LOCUS       NM_007567              15953 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus bassoon (Bsn), mRNA.
ACCESSION   NM_007567
VERSION     NM_007567.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 15953)
  AUTHORS   Blondiaux,A., Jia,S., Annamneedi,A., Caliskan,G., Nebel,J.,
            Montenegro-Venegas,C., Wykes,R.C., Fejtova,A., Walker,M.C.,
            Stork,O., Gundelfinger,E.D., Dityatev,A. and Seidenbecher,C.I.
  TITLE     Linking epileptic phenotypes and neural extracellular matrix
            remodeling signatures in mouse models of epilepsy
  JOURNAL   Neurobiol Dis 188, 106324 (2023)
   PUBMED   37838005
REFERENCE   2  (bases 1 to 15953)
  AUTHORS   Biswas,S., Chan,C.S., Rubenstein,J.L.R. and Gan,L.
  TITLE     The transcription regulator Lmo3 is required for the development of
            medial ganglionic eminence derived neurons in the external globus
            pallidus
  JOURNAL   Dev Biol 503, 10-24 (2023)
   PUBMED   37532091
REFERENCE   3  (bases 1 to 15953)
  AUTHORS   Li,L., Sun,Y., Davis,A.E., Shah,S.H., Hamed,L.K., Wu,M.R.,
            Lin,C.H., Ding,J.B. and Wang,S.
  TITLE     Mettl14-mediated m6A modification ensures the cell-cycle
            progression of late-born retinal progenitor cells
  JOURNAL   Cell Rep 42 (6), 112596 (2023)
   PUBMED   37269288
REFERENCE   4  (bases 1 to 15953)
  AUTHORS   Montenegro-Venegas,C., Guhathakurta,D., Pina-Fernandez,E.,
            Andres-Alonso,M., Plattner,F., Gundelfinger,E.D. and Fejtova,A.
  TITLE     Bassoon controls synaptic vesicle release via regulation of
            presynaptic phosphorylation and cAMP
  JOURNAL   EMBO Rep 23 (8), e53659 (2022)
   PUBMED   35766170
REFERENCE   5  (bases 1 to 15953)
  AUTHORS   Hallermann,S., Fejtova,A., Schmidt,H., Weyhersmuller,A.,
            Silver,R.A., Gundelfinger,E.D. and Eilers,J.
  TITLE     Bassoon speeds vesicle reloading at a central excitatory synapse
  JOURNAL   Neuron 68 (4), 710-723 (2010)
   PUBMED   21092860
REFERENCE   6  (bases 1 to 15953)
  AUTHORS   Dick,O., tom Dieck,S., Altrock,W.D., Ammermuller,J., Weiler,R.,
            Garner,C.C., Gundelfinger,E.D. and Brandstatter,J.H.
  TITLE     The presynaptic active zone protein bassoon is essential for
            photoreceptor ribbon synapse formation in the retina
  JOURNAL   Neuron 37 (5), 775-786 (2003)
   PUBMED   12628168
  REMARK    GeneRIF: Deficiency of Bassoon, a major component of the
            photoreceptor ribbon, results in impaired photoreceptor synaptic
            transmission, abnormal dendritic branching of neurons postsynaptic
            to photoreceptors, and the formation of ectopic synapses.
REFERENCE   7  (bases 1 to 15953)
  AUTHORS   Jellali,A., Stussi-Garaud,C., Gasnier,B., Rendon,A., Sahel,J.A.,
            Dreyfus,H. and Picaud,S.
  TITLE     Cellular localization of the vesicular inhibitory amino acid
            transporter in the mouse and human retina
  JOURNAL   J Comp Neurol 449 (1), 76-87 (2002)
   PUBMED   12115694
REFERENCE   8  (bases 1 to 15953)
  AUTHORS   Kneussel,M., Haverkamp,S., Fuhrmann,J.C., Wang,H., Wassle,H.,
            Olsen,R.W. and Betz,H.
  TITLE     The gamma-aminobutyric acid type A receptor (GABAAR)-associated
            protein GABARAP interacts with gephyrin but is not involved in
            receptor anchoring at the synapse
  JOURNAL   Proc Natl Acad Sci U S A 97 (15), 8594-8599 (2000)
   PUBMED   10900017
REFERENCE   9  (bases 1 to 15953)
  AUTHORS   Persons,D.A., Paulson,R.F., Loyd,M.R., Herley,M.T., Bodner,S.M.,
            Bernstein,A., Correll,P.H. and Ney,P.A.
  TITLE     Fv2 encodes a truncated form of the Stk receptor tyrosine kinase
  JOURNAL   Nat Genet 23 (2), 159-165 (1999)
   PUBMED   10508511
REFERENCE   10 (bases 1 to 15953)
  AUTHORS   tom Dieck,S., Sanmarti-Vila,L., Langnaese,K., Richter,K.,
            Kindler,S., Soyke,A., Wex,H., Smalla,K.H., Kampf,U., Franzer,J.T.,
            Stumm,M., Garner,C.C. and Gundelfinger,E.D.
  TITLE     Bassoon, a novel zinc-finger CAG/glutamine-repeat protein
            selectively localized at the active zone of presynaptic nerve
            terminals
  JOURNAL   J Cell Biol 142 (2), 499-509 (1998)
   PUBMED   9679147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY742476.1, AC137678.11, AK135719.1, AK129141.1 and AI836567.1.
            
            On Feb 6, 2007 this sequence version replaced NM_007567.1.
