LOCUS       NM_007568               2876 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus betacellulin, epidermal growth factor family member
            (Btc), mRNA.
ACCESSION   NM_007568
VERSION     NM_007568.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2876)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2876)
  AUTHORS   Zhang,X., Xiao,G., Johnson,C., Cai,Y., Horowitz,Z.K., Mennicke,C.,
            Coffey,R., Haider,M., Threadgill,D., Eliscu,R., Oldham,M.C.,
            Greenbaum,A. and Ghashghaei,H.T.
  TITLE     Bulk and mosaic deletions of Egfr reveal regionally defined
            gliogenesis in the developing mouse forebrain
  JOURNAL   iScience 26 (3), 106242 (2023)
   PUBMED   36915679
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2876)
  AUTHORS   Hedegger,K., Algul,H., Lesina,M., Blutke,A., Schmid,R.M.,
            Schneider,M.R. and Dahlhoff,M.
  TITLE     Unraveling ERBB network dynamics upon betacellulin signaling in
            pancreatic ductal adenocarcinoma in mice
  JOURNAL   Mol Oncol 14 (8), 1653-1669 (2020)
   PUBMED   32335999
  REMARK    GeneRIF: Unraveling ERBB network dynamics upon betacellulin
            signaling in pancreatic ductal adenocarcinoma in mice.
REFERENCE   4  (bases 1 to 2876)
  AUTHORS   Dahlhoff,M., Algul,H., Siveke,J.T., Lesina,M., Wanke,R.,
            Wartmann,T., Halangk,W., Schmid,R.M., Wolf,E. and Schneider,M.R.
  TITLE     Betacellulin protects from pancreatitis by activating
            stress-activated protein kinase
  JOURNAL   Gastroenterology 138 (4), 1585-1594 (2010)
   PUBMED   20038432
  REMARK    GeneRIF: Betacellulin protects from pancreatitis by activating
            stress-activated protein kinase.
REFERENCE   5  (bases 1 to 2876)
  AUTHORS   Yechoor,V., Liu,V., Paul,A., Lee,J., Buras,E., Ozer,K., Samson,S.
            and Chan,L.
  TITLE     Gene therapy with neurogenin 3 and betacellulin reverses major
            metabolic problems in insulin-deficient diabetic mice
  JOURNAL   Endocrinology 150 (11), 4863-4873 (2009)
   PUBMED   19819964
REFERENCE   6  (bases 1 to 2876)
  AUTHORS   Kojima,H., Fujimiya,M., Matsumura,K., Younan,P., Imaeda,H.,
            Maeda,M. and Chan,L.
  TITLE     NeuroD-betacellulin gene therapy induces islet neogenesis in the
            liver and reverses diabetes in mice
  JOURNAL   Nat Med 9 (5), 596-603 (2003)
   PUBMED   12704384
REFERENCE   7  (bases 1 to 2876)
  AUTHORS   Lawson,J., Wheldrake,J.F. and Dunbar,A.J.
  TITLE     Genomic structure and promoter characterization of the gene
            encoding the ErbB ligand betacellulin
  JOURNAL   Biochim Biophys Acta 1576 (1-2), 183-190 (2002)
   PUBMED   12031500
  REMARK    GeneRIF: structure of the BTC gene
REFERENCE   8  (bases 1 to 2876)
  AUTHORS   Chang,H., Riese,D.J. 2nd, Gilbert,W., Stern,D.F. and McMahan,U.J.
  TITLE     Ligands for ErbB-family receptors encoded by a neuregulin-like gene
  JOURNAL   Nature 387 (6632), 509-512 (1997)
   PUBMED   9168114
REFERENCE   9  (bases 1 to 2876)
  AUTHORS   Pathak,B.G., Gilbert,D.J., Harrison,C.A., Luetteke,N.C., Chen,X.,
            Klagsbrun,M., Plowman,G.D., Copeland,N.G., Jenkins,N.A. and
            Lee,D.C.
  TITLE     Mouse chromosomal location of three EGF receptor ligands:
            amphiregulin (Areg), betacellulin (Btc), and heparin-binding EGF
            (Hegfl)
  JOURNAL   Genomics 28 (1), 116-118 (1995)
   PUBMED   7590736
REFERENCE   10 (bases 1 to 2876)
  AUTHORS   Shing,Y., Christofori,G., Hanahan,D., Ono,Y., Sasada,R.,
            Igarashi,K. and Folkman,J.
