LOCUS       NM_145361               2443 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus BTB domain containing 2 (Btbd2), transcript variant 2,
            mRNA.
ACCESSION   NM_145361 XM_001000710 XM_910826
VERSION     NM_145361.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2443)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2443)
  AUTHORS   Sajedi,E., Gaston-Massuet,C., Andoniadou,C.L., Signore,M.,
            Hurd,P.J., Dattani,M. and Martinez-Barbera,J.P.
  TITLE     DNMT1 interacts with the developmental transcriptional repressor
            HESX1
  JOURNAL   Biochim Biophys Acta 1783 (1), 131-143 (2008)
   PUBMED   17931718
REFERENCE   3  (bases 1 to 2443)
  AUTHORS   Xu,L., Yang,L., Moitra,P.K., Hashimoto,K., Rallabhandi,P., Kaul,S.,
            Meroni,G., Jensen,J.P., Weissman,A.M. and D'Arpa,P.
  TITLE     BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the
            RBCC/tripartite motif protein, TRIM5delta
  JOURNAL   Exp Cell Res 288 (1), 84-93 (2003)
   PUBMED   12878161
REFERENCE   4  (bases 1 to 2443)
  AUTHORS   Carim-Todd,L., Sumoy,L., Andreu,N., Estivill,X. and Escarceller,M.
  TITLE     Identification and characterization of BTBD1, a novel BTB domain
            containing gene on human chromosome 15q24
  JOURNAL   Gene 262 (1-2), 275-281 (2001)
   PUBMED   11179693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152410.6.
            
            On Mar 20, 2020 this sequence version replaced NM_145361.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422603.197252.1,
                                           SRR13422590.298869.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               AC152410.6         82322-82686         c
            366-485             AC152410.6         74752-74871         c
            486-642             AC152410.6         73897-74053         c
            643-748             AC152410.6         72573-72678         c
            749-946             AC152410.6         71532-71729         c
            947-1139            AC152410.6         70795-70987         c
            1140-1227           AC152410.6         70454-70541         c
            1228-1374           AC152410.6         70018-70164         c
            1375-2443           AC152410.6         68815-69883         c
FEATURES             Location/Qualifiers
     source          1..2443
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2443
                     /gene="Btbd2"
                     /gene_synonym="2610037C03Rik; 4930512K17Rik"
                     /note="BTB domain containing 2"
                     /db_xref="GeneID:208198"
                     /db_xref="MGI:MGI:1933831"
     exon            1..365
                     /gene="Btbd2"
                     /gene_synonym="2610037C03Rik; 4930512K17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1536
                     /gene="Btbd2"
                     /gene_synonym="2610037C03Rik; 4930512K17Rik"
                     /note="isoform 2 is encoded by transcript variant 2; BTB
                     (POZ) domain containing 2"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein 2 isoform 2"
                     /protein_id="NP_663336.3"
                     /db_xref="CCDS:CCDS48639.1"
                     /db_xref="GeneID:208198"
                     /db_xref="MGI:MGI:1933831"
                     /translation="MAAGGSGRASCPPGVGAGAGSLGPSANAAAAPSNAAACAPVPPP
                     PPSPPPGPGTDAQAVGDERDDAGPGALLREPVYNWQATKPTVQERFAFLFNNEVLCDV
                     HFLVGKGLSSQRVPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKF
                     LYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKHLRADNAFMLLTQARLFDEP
                     QLASLCLESIDKNTADAIAAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAE
                     CQRQQLQVTPENKRKVLGKALSLIRFPLMTIEEFAAGPAQSGILVDREVVSLFLHFTV
                     NPKPRVEFIDRPRCCLRGKECSINRFQQVESRWGYSGTSDRIRFSVNKRIFVVGFGLY
                     GSIHGPTDYQVNIQIIHTDSNTVLGQNDTGFSCDGSASTFRVMFKEPVEVLPNVNYTA
                     CATLKGPDSHYGTKGLRKVTHESPTTGAKTCFTFCYAAGNNNGTSVEDGQIPEVIFYT
                     "
     exon            366..485
                     /gene="Btbd2"
                     /gene_synonym="2610037C03Rik; 4930512K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            486..642
                     /gene="Btbd2"
                     /gene_synonym="2610037C03Rik; 4930512K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            643..748
