LOCUS       NM_001170540             906 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus basic transcription factor 3 (Btf3), transcript
            variant 2, mRNA.
ACCESSION   NM_001170540
VERSION     NM_001170540.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 906)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 906)
  AUTHORS   Zeng,K.W., Wang,J.K., Wang,L.C., Guo,Q., Liu,T.T., Wang,F.J.,
            Feng,N., Zhang,X.W., Liao,L.X., Zhao,M.M., Liu,D., Jiang,Y. and
            Tu,P.
  TITLE     Small molecule induces mitochondrial fusion for neuroprotection via
            targeting CK2 without affecting its conventional kinase activity
  JOURNAL   Signal Transduct Target Ther 6 (1), 71 (2021)
   PUBMED   33602894
  REMARK    GeneRIF: Small molecule induces mitochondrial fusion for
            neuroprotection via targeting CK2 without affecting its
            conventional kinase activity.
            Erratum:[Signal Transduct Target Ther. 2021 Mar 12;6(1):120. doi:
            10.1038/s41392-021-00533-3.. PMID: 33712568]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 906)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   4  (bases 1 to 906)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 906)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 906)
  AUTHORS   Fu,H., Cai,J., Clevers,H., Fast,E., Gray,S., Greenberg,R.,
            Jain,M.K., Ma,Q., Qiu,M., Rowitch,D.H., Taylor,C.M. and Stiles,C.D.
  TITLE     A genome-wide screen for spatially restricted expression patterns
            identifies transcription factors that regulate glial development
  JOURNAL   J Neurosci 29 (36), 11399-11408 (2009)
   PUBMED   19741146
REFERENCE   7  (bases 1 to 906)
  AUTHORS   Bae,S., Ha,T.S., Yoon,Y., Lee,J., Cha,H.J., Yoo,H., Choe,T.B.,
            Li,S., Sohn,I., Kim,J.Y., Kim,C.S., Jin,H.O., Lee,H.C., Park,I.C.,
            Kim,C.S., Jin,Y.W. and Ahn,S.K.
  TITLE     Genome-wide screening and identification of novel proteolytic
            cleavage targets of caspase-8 and -10 in vitro
  JOURNAL   Int J Mol Med 21 (3), 381-386 (2008)
   PUBMED   18288386
  REMARK    GeneRIF: Six putative caspase substrates, including five novel
            proteins (ABCF1, AKAP1, CPE, DOPEY1 and GOPC1) that may be targeted
            specifically by the initiator caspases 8 and 10 during the early
            stages of apoptosis, were identified.[caspase 10]
REFERENCE   8  (bases 1 to 906)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 906)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 906)
  AUTHORS   Deng,J.M. and Behringer,R.R.
  TITLE     An insertional mutation in the BTF3 transcription factor gene leads
            to an early postimplantation lethality in mice
  JOURNAL   Transgenic Res 4 (4), 264-269 (1995)
   PUBMED   7655515
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ073405.1, AK139664.1 and BC064010.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. The encoded protein
            (isoform 2) is shorter when it is compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008233.1, BU513258.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                CJ073405.1         2-27
            27-867              AK139664.1         2-842
            868-906             BC064010.1         1071-1109
FEATURES             Location/Qualifiers
     source          1..906
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 51.92 cM"
     gene            1..906
                     /gene="Btf3"
                     /gene_synonym="1700054E11Rik"
                     /note="basic transcription factor 3"
                     /db_xref="GeneID:218490"
                     /db_xref="MGI:MGI:1202875"
     exon            1..141
                     /gene="Btf3"
                     /gene_synonym="1700054E11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..630
                     /gene="Btf3"
                     /gene_synonym="1700054E11Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transcription factor BTF3; RNA polymerase B transcription
                     factor 3; NAC-beta; nascent polypeptide-associated complex
                     subunit beta"
                     /codon_start=1
                     /product="transcription factor BTF3 isoform 2"
                     /protein_id="NP_001164011.1"
                     /db_xref="CCDS:CCDS49340.1"
                     /db_xref="GeneID:218490"
                     /db_xref="MGI:MGI:1202875"
                     /translation="MKETIMNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKL
                     QFSLKKLGVNNISGIEEVNMFTNQGTVIHFNNPKVQASLAANTFTITGHAETKQLTEM
                     LPSILNQLGADSLTSLRRLAEALPKQSVDGKAPLATGEDDDDEVPDLVENFDEASKNE
                     AN"
     exon            142..210
                     /gene="Btf3"
                     /gene_synonym="1700054E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            211..324
                     /gene="Btf3"
                     /gene_synonym="1700054E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            325..526
                     /gene="Btf3"
                     /gene_synonym="1700054E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            527..583
                     /gene="Btf3"
                     /gene_synonym="1700054E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            584..888
                     /gene="Btf3"
                     /gene_synonym="1700054E11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      868..873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btf3"
                     /gene_synonym="1700054E11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      888
                     /gene="Btf3"
                     /gene_synonym="1700054E11Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtggcgtcgc gttacttccg gcctccctct agctgccatc ttgcgtcccc gcgtgtgtgc
       61 gccttctctc agctggtctg cccgagaccc cctgagcgtg aaccttagtt ccccgcgcgg
      121 cgccatttcc actccgacaa gatgaaagaa acaatcatga accaggagaa actcgccaaa
      181 ctgcaggcac aagtgcgcat tggtgggaaa ggaactgctc gtaggaagaa gaaggtggtt
      241 cacagaacgg ccacagcaga cgataagaaa ctgcagttct ccttaaagaa gttaggggtg
      301 aacaacatct ctggtattga agaggtgaac atgtttacaa accaaggaac agtgatccat
      361 tttaacaacc ctaaagttca ggcatccctg gcagcaaaca ccttcaccat tacaggccac
      421 gctgagacaa agcagctgac agaaatgctt cccagcatcc tcaaccagct tggtgcagac
      481 agcctgacta gtttaaggag actggctgaa gctctgccca aacaatctgt ggatggaaaa
      541 gcaccccttg ctactggaga ggatgatgat gatgaagttc cagatctggt ggagaatttt
      601 gatgaggctt ctaagaatga ggcaaactga attgaagcaa cttctgaaga aggtgatact
      661 tgcagaaatt acaggagctg ctattttata tcatgactgc tttttaaaat ttttttgttt
      721 attatggatc tgataaaatc tagatctcta atatttttaa gcccaagccc ccggacactg
      781 cagctctttt cagttttcgc tatacctaat tcattctttg cggcaaataa agctgaagaa
      841 gcctgggaat aaagtttgga aagggttaat aaaattcttt gcctagtaaa aaaaaaaaaa
      901 aaaaaa
//