            
            CCDS Note: This CCDS ID represents the protein described in PMIDs:
            21092860 and 12628168. This variant is inferred from the human
            ortholog which is supported by AF052224.1. It should be noted this
            transcript is predicted to undergo nonsense-mediated mRNA decay
            (NMD). However, the protein is represented because it was detected
            endogenously in PMID: 21092860. It is likely that the majority of
            transcripts representing this variant will undergo NMD, while some
            low level of NMD escape may allow for the expression of this
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            NMD candidate             :: PMID: 21092860
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-542               BY742476.1         3-544
            543-749             AC137678.11        151714-151920       c
            750-1640            AC137678.11        138217-139107       c
            1641-2150           AC137678.11        129577-130086       c
            2151-8792           AC137678.11        122412-129053       c
            8793-10869          AC137678.11        118637-120713       c
            10870-11678         AC137678.11        117527-118335       c
            11679-11714         AC137678.11        117380-117415       c
            11715-13552         AK135719.1         3-1840
            13553-15936         AK129141.1         5123-7506
            15937-15953         AI836567.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..15953
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.07 cM"
     gene            1..15953
                     /gene="Bsn"
                     /note="bassoon"
                     /db_xref="GeneID:12217"
                     /db_xref="MGI:MGI:1277955"
     exon            1..340
                     /gene="Bsn"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..11954
                     /gene="Bsn"
                     /note="presynaptic cytomatrix protein"
                     /codon_start=1
                     /product="protein bassoon"
                     /protein_id="NP_031593.2"
                     /db_xref="CCDS:CCDS23517.1"
                     /db_xref="GeneID:12217"
                     /db_xref="MGI:MGI:1277955"
                     /translation="MGNEASLEGGAGEGPLPPGGSGLGPGPGAGKPPSALAGGGQLPV
                     AGAARAAGPPTPGLGPVPGPGPGPGPGSVPRRLDPKEPLGSQRTTSPTPKQASATAPG
                     RESPRETRAQGPSGQEAESPRRTLQVDSRTQRSGRSPSVSPDRGSTPTSPYSVPQIAP
                     LPSSTLCPICKTSDLTSTPSQPNFNTCTQCHNKVCNQCGFNPNPHLTQVKEWLCLNCQ
                     MQRALGMDMTTAPRSKSQQQLHSPALSPAHSPAKQPLGKPEQERSPRGPGATQSGPRQ
                     AEAARATSVPGPTQATAPPEVGRVSPQPPLSTKPSTAEPRPPAGEAQGKSATTVPSGL
                     GAGEQTQEGLTGKLFGLGASLLTQASTLMSVQPEADTQGQPSPSKGQPKIVFSDASKE
                     AGPRPPGSGPGPGPTPGAKTEPGARMGPGSGPGALAKTGGTASPKHGRAEHQAASKAA
                     AKPKTMPKERASACPLCQAELNMGSRGPANYNTCTACKLQVCNLCGFNPTPHLVEKTE
                     WLCLNCQTKRLLEGSLGEPAPLPLPTPQQPPAGVPHRAAGAAPLKQKGPQGLGQPSGS
                     LPAKASPQATKASPQATKASPQATKASPQTTKASPQAKPLRATEPSKTSSSAQEKKTV
                     TSAKAEPVPKPPPETTVPPGTPKAKSGVKRTDPATPVVKPVPEAPKGGEAEEPVPKPY
                     SQDLSRSPQSLSDTGYSSDGVSSSQSEITGVVQQEVEQLDSAGVTGPRPPSPSELHKV
                     GSSLRPSLEAQAVAPSAEWSKPPRSSSSAVEDQKRRPHSLSITPEAFDSDEELGDILE
                     EDDSLAWGRQREQQDTAESSDDFGSQLRHDYVEDSSEGGLSPLPPQPPARADMTDEEF
                     MRRQILEMSAEEDNLEEDDTAVSGRGLAKHSAQKASARPRPESSQEPKRRLPHNATTG
                     YEELLSEAGPAEPTDSSGALQGGLRRFKTIELNSTGSYGHELDLGQGPDPNLDREPEL
                     EMESLTGSPEDRSRGEHSSTLPASTPSYTSGTSPTSLSSLEEDSDSSPSRRQRLEEAK
                     QQRKARHRSHGPLLPTIEDSSEEEELREEEELLREQEKMREVEQQRIRSTARKTRRDK
