LOCUS       NM_001145100            3520 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus BTB domain containing 18 (Btbd18), mRNA.
ACCESSION   NM_001145100
VERSION     NM_001145100.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3520)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3520)
  AUTHORS   Zhou,L., Canagarajah,B., Zhao,Y., Baibakov,B., Tokuhiro,K.,
            Maric,D. and Dean,J.
  TITLE     BTBD18 Regulates a Subset of piRNA-Generating Loci through
            Transcription Elongation in Mice
  JOURNAL   Dev Cell 40 (5), 453-466 (2017)
   PUBMED   28292424
  REMARK    GeneRIF: BTBD18 is a specific controller for transcription
            activation through RNA polymerase II elongation at a subset of
            genomic PIWI-interacting RNA loci.
REFERENCE   3  (bases 1 to 3520)
  AUTHORS   Harrow,J.L., Steward,C.A., Frankish,A., Gilbert,J.G.,
            Gonzalez,J.M., Loveland,J.E., Mudge,J., Sheppard,D., Thomas,M.,
            Trevanion,S. and Wilming,L.G.
  TITLE     The Vertebrate Genome Annotation browser 10 years on
  JOURNAL   Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
   PUBMED   24316575
REFERENCE   4  (bases 1 to 3520)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY725353.1, CN721982.1, CN719836.1 and AL929079.14.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CN721982.1, CN719836.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849384,
                                           SAMN01164134 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               BY725353.1         1-467
            468-724             CN721982.1         1-257
            725-1006            CN719836.1         230-511
            1007-3520           AL929079.14        66937-69450
FEATURES             Location/Qualifiers
     source          1..3520
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 49.45 cM"
     gene            1..3520
                     /gene="Btbd18"
                     /gene_synonym="Btbd18-ps; Gm13718"
                     /note="BTB domain containing 18"
                     /db_xref="GeneID:100270744"
                     /db_xref="MGI:MGI:3650217"
     exon            1..515
                     /gene="Btbd18"
                     /gene_synonym="Btbd18-ps; Gm13718"
                     /inference="alignment:Splign:2.1.0"
     exon            516..600
                     /gene="Btbd18"
                     /gene_synonym="Btbd18-ps; Gm13718"
                     /inference="alignment:Splign:2.1.0"
     exon            601..712
                     /gene="Btbd18"
                     /gene_synonym="Btbd18-ps; Gm13718"
                     /inference="alignment:Splign:2.1.0"
     exon            713..882
                     /gene="Btbd18"
                     /gene_synonym="Btbd18-ps; Gm13718"
                     /inference="alignment:Splign:2.1.0"
     CDS             759..2930
                     /gene="Btbd18"
                     /gene_synonym="Btbd18-ps; Gm13718"
