LOCUS       NM_001033418             823 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus binder of sperm protein homolog 1 (Bsph1), transcript
            variant 1, mRNA.
ACCESSION   NM_001033418 XM_284265 XM_914050
VERSION     NM_001033418.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 823)
  AUTHORS   Heidari-Vala,H., Sabouhi-Zarafshan,S., Prud'homme,B., Alnoman,A.
            and Manjunath,P.
  TITLE     Role of Binder of SPerm homolog 1 (BSPH1) protein in mouse
            sperm-egg interaction and fertilization
  JOURNAL   Biochem Biophys Res Commun 527 (2), 358-364 (2020)
   PUBMED   32253033
  REMARK    GeneRIF: Role of Binder of SPerm homolog 1 (BSPH1) protein in mouse
            sperm-egg interaction and fertilization.
REFERENCE   2  (bases 1 to 823)
  AUTHORS   Eskandari-Shahraki,M., Prud'homme,B., Bergeron,F. and Manjunath,P.
  TITLE     Epididymal proteins Binder of SPerm Homologs 1 and 2 (BSPH1/2) are
            dispensable for male fertility and sperm motility in mice
  JOURNAL   Sci Rep 10 (1), 8982 (2020)
   PUBMED   32488144
  REMARK    GeneRIF: Epididymal proteins Binder of SPerm Homologs 1 and 2
            (BSPH1/2) are dispensable for male fertility and sperm motility in
            mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 823)
  AUTHORS   Plante,G., Therien,I. and Manjunath,P.
  TITLE     Characterization of recombinant murine binder of sperm protein
            homolog 1 and its role in capacitation
  JOURNAL   Biol Reprod 87 (1), 20,1-11 (2012)
   PUBMED   22539676
  REMARK    GeneRIF: Both native BSPH1 and recombinant-BSPH1 were detected on
            the head and the midpiece region of sperm, although a stronger
            signal was detected on the midpiece region when sperm were
            incubated in a capacitating media.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 823)
  AUTHORS   Manjunath,P., Lefebvre,J., Jois,P.S., Fan,J. and Wright,M.W.
  TITLE     New nomenclature for mammalian BSP genes
  JOURNAL   Biol Reprod 80 (3), 394-397 (2009)
   PUBMED   18923155
  REMARK    Review article
REFERENCE   5  (bases 1 to 823)
  AUTHORS   Lefebvre,J., Boileau,G. and Manjunath,P.
  TITLE     Recombinant expression and affinity purification of a novel
            epididymal human sperm-binding protein, BSPH1
  JOURNAL   Mol Hum Reprod 15 (2), 105-114 (2009)
   PUBMED   19091820
REFERENCE   6  (bases 1 to 823)
  AUTHORS   Ekhlasi-Hundrieser,M., Schafer,B., Philipp,U., Kuiper,H., Leeb,T.,
            Mehta,M., Kirchhoff,C. and Topfer-Petersen,E.
  TITLE     Sperm-binding fibronectin type II-module proteins are genetically
            linked and functionally related
  JOURNAL   Gene 392 (1-2), 253-265 (2007)
   PUBMED   17307309
  REMARK    GeneRIF: Sperm-binding fibronectin type II-module proteins are
            genetically linked and functionally related.
REFERENCE   7  (bases 1 to 823)
  AUTHORS   Lefebvre,J., Fan,J., Chevalier,S., Sullivan,R., Carmona,E. and
            Manjunath,P.
  TITLE     Genomic structure and tissue-specific expression of human and mouse
            genes encoding homologues of the major bovine seminal plasma
            proteins
  JOURNAL   Mol Hum Reprod 13 (1), 45-53 (2007)
   PUBMED   17085770
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK136662.1, AC156985.12 and
            BB073190.1.
            
            On Sep 4, 2014 this sequence version replaced NM_001033418.3.
            
            Summary: This gene encodes a member of the binder of sperm family.