                     EELRAQRRRERSKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCSEYSPSPSLDSEA
                     ETLDGGPTRLYKSGSEYNLPAFMSLYSPTETPSGSSTTPSSGRPLKSAEEAYEDMMRK
                     AEMLQRQQGQVAGARGPHGGPSQPTGPRSQGSFEYQDTQDHDYGGRASQPVAESTPAG
                     LGAAVYEEILQTSQSIARMRQASSRDLGFTEDKKKEKQFLNAESAYMDPMKQNGGPLT
                     PGTSPTQLAAPVSFSTSTSSDSSGGRVIPDVRVTQHFAKEPQDPLKLHSSPVSSTLTS
                     KEVGMTFSQGPGSPATTASPTRGYMTPTSPAGSERSPSTSSTIHSYGQPPTTANYGSQ
                     TEELPHAPSGPPGSGRAPREKPLSGGDSEVGAPQPSRGYSYFTGSSPPLSPSTPSESP
                     TFSPGKLGPRATAEFSTQTPSLTLSSDIPRSPGPPSPMVAQGTQTPHRPSTPRLVWQQ
                     SSQEAPIMVITLASDASSQTRMVHASASTSPLCSPTDSQPTSHSYSQTTPPSASQMPS
                     EPAGPPGFPRAPSAGTDGPLALYGWGALPAENISLCRISSVPGTSRVEPGPRPPGTAV
                     VDLRTAVKPTPIILTDQGMDLTSLAVEARKYGLALDPVSGRQSTAVQPLVINLNAQEQ
                     THTFLATATTVSITMASSVLMAQQKQPVVYGDPFQSRLDFGQGSGSPVCLAQVKQVEQ
                     AVQTAPYRGGPRGRPREAKFARYNLPNQVTPLARRDILITQMGTAQGVGLKPGPVPEP
                     GAEPHRATPAELRSHAPPGTRKPHTVVVQMGEGTAGTVTTLLPEEPAGALDLTGMRPE
                     SQLACCDMVYKFPFGSSCTGTFHPAPSAPDKSVTDTALPGQSSGPFYSPRDPEPPEPL
                     TFRTQGVVGPGPHEEQRPYPQGLPGRLYSSMSDTNLAEAGLNYHAQRLGQLFQGPGRD
                     SAVDLSSLKHSYSLGFADGRYLGQGLQYGSFTDLRHPTDLLSHPLPLRRYSSVSNIYS
                     DHRYGPRGDAVGFQEASLAQYSATTAREISRMCAALNSMDQYGGRHGSGSGGPDLVQY
                     QPQHGPGLSAPQGLAPLRSGLLGNPTYPEGQPSPGNLAQYGPAASQATAVRQLLPSTA
                     TVRAADGMIYSTINTPIAATLPITTQPASVLRPMVRGGMYRPYVSGGVTAVPLTSLTR
                     VPMIAPRVPLGPAGLYRYPAPRFPIASSVPPAEGPVYLGKPAAAKASGAGGPPRPELP
                     AGVAREEPFSTTAPAVIKEAPVAPAPGPAPAPPPGQKPAGEAVAGSGSGVLSRPASEK
                     EEASQEDRQRKQQEQLLQLERERVELEKLRQLRLQEELERERVELQRHREEEQLLVQR
                     ELQELQTIKQHVLQQQQEERQAQFALQREQLAQQRLQLEQIQQLQQQLQLQLEEQKQR
                     QKAPFPATCEAPSRGPPPAATELAQNGQYWPPLTHAAFIAVAGTEGPGQPREPVLHRG
                     LPSSASDMSLQTEEQWEAGRSGIKKRHSMPRLRDACEPESGPDPSTVRRIADSSVQTD
                     DEEGEGRYLVTRRRRTRRSADCSVQTDDEDNADWEQPVRRRRSRLSRHSDSGSDSKHD
                     ATASSSTTAAATARAMSSVGIQTISDCSVQTEPEQLPRVSPAIHITAATDPKVEIVRY
                     ISAPEKTGRGESLACQTEPDGQAQGVAGPQLIGPTAISPYLPGIQIVTPGALGRFEKK
                     KPDPLEIGYQAHLPPESLSQLVSRQPPKSPQVLYSPVSPLSPHRLLDTSFASSERLNK
                     AHVSPQKQFIADSTLRQQTLPRPMKTLQRSLSDPKPLSPTAEESAKERFSLYQHQGGL
                     GSQVSALPPNGLVRKVKRTLPSPPPEEAHLPLAGQVPSQLYAASLLQRGLAGPTTVPA
                     TKASLLRELDRDLRLVEHESTKLRKKQAELDEEEKEIDAKLKYLELGITQRKESLAKD
                     RGGRDYPPLRGLGEHRDYLSDSELNQLRLQGCTTPAGQYVDYPASAAVPATPSGPTAF
                     QQPRFPPAAPQYTAGSSGPTQNGFPAHQAPTYTGPSTYPAPTYPPGTGYPAEPGLPSQ
                     PAFHPTGHYAAPTPMPTTQSAPFPVQADSRAAHQKPRQTSLADLEQKVPTNYEVIGSP
                     AVTMSSAPPETGYSGPAVSGSYEQGKAPEHPRGSDRSSVSQSPAPTYPSDSHYTSLEQ
                     NVPRNYVMIDDISELTKDSTPTASESQRLEPLGPGGVSGRPGKDPGEPAVLEGPTLPC
                     CYGRGEEESEEDSYDPRGKSGHHRSMESNGRPSTHYYGDSDYRHGARADKYGPGPMGP
                     KHPSKSLAPAAISSKRSKHRKQGMEQKISKFSPIEEAKDVESDLASYPPPTVSSSLTS
                     RGRKFQDEITYGLKKNVYEQQRYYGVSSRDAAEEDERMYGSSSRSRMASAYSGEKLSS
                     HDYSSRGKGYERERDTAERLQKAGSKPSSLSMAHGRARPPMRSQASEEESPVSPLGRP
                     RPAGGALPPGDTCPQFCSSHSMPDVQEHVKDGPRAHAYKREEGYMLDDSHCVVSDSEA
                     YHLGQEETDWFDKPRDARSDRFRHHGGHTVSSSQKRGPARHSYHDYDEPPEEGLWPHD
                     EGGPGRHTSAKEHRHHSDHGRHSGRHAGEEPGRRAAKPHARDMGRHEARPHPQASPAP
                     AMQKKGQPGYPSSADYSQSSRAPSAYHHASESKKGSRQAHTGPSALQPKADTQAQPQM
                     QGRQAAPGPQQSQPPSSRQTPSGTASRQPQTQQQQQQQQQQQGLGQQAPQQAPSQARL
                     QPQSQPTTRGTAPAASQPAGKPQPGPTTAPGPQPAGPPRAEQASSSKPPAAKAPQQGR