                     /gene="Btbd2"
                     /gene_synonym="2610037C03Rik; 4930512K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            749..946
                     /gene="Btbd2"
                     /gene_synonym="2610037C03Rik; 4930512K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1139
                     /gene="Btbd2"
                     /gene_synonym="2610037C03Rik; 4930512K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1227
                     /gene="Btbd2"
                     /gene_synonym="2610037C03Rik; 4930512K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1374
                     /gene="Btbd2"
                     /gene_synonym="2610037C03Rik; 4930512K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..2443
                     /gene="Btbd2"
                     /gene_synonym="2610037C03Rik; 4930512K17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2419..2424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btbd2"
                     /gene_synonym="2610037C03Rik; 4930512K17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2443
                     /gene="Btbd2"
                     /gene_synonym="2610037C03Rik; 4930512K17Rik"
                     /note="major polyA site"
ORIGIN      
        1 agcgacaaga tggcggcggg cggcagcggg cgcgcgtctt gcccgccggg ggtcggggcc
       61 ggcgcgggca gcctgggtcc cagtgctaac gcggccgccg cccccagcaa cgccgctgcc
      121 tgcgccccgg tgcctccgcc gcccccgtcc ccgccgcctg ggcccgggac tgacgcgcag
      181 gccgtgggcg acgagcgcga cgacgcgggc ccaggcgcgc tgctgcgcga gcccgtgtac
      241 aactggcagg ccaccaagcc cacggtgcag gagcgcttcg ccttcctctt caacaacgag
      301 gtgctgtgcg acgtgcactt cctggtgggc aaggggctca gctcgcagcg cgtccccgcg
      361 cacaggtttg tgctagctgt gggaagcgct gtctttgacg ccatgttcaa tggtgggatg
      421 gctaccacgt ccaccgagat tgagctgcct gatgtggaac ctgctgcctt cctggcgctg
      481 ctcaagttcc tgtactcaga tgaagtgcag atcgggccag agacagtgat gaccacactg
      541 tacacggcca agaagtacgc agtgcccgcg ctcgaggccc actgtgtgga gttcctgaag
      601 aagcacctgc gggctgacaa tgccttcatg ctgctcacac aggcacggct cttcgatgag
      661 ccccagctgg ccagcctgtg cctggagagt atagacaaga acacagcgga cgccattgct
      721 gccgagggct tcactgacat tgacctggac acgctggtgg cagtgctgga gcgggatacc
      781 ctgggcattc gtgaggttcg gctcttcaat gcagtcgtgc gctggtctga ggctgagtgt
      841 caacggcagc agcttcaggt gacacccgag aacaagagga aggtgctggg caaggccctg
      901 agtctcatcc gattccccct gatgaccatc gaggagtttg ccgcaggccc ggcacagtca
      961 ggcatcctgg tggaccggga ggtggtcagc ctcttcctac attttactgt caaccccaag
     1021 ccgcgtgtgg agttcatcga ccggccccgg tgttgcctgc ggggcaagga gtgtagcatt
     1081 aaccggttcc agcaggtgga gagccgctgg ggctacagcg gcaccagtga ccgcatcagg
     1141 ttctcggtca acaagcgcat ttttgtggtg ggttttgggc tctatggatc tattcacggg
     1201 cctactgact accaagtgaa catccagatc atccacacgg acagcaacac agtccttggc
     1261 cagaacgaca caggtttcag ctgcgacggt tctgccagca ccttccgtgt tatgttcaag
     1321 gagcccgtgg aggtcctgcc caatgtgaac tacaccgcct gtgccacgct gaagggccca
     1381 gactctcact atggcaccaa aggtctacgc aaggtgaccc acgagtctcc caccacgggg
     1441 gctaagacct gcttcacctt ctgttacgcg gctgggaaca acaacggcac atctgtggag
     1501 gatgggcaga tccctgaagt catcttctac acctaggcca tccacccagg tcaccctggc
     1561 cagccatagg cctgcctccc tccccaccac ctcccacatc atcatggaag gggctgcctg
     1621 tgtccacagt gacaagtgtg accgcctgtc ccaaggcact gaggaggtgg ttaggccatg
     1681 ggctgggccc cgttgagaca atccttcagt cttgggggac agagtgggac tagccttgga
     1741 tggacagagc gtggtgggtc gcagtccctg aagctcaggg cagcaggcca gctccgagcc
     1801 ctggtgctgc cctgctcctc cgttctcttc aactgcacac tgcaatgcat acaagcccac
     1861 actcagctgg agcccgcgcc gggcctctcc tccagccagt ggtctgggtt tcatgttcct
     1921 tttcttctcc gctgctccct gggaggtccc aggtcctgac ctgcgtgcac tgctgccccc
     1981 tgaagccctg gcctgctggg catgtacaca gagccactgg gagctctgcc ccagggtagg
     2041 tgacatgtgg ccgtggttcc tacttctcac agcagcgcaa gtgcccagtc agcactgtcc
     2101 acccaaggcg gacagactcc tcacaggtgt gctcagcaga gctcagcctt gagcctgcag
     2161 acccatcaaa atgcactggg cacccagctg gcctgatgtg gctctccggg ggtaccacag
     2221 aacacccctg tacataccac agccctggcc ctctaggcca ccacatcacc ccatccagtg
     2281 atgtcccaga aggcgcagtc tccagtttgg ggttccactt cctcatattt ctgtaccagt
     2341 gacctcctgc ccagaaccca tcccaaagcc atgggaggtg tgccctccac actgtgtccc
     2401 caaatgattt tttttttaaa taaaggaaaa catctgcctt gaa
//