                     /note="BTB (POZ) domain containing 18, pseudogene"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein 18"
                     /protein_id="NP_001138572.1"
                     /db_xref="CCDS:CCDS79815.1"
                     /db_xref="GeneID:100270744"
                     /db_xref="MGI:MGI:3650217"
                     /translation="MCSPASSKILYRNPRFLRVAFLQLHHQQQSGVFCDALLQAEGEA
                     VPAHCCILSACSPFFTERLERERPVQGRKVVLEMGGLKIQTLRKLVDFLYTSEMEVSQ
                     EEAQDVLSAARQLRVSELETLQLEGGKLVKAPQGRRLNRECLQPPAAAPISARVVGPK
                     SRPQTPLPVTQTPSPLGAVRLKSLGEEEGAHKKTNLPNADSLSDTQLKKKARVCLTQE
                     SRSSPSSQREGPKETKSNPGPTALPSLYPSVDEQLLPRKIRLSRSKPSPHVYTSTPSS
                     ILSGPSSMPTAPGRRLWRQRTVSKEAQGVDKQKPGEVRPLQSTPDPSDVGKPAENKKQ
                     SPELRAPTSSSVEEGQVGRVKLRKIVNGTCWEVVQEPPLRNTQDSPQILEPSDVEEPS
                     GTLLSSVNEQEIPARIQLCQDSPESPRLQDILLSASHSPDHPMVKSEFGSSPMLTGKE
                     SDLNIDCREPYTFDTTLLGQPCEAEQYRITSAAATSELEEIFDFMLCGSDVEPPVGSL
                     ESPGAEGCRTPSYHLSETGKNWIEGEEWCLPDMELWPRDLTGLEKEPVSENKEPVEPF
                     SPLVMRSENTESFEPLSPLVMPSEVSREELSLRGSWTPDLEITSSQPLDGQGEKLLHF
                     DSSDPSQRSYNHLSPPCSDWAETGLEVSLGMDDVLCPVPKAVREVSANPEQLDPLPGS
                     SEDEEIDVVDWTVEKKLGPTSVPSVWPDPSSESETEVDILT"
     exon            883..3520
                     /gene="Btbd18"
                     /gene_synonym="Btbd18-ps; Gm13718"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaaccctc gacgcccgga gcgcgaggct ggcagcgcgc ggtgtttagc ctgggccgcg
       61 tggcctcaga cctcgtcgtc atcactccca gtgcatgtgg gtgctggaga cccgcagcgg
      121 cccgagggcg ccaaggagaa actacagaac ccgtgtggac gaagccagcg gtgaccgcga
      181 gggccagccc tgatttcagg cctccactag cgccttgctc cattcccagc acccctcgcg
      241 ccgaagagcc ttcttcaaag gagttgggcc tgggggcccc aggcgtgtgg gggtgacctg
      301 ctttgcaggg ccttctgtgc caccgtttcg ccactaaccc tcattttctt gtttctggag
      361 tgggagggga tcgctgaggt tgtgggggca acctctgctg cttgtcgcaa cctttcggct
      421 tgaggctgga cattaggagg agaccagcaa gcagacaaga ggaccggagg aaagtgagga
      481 caacaggaac aaattctact gcagaacaat ttcagttttg acgtgaacta tttggactct
      541 tcagtgctac ctgacagaaa actacgtaac ggtaccggaa aaagaacgca cagttgtacg
      601 ggtctcatat agcctaggct ggccttgatg gatgtctgcc tcctaagaac tggaatttta
      661 gacatgctcc cccatgtctg gcttatttaa aaatttttag aagccttaca aggaatctga
      721 accaggaaaa cctagaaggt ttattaacca aatacaacat gtgctctcct gccagttcca
      781 aaatcctgta caggaacccc cggttcctcc gggtagcttt tctacagctt catcaccagc
      841 agcagagtgg tgtgttttgt gatgcccttc tgcaggcaga gggtgaggct gtcccagccc
      901 actgctgcat cctgtctgcc tgcagtcctt tcttcacaga acgcttggag cgggaaaggc
      961 cggttcaggg tcggaaggtt gtgctggaga tgggaggcct aaagatccaa acactaagga
     1021 agcttgtgga cttcctgtat acgtcagaga tggaagtatc tcaggaagaa gcccaggatg
     1081 tgctgtctgc tgcccgtcag ctccgagtgt cagagctgga aacccttcag ctagagggtg