                     APQAQTTPGPGPAGAKPGARPGGTPGAPASQPGAEGESVFSKILPGGAAEQAGKLTEA
                     VSAFGKKFSSFW"
     exon            341..749
                     /gene="Bsn"
                     /inference="alignment:Splign:2.1.0"
     exon            750..1640
                     /gene="Bsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..2150
                     /gene="Bsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..8792
                     /gene="Bsn"
                     /inference="alignment:Splign:2.1.0"
     exon            8793..10869
                     /gene="Bsn"
                     /inference="alignment:Splign:2.1.0"
     exon            10870..11678
                     /gene="Bsn"
                     /inference="alignment:Splign:2.1.0"
     exon            11679..11781
                     /gene="Bsn"
                     /inference="alignment:Splign:2.1.0"
     exon            11782..11913
                     /gene="Bsn"
                     /inference="alignment:Splign:2.1.0"
     exon            11914..11968
                     /gene="Bsn"
                     /inference="alignment:Splign:2.1.0"
     exon            11969..12061
                     /gene="Bsn"
                     /inference="alignment:Splign:2.1.0"
     exon            12062..15937
                     /gene="Bsn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15908..15913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bsn"
                     /note="hexamer: AATAAA"
     polyA_site      15931
                     /gene="Bsn"
                     /note="major polyA site"
ORIGIN      
        1 ggcggctgtg cgagccgagc tgggagatgg cggcagctgc ggtggagcgg agagtgtgag
       61 cgccgcccgg gagccgccgg cccgggcgca gtgcgacccc gaccccgccc gcccgcctgc
      121 ccaccatggg caacgaggcc agcctggagg gcggcgcggg cgaagggccg ctgccgcccg
      181 gaggctctgg tctgggtccg ggccccggag cagggaagcc gccttcagca ctagctggcg
      241 gcggacagct ccccgtggct ggcgctgcgc gagcggcggg acccccgacc cctggtctcg
      301 gtccggtccc cggccctggc cccggccccg gcccgggcag tgttccccgg agactggacc
      361 ccaaagagcc cctgggcagc cagagaacaa cttctccaac cccaaagcaa gcatctgcta
      421 ctgctcctgg ccgagagagc ccccgagaga caagggccca aggcccatca ggccaggagg
      481 ccgaaagtcc ccgcaggacg ctgcaggtag acagcaggac acagagatca ggacggtccc
      541 cctcggtgtc accggacaga ggcagcactc ccacgtcacc ctactctgtc ccccagattg
      601 cccctcttcc cagcagcacc ctgtgtccaa tatgcaagac ctcggacctc acatcaaccc
      661 ccagccagcc aaacttcaac acctgcaccc agtgtcacaa caaggtctgc aaccaatgtg
      721 ggttcaaccc caaccctcac ctcacccagg tgaaggagtg gctctgtttg aactgtcaga
      781 tgcagagggc cctaggaatg gacatgacca ctgcgcctcg gtccaagagc cagcagcagc
      841 tacactcccc ggccctgtct cctgcccact ccccagccaa acagcctctg gggaagccag
      901 agcaagagcg atctcctcgg ggcccagggg ccacacagtc tggtccccgc caggctgaag
      961 cagccagggc cacctcagtg cctgggccta cccaggcaac tgcccctcca gaggtgggaa
     1021 gggtgtctcc tcagccccct ctctccacca agccttccac agctgagccc aggccacctg
     1081 caggagaggc ccagggcaaa agtgccacca cagtgccctc tgggcttggt gctggtgaac
     1141 agacccagga aggcctcacc gggaagctct tcggccttgg agcatcactg ctgacccagg
     1201 cgagcaccct tatgtctgtg cagccagagg ctgacaccca gggccagcct tccccaagca
     1261 aggggcaacc caagattgtc ttcagtgatg ccagcaagga ggcgggtcca agacccccag
     1321 gctcagggcc tgggcctggg ccaacacctg gagccaaaac cgagcctggg gctagaatgg
     1381 gtcctggatc agggcctgga gccctggcaa aaactggagg aaccgccagt ccaaagcacg
     1441 gcagagcaga acaccaggca gcatccaagg ctgctgccaa gccaaagacc atgccgaagg
     1501 aaagggcctc cgcctgccca ctgtgccaag ccgagctcaa catgggtagc aggggcccag
     1561 ccaactacaa cacctgcact gcctgcaagc tccaggtgtg caacctgtgt ggctttaacc
     1621 caacaccgca tctggtggag aaaacagagt ggctctgtct gaactgccaa actaagcggc
     1681 tgctggaggg cagcttgggg gagccagccc ccctgcctct gcccacccca cagcagcctc
     1741 ctgcaggagt ccctcaccga gcagctggag cagcccctct gaagcagaaa gggccacagg
