LOCUS       NM_145534               4979 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus BTB domain containing 3 (Btbd3), transcript variant 1,
            mRNA.
ACCESSION   NM_145534
VERSION     NM_145534.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4979)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4979)
  AUTHORS   Sato,H., Hatakeyama,J., Iwasato,T., Araki,K., Yamamoto,N. and
            Shimamura,K.
  TITLE     Thalamocortical axons control the cytoarchitecture of neocortical
            layers by area-specific supply of VGF
  JOURNAL   Elife 11, e67549 (2022)
   PUBMED   35289744
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4979)
  AUTHORS   Thompson,S.L., Welch,A.C., Ho,E.V., Bessa,J.M., Portugal-Nunes,C.,
            Morais,M., Young,J.W., Knowles,J.A. and Dulawa,S.C.
  TITLE     Btbd3 expression regulates compulsive-like and exploratory
            behaviors in mice
  JOURNAL   Transl Psychiatry 9 (1), 222 (2019)
   PUBMED   31501410
  REMARK    GeneRIF: Our findings reveal that hippocampal Btbd3 expression
            selectively modulates compulsive-like and exploratory behavior
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4979)
  AUTHORS   Botella-Lopez,A., Garcia-Lopez,R., Pombero,A. and Martinez,S.
  TITLE     Radial glia fibers translate Fgf8 morphogenetic signals to generate
            a thalamic nuclear complex protomap in the mantle layer
  JOURNAL   Brain Struct Funct 224 (2), 661-679 (2019)
   PUBMED   30470893
REFERENCE   5  (bases 1 to 4979)
  AUTHORS   Bechara,A., Laumonnerie,C., Vilain,N., Kratochwil,C.F.,
            Cankovic,V., Maiorano,N.A., Kirschmann,M.A., Ducret,S. and
            Rijli,F.M.
  TITLE     Hoxa2 Selects Barrelette Neuron Identity and Connectivity in the
            Mouse Somatosensory Brainstem
  JOURNAL   Cell Rep 13 (4), 783-797 (2015)
   PUBMED   26489473
REFERENCE   6  (bases 1 to 4979)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 4979)
  AUTHORS   Matsui,A., Tran,M., Yoshida,A.C., Kikuchi,S.S., U,M., Ogawa,M. and
            Shimogori,T.
  TITLE     BTBD3 controls dendrite orientation toward active axons in
            mammalian neocortex
  JOURNAL   Science 342 (6162), 1114-1118 (2013)
   PUBMED   24179155
  REMARK    GeneRIF: during the development of the sensory cortex, dendritic
            field orientation is controlled by the BTB/POZ domain-containing 3
            (BTBD3).
REFERENCE   8  (bases 1 to 4979)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB093275.1 and BC062968.1.
            
            On Jul 15, 2005 this sequence version replaced NM_145534.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062968.1, AB093275.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2914              AB093275.1         1-2914
            2915-4979           BC062968.1         2611-4675
FEATURES             Location/Qualifiers
     source          1..4979
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 68.28 cM"
     gene            1..4979
                     /gene="Btbd3"
                     /gene_synonym="mKIAA0952"
                     /note="BTB domain containing 3"
                     /db_xref="GeneID:228662"
                     /db_xref="MGI:MGI:2385155"
     exon            1..765
                     /gene="Btbd3"
                     /gene_synonym="mKIAA0952"
                     /inference="alignment:Splign:2.1.0"
     CDS             416..2008
                     /gene="Btbd3"
                     /gene_synonym="mKIAA0952"
                     /note="isoform 1 is encoded by transcript variant 1;
                     BTB/POZ domain-containing protein 3; BTB (POZ) domain
                     containing 3"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein 3 isoform 1"
                     /protein_id="NP_663509.2"
                     /db_xref="CCDS:CCDS16798.1"
                     /db_xref="GeneID:228662"
                     /db_xref="MGI:MGI:2385155"