  TITLE     Betacellulin: a mitogen from pancreatic beta cell tumors
  JOURNAL   Science 259 (5101), 1604-1607 (1993)
   PUBMED   8456283
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK164633.1 and AK076272.1.
            
            On Apr 5, 2011 this sequence version replaced NM_007568.4.
            
            Summary: This gene encodes a member of the epidermal growth factor
            (EGF) family. These growth factors are ligands for the EGFR/ErbB
            receptor tyrosine kinases, and play roles in cell growth and
            differentiation. The encoded protein is synthesized as a
            transmembrane precursor that is proteolytically cleaved to generate
            a mature peptide, and plays a role in the differentiation of
            pancreatic beta cells. This gene may also play a protective role in
            acute pancreatitis, whereas increased expression of this gene may
            contribute to diabetic macular edema. Gene therapy using
            combinations of this gene and other pancreas-specific transcription
            factors may induce islet neogenesis and remediate hyperglycemia in
            type 1 diabetes. [provided by RefSeq, Apr 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076272.1, AK050206.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AK164633.1         2-82
            82-2146             AK076272.1         2-2066
            2147-2876           AK076272.1         2068-2797
FEATURES             Location/Qualifiers
     source          1..2876
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 44.78 cM"
     gene            1..2876
                     /gene="Btc"
                     /gene_synonym="Bcn"
                     /note="betacellulin, epidermal growth factor family
                     member"
                     /db_xref="GeneID:12223"
                     /db_xref="MGI:MGI:99439"
     exon            1..337
                     /gene="Btc"
                     /gene_synonym="Bcn"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..807
                     /gene="Btc"
                     /gene_synonym="Bcn"
                     /note="probetacellulin"
                     /codon_start=1
                     /product="betacellulin preproprotein"
                     /protein_id="NP_031594.1"
                     /db_xref="CCDS:CCDS19422.1"
                     /db_xref="GeneID:12223"
                     /db_xref="MGI:MGI:99439"
                     /translation="MDPTAPGSSVSSLPLLLVLALGLAILHCVVADGNTTRTPETNGS
                     LCGAPGENCTGTTPRQKVKTHFSRCPKQYKHYCIHGRCRFVVDEQTPSCICEKGYFGA
                     RCERVDLFYLQQDRGQILVVCLIVVMVVFIILVIGVCTCCHPLRKHRKKKKEEKMETL
                     DKDKTPISEDIQETNIA"
     exon            338..436
                     /gene="Btc"
                     /gene_synonym="Bcn"
                     /inference="alignment:Splign:2.1.0"
     exon            437..554
                     /gene="Btc"
                     /gene_synonym="Bcn"
                     /inference="alignment:Splign:2.1.0"
     exon            555..701
                     /gene="Btc"
                     /gene_synonym="Bcn"
                     /inference="alignment:Splign:2.1.0"
     exon            702..809
                     /gene="Btc"
                     /gene_synonym="Bcn"
                     /inference="alignment:Splign:2.1.0"
     exon            810..2876
                     /gene="Btc"
                     /gene_synonym="Bcn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2725..2730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btc"
                     /gene_synonym="Bcn"
                     /note="hexamer: AATAAA"
     polyA_site      2746
                     /gene="Btc"
                     /gene_synonym="Bcn"
                     /note="major polyA site"
     regulatory      2855..2860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btc"
