LOCUS       NM_138653               1743 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus B-box and SPRY domain containing (Bspry), transcript
            variant 1, mRNA.
ACCESSION   NM_138653
VERSION     NM_138653.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1743)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1743)
  AUTHORS   Li,X., Xu,A., Li,K., Zhang,J., Li,Q., Zhao,G., Zhang,Y., Yuan,H.,
            Guo,Y., Lin,P. and Huang,L.
  TITLE     CXCR4-SF1 bifunctional adipose-derived stem cells benefit for the
            treatment of Leydig cell dysfunction-related diseases
  JOURNAL   J Cell Mol Med 24 (8), 4633-4645 (2020)
   PUBMED   32181567
  REMARK    GeneRIF: CXCR4-SF1 bifunctional adipose-derived stem cells benefit
            for the treatment of Leydig cell dysfunction-related diseases.
REFERENCE   3  (bases 1 to 1743)
  AUTHORS   Jones,M.R., Dilai,S., Lingampally,A., Chao,C.M., Danopoulos,S.,
            Carraro,G., Mukhametshina,R., Wilhelm,J., Baumgart-Vogt,E., Al
            Alam,D., Chen,C., Minoo,P., Zhang,J.S. and Bellusci,S.
  TITLE     A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b
            Signaling on Epithelial Tip Progenitor Cells During Early Mouse
            Lung Branching Morphogenesis
  JOURNAL   Front Genet 9, 746 (2019)
   PUBMED   30728831
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1743)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1743)
  AUTHORS   Ikeda,M., Inoue,F., Ohkoshi,K., Yokoyama,S., Tatemizo,A.,
            Tokunaga,T. and Furusawa,T.
  TITLE     B-box and SPRY domain containing protein (BSPRY) is associated with
            the maintenance of mouse embryonic stem cell pluripotency and early
            embryonic development
  JOURNAL   J Reprod Dev 58 (6), 691-699 (2012)
   PUBMED   22972184
  REMARK    GeneRIF: associated with both embryonic stem cell pluripotency and
            early embryonic development
REFERENCE   6  (bases 1 to 1743)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   7  (bases 1 to 1743)
  AUTHORS   van de Graaf,S.F., van der Kemp,A.W., van den Berg,D., van
            Oorschot,M., Hoenderop,J.G. and Bindels,R.J.
  TITLE     Identification of BSPRY as a novel auxiliary protein inhibiting
            TRPV5 activity
  JOURNAL   J Am Soc Nephrol 17 (1), 26-30 (2006)
   PUBMED   16380433
REFERENCE   8  (bases 1 to 1743)
  AUTHORS   Birkenfeld,J., Kartmann,B., Anliker,B., Ono,K., Schlotcke,B.,
            Betz,H. and Roth,D.
  TITLE     Characterization of zetin 1/rBSPRY, a novel binding partner of
            14-3-3 proteins
  JOURNAL   Biochem Biophys Res Commun 302 (3), 526-533 (2003)
   PUBMED   12615066
REFERENCE   9  (bases 1 to 1743)
  AUTHORS   Gisler,S.M., Stagljar,I., Traebert,M., Bacic,D., Biber,J. and
            Murer,H.
  TITLE     Interaction of the type IIa Na/Pi cotransporter with PDZ proteins
  JOURNAL   J Biol Chem 276 (12), 9206-9213 (2001)
   PUBMED   11099500
REFERENCE   10 (bases 1 to 1743)
  AUTHORS   Schenker,T. and Trueb,B.
  TITLE     BSPRY, a novel protein of the Ro-Ret family
  JOURNAL   Biochim Biophys Acta 1493 (1-2), 255-258 (2000)
   PUBMED   10978534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ276690.1.