                     /translation="MVDDKEKNMKCLTFFLMLPETVKNRSKKGSKKANSSGGGGGGGS
                     VGSGSSKLPPVCYEIITLKTKKKKKMAADIFPRKKPANSSSTTVQQQHQHNLCNNNLI
                     PAPNWQGLYPTIRERNAVMFNNDLMADVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAM
                     FYGELAEDKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLAR
                     ACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQT
                     LESILRRETLNAKEIVVFEAALNWAEVECQRQDLALSIENKRKVLGKALYLIRIPTMA
                     LDDFANGAAQSGVLTLNETNDIFLWYTASKKPELQFVSKARKGLVPQRCHRFQSCAYR
                     SNQWRYRGRCDSIQFAVDKRVFIAGFGLYGSSCGSAEYSAKIELKRQGVVLGQNLSKY
                     FSDGSSNTFPVWFEYPVQIEPDTFYTASVVLDGNELSYFGQEGMTEVQCGKVTVQFQC
                     SSDSTNGTGVQGGQIPELIFYA"
     exon            766..856
                     /gene="Btbd3"
                     /gene_synonym="mKIAA0952"
                     /inference="alignment:Splign:2.1.0"
     exon            857..975
                     /gene="Btbd3"
                     /gene_synonym="mKIAA0952"
                     /inference="alignment:Splign:2.1.0"
     exon            976..4940
                     /gene="Btbd3"
                     /gene_synonym="mKIAA0952"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4924..4929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btbd3"
                     /gene_synonym="mKIAA0952"
                     /note="hexamer: AATAAA"
     polyA_site      4940
                     /gene="Btbd3"
                     /gene_synonym="mKIAA0952"
                     /note="major polyA site"
ORIGIN      
        1 cctactctcc tctcccgatc cattcaccac acaacttcac cggccggccg cggccgtact
       61 gactcgctgg gctcgccaca tcttgctaac ctaattcaga aagcaagcgc ctcagctctc
      121 tctctgcctg cctcctttgc tcagctttgc aggtgatcca gagaacggct ggttttatgc
      181 gcaagtaaga aaaccaggaa tcatgatggg aatgtattta acagatccgg tcctggataa
      241 aacttaaagc cagtttctct tcaacatagt gaaaaggtca ccttgcctgg ctgggaaaag
      301 caggaagaaa gcagcctgcc ggtctctgtt aacatcttag ctccggctag cctctttgcc
      361 ttgatgtttg agcagttttg cgagatctag ctctaaagag agacatcctg tactcatggt
      421 agatgataaa gaaaagaaca tgaaatgtct caccttcttc ttgatgcttc cagagacagt
      481 aaagaacagg tccaaaaaag gttcaaagaa agccaacagc agcggtggcg gcggcggcgg
      541 cggcagcgtt ggcagtggga gcagcaagtt gcccccagtt tgttatgaaa taattacctt
      601 gaagactaaa aagaagaaga agatggctgc tgatatattc ccccgtaaga agccagccaa
      661 ctccagcagc accactgtcc agcagcaaca ccagcacaac ctctgtaaca acaacctcat
      721 cccggccccc aactggcagg gtctttatcc caccatccga gaaagaaatg cggtgatgtt
      781 caataatgac ttgatggcag acgtacattt tgtggttggg ccaccaggtg ggactcagcg
      841 gttgccagga cacaaatacg tcctcgctgt cgggagctca gtgttccatg caatgtttta
      901 cggagaactc gctgaggaca aagatgaaat ccgaatccca gacgtcgaac ctgctgcctt
      961 cctcgccatg ctgaaataca tctattgtga tgaaattgac ttggctgcag acacagtgct
     1021 ggccacactg tatgctgcca aaaagtacat agttcctcac ctcgccagag cctgtgttaa
     1081 tttcctggag accagcctaa gcgccaagaa cgcctgcgta ctcctctccc agagctgcct
     1141 gtttgaggag ccggacctga cacagcgttg ctgggaggtg attgatgccc aggccgagtt
     1201 agcgctcaag tctgagggat tctgtgacat cgacttccag acactcgaaa gtatcctccg
     1261 cagggaaact ctgaatgcca aagaaatagt ggtttttgag gcagccctga actgggctga
     1321 ggtagaatgc cagcggcaag atctggccct gagcattgaa aataaacgca aggtcctagg
     1381 aaaggccctg tacttgatcc gcatccctac catggccctg gatgactttg caaatggtgc
     1441 tgcacagtct ggggtattga ctctcaatga gaccaatgac atcttcctct ggtacactgc
     1501 atccaaaaaa ccagagctgc agtttgtgag taaagcccgc aagggcctgg tcccccagcg
     1561 ttgccaccga tttcagtcat gtgcctatcg gagcaaccag tggcgctatc ggggtcgctg
     1621 tgacagcatc cagtttgctg ttgataagag ggtgttcatc gcaggctttg ggctgtacgg
     1681 ctccagctgt ggctctgccg agtacagcgc aaagatcgaa ctcaaacggc agggcgttgt
     1741 cctgggccag aacttgagca agtacttctc agacggatcc agcaatacct tccctgtgtg
     1801 gtttgagtat ccagtgcaga ttgagccgga caccttctac acagccagtg tagtgctgga