     1141 ggaagttagt aaaggctccg cagggtcgaa gactaaacag agagtgctta caaccgccgg
     1201 ctgctgcgcc aatctctgcc agagtggtgg gacccaagag tcgccctcaa actccactgc
     1261 ctgtcaccca gactcctagt cctcttgggg cagtgaggtt gaagtcctta ggggaagaag
     1321 agggggctca caaaaagact aacctgccaa atgcagatag cttgtcagat actcagctca
     1381 agaagaaagc cagagtttgc ctgactcaag aaagcagatc atctccatca agccagagag
     1441 aaggacctaa ggaaaccaag agtaaccctg gtcctacagc acttcccagc ttgtaccctt
     1501 ctgtggatga gcaactgttg cccagaaaga tcaggctgag ccgctcaaag ccttcacccc
     1561 atgtctatac atctacacct tccagcatat taagtggtcc cagctcaatg cccacagccc
     1621 ctggccgccg tctttggagg cagagaactg taagtaaaga agcacagggt gtggataagc
     1681 agaaaccagg ggaagtccgt cctctacaga gcactccaga cccatccgat gttgggaagc
     1741 cggctgagaa caagaagcag agccctgaac tcagagcccc tacctccagc tctgtagagg
     1801 aggggcaggt tggaagagta aaacttagga agattgtcaa tggcacctgc tgggaggtgg
     1861 tacaggagcc tcccctcaga aacactcaag atagccccca gatcctagaa ccctcagatg
     1921 tagaagagcc ttctggaact ctgctgtcct cagttaatga gcaggaaata cctgctagaa
     1981 tacaactgtg tcaggactcc ccagagagcc ctaggcttca agacattctg ctctctgcta
     2041 gccactcccc agaccaccct atggtgaagt cagagtttgg gtctagtcca atgctgacag
     2101 ggaaggaatc tgacttgaat attgactgca gagagcccta cacattcgac acaaccttgc
     2161 ttggccaacc ttgtgaggct gagcagtatc gaatcacaag tgctgcagct accagtgaac
     2221 tggaagagat ttttgatttt atgctatgtg gctcagatgt tgagccacca gtaggatctt
     2281 tggagagtcc tggggctgaa ggctgcagaa ccccaagtta tcacctgtca gaaacaggaa
     2341 agaattggat tgaaggggaa gaatggtgtt tgccagacat ggaactctgg cccagagacc
     2401 tcacaggatt ggaaaaggaa ccagttagtg agaacaaaga gccagttgag ccctttagtc
     2461 cccttgtcat gcgctctgag aacacagaat catttgagcc ccttagcccc cttgtcatgc
     2521 cctctgaggt gagtagagag gaactttcac taagaggctc ttggactcca gaccttgaaa
     2581 ttaccagctc ccagccactg gatggtcagg gagaaaaact tctccacttt gactcctctg
     2641 acccttcgca gagatcttat aatcatctct ctcctccatg ctcagactgg gcagagacag
     2701 gtctggaagt gtccctaggc atggatgacg tattgtgtcc tgttcccaag gcagtcagag
     2761 aagtgtctgc caaccctgaa cagctggacc cacttcctgg cagttctgaa gatgaagaga
     2821 ttgatgtggt agactggaca gtggaaaaga agctggggcc cactagtgtt ccctctgttt
     2881 ggcctgaccc ttcctcagag tcagaaactg aggtagatat actaacatag tggaggcagg
     2941 agggcaggtt agagttcctg ggagggtgat aactgttcat caacagaagg cgttcttggc
     3001 agaaaagcaa gcacctcctc agaactgatc tcccctcctc aggtttccgc accaggcaga
     3061 agtcaaacag caataccatg gttagaaaat tatgaacaaa gcaatttctt tgtaatccat
     3121 ttttcagtga caaaactatg tggtacccaa ctcaggtcat aaggatagtt atgagtagcc
     3181 tctcaattca tgagatatct tatagtcact gaaaattcag ggaacttcaa gcactgtttg
     3241 tggttgtatt caaagaaggt ttgagaagga atgaagccat gttaagtaga acactgaaat
     3301 gagtggaatc tctaaattgc ccaggctggc tttgaacttt gacttctgcc tcagcctcct
     3361 gtagctagtg ttacaggctt gtgcctctaa gcccagccta tggggcttac tcactgccag
     3421 tatgggaagt caaggaaaag ctgccacaga agctagaaag atgttacttc cacgaccact
     3481 tctgagaagt agattaaaag tagttgcttt taaaaaacag
//
