LOCUS       NM_025295               1956 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus biotinidase (Btd), transcript variant 1, mRNA.
ACCESSION   NM_025295
VERSION     NM_025295.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1956)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1956)
  AUTHORS   Pindolia,K., Li,H., Cardwell,C. and Wolf,B.
  TITLE     Characterization and functional analysis of cellular immunity in
            mice with biotinidase deficiency
  JOURNAL   Mol Genet Metab 112 (1), 49-56 (2014)
   PUBMED   24630269
REFERENCE   3  (bases 1 to 1956)
  AUTHORS   Hernandez-Vazquez,A., Wolf,B., Pindolia,K., Ortega-Cuellar,D.,
            Hernandez-Gonzalez,R., Heredia-Antunez,A., Ibarra-Gonzalez,I. and
            Velazquez-Arellano,A.
  TITLE     Biotinidase knockout mice show cellular energy deficit and altered
            carbon metabolism gene expression similar to that of nutritional
            biotin deprivation: clues for the pathogenesis in the human
            inherited disorder
  JOURNAL   Mol Genet Metab 110 (3), 248-254 (2013)
   PUBMED   24075304
  REMARK    GeneRIF: Biotinidase knockout mice show cellular energy deficit and
            altered carbon metabolism gene expression similar to that of
            nutritional biotin deprivation.
REFERENCE   4  (bases 1 to 1956)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 1956)
  AUTHORS   Pindolia,K., Chen,J., Cardwell,C., Cui,X., Chopp,M. and Wolf,B.
  TITLE     Neurological deficits in mice with profound biotinidase deficiency
            are associated with demylination and axonal degeneration
  JOURNAL   Neurobiol Dis 47 (3), 428-435 (2012)
   PUBMED   22579707
  REMARK    GeneRIF: This study demonistrated that biotinidase deficiency mice
            showed demylination and axonal degeneration.
REFERENCE   6  (bases 1 to 1956)
  AUTHORS   Pindolia,K., Jordan,M., Guo,C., Matthews,N., Mock,D.M., Strovel,E.,
            Blitzer,M. and Wolf,B.
  TITLE     Development and characterization of a mouse with profound
            biotinidase deficiency: a biotin-responsive neurocutaneous disorder
  JOURNAL   Mol Genet Metab 102 (2), 161-169 (2011)
   PUBMED   21051254
REFERENCE   7  (bases 1 to 1956)
  AUTHORS   Ghesquiere,B., Van Damme,J., Martens,L., Vandekerckhove,J. and
            Gevaert,K.
  TITLE     Proteome-wide characterization of N-glycosylation events by
            diagonal chromatography
  JOURNAL   J Proteome Res 5 (9), 2438-2447 (2006)
   PUBMED   16944957
REFERENCE   8  (bases 1 to 1956)
  AUTHORS   Brumwell,C.L., Hossain,W.A., Morest,D.K. and Wolf,B.
  TITLE     Biotinidase reveals the morphogenetic sequence in cochlea and
            cochlear nucleus of mice
  JOURNAL   Hear Res 209 (1-2), 104-121 (2005)
   PUBMED   16107307
REFERENCE   9  (bases 1 to 1956)
  AUTHORS   Heller,A.J., Stanley,C., Shaia,W.T., Sismanis,A., Spencer,R.F. and
            Wolf,B.
  TITLE     Localization of biotinidase in the brain: implications for its role
            in hearing loss in biotinidase deficiency
  JOURNAL   Hear Res 173 (1-2), 62-68 (2002)
   PUBMED   12372635
  REMARK    GeneRIF: results indicate low expression of biotinidase throughout
            the brain, but increased concentrations within the dorsal cochlear
            nucleus, ventral cochlear nucleus, and superior olivary complex as
            well as in the hair cells and spiral ganglion of the cochlea
REFERENCE   10 (bases 1 to 1956)
  AUTHORS   Granjeaud,S., Naquet,P. and Galland,F.
  TITLE     An ESTs description of the new Vanin gene family conserved from fly
            to human
  JOURNAL   Immunogenetics 49 (11-12), 964-972 (1999)
   PUBMED   10501839
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ181966.1, AK135375.1, AK005506.1 and BU700769.1.