     1861 cggcaatgaa ctcagctact ttgggcagga aggcatgacg gaagttcagt gtggcaaggt
     1921 gactgtccag ttccagtgct cctcagacag caccaatggc actggtgtac agggagggca
     1981 gatccccgaa ctcatattct acgcctgaac ttttcttctt ttatgcagca tgaggtgccc
     2041 acatgggccc tccttgcctg acgcttagct catctgcaga tatgtggtca gcacaggtaa
     2101 tttgtaatga atgaagcagt aggcagtttc taatgtcttt gaacctttta attatgtaca
     2161 ggctaaaatg caacattccg cttttaactc tatgcttaga agagccaagt tcttactcag
     2221 gctttgtggg tttcgagttg cgtctgtacg cctagggaga tcgtgtgctt ttccaagtgc
     2281 ccaccaacct cctacttctg tacctctgaa gaaaattttg gatcaacttg aatttccttt
     2341 gatgaatgga attatgtatc ctaaagtagt atcattattt ttaaacagaa cccctttctc
     2401 tcaataaata aataaaagca aaaacaaaga acaggtaaac ctcagtgtac gaatttgaaa
     2461 gaatatttgc tttgtaccaa gtaaacttag aaagtaaaca ctaggccagt agtcaagttt
     2521 gctgctgttc ttttacattc gttatttctg ggccttgctt ttatagtctt tgtatttcaa
     2581 gttcatatat gtgttactca ctaaacagtt cagactcttg atgtaaggaa ttagatattt
     2641 gtttaggcca tgattccaac tacaaagcag acttatattc tttcaggtta gaagacaaga
     2701 taccagaatg cagaccgctt ccttcagaag tgatgcaatt ggaaaatgtc attgttgata
     2761 gaaagaaagg ttgcaaactt gctaatttgt actctaatgg gtaaaaggga agcctgaaaa
     2821 tgcctataca accagcagtc agtttaccag tgagaaagaa ggatatacaa ttcagaaaag
     2881 ccactctggc ctggtagttt tggacccccc acaaatacac actcacacac acactattgg
     2941 tttgttctta agtcttactg cataggactc ccgtttctcc tcccccctcc cctgttaaaa
     3001 gaggaccaaa cagttcttta gaggtatggt atggagtaac ggttttgtag cactacttgt
     3061 cagtgtgata aagtactttt tatgcttttt cttttaaatc gaaacattct ttatctgatg
     3121 tttgaccata gacgatctta tttgttgatt atgaacaagc ttctggactg ctagaacctg
     3181 gcctctggcc atcttaaagt gccaatatat gactgcaggg tttttgaaaa atggttcgga
     3241 gtgacactgg gttataccga gtattcacct catcagcatc acatgcagtt cttatttgtc
     3301 catgatacca tacgccaaga gggaaaagct cgcagacaac ttctcctttt ccatgatggc
     3361 tcctgttggc ttagtgcctg tggccctggt agtgtccagt gtagtcactt gaagctgaaa
     3421 tatccatgtg tttctgggca gcttttctgc tcagtgtgat cctgagatgg ctccctgcca
     3481 cccagagtgt ggtccctggc cgcctccttc tcctgctctg taagccaaag ttgacttatc
     3541 tggagcaggg gctagtcctg gggtgtgtgt gcctgcgcaa tatgtgcatg caaatgtgct
     3601 tgccaactca ggaactgcct cctccctgcc tggctagtgg tgggtgtgtc agaactaacc
     3661 tacacacccc ctgccggtac cagcaatgcc cagtgaagtg actgctttta ctctctgggc
     3721 ttctgggcca tttcttccct tggagatatg ggcttgtggc ctttggccag cttccctggt
     3781 ggaggagagc actggattat gggaaatgtt ttaatcattt tgccattaca tacatctgtt
     3841 aacatagttg accaaaagct gttattgatg acaactttcc aaaattatct cttaattgct
     3901 tcctaataaa ggggatgaca ggttgtagtt ttggcaaagc atcaatgaga taaaggtaca
     3961 ttgtcaatta aaattacttc aacaaaggtt tttgctttac aattatggtt aaacatttca
     4021 gtaactcata gctaccatac aaattggtat ggtacatgca gagtgactag aaggcactta
     4081 cttttaagcc agaggagaag gaactttgtt tagcacagat tgcatcctgt aagatagttg
     4141 ggctgggtgt gatagcctta aaggggcagt gtctatcccc aactcactct tactgtgact
     4201 gagccaccct ccatgtggct gggcaagtgc agttcactga ggatggaaga acttaacttt
     4261 ctattaatca ttattatgtt tccaaaaaga tatatccact ttctgacttg gcctatgcca
     4321 agaactgtgg gtaagattga aaagctgtac ctaacgtaag aaattttagg ttctgaacct
     4381 attctcctgt atgcattttc agcaaactga aagataatgc gcttgctttg gttttctttg
     4441 gtaattttga acttgtagtt tgtaagaata aaaatcattg ttctgacagg gctggcagct
     4501 ctagtgtata aacacaactt cattaagcag aaaacgctgt agatgctttg cccagcatac
     4561 ctggcagttt tcatcattgt tcatactggg gataagggta actaggctag cagttctaat
     4621 gcaacattct ttaatcatat cttaagatag tatttaagta aatggtctaa tttctacata
     4681 attattgcac tgaactgtct tttttttttt tttttaaggt gtttaaataa gctcagctaa
     4741 ttcaggacac tgcatccaac cgtgcatcag tgtgcttgac tttagcagct taccgcatta
     4801 tttatgaagg aaaatataaa tatgaagtac ctcatgttga atgttattgt actgtatttt
     4861 taatgtaaca gtgcagatct tgttagacac atgaatgtgt ataatcatgt taaatgcaaa
     4921 taaaataaaa ctggttcata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
