LOCUS       NM_001081038            3459 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus BTB domain containing 16 (Btbd16), transcript variant
            1, mRNA.
ACCESSION   NM_001081038 NM_183314 XM_001004560
VERSION     NM_001081038.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3459)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3459)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 3459)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB666983.1, BB559682.2, AC115697.19, BY255452.1 and CF580876.1.
            
            On or before Feb 15, 2011 this sequence version replaced
            NM_183314.1, NM_001081038.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on orthologous transcript alignments
            from rat.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-577               BB666983.1         2-578
            578-981             BB559682.2         137-540
            982-1051            AC115697.19        151042-151111       c
            1052-1182           AC115697.19        149318-149448       c
            1183-1302           AC115697.19        140480-140599       c
            1303-1394           AC115697.19        130613-130704       c
            1395-1477           AC115697.19        127320-127402       c
            1478-1555           AC115697.19        125905-125982       c
            1556-1558           AC115697.19        124988-124990       c
            1559-1746           BY255452.1         314-501
            1747-1843           AC115697.19        123078-123174       c
            1844-1995           AC115697.19        121960-122111       c
            1996-3431           AC115697.19        120524-121959       c
            3432-3459           CF580876.1         25-52               c
FEATURES             Location/Qualifiers
     source          1..3459
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 73.19 cM"
     gene            1..3459
                     /gene="Btbd16"
                     /gene_synonym="E330040A16Rik"
                     /note="BTB domain containing 16"
                     /db_xref="GeneID:330660"
                     /db_xref="MGI:MGI:3045247"
     exon            1..302
                     /gene="Btbd16"
                     /gene_synonym="E330040A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            303..409
                     /gene="Btbd16"
                     /gene_synonym="E330040A16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..1912
                     /gene="Btbd16"
                     /gene_synonym="E330040A16Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     BTB/POZ domain-containing protein 16; BTB (POZ) domain
                     containing 16"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein 16 isoform 1"
                     /protein_id="NP_001074507.2"
                     /db_xref="CCDS:CCDS52416.1"
                     /db_xref="GeneID:330660"
                     /db_xref="MGI:MGI:3045247"
                     /translation="MKMLNSVSGSFRKKAGDSRSRECRTRLERRIVGATNRWRFPQDH
                     FCGDLLALSQMCNVLNVDLDEALKNPDRLCISKFQKLFSENIMNSGTQSGEADVILEC
                     LGFKWELHHPQIFQSGTLAKLYLTALIQNMKSSQRELDKVQKAHPSGKIKKRSPVKKI
                     IISMRINDPAVTRVAFALALKNLYMKEVEMTVDNVLGVLASAHILQFNRLFQKCVNMM
                     MNRLAPSTIKNFYLAGCKYEEEQLTMACEKWLAMNLVPLVGTQIHLRQIPEPLLYKVL
                     KSPRLFTFSEFHLLKTLLMWVYLQMNCKVQMVPIHETILAFFNSFPKKCCFLEQDPGQ
                     NWMPLFLCLRLHGITSGKDLEVLKHINFFPESWLVRVTANHYHALESGGNMVHLKDLS
                     TQAMRFGLLFRQEYTTYSERISIYGYFFEIKGIKHDPTSYSFSMQRIKHTDLECPSPV
                     CEHSTISLRSERLVKYEIQAQTLVDGRWQEFRTNQIMQKFGFIKPGCKSHVLKIQTVG
                     IPIYASFAFIFPAS"
     exon            410..558
                     /gene="Btbd16"
                     /gene_synonym="E330040A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            559..632
                     /gene="Btbd16"
                     /gene_synonym="E330040A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            633..776
                     /gene="Btbd16"
                     /gene_synonym="E330040A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            777..866
                     /gene="Btbd16"
                     /gene_synonym="E330040A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            867..981
                     /gene="Btbd16"
                     /gene_synonym="E330040A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1051
                     /gene="Btbd16"
                     /gene_synonym="E330040A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1182
                     /gene="Btbd16"
                     /gene_synonym="E330040A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1302
                     /gene="Btbd16"
                     /gene_synonym="E330040A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1394
                     /gene="Btbd16"
                     /gene_synonym="E330040A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1477
                     /gene="Btbd16"
                     /gene_synonym="E330040A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1555
                     /gene="Btbd16"
