgg ggccgagccc cggccgcccc
      301 gggccacccc cggccgccgc ccccatgcat cccttctaca cccgggccgc caccatgata
      361 ggcgagatcg ccgccgcggt gtccttcatc tccaagttcc tccgcaccaa ggggctcacg
      421 agcgagcgac agctgcagac tttcagccag agcctgcagg agctgctggc agaacattac
      481 aaacatcact ggttcccaga aaagccgtgc aagggatcag gttaccgttg tattcgcatc
      541 aaccataaga tggatcctct gattggacag gcagcccagc ggattggact gagcagtcag
      601 gagttgttca ggcttctccc aagtgaactc acactctggg ttgaccccta cgaagtgtcc
      661 taccggattg gagaggatgg ctccatctgc gtgctgtacg aagcctcacc agcaggaggt
      721 agcactcaaa acagcaccaa cgtgcaaatg gtagacagca gaatcagctg taaggaggaa
      781 cttctcttgg gcagaacaag cccttccaaa aactacaata tgatgactgt atcaggttaa
      841 gatatagtct attggatgga tcatcttata atggatggat gaatttgatt ttttttgctt
      901 tgggtgggct cctcttgggg atggattatg gaatttaaac catgtcacag ctgtgaagat
      961 ctggcacaag atagagtggt aataattttt ttatttcttt cttttttttt ttttttaatt
     1021 tagtgacagt gccatagttt ggacagtacc tttcagtgat ttaaatagcc tgtgagtcca
     1081 aggaaaggat cactttattt gctagggagt gaagtcgaag ggtggtttca gtttctccca
     1141 gaccttatac ccaatttgtc acagcagtcc ctttaaggaa attctgtctt tcaaagaacc
     1201 ctctttcgca gtcaaccttg caggggaatt tgcactatta cacttgaaag ttctcagtaa
     1261 cttttttggc agctcaatag gaaagctcaa tgttttaagc atggtagtac tggaaaaatt
     1321 tttacacgga gacttttacc tagcacttaa aatgtataaa tgtacataaa gacaaactta
     1381 gtacgcatga cctgggggaa atggtcagac cttgtgtttt tggcgttgag agtagggagc
     1441 gaccaggctc tgccatggca gcaggctttg aaaagaccct tcaaaaagac actgtctcaa
     1501 ctgtggttgt tagcaccagc cagctctctg tacatttgct agcttgtagt tttctaagac
     1561 tgagtggagt aaacttctta tttttagaaa gtggaggtct ggtttgtaac tttccttgta
     1621 ctcaattggg taagagtctt tcccacaaac caccatctat tttgtgaact ttgttagtca
     1681 tcttttattt ggtaaattat gaactggtgt aaatttgtac agttcatgta tattgattgt
     1741 ggcaaagttg tacagatttc tatattttgg atgagaaatt tttcttctct ctataataaa
     1801 ttgtttctta tcttggcatt ttaatcaatc tcttgtcatg attacagagg ttcagctaca
     1861 aaatattttt ctcagacgtc ttagatttgt aagctgtgtg gatgtcactt gcacactggt
     1921 cacacaaaca cattgggaga ggtgtaatta gaaactaatc agaaggaact agaggaaggc
     1981 ttttagattt tttaactcag gttaaaagca tggacacatt cacaagctaa tgatctcatg
     2041 aggataaaga cagaggtaac atcttccaaa agtggcgatg cccaaaggat cccagtcact
     2101 gcttcctggg gaagtgaaga taacaatcct ctctggccct cctttgagaa acagttcttt
     2161 tgcccccttg gatttgttcc tttagaaaat cctggggcag gtgacctata gccttaaaga
     2221 acaggcttat cacagcagag ccatctgccg ctttctggtt ctcatcttgc aagagttaca
     2281 taaaataaaa tcccctaagc tggaatccaa caacaggtac gttgatgcac ttcttttctc
     2341 aaaagttgaa gccctggctt tgtccgcatt tccatagcag gggaaactga gtgttgtgct
     2401 ggaggttagt aacgtgtacc tcatgggcaa agacatgctg ctagtttggg ggttgtagaa
     2461 gataaactga tattttggtg gaaattgaaa gcagaaattt gagttctgct ttacagttaa
     2521 aattaactgg attgggggag gggcagcatg tgaaaacatg tgaacactgg gaattgaggc
     2581 aatttaaatg actttaagtc agtaattgtt ctaagtcagt agtatttcca aacaaattgg
