LOCUS       NM_198095                823 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus bone marrow stromal cell antigen 2 (Bst2), mRNA.
ACCESSION   NM_198095 XM_134266
VERSION     NM_198095.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 823)
  AUTHORS   Li,Y., Chen,W., Zhu,X., Mei,H., Steinhoff,M., Buddenkotte,J.,
            Wang,J., Zhang,W., Li,Z., Dai,X., Shan,C., Wang,J. and Meng,J.
  TITLE     Neuronal BST2: A Pruritic Mediator alongside Protease-Activated
            Receptor 2 in the IL-27-Driven Itch Pathway
  JOURNAL   J Invest Dermatol 144 (8), 1829-1842 (2024)
   PUBMED   38360199
  REMARK    GeneRIF: Neuronal BST2: A Pruritic Mediator alongside
            Protease-Activated Receptor 2 in the IL-27-Driven Itch Pathway.
REFERENCE   2  (bases 1 to 823)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 823)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 823)
  AUTHORS   Li,J., He,Y., Qu,Y., Ren,C., Wang,X., Cheng,Y., Sun,L., Zhang,X.
            and Zhang,G.
  TITLE     Promotion of BST2 expression by the transcription factor IRF6
            affects the progression of endometriosis
  JOURNAL   Front Immunol 14, 1115504 (2023)
   PUBMED   37143676
  REMARK    GeneRIF: Promotion of BST2 expression by the transcription factor
            IRF6 affects the progression of endometriosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 823)
  AUTHORS   Urata,S., Yamaguchi,S., Nambu,A., Sudo,K., Nakae,S. and Yasuda,J.
  TITLE     The roles of BST-2 in murine B cell development and on virus
            propagation
  JOURNAL   Microbiol Immunol 67 (3), 105-113 (2023)
   PUBMED   36604771
  REMARK    GeneRIF: The roles of BST-2 in murine B cell development and on
            virus propagation.
REFERENCE   6  (bases 1 to 823)
  AUTHORS   Radoshitzky,S.R., Dong,L., Chi,X., Clester,J.C., Retterer,C.,
            Spurgers,K., Kuhn,J.H., Sandwick,S., Ruthel,G., Kota,K., Boltz,D.,
            Warren,T., Kranzusch,P.J., Whelan,S.P. and Bavari,S.
  TITLE     Infectious Lassa virus, but not filoviruses, is restricted by
            BST-2/tetherin
  JOURNAL   J Virol 84 (20), 10569-10580 (2010)
   PUBMED   20686043
  REMARK    GeneRIF: Elevated cellular levels of BST-2 inhibited the release of
            virus-like particles consisting of the matrix proteins of multiple
            highly virulent NIAID Priority Pathogens
REFERENCE   7  (bases 1 to 823)
  AUTHORS   Schliemann,C., Roesli,C., Kamada,H., Borgia,B., Fugmann,T.,
            Klapper,W. and Neri,D.
  TITLE     In vivo biotinylation of the vasculature in B-cell lymphoma
            identifies BST-2 as a target for antibody-based therapy
  JOURNAL   Blood 115 (3), 736-744 (2010)
   PUBMED   19903902
  REMARK    GeneRIF: Targeting BST-2 with 2 independent monoclonal antibodies
            delayed lymphoma growth in a syngeneic mouse model of the disease.
REFERENCE   8  (bases 1 to 823)
  AUTHORS   Li,X., Kaloyanova,D., van Eijk,M., Eerland,R., van der Goot,G.,
            Oorschot,V., Klumperman,J., Lottspeich,F., Starkuviene,V.,
            Wieland,F.T. and Helms,J.B.
  TITLE     Involvement of a Golgi-resident GPI-anchored protein in maintenance
            of the Golgi structure
  JOURNAL   Mol Biol Cell 18 (4), 1261-1271 (2007)
   PUBMED   17251550
REFERENCE   9  (bases 1 to 823)
  AUTHORS   Blasius,A.L., Giurisato,E., Cella,M., Schreiber,R.D., Shaw,A.S. and
            Colonna,M.