            The encoded protein may be involved in sperm capacitation.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136662.1, BY721041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-518               AK136662.1         2-519
            519-519             AC156985.12        65075-65075         c
            520-822             AK136662.1         521-823
            823-823             BB073190.1         199-199
FEATURES             Location/Qualifiers
     source          1..823
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 7.89 cM"
     gene            1..823
                     /gene="Bsph1"
                     /gene_synonym="Gm767"
                     /note="binder of sperm protein homolog 1"
                     /db_xref="GeneID:330470"
                     /db_xref="MGI:MGI:2685613"
     exon            1..146
                     /gene="Bsph1"
                     /gene_synonym="Gm767"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..475
                     /gene="Bsph1"
                     /gene_synonym="Gm767"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; bovine seminal plasma protein homolog 1; bovine
                     seminal plasma protein-like 1"
                     /codon_start=1
                     /product="binder of sperm protein homolog 1 isoform 1
                     precursor"
                     /protein_id="NP_001028590.1"
                     /db_xref="CCDS:CCDS20832.1"
                     /db_xref="GeneID:330470"
                     /db_xref="MGI:MGI:2685613"
                     /translation="MAQPLDFLLVSICLFHSLFSFQVEDYYAPTIESLIRNPETEDGA
                     CVFPFLYRSEIFYDCVNFNLKHKWCSLNKTYQGYWKYCALSDYAPCAFPFWYRHMIYW
                     DCTEDGEVFGKKWCSLTPNYNKDQVWKYCIE"
     exon            147..167
                     /gene="Bsph1"
                     /gene_synonym="Gm767"
                     /inference="alignment:Splign:2.1.0"
     exon            168..197
                     /gene="Bsph1"
                     /gene_synonym="Gm767"
                     /inference="alignment:Splign:2.1.0"
     exon            198..329
                     /gene="Bsph1"
                     /gene_synonym="Gm767"
                     /inference="alignment:Splign:2.1.0"
     exon            330..823
                     /gene="Bsph1"
                     /gene_synonym="Gm767"
                     /inference="alignment:Splign:2.1.0"
     regulatory      611..616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bsph1"
                     /gene_synonym="Gm767"
                     /note="hexamer: ATTAAA"
     polyA_site      637
                     /gene="Bsph1"
                     /gene_synonym="Gm767"
                     /note="major polyA site"
ORIGIN      
        1 agaggctgtg actggatgcc aggcctgcaa gattttcaga gtgagctaca tttgccaacc
       61 tgacagcagg aacatggccc agcctttgga ttttctattg gtttcaatct gcctgtttca
      121 cagccttttc agttttcaag tagaagatta ttatgcacca actatagagt ctttaattag
      181 aaatccagag acagaagatg gtgcatgtgt ctttccgttc ttgtatagaa gtgaaatatt
      241 ctatgactgt gtcaatttca atctgaaaca caagtggtgt tctttgaaca agacttacca
      301 aggttactgg aaatactgtg ctctttcaga ctatgctcca tgtgcctttc ccttctggta
      361 cagacatatg atctactggg attgcacaga ggatggagag gtgtttggga aaaagtggtg
      421 ttcactcacc ccaaattaca acaaagacca agtttggaaa tattgtatag agtgatgaga
      481 tttattggat aatggtgatg ataatgatga caacaacgac aataatgaag ataactggtt
      541 gtagagagaa ggaagaaaaa tgcaaattct ttttggaaag gactttccct cctgaagagg
      601 ttgaatcttc attaaaagtt tttgttaaaa tttaaagctt ttttctgaga tgcaagttga
      661 agatgctctg actatagata acttagggta tagattatga ctatagataa cttagggtat
      721 agattatggg ttgtgggatt taagatggag cgttattctt caaccaccac tttctatttg
      781 ctaggcatat aaattgaagc cattaaaaat cataccagtg tga
//