            
            [WARNING] On May 2, 2024 this sequence was replaced by NM_138653.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ276690.1, SRR1660819.108497.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1743
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 33.16 cM"
     gene            1..1743
                     /gene="Bspry"
                     /note="B-box and SPRY domain containing"
                     /db_xref="GeneID:192120"
                     /db_xref="MGI:MGI:2177191"
     exon            1..371
                     /gene="Bspry"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1487
                     /gene="Bspry"
                     /function="unknown"
                     /note="isoform 1 is encoded by transcript variant 1; b box
                     and SPRY domain-containing protein; zetin 1"
                     /codon_start=1
                     /product="B box and SPRY domain-containing protein isoform
                     1"
                     /protein_id="NP_619594.1"
                     /db_xref="CCDS:CCDS18241.1"
                     /db_xref="GeneID:192120"
                     /db_xref="MGI:MGI:2177191"
                     /translation="MSADVSGTESGSESGPEPEPGPEPGPESRPESRPKPGPGPEPRP
                     ESGPEPGPRSGLRRGPKQGSERSQLCPEHFEPLSWFCLSERRPVCATCAGFGGRCHRH
                     RIRRAEEHAEELRNKIVDQCERLQLQSAGISKYMAEVLQGKNQKAVVMASAARDLIIQ
                     RLSLVRSLCESEEQRLLEQVHGEEERAHQSILTQRAHWVDAVQKLDTLRTNMVDMITH
                     LDDLQLIQREQEIFERAEEAEGILDPQDSEKLSFNEKCAWSPLLTQLWAASVLGSLSG
                     VEEVLIDERTVSPLLHLSEDRRTLTFIAKKSKVCSDEPERFDHWPNALAATAFQTGLH
                     AWIVNVKHSCAYKVGVASDQLPRKGSGNDCRLGHNAFSWVFSRYDQEFCFSHNGYHEP
                     LPLLRCPAQLGMLLDLQAGELVFYEPASGTVLHIHRASFPQVLFPVFAVADQLISIVR
                     GPLATVRLDSPPHHPCSIRRTTCQDTVGQNVVVGVW"
     exon            372..470
                     /gene="Bspry"
                     /inference="alignment:Splign:2.1.0"
     exon            471..701
                     /gene="Bspry"
                     /inference="alignment:Splign:2.1.0"
     exon            702..727
                     /gene="Bspry"
                     /inference="alignment:Splign:2.1.0"
     exon            728..852
                     /gene="Bspry"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1426
                     /gene="Bspry"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1743
                     /gene="Bspry"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1700..1705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bspry"
                     /note="hexamer: AATAAA"
     polyA_site      1740
                     /gene="Bspry"
                     /note="major polyA site"
ORIGIN      
        1 gagcgcgcgg cctccggctc tcggccatgt ccgcggatgt ctccgggacg gagtccgggt
       61 ccgagtccgg gccggagccg gagccgggac cggagcccgg accggagtcc cgaccggagt
      121 cccggccgaa gccgggaccg ggaccggagc ccagacccga gtccgggccg gagccggggc
      181 cgcgatccgg actgaggagg ggaccgaagc aggggtccga gcggagccag ttgtgccccg
      241 agcacttcga gcctctgagc tggttctgcc tctcggagcg acggccggta tgcgccacct
      301 gcgccgggtt tggcggccgc tgtcaccggc accgcatccg tcgagcggag gagcacgcgg
      361 aggagctgag aaacaagatt gtggaccagt gtgagaggct gcagttacag agtgctggca
      421 tctccaagta tatggccgag gtcctgcagg ggaagaacca gaaagcagtg gtcatggcta
      481 gtgcagcgag ggacctgatc atccagaggc tgagtctggt gcggagcctg tgtgagagtg
      541 aggaacagcg gttattggag caggtgcacg gcgaagagga gcgggcccac cagagtatcc
      601 tgactcagcg ggcacactgg gtggacgcag tccagaaact ggacaccctc cgcaccaaca
      661 tggtggacat gatcacccac ctggatgacc tccagctgat tcagagggaa caggagattt
      721 ttgagagggc cgaggaagca gagggcattt tggatcccca ggattcggag aaattaagct
      781 ttaatgagaa gtgtgcttgg agcccactac tgacgcaact gtgggcagca tcggttctcg
      841 ggtctctctc aggcgtggag gaggtgctga ttgatgaaag gactgtcagc cccttactgc
      901 atctgtctga agatcgaagg accctgacct tcattgccaa gaagtctaag gtctgctcag
      961 atgaaccaga gcgctttgac cactggccca atgccctggc tgccactgcc ttccagactg
     1021 ggctccatgc ctggatagtg aacgttaaac acagttgtgc ttataaagtg ggtgtggcct
     1081 cagatcagct gccccgaaag ggctctggca atgactgccg cctgggccac aatgccttct
     1141 cctgggtctt ctcccgctat gatcaagagt tctgtttctc acacaatggg tatcatgagc
     1201 ctctgccact acttcggtgc ccagcacagc tgggcatgct gctggacctg caggcaggag
     1261 agctggtctt ctacgagcct gcctcaggga cggtgcttca tatccaccgt gcgtccttcc
     1321 ctcaggtgct cttcccagtc tttgctgtgg ctgaccagct catctccatc gttcgcggac
     1381 ctctggccac agtgagacta gattcacctc cccatcaccc ttgcagcata cgaaggacaa
     1441 cctgccagga tactgttggc cagaacgtcg tcgtgggagt gtggtagcct cctcccgcct
     1501 cctctgtctc caggaaacct gcttgcagca cacttgttgg catctgtccc aggccctgag
     1561 gctgagctct agcatggacc tacgtgtgag aagggtgaca aacattcccc ctcactgtgc
     1621 tgctgaacac cccatttcat gactcgtagg gtagagagcg gcaagcaaga aaagctgagg
     1681 gcaaaggaga gctagcctta ataaatcaat gtgcgcatta ttaaaggttt ctaaagactt
     1741 ggt
//