                     /gene_synonym="E330040A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1654
                     /gene="Btbd16"
                     /gene_synonym="E330040A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1843
                     /gene="Btbd16"
                     /gene_synonym="E330040A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..3434
                     /gene="Btbd16"
                     /gene_synonym="E330040A16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1971..1976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btbd16"
                     /gene_synonym="E330040A16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1995
                     /gene="Btbd16"
                     /gene_synonym="E330040A16Rik"
                     /note="major polyA site"
ORIGIN      
        1 agaaagcctg aagcctcaag ctgagataac accagaaccc ggaacaggaa gtccttagaa
       61 tctgactgct gttgccatgg tacccacaac tacccccagg aagccaaagg caggctcccc
      121 cagcaaagca tcgccgtagg agaaggggtg agccccaggt gtcatgagag cgttcaagat
      181 tcaggctcag aaggtgccca gcctccaact ctcccttggt tccgagacca gtgcaaccag
      241 cacccctctg cttcactctc aacctctgtg accgtccccg tgggcagcag gactgcagaa
      301 ctgtgctcat cactgtcctg ctgtgtcatc tccactgtca ttcatgaaaa tgttgaattc
      361 agtaagtgga tcctttcgca agaaggccgg tgacagcagg tctagagagt gcaggactcg
      421 gctggagcgc aggattgttg gtgcaaccaa ccgatggcgt tttccccaag accatttctg
      481 cggagacctg ttggcactct cccagatgtg caatgtttta aatgtagatc ttgacgaagc
      541 tctgaagaac ccagacagat tatgtatctc aaaattccag aagcttttct ccgaaaatat
      601 catgaacagt ggcacccaaa gcggggaagc agacgtgatc cttgaatgcc tcggcttcaa
      661 gtgggaactc caccaccctc agatctttca gtctgggacc ttggccaagc tctacctgac
      721 agccttgata cagaacatga aaagctccca gagggagctg gacaaggttc agaaagctca
      781 tccatccggg aagatcaaaa aaaggtcccc tgtaaagaag atcatcattt ccatgaggat
      841 caatgacccg gcagtcacca gagttgcctt cgccctggcc ctgaagaacc tctacatgaa
      901 ggaggtggaa atgaccgtgg acaatgtgct gggcgtgctg gcttctgctc acatcctcca
      961 gttcaaccga ctatttcaaa agtgtgtcaa catgatgatg aacagactcg caccaagcac
     1021 catcaagaac ttctacttgg ccggctgtaa gtacgaagaa gagcagctca ccatggcctg
     1081 tgagaagtgg ctggcaatga acctggtccc tctagtgggg actcagatcc acctccgaca
     1141 gatccctgaa cctctgctgt acaaggtgct gaagtcgccc aggttgttca ccttcagtga
     1201 gttccatctc ctgaaaacct tactcatgtg ggtttaccta cagatgaact gcaaggttca
     1261 gatggtccca atccacgaga ccattttggc attttttaac agctttccca agaagtgctg
     1321 cttcctagaa caggatccag gacagaactg gatgccactc ttcctttgcc tgcgtctgca
     1381 cggcatcacc agtggcaagg atctggaggt gttgaagcac attaatttct tccctgagtc
     1441 ctggctggtc cgggttacag ccaaccatta ccacgcactg gagagcgggg gcaacatggt
     1501 ccacctgaaa gatctttcca cacaggccat gaggttcggg ctgctcttta ggcaggaata
     1561 caccacttac tcggaaagga tttctatata cggatacttc tttgagataa agggaatcaa
     1621 acacgaccct acctcttaca gtttttctat gcagagaata aaacatacag acttggagtg
     1681 cccctcacca gtctgtgagc acagtaccat cagcttgagg tcggagcgcc tggtgaagta
     1741 tgagatccaa gcccagacgc tggtggacgg caggtggcag gagttcagga ccaaccaaat
     1801 catgcaaaag tttgggttta tcaagccagg ctgcaaaagc cacgtcttga aaatccaaac
     1861 cgtgggcatc ccgatctacg ccagctttgc cttcatcttc ccagcatctt gatagctttc
     1921 ataggaatct atgggatccc cttccctggc cggcctgact tcataagaga aataaaaatg
     1981 acattaagga ggggagcact gtgtccggct gcctgagcgc gtcagctccc ctgggtcgtc
     2041 ggctcaggca ttagagttta gtgccaatct gcttccgttt tcatctgaag ataagattgg
     2101 gaaaattcac atttaagctc actcggtctg ttgacaggct aatcttcttg cagatgcctg
     2161 accaaggacc ttagcagcta ctaattgttt cacacaatga tctgcagacc taagatatcc
     2221 cttcccctct ggtttcgaag ttaagtcaca cactgcaccc tttcctaaga gagaggactg
     2281 tacaaagggt cacctttgtc cacccctccg tgatgccagt tttctttgag aacctggaga
     2341 gttggtagag ttatgaagac agtcaggtgg gtacgtccag cctacctaat gtctggtgtg
     2401 ggatggcaca cagctgaggg agtcttcctt ccaacagaga atctcaggag gttagaaggg
     2461 ctggtaggac cgtgggaggt gggcctggga gaagaatcag cgccaaagca ctgggctttg
     2521 ggagcctgct tccagaacca cttcttcctc ctgtgtccca ctcttctatg ctgttgctcc
     2581 cactcaagac cagtaaaaga gaagtagtcg tgggagctag agagacagga gaggagagaa
     2641 attgggatag ctatcacctc tctgggttca tgggcatctt tctgcagtga ctgtgtccct
     2701 ttgtggcccc agctttctct gatccttcct tccatttgct accctgaagt ttccttccat
     2761 ccttccaggg tccaacacag ggcctgtcct tgctctgata ttagccacct accagccttc
     2821 aagtgatgga ggcatctgcc aaggctgcag tcctgggctg catcaatctc ctgtgcttga
     2881 ccaactagat ctcgcttcat cattatatct gggtctccat attctgttta ctctgcttca
     2941 actgtctggg ttttgggggt tttgtttgtt tgggtttttt tttttttaat gttttccagg
     3001 ttacatagga atggtttggt agtgttggag acacatatga cacagtgcaa tagatattgg
     3061 aaaacatggc ctccataatt cacattagtg tgaggaccag tgagacactc aggtacaaat
     3121 tatatgaagt atcaaagccc cataatggtc agtgtgatgg tttgtatatg ctctgcccag
     3181 ggagtggcac tattagaagg tgtggccctg ttgaagtagg tgtgtcactg tgggtgtggg
     3241 ctttaagacc ctcaacctag ctgcctggaa gtcagttttc tgctagcagc cttcagatga
     3301 agacgatgaa gatgtagaac tctcagctcc tcctgcacca tgcctgcttg gatgctgcca
     3361 tgttcccgcc ttgataataa tggactgaac ctctgaacct gtaagccagc cccaattaaa
     3421 tgttatcctt ctaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
