LOCUS       NP_031595                171 aa            linear   ROD 12-JUN-2025
DEFINITION  protein BTG1 [Mus musculus].
ACCESSION   NP_031595 XP_125842 XP_354562
VERSION     NP_031595.1
DBSOURCE    REFSEQ: accession NM_007569.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 171)
  AUTHORS   Duot,M., Coomson,S.Y., Shrestha,S.K., Nagulla,M.V.M.K., Audic,Y.,
            Barve,R.A., Huang,H., Gautier-Courteille,C., Paillard,L. and
            Lachke,S.A.
  TITLE     Transcriptome Meta-Analysis Uncovers Cell-Specific Regulatory
            Relationships in Embryonic, Juvenile, Adult, and Aged Mouse Lens
            Epithelium and Fibers
  JOURNAL   Invest Ophthalmol Vis Sci 66 (4), 42 (2025)
   PUBMED   40238114
REFERENCE   2  (residues 1 to 171)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 171)
  AUTHORS   Sulic,A.M., Das Roy,R., Papagno,V., Lan,Q., Saikkonen,R.,
            Jernvall,J., Thesleff,I. and Mikkola,M.L.
  TITLE     Transcriptomic landscape of early hair follicle and epidermal
            development
  JOURNAL   Cell Rep 42 (6), 112643 (2023)
   PUBMED   37318953
REFERENCE   4  (residues 1 to 171)
  AUTHORS   Velayutham,N., Calderon,M.U., Alfieri,C.M., Padula,S.L., van
            Leeuwen,F.N., Scheijen,B. and Yutzey,K.E.
  TITLE     Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle arrest
  JOURNAL   J Mol Cell Cardiol 179, 30-41 (2023)
   PUBMED   37062247
  REMARK    GeneRIF: Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle
            arrest.
REFERENCE   5  (residues 1 to 171)
  AUTHORS   Mlynarczyk,C., Teater,M., Pae,J., Chin,C.R., Wang,L., Arulraj,T.,
            Barisic,D., Papin,A., Hoehn,K.B., Kots,E., Ersching,J.,
            Bandyopadhyay,A., Barin,E., Poh,H.X., Evans,C.M., Chadburn,A.,
            Chen,Z., Shen,H., Isles,H.M., Pelzer,B., Tsialta,I., Doane,A.S.,
            Geng,H., Rehman,M.H., Melnick,J., Morgan,W., Nguyen,D.T.T.,
            Elemento,O., Kharas,M.G., Jaffrey,S.R., Scott,D.W., Khelashvili,G.,
            Meyer-Hermann,M., Victora,G.D. and Melnick,A.
  TITLE     BTG1 mutation yields supercompetitive B cells primed for malignant
            transformation
  JOURNAL   Science 379 (6629), eabj7412 (2023)
   PUBMED   36656933
  REMARK    GeneRIF: BTG1 mutation yields supercompetitive B cells primed for
            malignant transformation.
REFERENCE   6  (residues 1 to 171)
  AUTHORS   Saka,Y., Tada,M. and Smith,J.C.
  TITLE     A screen for targets of the Xenopus T-box gene Xbra
  JOURNAL   Mech Dev 93 (1-2), 27-39 (2000)
   PUBMED   10781937
REFERENCE   7  (residues 1 to 171)
  AUTHORS   Suk,K., Sipes,D.G. and Erickson,K.L.
  TITLE     Enhancement of B-cell translocation gene-1 expression by
            prostaglandin E2 in macrophages and the relationship to
            proliferation
  JOURNAL   Immunology 91 (1), 121-129 (1997)
   PUBMED   9203975
REFERENCE   8  (residues 1 to 171)
  AUTHORS   Guehenneux,F., Duret,L., Callanan,M.B., Bouhas,R., Hayette,S.,
            Berthet,C., Samarut,C., Rimokh,R., Birot,A.M., Wang,Q., Magaud,J.P.
            and Rouault,J.P.
  TITLE     Cloning of the mouse BTG3 gene and definition of a new gene family
            (the BTG family) involved in the negative control of the cell cycle
  JOURNAL   Leukemia 11 (3), 370-375 (1997)
   PUBMED   9067576
REFERENCE   9  (residues 1 to 171)
  AUTHORS   Lin,W.J., Gary,J.D., Yang,M.C., Clarke,S. and Herschman,H.R.
  TITLE     The mammalian immediate-early TIS21 protein and the
            leukemia-associated BTG1 protein interact with a protein-arginine
            N-methyltransferase
  JOURNAL   J Biol Chem 271 (25), 15034-15044 (1996)
   PUBMED   8663146
REFERENCE   10 (residues 1 to 171)
  AUTHORS   Rouault,J.P., Samarut,C., Duret,L., Tessa,C., Samarut,J. and
            Magaud,J.P.
  TITLE     Sequence analysis reveals that the BTG1 anti-proliferative gene is
            conserved throughout evolution in its coding and 3' non-coding
            regions
  JOURNAL   Gene 129 (2), 303-306 (1993)
   PUBMED   8325512
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155936.7.
            
            On or before Dec 25, 2003 this sequence version replaced
            XP_125842.1, XP_354562.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149547.1, AK162764.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..171
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 49.89 cM"
     Protein         1..171
                     /product="protein BTG1"
                     /note="B-cell translocation gene 1 protein; B cell
                     translocation gene 1, anti-proliferative"
                     /calculated_mol_wt=19078
     Region          11..118
                     /region_name="btg1"
                     /note="tob/btg1 family; smart00099"
                     /db_xref="CDD:128410"
     Site            159
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P62324; propagated from
                     UniProtKB/Swiss-Prot (P62325.1)"
     CDS             1..171
                     /gene="Btg1"
                     /coded_by="NM_007569.2:325..840"
                     /db_xref="CCDS:CCDS24140.1"
                     /db_xref="GeneID:12226"
                     /db_xref="MGI:MGI:88215"
ORIGIN      
        1 mhpfytraat migeiaaavs fiskflrtkg ltserqlqtf sqslqellae hykhhwfpek
       61 pckgsgyrci rinhkmdpli gqaaqrigls sqelfrllps eltlwvdpye vsyrigedgs
      121 icvlyeaspa ggstqnstnv qmvdsrisck eelllgrtsp sknynmmtvs g
//
