LOCUS       NM_133700               2604 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus BTB domain containing 10 (Btbd10), mRNA.
ACCESSION   NM_133700 XM_912186
VERSION     NM_133700.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2604)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2604)
  AUTHORS   Nawa,M., Kanekura,K., Hashimoto,Y., Aiso,S. and Matsuoka,M.
  TITLE     A novel Akt/PKB-interacting protein promotes cell adhesion and
            inhibits familial amyotrophic lateral sclerosis-linked mutant
            SOD1-induced neuronal death via inhibition of PP2A-mediated
            dephosphorylation of Akt/PKB
  JOURNAL   Cell Signal 20 (3), 493-505 (2008)
   PUBMED   18160256
  REMARK    GeneRIF: BTBD10 appears to behave as a suppressor of cell death
            including neuronal cell death related to amyotrophic lateral
            sclerosis and an enhancer of cell growth via its positive
            regulation of Akt phosphorylation.
REFERENCE   3  (bases 1 to 2604)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156987.7 and AC156605.13.
            
            On Jan 7, 2022 this sequence version replaced NM_133700.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.718722.1, BC050781.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AC156987.7         193998-194179
            183-269             AC156987.7         194420-194506
            270-334             AC156987.7         198409-198473
            335-492             AC156605.13        231067-231224       c
            493-689             AC156605.13        214608-214804       c
            690-975             AC156605.13        211896-212181       c
            976-1078            AC156605.13        209141-209243       c
            1079-1199           AC156605.13        207625-207745       c
            1200-1397           AC156605.13        205064-205261       c
            1398-1508           AC156605.13        201966-202076       c
            1509-2604           AC156605.13        194930-196025       c
FEATURES             Location/Qualifiers
     source          1..2604
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 59.18 cM"
     gene            1..2604
                     /gene="Btbd10"
                     /gene_synonym="1110056N09Rik; Gmrp1"
                     /note="BTB domain containing 10"
                     /db_xref="GeneID:68815"
                     /db_xref="MGI:MGI:1916065"
     exon            1..182
                     /gene="Btbd10"
                     /gene_synonym="1110056N09Rik; Gmrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            183..269
                     /gene="Btbd10"
                     /gene_synonym="1110056N09Rik; Gmrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            270..334
                     /gene="Btbd10"
                     /gene_synonym="1110056N09Rik; Gmrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            335..492
                     /gene="Btbd10"
                     /gene_synonym="1110056N09Rik; Gmrp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..1819
                     /gene="Btbd10"
                     /gene_synonym="1110056N09Rik; Gmrp1"
                     /note="K+ channel tetramerization protein; glucose
                     metabolism-related protein 1; BTB (POZ) domain containing
                     10"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein 10"
                     /protein_id="NP_598461.1"
                     /db_xref="CCDS:CCDS21755.1"
                     /db_xref="GeneID:68815"
                     /db_xref="MGI:MGI:1916065"
                     /translation="MAGRPHPYDSNSSDPENWDRKLHSRPRKLYKHSSSASRVAKGGV
                     DHTKMSLHGASGGHERSRDRRRSSDRSRDSSHERAESQLTPCIRNVTSPTRQHHIERE
                     KDHSSSRPSSPRPQRASPNGSMSSAGNSSRNSSQSSSDGSCKTSGEMVFVYENAKEGA
                     RNVRTSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAE
                     GIGSTVFRAILDYYKTGIIRCPDGISIPELREACDYLCISFEYSTIKCRDLSALMHEL
                     SNDGARRQFEFYLEEMILPLMVASAQSGERECHIVVLTDDDVVDWDEEYPPQMGEEYS
                     QIIYSTKLYRFFKYIENRDVAKSVLKERGLKKIRLGIEGYPTYKEKVKKRPGGRPEVI
                     YNYVQRPFIRMSWEKEEGKSRHVDFQCVKSKSITNLAAAAADIPQDQLVVMHPTPQVD
                     ELDILPSHPASGNNDLDPDAQNPML"
     exon            493..689
                     /gene="Btbd10"
                     /gene_synonym="1110056N09Rik; Gmrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..975
                     /gene="Btbd10"
                     /gene_synonym="1110056N09Rik; Gmrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1078
                     /gene="Btbd10"