     1801 ggctgggcca gccctcaggc tccctgcctg ccaaggccag cccccaggcc accaaggcca
     1861 gccctcaggc caccaaggcc agccctcagg ccaccaaggc cagccctcag accaccaagg
     1921 ccagccctca ggccaagcct ctcagggcta ctgaacccag caagacctct agcagcgccc
     1981 aggaaaagaa gacagtgacc tctgctaaag ctgagcctgt gccgaagcca cctccagaga
     2041 ctactgtgcc tcctgggact cctaaagcaa aaagtggggt gaagaggact gaccctgcca
     2101 ccccagttgt caagcctgtt ccagaagctc ccaagggtgg ggaggctgag gaaccagtcc
     2161 ccaagcctta ttctcaggac ctgtctcgaa gcccacagag cctcagtgac acaggctact
     2221 cctccgacgg tgtctccagc tcccagagcg agatcacagg tgttgtacag caagaagtgg
     2281 aacagcttga cagtgcaggg gtgacaggcc cacgtccacc cagcccctcg gagctccaca
     2341 aagtgggtag tagcttgcgc ccttcactgg aggcccaggc tgtagctccc agtgcggaat
     2401 ggagcaagcc accccgcagc agcagcagtg cggttgaaga ccagaaacgg cgtcctcact
     2461 ccctgtccat cacgcccgag gccttcgact cggatgagga actgggggac attctagagg
     2521 aggacgactc cttggcatgg ggacgtcaga gggaacagca ggacacagct gagtcttcag
     2581 atgactttgg cagccagctg aggcatgact acgtggaaga cagcagcgaa ggcggcttgt
     2641 ctcccctccc acctcagccc ccagcccggg cagacatgac tgatgaagaa ttcatgcggc
     2701 gacagatcct agaaatgagt gccgaggaag acaacttgga ggaagacgac actgctgtct
     2761 ctggacgagg cctggccaaa cacagcgccc agaaggcaag tgccaggccc agaccggaat
     2821 ctagccaaga acccaagagg cgccttcccc ataatgccac cacaggctac gaggaactcc
     2881 tatctgaggc aggcccagca gagcccacgg atagcagcgg agcccttcag ggaggtctcc
     2941 gacgttttaa aaccatcgag ctcaacagca cgggtagcta tggtcatgag ctagaccttg
     3001 gccaaggtcc tgatcccaac ctggaccggg agcctgagct ggagatggag agcctcacag
     3061 gctcacccga agaccgctct cgtggggagc actcctctac gttgccggcc tccacaccta
     3121 gctatacatc tggcacctca cccacctccc tgtcttcact ggaggaggac agtgacagca
     3181 gccccagccg ccggcagcgc ctagaagaag caaagcagca gcgcaaggcg cggcaccgct
     3241 cccacgggcc cctgctgccc accatcgagg actcctccga ggaggaggag ctgcgggaag
     3301 aagaggagct gctgcgtgag caggagaaga tgcgggaggt ggaacagcag cgaattcgaa
     3361 gcacagcccg caagacccgg cgtgacaagg aagagcttcg agctcagcgg cggcgtgaac
     3421 gctccaagac accacccagt aacctgtcac ccattgaaga tgcgtcccct acagaggagc
     3481 tgaggcaggc agcggagatg gaggagctac accgctcttc ctgctctgag tactccccct
     3541 ccccctccct ggactcagag gcggagaccc tagatggcgg ccccactcgg ctctacaagt
     3601 ctggcagcga gtacaacctg ccggccttta tgtctctcta ctcaccgact gagacccctt
     3661 cgggcagttc caccacgccc agttctggac ggccccttaa gagtgcggag gaggcctacg
     3721 aggacatgat gagaaaagct gagatgctcc agagacagca gggccaggtg gcaggggccc
     3781 ggggacccca tggtggcccc tctcagccca cgggcccccg cagccagggc tcctttgaat
     3841 atcaagacac ccaagaccat gactatggcg gcagggcttc tcagccggtg gcagaaagca
     3901 cgcccgcagg ccttggagcg gccgtgtacg aggagatcct tcagacatcc cagagcatag
     3961 cccggatgcg gcaggcctcc tcgcgggatc tgggcttcac tgaggacaaa aagaaggaga
     4021 agcagtttct gaatgccgag agcgcataca tggacccaat gaagcaaaat ggtggcccac
     4081 ttacccctgg gaccagcccc acccagcttg ctgcccccgt gtctttttcc acctccacct
     4141 cctcagacag cagcggtggc cgagttatcc ccgatgtccg agtcactcag cattttgcaa
     4201 aagagcctca ggatcctctc aagctgcaca gctctcctgt ctcctccact ttgacctcta
     4261 aggaggtagg catgaccttc tcccagggtc ctgggtcacc agccaccaca gccagtccga
     4321 cacgagggta tatgactcca acctccccag ctggctctga gcgtagccca tcaacgtctt
     4381 ccacaatcca cagctatggg cagcccccaa ccactgctaa ctatgggtct caaacggagg
     4441 agctgcccca cgctcccagt ggccctcctg gaagtggacg ggcccccaga gagaagcctc
     4501 tgagtggggg tgacagtgag gtcggtgccc cccagccttc tcggggatat tcttacttta
     4561 cgggctctag cccacctctc tctccatcta ccccctctga gagccccaca ttctcaccag
     4621 gcaagctggg ccccagggcc acagcagagt tctctacaca gacgccaagc ctaacgcttt
     4681 cctctgacat tccgaggagc cccggccccc cctcccccat ggtagcccaa ggcacacaga
     4741 ctccacaccg acctagcact cctcgattgg tgtggcagca gtcttcccag gaggccccta
     4801 ttatggtcat cactctggcg tcggatgctt cgagccagac cagaatggtg catgccagtg
