LOCUS       NM_145455               1108 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus basic transcription factor 3 (Btf3), transcript
            variant 1, mRNA.
ACCESSION   NM_145455
VERSION     NM_145455.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1108)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1108)
  AUTHORS   Zeng,K.W., Wang,J.K., Wang,L.C., Guo,Q., Liu,T.T., Wang,F.J.,
            Feng,N., Zhang,X.W., Liao,L.X., Zhao,M.M., Liu,D., Jiang,Y. and
            Tu,P.
  TITLE     Small molecule induces mitochondrial fusion for neuroprotection via
            targeting CK2 without affecting its conventional kinase activity
  JOURNAL   Signal Transduct Target Ther 6 (1), 71 (2021)
   PUBMED   33602894
  REMARK    GeneRIF: Small molecule induces mitochondrial fusion for
            neuroprotection via targeting CK2 without affecting its
            conventional kinase activity.
            Erratum:[Signal Transduct Target Ther. 2021 Mar 12;6(1):120. doi:
            10.1038/s41392-021-00533-3.. PMID: 33712568]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1108)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   4  (bases 1 to 1108)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1108)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 1108)
  AUTHORS   Fu,H., Cai,J., Clevers,H., Fast,E., Gray,S., Greenberg,R.,
            Jain,M.K., Ma,Q., Qiu,M., Rowitch,D.H., Taylor,C.M. and Stiles,C.D.
  TITLE     A genome-wide screen for spatially restricted expression patterns
            identifies transcription factors that regulate glial development
  JOURNAL   J Neurosci 29 (36), 11399-11408 (2009)
   PUBMED   19741146
REFERENCE   7  (bases 1 to 1108)
  AUTHORS   Bae,S., Ha,T.S., Yoon,Y., Lee,J., Cha,H.J., Yoo,H., Choe,T.B.,
            Li,S., Sohn,I., Kim,J.Y., Kim,C.S., Jin,H.O., Lee,H.C., Park,I.C.,
            Kim,C.S., Jin,Y.W. and Ahn,S.K.
  TITLE     Genome-wide screening and identification of novel proteolytic
            cleavage targets of caspase-8 and -10 in vitro
  JOURNAL   Int J Mol Med 21 (3), 381-386 (2008)
   PUBMED   18288386
  REMARK    GeneRIF: Six putative caspase substrates, including five novel
            proteins (ABCF1, AKAP1, CPE, DOPEY1 and GOPC1) that may be targeted
            specifically by the initiator caspases 8 and 10 during the early
            stages of apoptosis, were identified.[caspase 10]
REFERENCE   8  (bases 1 to 1108)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 1108)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 1108)
  AUTHORS   Deng,J.M. and Behringer,R.R.
  TITLE     An insertional mutation in the BTF3 transcription factor gene leads
            to an early postimplantation lethality in mice
  JOURNAL   Transgenic Res 4 (4), 264-269 (1995)
   PUBMED   7655515
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC064010.1.
            
            On Dec 23, 2009 this sequence version replaced NM_145455.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064010.1, BI411367.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-918               BC064010.1         1-918
            919-1108            BC064010.1         920-1109
FEATURES             Location/Qualifiers
     source          1..1108
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 51.92 cM"
     gene            1..1108
                     /gene="Btf3"
                     /gene_synonym="1700054E11Rik"
                     /note="basic transcription factor 3"
                     /db_xref="GeneID:218490"
                     /db_xref="MGI:MGI:1202875"
     exon            1..343
                     /gene="Btf3"
                     /gene_synonym="1700054E11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..832
                     /gene="Btf3"
                     /gene_synonym="1700054E11Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor BTF3; RNA polymerase B transcription
                     factor 3; NAC-beta; nascent polypeptide-associated complex
                     subunit beta"
                     /codon_start=1
                     /product="transcription factor BTF3 isoform 1"
                     /protein_id="NP_663430.2"
                     /db_xref="CCDS:CCDS26714.1"
                     /db_xref="GeneID:218490"
                     /db_xref="MGI:MGI:1202875"
                     /translation="MRRTGAPTQADSRGRGRARGGWPGAEATPSLPLGGSRGRESQMK
                     ETIMNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQFSLKKLGVNNISGIE
                     EVNMFTNQGTVIHFNNPKVQASLAANTFTITGHAETKQLTEMLPSILNQLGADSLTSL
                     RRLAEALPKQSVDGKAPLATGEDDDDEVPDLVENFDEASKNEAN"
     exon            344..412
                     /gene="Btf3"
                     /gene_synonym="1700054E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            413..526
                     /gene="Btf3"
                     /gene_synonym="1700054E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            527..728
                     /gene="Btf3"
                     /gene_synonym="1700054E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            729..785
                     /gene="Btf3"
                     /gene_synonym="1700054E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            786..1090
                     /gene="Btf3"
                     /gene_synonym="1700054E11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1070..1075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btf3"
                     /gene_synonym="1700054E11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1090
                     /gene="Btf3"
                     /gene_synonym="1700054E11Rik"
                     /note="major polyA site"
ORIGIN      
        1 cttgcgtccc cgcgtgtgtg cgccttctct cagctggtct gcccgagacc ccctgagcgt
       61 gaaccttagt tccccgcgcg gcgccatttc cactccgaca aggtacagaa aaaaggccgt
      121 ggacgccggc gtgggaggag accgggagtt gggggtgggg cgggcgtttc ccggcaggag
      181 cgaggcaggg aggggacgga cggagctgag gaaagcgatg cgacggacgg gcgctcccac
      241 ccaggcggac tctcgggggc gagggcgagc caggggcggc tggcccgggg ccgaagcgac
      301 gccctctctc cctctcggcg gaagccgagg acgggagtct cagatgaaag aaacaatcat
      361 gaaccaggag aaactcgcca aactgcaggc acaagtgcgc attggtggga aaggaactgc
      421 tcgtaggaag aagaaggtgg ttcacagaac ggccacagca gacgataaga aactgcagtt
      481 ctccttaaag aagttagggg tgaacaacat ctctggtatt gaagaggtga acatgtttac
      541 aaaccaagga acagtgatcc attttaacaa ccctaaagtt caggcatccc tggcagcaaa
      601 caccttcacc attacaggcc acgctgagac aaagcagctg acagaaatgc ttcccagcat
      661 cctcaaccag cttggtgcag acagcctgac tagtttaagg agactggctg aagctctgcc
      721 caaacaatct gtggatggaa aagcacccct tgctactgga gaggatgatg atgatgaagt
      781 tccagatctg gtggagaatt ttgatgaggc ttctaagaat gaggcaaact gaattgaagc
      841 aacttctgaa gaaggtgata cttgcagaaa ttacaggagc tgctatttta tatcatgact
      901 gctttttaaa atttttttgt ttattatgga tctgataaaa tctagatctc taatattttt
      961 aagcccaagc ccccggacac tgcagctctt ttcagttttc gctataccta attcattctt
     1021 tgcggcaaat aaagctgaag aagcctggga ataaagtttg gaaagggtta ataaaattct
     1081 ttgcctagta aaaaaaaaaa aaaaaaaa
//