                     /gene_synonym="Bcn"
                     /note="hexamer: ATTAAA"
     polyA_site      2874
                     /gene="Btc"
                     /gene_synonym="Bcn"
ORIGIN      
        1 accagcacca agtggtgtgc ctctccgggg gtgtgtgcag aaggctccag gataaatagg
       61 aggctcccag ttctgggtga cactggagcc cgctggctgc ccgccccggg tgtttccctg
      121 ctctgtaggc aggctgcctg ctgcttagtt tcgcttcctc ctggctcagg gattagtttt
      181 caagcaccct ctcggtgcca gggcccagga agggcataga gaaggaacct gaggactcat
      241 ccaggggctg ccctgcccct cacagcacag ttgatggacc caacagcccc gggtagcagt
      301 gtcagctccc tgccgctgct cctggtcctt gccctgggtc ttgcaattct ccactgtgtg
      361 gtagcagatg ggaacacaac cagaacacca gaaaccaatg gctctctttg tggagctcct
      421 ggggaaaact gcacaggtac cacccctaga cagaaagtga aaacccactt ctctcggtgc
      481 cccaagcagt acaagcatta ctgcatccat gggagatgcc gcttcgtggt ggacgagcaa
      541 actccctcct gcatctgtga gaaaggctac tttggggctc ggtgtgagcg agtggacctg
      601 ttttacctcc agcaggaccg ggggcagatc ctggtggtct gcttgatagt ggtcatggtg
      661 gtgttcatca ttttagtcat cggcgtctgc acctgctgtc atcctcttcg gaaacatcgt
      721 aaaaaaaaga aggaagagaa aatggagact ttggataaag ataaaactcc cataagtgaa
      781 gatattcaag agaccaatat tgcttaacgg ttataaagtt atcacaagct ggtggcaagc
      841 tacaaaagac ctgactcatt cccagatgga caggacatgt ctcaggaaaa cagctagcag
      901 aaatgaatgt ttaaatattg tatttacttt ttttatttgt aactgtgtgt tgcttgttat
      961 tgtttttaat aacgatatat tttttttgtt acagcctagt agttgagaaa aaataacctg
     1021 gttaggtgat gacaaaaata agggacattt gaatataaac tttgttgcca ggattattaa
     1081 ataaataaaa gaaaagtgga aaagaagtta gatttttaag aactaattca ccaccacgca
     1141 atggtagtac atgcctttaa tcccaggact tgggaggcag aggcaggcaa atctctgtga
     1201 gttcaaggcc agcctggtct acaaagaaag ttccaaaata gccaagacta caacagagga
     1261 acactgtctc aaaaaaccta accaaccaac caaccaaaca agcaagcaaa accctgtcaa
     1321 taatagggct tcccgggttt atacacttat catatgctaa gagcttgaaa tgtattattt
     1381 tattttatca tttcagtggt ctgtgagatt gcatattttt gtcctcattc ctatatatgc
     1441 aaaagttaaa tgatttcact taacttttta gagatagaag aattgagaga gccagaactg
     1501 atatggaccc agagtcaaag ctgatgtgct tatctttttt gtgaatttga gttccaacat
     1561 ctaactcaat agcgtaatcc aagatttcca actgaaccac actttgctat gattctgaga
     1621 tggtagggcg attttccatg ttgacacaga atacagagtc ctggttagaa ctgatgtcag
     1681 catcatgatt ccttcaggat tgacttcatg gatattatta gtttgctttc tcataaagtc
     1741 tcaatgacat gagaaaattc ttagatcacc aaaacaaaca gcaaaagtga aaggtgggtt
     1801 ttcgttcgcc cttgcatggg tattgatcct cagtaaagta taaacagcac aggaagagac
     1861 tgttagtatt ggtggtaacc atatgcaact atagcctcaa agtccaatgc atgtatattt
     1921 gctctcaggt gaactttaat gccagagaaa acatcctgaa ttgacccatt ttcccactct
     1981 tgtggtcctt tgactacata ctgtatttag tagaaactat attaaacata aagaattaaa
     2041 attttcattt ggtcagtatt ctatagaacg tggaaatgtc cacattgctt aggtaggtca
     2101 cttacagcag ccaatgggaa gatgtcttca gacaatgttg ctttgctgcc tgtttggatc
     2161 cttgtacatt ttactttaca agagagattc catagattca aacaaatgcc tgaactccct
     2221 atgttcttct agcacagtgt ttataagtag gctggagctt caataatgaa gatctcctgc
     2281 caattccact aagtctaaga actgacaact ctcaaaatgc tttttcttcc ttgtgactta
     2341 atgttcattc ttgaaaaacg gctgcccata cttgattcag attcgtgtct tatttagtct
     2401 tcttgggctc atgtgcgagt attctctcca gtcttttttt tttttttaac actaaacagg
     2461 tttgaataac atggccacta gaacattaaa aataccacca gtactgttaa gtgtctctgc
     2521 ttcctggtcc ctggttgact gaccaaagca gtcaatattg ggaaactcct cattttttta
     2581 tctgaaatgt ttgtggtgtc tcttgaaatt ctgttattat gaaagaattt caagaactct
     2641 catgttttta ttcaaagtgt attttgtaat tgctttgtat atactatgtt gtttatatag
     2701 actgttaagg ttataatgaa atcaaataaa tttattttta aacaaagcag acatattttt
     2761 tcttgggaat tttctactgg tactatgaat tattagtgga aataaatgta aatgtaaatg
     2821 ctcttaaaag tttatagaaa gcattcattg aagcattaaa gatattctac ttggct
//