     4861 cctcgacttc ccctctgtgc tcacctacag actctcagcc cacctcccac agctacagcc
     4921 agacaacacc tccaagtgca tctcaaatgc cctcggaacc ggctgggcca cctggctttc
     4981 cacgagcacc cagtgctggt acagacggac ccctggcact gtacggctgg ggtgccctcc
     5041 ctgctgaaaa catctcgcta tgccggatct cctctgtccc tggaacatct agagttgagc
     5101 caggcccccg gcccccgggc actgcggtgg tagacctccg cacagccgtc aagcccaccc
     5161 ccattatcct taccgaccag ggtatggatc tgacctctct tgctgtggaa gcaaggaagt
     5221 atggcctggc cctggatcca gtctcaggac gccagtcaac cgctgtgcag cctttggtta
     5281 tcaacctcaa tgcccaagag cagacccata ccttcctggc cactgccacc acggtgagca
     5341 tcacaatggc ctcatctgtg ctcatggctc agcaaaagca gccagtggta tacggagatc
     5401 ctttccagag ccgcctcgac tttggccagg gttcaggtag ccccgtgtgc ctggcgcagg
     5461 tcaagcaagt agagcaggct gtccagacag ccccgtaccg aggtgggccc aggggaagac
     5521 ccagggaggc taagtttgcc aggtataacc ttcccaacca agtaacacct ctggccagaa
     5581 gggacattct gatcacccag atgggcaccg cccagggtgt gggcctgaag ccaggaccag
     5641 tgccagagcc cggtgctgaa ccccaccggg ctactcctgc agagctccgg tcacatgctc
     5701 ctccaggtac caggaagcca cacacagtgg tggtacagat gggagagggc acagccggca
     5761 cagtgactac cctgctccca gaagagccgg caggtgccct ggacctcacc ggaatgaggc
     5821 ccgagagcca gctggcatgc tgtgacatgg tctacaagtt tccttttggc agtagctgca
     5881 ctggcacctt ccatcctgcc cctagcgcac ccgacaagag tgtgaccgat acagccctgc
     5941 ctggccaaag cagtggcccc ttctacagtc ccagagaccc tgagccccct gagcccctca
     6001 ccttccgcac acagggggta gtaggacctg ggccccatga agaacagagg ccctacccac
     6061 agggcctgcc tggaaggcta tactcctcca tgtctgacac caatttggcc gaagctggcc
     6121 tcaactacca tgcccagagg cttgggcagc tcttccaggg acctgggagg gactcggcag
     6181 tggacctcag ctcactgaag cactcgtaca gcttaggctt tgctgatgga cgctacttag
     6241 ggcagggctt acagtatggc tccttcacgg acctgcgtca ccccacagac cttttgtctc
     6301 acccacttcc cctgcggcgc tatagctcgg tgtcaaacat ctattcagat cataggtacg
     6361 gcccacgggg agatgcagtt ggcttccagg aggccagcct ggcccagtac agtgccacca
     6421 cagcccgaga gatcagccgc atgtgtgctg ccctcaactc catggaccag tacggtgggc
     6481 ggcatggcag cgggagtggt gggcctgacc ttgtgcagta tcagccccag catgggcctg
     6541 gcctcagtgc tccacagggt ctggctcccc ttagatccgg cctccttggc aaccccacct
     6601 acccagaagg gcagccaagc cctggaaacc ttgctcagta tgggcctgca gcaagccaag
     6661 caacagcagt cagacagcta ctcccgtcca cagcaacagt gcgcgcagcc gatggcatga
     6721 tctattcgac tatcaatacc ccaattgctg caacgctgcc catcaccacc cagcctgcct
     6781 cggtactgcg gcccatggtg cgtggtggca tgtacaggcc ttatgtatct ggtggagtca
     6841 cagctgtgcc ccttaccagc ctgacccgtg tgcccatgat tgctcctcgg gtacctcttg
     6901 gaccagcagg gctataccgc tatcctgcac caagattccc cattgcttcc agcgttccac
     6961 ctgctgaagg acctgtctat ttggggaagc ctgctgcagc caaggcctcg ggggcaggag
     7021 gtccgccaag gcctgagcta ccagcagggg ttgctcgtga agaacccttt tccacaactg
     7081 cccctgctgt catcaaggaa gcccccgtgg cccctgcccc gggcccggcc ccggccccac
     7141 cacctggcca gaagccagca ggagaggccg tcgctgggag tggcagtggg gtcctcagcc
     7201 ggcctgcgtc ggagaaggag gaagcgtctc aggaggaccg gcagcggaag caacaggagc
     7261 agctgctgca gctggagcgg gaacgggtag agttggaaaa gctgcggcag ttgcggctgc
     7321 aggaggagct ggagcgggag agggtggagc tgcagaggca tcgtgaggag gagcagctgc
     7381 tggtgcagcg agagctgcag gagctgcaga ccatcaagca gcatgtgctg cagcagcagc
     7441 aggaagagcg ccaggctcag tttgcactgc agcgtgagca gctggcacag cagcgactgc
     7501 aactagagca gatccagcaa ctgcagcagc agctgcagct gcagctggag gagcagaagc
     7561 agaggcagaa ggcccccttt cctgccacct gtgaggcacc tagccgaggg cctcccccgg
     7621 ctgccaccga gctggcccag aatggccagt actggccacc gctgacccac gcggccttca
     7681 ttgctgtggc ggggactgaa gggcccgggc aacctcgtga gcctgtgctg cacaggggcc
     7741 tccccagctc cgcctcagac atgtcactgc aaaccgagga gcagtgggag gcaggccgta
     7801 gtggcatcaa gaaacgtcac tccatgccac gcctgagaga tgcctgtgag ccagagtcgg
     7861 gacctgatcc cagcacggtc aggagaattg cagacagcag tgttcagaca gatgatgagg