     2641 aggttttttg gttttgtttt gttttgtttt ttaatttgta ataagtttcc ctgatacttt
     2701 tattaacgat ccagaaacac atcactaaac cctaaacatg ccatgtattt aagagtacga
     2761 atggaattca tatatttttg tcagtaggct atttggaaga gtttggattt tgtttccctt
     2821 attttgcttt ctgagatggt ctcttgttct atatgtagct caggctggcc cccccactct
     2881 agatcttcct gctttagccc ccagaatgca ggcgtctcgg ataatatggc acagctccag
     2941 accaggagct cagattcttc ttctttctac acaataatgg gtctcattgt gacatttttt
     3001 ttaaatgaca tatttcatct agccctttct ctaaaaggtc cctcatttca aatttgagtt
     3061 tgagcattat atcccaggct ggtttaaagc aggtctcact ctcctgctgg ccaatttgtg
     3121 tatcatttgg gaactccttg gaagctgcct gactggcttt gaacactgga ctcttccaca
     3181 ctgttcaggt ctatcctgag tacctaagat gtcatcatca taaatgaaat agagaagtgt
     3241 ctttgacttt gctgtcaaga ctttttgttg ctgcttgaac aaaagaagcg cctattcaaa
     3301 ctgcagtttt agagttcagg tgacatccgg cctgtgaagc ctgcaagtat ctcagaccta
     3361 gcatccagct gtttcctgtg actctcacct ccattcccca gaccactgag ccgagcctgt
     3421 gtgtgcagca cagcatagct acttgagtag ttcgtgccaa ctgcttctgg ctaatgtttg
     3481 gtttagctat tttaacaaaa caaaaaaact gagtgtctgc tgctgtgtca tttactacca
     3541 gttttttgtt tttttgtttt ttgttttttt tttttttttt ttttatttcg agaggtgtaa
     3601 tttaaaaggg tttacactgc ccaaattaaa gaaaaaaaat aatttataaa agatgactgc
     3661 taaaattagg aattcataat taacagtaag tttgaggact tatttttaca agttgggtct
     3721 tgctttgtga tcctaaaaca agccttgaca tgctaatgtt ttgttttgag accagaggtc
     3781 ttgaggctct gggctagcct tgaacttgcc atatagctaa ggaagaccag aattcctgat
     3841 cctcctgtct gactgagatt acacttagca ccatgaagcc tggcttgatg tggactgtag
     3901 gaaaattacc ccattcaata caggatgtga ctatccctta tgtcatcctt acctttgaga
     3961 tagttctgga attgcaggcc tttctgccgg aagtggcttt ctgttatgat tgtttatgag
     4021 gtttctttgt cgccataact cacactttga caagtaattt ttgggttttt tgtttgtttt
     4081 ttgaaaaagg gtctcactgt gtatccttga ctggctcgga gctcagtatg tacaccatga
     4141 taccctggaa cgcagagatt tacctgtctc tgcctcccaa atactggaat taaaggcgtg
     4201 caccaccaca cctgactagt aattttgctg taaatattaa cggggtttga gcttcacatt
     4261 ccaaggaagg gagggagggg tcctggtgtc catgtttagt gattaaaggt ttctgggtct
     4321 ccccccacct taggactctt ccctggtcat atattaatga tttttgagac ttcttcgtct
     4381 ttataaattt agcgggctgc attttgcatg tgaaagttta aagaaacttg ccccgtcttt
     4441 ttccgatttc aggttgtggt gctttcgata agcttctcgg agtttgccag cagctttaga
     4501 aagcatcatc acctgaaact gcaaagattt tgtttaccta cggggagcac gcagagccca
     4561 gatgacgctg tctttgcagt caaactttta caggtggacc ctgtcagtct gcccagttca
     4621 ttttttgtgt caggaccgta gctgagtcaa aacatctttt agggtaaaat gccctgtgtt
     4681 acaaattgga ctgagctgcg acacaggctt cctgccagga ttgcagactt gggtaatcca
     4741 gagaaatgtg tattgttggt agtttctggt ggtttagttt atgcttaagt taaaaagcag
     4801 cattgctaag gtgttgtgtc ttgattttga gctgctccag ggtaaacctc ctgttagcag
     4861 tgaggtttga taacatgttt ttaaaaccat ttgtggaata ttaacactag tgttctgatt
     4921 gcagctttaa atcagtcgga tttatgaata acttcattgc ttaggttgtc aaacaggaat
     4981 taaaaaaaaa aaaagacacc catcataaaa
//