            
            On Dec 9, 2009 this sequence version replaced NM_025295.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AU067281.1, AK135375.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CJ181966.1         1-11
            12-336              AK135375.1         2-326
            337-1928            AK005506.1         330-1921
            1929-1956           BU700769.1         1-28                c
FEATURES             Location/Qualifiers
     source          1..1956
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.36 cM"
     gene            1..1956
                     /gene="Btd"
                     /note="biotinidase"
                     /db_xref="GeneID:26363"
                     /db_xref="MGI:MGI:1347001"
     exon            1..79
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1658
                     /gene="Btd"
                     /EC_number="3.5.1.12"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; biotinase"
                     /codon_start=1
                     /product="biotinidase isoform 1 precursor"
                     /protein_id="NP_079571.1"
                     /db_xref="CCDS:CCDS36857.1"
                     /db_xref="GeneID:26363"
                     /db_xref="MGI:MGI:1347001"
                     /translation="MRSRFMVCIMSGARTAPALFFLGCSALALGVSSASQEHREAEYY
                     VAAVYEHPSVLSPNPLELVSRQEALELMKQNLDVYEQQVMAAAQKGVQIIVFPEDGIH
                     GFNFTRTSIYPFLDFMPSPKLVRWNPCLEPFRFNDTEVLQRLSCMAIKGGMFLVANLG
                     TKQPCLSSDPGCPQDGRYQFNTNVVFSDNGTLVDRYRKHNLYFEAAFDTPANVDLITF
                     DTPFAGKFGVFTCFDILFFDPAVRLLRDFEVKHIVYPTAWMNQLPLLAAIEIQKAFAT
                     AFGVNVLAANIHHPTLGMTGSGIHTPLKSFWYHDMDDPKGHLIIAQVATNPQGLTGTG
                     NTTSEMDPSHRKFLKILSGDPYCEKDAQEVHCDEAAKWNVNVPPTFHSEMMYDNFTLV
                     PVWGTEGHLQVCSNSLCCHLLYERPTLSKELYALGVFDGLHTVHGTYYIQTCALVKCG
                     GLGFDTCGQEITEAEGLFDFHLWGNFSTLYIFPLFLTSGMTLDTPDQLGWENDHYFLR
                     KRGLSSGLVTAALYGRLYERK"
     exon            80..335
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            336..485
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            486..1942
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1907..1912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btd"
                     /note="hexamer: AATAAA"
     polyA_site      1933
                     /gene="Btd"
                     /note="major polyA site"
ORIGIN      
        1 attctccagt cagtcttttc cggactccgc catcagcagg aggcgggacg agccggaggc
       61 cgcgtcctat gcgaagcaga tttatggtct gcattatgtc tggagcccgc actgcgcctg
      121 ctctcttctt cctcggctgt tctgcgcttg cgttgggcgt cagctcggcc tcccaggagc
      181 accgcgaggc tgagtactac gtggctgctg tgtacgagca tccatcggtc ctgagcccaa
      241 accccctgga gctcgttagc cgccaggagg ccctggagct catgaagcag aacctcgacg
      301 tctatgaaca gcaagtgatg gctgcagccc agaagggtgt gcagattata gtgttcccag
      361 aagatggtat ccacggattc aactttacaa gaacatccat ttacccgttc ttggatttta
      421 tgccgtctcc caagctggtc aggtggaacc cgtgtctgga gccctttcgg ttcaatgaca
      481 cggaggtcct ccagcgcctg agttgtatgg ccatcaaggg agggatgttc ttggtggcca
      541 atcttggaac gaaacagcct tgcctcagca gcgaccctgg ttgcccacag gacgggagat
      601 accagtttaa cacaaatgtg gtgttcagcg acaatggaac tcttgtcgac cgctaccgta
      661 agcacaacct gtactttgag gcggcctttg atacccctgc taacgtggac ctcatcacct
      721 ttgatacgcc ctttgctggc aagtttggcg tgttcacttg ctttgacatc ctattctttg
      781 accctgccgt ccgactcctc agagactttg aggtgaaaca cattgtgtac cccacagcct
      841 ggatgaacca gctaccgctc ttggcagcca ttgaaattca gaaagcattc gccaccgcct
      901 tcggtgtcaa cgttttggca gctaacatcc accacccgac tctggggatg accggcagtg
      961 gcatacacac ccctctcaag tccttttggt accatgacat ggacgacccc aaaggtcacc
     1021 ttataattgc ccaggtagcc acaaacccac agggcctcac tgggacaggg aatacaacta
     1081 gtgagatgga cccgtcccat aggaagttct taaaaatcct gtccggagat ccgtactgtg
     1141 agaaggatgc ccaggaagtg cactgtgatg aggccgccaa gtggaacgtg aatgtcccgc
     1201 ccaccttcca ctcggaaatg atgtatgaca atttcaccct ggtccctgtc tggggaacgg
     1261 aaggccacct gcaggtgtgc tccaacagcc tctgttgcca cttactgtat gagaggccca
     1321 ccctgtccaa agagctatat gccctgggag tctttgacgg actccacacc gtgcacggca
     1381 cctactacat tcaaacctgt gccctggtta agtgcggggg ccttggcttc gacacctgcg
     1441 ggcaggagat cacggaggcc gagggcttgt ttgactttca tctgtggggg aacttcagca
     1501 ctttgtatat ctttccttta tttctcacct cggggatgac tctggacacc cctgaccagc
     1561 ttggctggga gaatgaccac tatttcttga ggaagagggg actgtcctcc ggcctggtga
     1621 cagcagctct ctatggacgg ttgtatgaga ggaagtagga aaactgtggt cagcggggtg
     1681 ggctctgggg gacgacctgc ctttccaggg ccacagatcc caagtgctgg gaaagccacc
     1741 cttgtggcac tggctcccac cctggggagc cgtaagaaaa tgggaggggc agttccttcc
     1801 tttctacata atgactgaga cattttctgg tattttctat tcactttagt ctgtcaggcc
     1861 acaccctctt cccactacac aattggtttt aaatttgaag ccagaaaata aacctcagtt
     1921 gctattttac aaatccgcag aaaaaaaaaa aaaaaa
//