     7921 agggtgaggg ccgctacctt gtgactcgca ggcgcaggac gcggcgcagt gctgactgca
     7981 gtgtgcagac agatgatgag gacaatgccg actgggagca acccgtccgc cgccgcaggt
     8041 ctcgtctttc ccgtcactca gactcaggct ctgacagcaa gcacgatgcc actgcttcct
     8101 catccaccac ggccgccgcc actgcgaggg ccatgagcag cgtgggcata cagaccatca
     8161 gcgactgctc cgtccagacc gagcccgagc agctgcccag ggtctctcca gccatccaca
     8221 tcacggctgc caccgaccca aaggtggaga ttgtcaggta catatcagca ccagaaaaga
     8281 ctgggcgcgg ggagagcctg gcctgccaga cagaaccgga tggacaggct cagggtgtgg
     8341 ctgggccaca gctcatagga ccaactgcca tcagccccta cctacctggc atccagatag
     8401 tcaccccagg agccctgggc agatttgaga agaagaagcc ggatcctctg gaaatcggtt
     8461 accaggccca cctgcccccg gagtccctgt cgcagcttgt gagccgccag cctcctaagt
     8521 ctccacaagt gctctactct ccagtgtcgc ccctgtcccc acaccggctc ctggacactt
     8581 cgtttgcttc cagtgagagg ctgaacaagg ctcatgtgag tccccagaag caattcatag
     8641 ctgacagcac ccttcgccag cagactctgc ctcgccccat gaagaccctg cagcggtctc
     8701 tgtccgaccc taagcccctg agccccaccg ccgaggagtc tgccaaagag agattctccc
     8761 tctaccagca ccagggggga ctaggtagcc aggtgtcggc gctgccaccc aacggcctgg
     8821 tccgcaaggt gaagcggaca ctgcccagcc cccctccaga ggaagctcac cttcccctgg
     8881 ctggccaggt gccctcacag ctgtatgcag ccagtctgct gcagcgaggg ttggcggggc
     8941 ccaccaccgt ccctgctacc aaggccagcc tgctccggga gctggaccgg gacctgcggc
     9001 tggtggagca tgagtccacc aagctgcgca agaagcaggc ggagttggac gaggaggaga
     9061 aggagattga cgccaagctc aagtacctgg aactgggcat cacccagcgc aaggagtcgt
     9121 tggccaaaga ccggggtggc cgtgactacc cacctttacg tggccttggt gagcatcgtg
     9181 actacctgtc tgacagcgag ctcaaccagc tgcggctcca gggttgcacc acacccgctg
     9241 gccagtatgt ggactaccct gcctcagctg ctgtgcctgc cactccctct ggccccactg
     9301 ccttccaaca gccccggttc ccacctgcag ccccacagta cactgcaggc agtagtggac
     9361 caactcaaaa tggatttcca gcccaccagg cacctaccta cactggccct agcacatacc
     9421 cagcacctac ctaccctcct gggactggtt atccagctga gcctggcctg ccaagccaac
     9481 cggctttcca ccccacaggc cattacgcag ccccaacgcc catgccaacc acgcagagcg
     9541 cccctttccc agtgcaagct gacagtcgtg ctgcccacca gaagccacgg cagacttcac
     9601 tggctgatct ggagcagaaa gttcccacca attacgaggt gattggcagc cctgctgtca
     9661 ccatgtcttc agcgccccct gaaaccggct acagtggtcc agctgtgagc ggcagctatg
     9721 agcagggtaa agcccccgag cacccccggg gcagtgatcg aagcagcgtg agccagagcc
     9781 cagcccccac gtatccctct gactcccact acaccagtct ggaacagaat gttcctcgaa
     9841 actatgtgat gatcgacgac atcagcgaac tgacgaagga cagcaccccc actgcctcgg
     9901 agagccagcg gctggagcct ttggggccag gtggagtcag tgggcgtccc gggaaggatc
     9961 ctggggaacc agccgtcctt gagggaccca ctctgccctg ctgctatggc agaggtgagg
    10021 aagaatctga ggaggactca tatgaccccc gtgggaaatc tggtcatcac cggagcatgg
    10081 agagcaacgg ccggccaagc acccactatt acggtgacag tgactataga cacggggctc
    10141 gagcagacaa gtacggtcca ggacccatgg ggccaaagca tccctctaag agcctggccc
    10201 cagctgccat ctcctcaaag cgcagcaagc accggaagca aggcatggag caaaagatct
    10261 ccaagttctc acccatcgag gaggccaagg atgtggaatc cgacctggcc tcctatcccc
    10321 cgcccaccgt cagcagcagt ctgacctctc ggggcagaaa gttccaggat gaaatcacct
    10381 atgggctcaa gaagaacgtg tacgaacagc agcggtacta cggggtgtcc agccgcgacg
    10441 cggcagagga ggatgagcgc atgtacggta gcagcagccg gtcccgaatg gcgtcggcat
    10501 acagtgggga gaagctgtcc agccatgact atagcagccg aggcaaaggg tatgaacggg
    10561 aacgggacac tgcagagcga cttcaaaagg cgggctccaa gccctcatcc ctgagcatgg
    10621 cccatggccg ggcacggccc cccatgagga gccaggcctc tgaagaggag agccctgtca
    10681 gccccttagg gcggccccgc cccgcagggg gcgctcttcc tcccggggac acctgcccac
    10741 agttctgctc cagccattcc atgcctgacg tccaggaaca tgtcaaggac ggaccgcggg
    10801 cccacgcgta taagcgtgag gagggctaca tgttggatga ttcccactgc gtggtttctg
    10861 acagcgaagc gtatcacctg ggccaggagg agacagactg gtttgataag ccccgagatg