  TITLE     Bone marrow stromal cell antigen 2 is a specific marker of type I
            IFN-producing cells in the naive mouse, but a promiscuous cell
            surface antigen following IFN stimulation
  JOURNAL   J Immunol 177 (5), 3260-3265 (2006)
   PUBMED   16920966
  REMARK    GeneRIF: BST2 resides within an intracellular compartment
            corresponding to the Golgi apparatus, and may be involved in
            trafficking secreted cytokines in type I IFN-producing cells
REFERENCE   10 (bases 1 to 823)
  AUTHORS   Ohtomo,T., Sugamata,Y., Ozaki,Y., Ono,K., Yoshimura,Y., Kawai,S.,
            Koishihara,Y., Ozaki,S., Kosaka,M., Hirano,T. and Tsuchiya,M.
  TITLE     Molecular cloning and characterization of a surface antigen
            preferentially overexpressed on multiple myeloma cells
  JOURNAL   Biochem Biophys Res Commun 258 (3), 583-591 (1999)
   PUBMED   10329429
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY166837.1 and BC087949.1.
            
            On Jul 30, 2018 this sequence version replaced NM_198095.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087949.1, SRR7345562.1840805.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                BY166837.1         2-44
            44-823              BC087949.1         1-780
FEATURES             Location/Qualifiers
     source          1..823
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.43 cM"
     gene            1..823
                     /gene="Bst2"
                     /gene_synonym="2310015I10Rik; Bst-2; CD317; DAMP-1; GREG"
                     /note="bone marrow stromal cell antigen 2"
                     /db_xref="GeneID:69550"
                     /db_xref="MGI:MGI:1916800"
     exon            1..345
                     /gene="Bst2"
                     /gene_synonym="2310015I10Rik; Bst-2; CD317; DAMP-1; GREG"
                     /inference="alignment:Splign:2.1.0"
     exon            346..421
                     /gene="Bst2"
                     /gene_synonym="2310015I10Rik; Bst-2; CD317; DAMP-1; GREG"
                     /inference="alignment:Splign:2.1.0"
     exon            422..461
                     /gene="Bst2"
                     /gene_synonym="2310015I10Rik; Bst-2; CD317; DAMP-1; GREG"
                     /inference="alignment:Splign:2.1.0"
     exon            462..582
                     /gene="Bst2"
                     /gene_synonym="2310015I10Rik; Bst-2; CD317; DAMP-1; GREG"
                     /inference="alignment:Splign:2.1.0"
     exon            583..808
                     /gene="Bst2"
                     /gene_synonym="2310015I10Rik; Bst-2; CD317; DAMP-1; GREG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      787..792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bst2"
                     /gene_synonym="2310015I10Rik; Bst-2; CD317; DAMP-1; GREG"
                     /note="hexamer: AATAAA"
     polyA_site      808
                     /gene="Bst2"
                     /gene_synonym="2310015I10Rik; Bst-2; CD317; DAMP-1; GREG"
                     /note="major polyA site"
ORIGIN      
        1 gtggcctgga aagggttcct gagccctcta ggatcgacgg atcacatggc gccctctttc
       61 tatcactatc tgcccgtgcc catggatgag atggggggga agcaaggatg gggcagccac
      121 cggcagtggc tgggggccgc gatcttggtg gtcctgttcg gggttacctt agtcatcctg
      181 acaatctact tcgccgtcac agcgaacagc gtggcctgta gagacgggtt gcgagcgcag
      241 gctgagtgcc ggaacaccac gcacctgttg cagcgccagc tcacccgcac ccaggacagt
      301 ctgctgcagg ccgagacaca ggcaaactcc tgcaacctga ccgtggtgac ccttcaggag
      361 tccctggaga agaaggtgtc tcaagccctg gagcagcagg cccgcatcaa ggagcttgag
      421 aatgaagtca cgaagctgaa ccaggagctg gagaatctga ggatccaaaa ggagacttct
      481 agcacagtgc aggtgaactc tggcagctcc atggtggtct ccagcctact ggtgctcaaa
      541 gtgtcactgt tcctgctctt ttgaggactc attagttggc aggtcacagt tgtttgaagt
      601 cactatgggt catagtgact ctggagaggt cctggcagcc ctgaggatgt ggaaaccact
      661 agggggctcc agattgggtc ttcctccgca gaactttagg actggggagt ggggagggag
      721 ttctgcttta ttgcttttgc agttattggg gggggtcaca tatttctggt gtctttgacc
      781 tggaaaaata aagtaattta aaaagaaaaa aaaaaaaaaa aaa
//