                     /gene_synonym="1110056N09Rik; Gmrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1199
                     /gene="Btbd10"
                     /gene_synonym="1110056N09Rik; Gmrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1397
                     /gene="Btbd10"
                     /gene_synonym="1110056N09Rik; Gmrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1508
                     /gene="Btbd10"
                     /gene_synonym="1110056N09Rik; Gmrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..2604
                     /gene="Btbd10"
                     /gene_synonym="1110056N09Rik; Gmrp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2012..2017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btbd10"
                     /gene_synonym="1110056N09Rik; Gmrp1"
                     /note="hexamer: TATAAA"
     polyA_site      2035
                     /gene="Btbd10"
                     /gene_synonym="1110056N09Rik; Gmrp1"
                     /note="major polyA site"
     regulatory      2584..2589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Btbd10"
                     /gene_synonym="1110056N09Rik; Gmrp1"
                     /note="hexamer: AATAAA"
     polyA_site      2604
                     /gene="Btbd10"
                     /gene_synonym="1110056N09Rik; Gmrp1"
                     /note="major polyA site"
ORIGIN      
        1 gagaagcagc taaggagccg gcctgcaacc tgccggggcg gctctggtag gcgcagccgg
       61 tggagcggcc gcctcacacc tagcaccgga ggggtccggt tcagtgggcg gagggagcgg
      121 agcgtcgctc tctcttggag ctcttcccca agaccctcgg tggacgtctc aggggccagc
      181 agggcagagt aacccagtgc cccgcccctt tcctgtcatc tttgggtcac cgcggcgaca
      241 aaccgaagaa ggcgcatcac aatagggcgg tttatctgag caggctggac ctctgtgagg
      301 gagaaggaaa tggaacacct acatttctaa ctgggttatg ggtgctacat gtgtgctttc
      361 agagcagtag tgtgaggaaa cttgaagtgg gatggcagga cggcctcatc cctatgacag
      421 taactccagt gatccagaga attgggatcg gaaattgcat agtagacctc gtaaacttta
      481 taaacattca agctctgcct cacgtgttgc taagggagga gtcgaccaca ccaaaatgag
      541 tctgcatggt gctagtgggg gccatgagag atcaagagat agacgccggt caagtgacag
      601 atcacgagat tcatctcatg agagagcaga gtctcagctt actccttgta ttcgaaatgt
      661 gacttcacca acaaggcagc atcatattga acgagaaaaa gaccatagtt cttctcgtcc
      721 aagcagtcct cgtcctcaaa gagcatcccc aaatggctcc atgagcagtg ctgggaacag
      781 tagcaggaac agcagccagt caagctcaga tggtagctgt aaaacatctg gggagatggt
      841 gtttgtgtat gagaatgcga aagaaggggc tcggaatgtg aggacatctg agcgagtgac
      901 tctgatagtg gataacacca gatttgttgt ggacccgtcc atttttactg cacagccaaa
      961 tacaatgttg ggcaggatgt ttggatctgg ccgggaacat aatttcacac gtcccaatga
     1021 gaagggagaa tatgaggtgg cagagggaat tggttctact gtgtttcgag ctattttgga
     1081 ttactataag acaggaatca tccgctgtcc tgatggcata tcgattcctg aactgcgaga
     1141 agcatgtgat tacctttgta tctcttttga atacagtaca attaaatgta gagatctcag
     1201 tgcccttatg catgagttat caaatgatgg tgctcgtaga caatttgaat tttatctgga
     1261 agaaatgatc ctccctctca tggtagcaag cgcccagagt ggggaacgag agtgccatat
     1321 cgtagtgctt acagatgatg atgtagttga ttgggatgag gagtatccac cacagatggg
     1381 agaagaatat tcacagatta tttatagcac aaaattatat agatttttca agtacattga
     1441 aaacagagat gtggccaaat cagttttgaa ggagaggggt cttaagaaga ttagattggg
     1501 aatagaaggc tatcctacct acaaagaaaa agtaaagaaa aggccagggg gccgtccaga
     1561 agtcatttac aattatgtcc aaagaccctt cattcgaatg tcctgggaga aggaggaagg
     1621 aaagagtcgg catgtagact ttcagtgtgt aaagagtaaa tccattacca atctggcagc
     1681 agctgctgca gacattcccc aggaccagct agtagtcatg caccctactc cacaggtgga
     1741 cgagctggat atccttccca gccaccctgc ctcgggcaac aatgacctcg atcctgatgc
     1801 acagaatcca atgctgtgat gctgatgttc ctgaaaccat agcatgctac tcttcacagt
     1861 gacgtcgtac tcctccttct gcactgcgag gccacttttc ttcattgtga gatgcacatg
     1921 tttaggatac tgcagtgtag gcttttttaa agaccaaagg tagctgaatg gttttttaat
     1981 gagtacaact ttagcatcct cgttcgagtt ctataaatgt atttgtttac cagtaggttt
     2041 gtgaaattgg ttctttgtat ggggacagtc ctttttcaca tatctaggtt ttctcagaag
     2101 tggtgggaat ttggcagctg gggtacttta agtgtagatt gatatttatc ttgcctcagg
     2161 taagatgaat attacaaagt tgcactttat agatggtggt taaatggagc tgttgaagcc
     2221 attttagagc tgtgatgcac agtataacat aagtgcttct atcagagtat tcctcagtac
     2281 agtatgtata gttggcccac atcaagcaaa aacatattta tcttgggttt atttaaacaa
     2341 ttaggataaa atttgatgct tatagtgttg gttcactcat ctccagagcc ctgcagccct
     2401 attagagtga gtcacatgca gggagggtga acgtcaagag gtggtttact gtccagtctg
     2461 ccttatcctt aatctgttca tatatttatt tactaatgct tttttcttaa gagttatggg
     2521 atagaaaaac aaactgtttg ctcttcattt actaaatgat tgtaaactcg agtttttcat
     2581 caaaataaaa tttcattgtt ttaa
//