    10921 cccgctccga ccggttcagg caccatgggg gccatacagt ctcctcctcc cagaagcgag
    10981 gccctgccag gcacagctac catgactacg atgagccccc tgaggagggc ctatggcctc
    11041 atgatgaggg tggtccaggc cggcatacct cagccaagga acaccggcac cacagtgacc
    11101 acgggaggca ctcaggccgc cacgctggtg aggagccagg acggcgggct gccaaaccgc
    11161 acgctcggga catgggtcgc cacgaggccc gacctcaccc tcaggccagc cctgcccctg
    11221 ccatgcagaa gaagggtcag cccgggtacc ccagctctgc tgattattca cagtcgtccc
    11281 gggctccgtc agcataccac catgcctctg agagcaaaaa gggctcccgg caggcccaca
    11341 ctgggccttc tgcactgcag ccaaaggcag acacccaggc tcagccacag atgcaaggtc
    11401 ggcaggcggc tccaggaccg cagcagtcgc agccaccatc atccaggcag acaccctcgg
    11461 gcacagcatc acgtcagcca cagacacaac agcagcaaca gcagcagcag caacagcagg
    11521 gtcttgggca acaagccccc cagcaggctc catcccaggc tcggctacag cctcagagcc
    11581 agccaaccac ccggggcaca gcccctgctg ccagccaacc agcggggaaa cctcagccag
    11641 gccccaccac agccccaggg ccccagccag caggaccgcc acgtgcagag caggccagca
    11701 gctctaaacc acccgcagcc aaagcgcccc agcagggacg ggctcctcag gcgcagacaa
    11761 ctccaggacc tggacctgca ggggcgaagc ctggagccag gcctggaggg accccagggg
    11821 ctcccgctag tcagccaggg gcagaaggag agagtgtatt ctctaagatc ctccctggtg
    11881 gggcagcaga acaagctgga aagctgacag aagctgtctc tgcttttggc aaaaaatttt
    11941 cctcattctg gtgattgtgt ccagaagggc tcctgaagac ctgaagaaag acaatctcat
    12001 tgctgtggaa aaatctctgg agtcaaaggc ctgggcgcag ctctggactc tgcgtataac
    12061 gcatctacaa gctggcaaac ctttggccca aagattccca gcaggcgggc cccagcaggc
    12121 aggcctcaac caagcatgag aatgacatgt gttctcacag cagcgaccta ggtgaagcat
    12181 ctgccggacc aatgggacca ttggcttggg ggacctttca tgtctttcaa gagaccctgc
    12241 cttactcagg ccagccgtcc ttgggagcga ggagccctcc tcaccagaac gcggttgctg
    12301 ctgttgctgt ctgctgctct tcccgcagcc tcctgtggcc tggccaccag gcttccaatg
    12361 cgttatacac agagtttggg tgcacactgc cctcctctaa gatgccagaa gttttttcca
    12421 cagccttgga gaggggcttt gactgagggc tggggccctg ggctccgatt ccttcacatt
    12481 ccagctggcc cggatccctg tgtggccata aggccttgcc ctcgtcaccc tgctctgggg
    12541 gtgacactgg agcagacgtc cacatggcca gcatgggttt gggagaactt tacaaacatt
    12601 aggaccctaa cactgtctca tcgctgaaac aagaggccat agcaccgaaa cgcagcgtgg
    12661 gcaccggctg aggcttctcc cagcccgtgg atggcagcgt aactaggcat gcctgccatc
    12721 accttaaagc catcccccca gccattgtga gcaccccagc agcaccgcca ttgtctcgac
    12781 cagccggctc ctcggctcct catctctaca cctgaggatt tcttttgatt tcaggaacag
    12841 ccttaatcat tccagtttga tttacatgta tacctcatga acattttttt gttgttgttg
    12901 ttttattttt ctttctctcc ctttcttttc tttgctttta tccctttgtc tctcccccac
    12961 cccaccccca ccccgcaacc tcgtgactga tggtttggtt tcctctctgc tctgcccctg
    13021 ctcagcacag ggagaaacgt tgatttagaa gcaatagcgg gcagcaggcc accaagagca
    13081 caaacccagg gcgaggtcta gggaggctcc tcagcccgcc tgtttactgt cttcttaagc
    13141 catcagcagt gggtgtgctc agagcagagg agccaaggga gagcttcaga gacctgtgag
    13201 gtaaggggag tataacaccg tccattcacc tcgtggactg ggctacatgc ctccccaaag
    13261 cccttccctg ggaggcctcc cttcatctcg ggcccagcca caagtctcat ctctaatgtt
    13321 ctatgcaatg aaatataaac cctcaaagac aactgttaat atttaataaa ttccgtgtta
    13381 catataagga gttaattgca aacatgcagt tgagaaactg gatagctcta tctgctcata
    13441 ccatcacccc aacccaatcc ttgtccccac attctgtgtg tgtgagagag aaatggagag
    13501 cgtgagtgcg tgtgtgcgtg cgtgcgtgcg tgcgtgcgtg tgtgtgtgtg tgtgtgtgtg
    13561 tatgcgcgtg tgcaggtgtg catgtgtaaa ttttaagtct gtggcatgtt tgacctgtgg
    13621 caggactcgc tgcttgccag gtgagtcgcc gcctgtctgg cactggagca tgcacggctc
    13681 gaagcttctt tgcacgattt cattcatttt aaatgcccga cctcttgctt ggagttcttt
    13741 tcgcctccaa acctctcctt taggagcgct tctccctgac tttgggacac gctagtaaag
    13801 acctgccaga actgcctaca tttgccaggc cagggagcag gcagtgaggc cccagacacc
    13861 ttgcagtttt tatctgtgta caatagcaga taaaaacaaa ccttagacta gacagagagg
    13921 ggagcccgca caggatgcat gtgtatggac attctgtggg tttgctgtag gatttctact
    13981 tgtatatcat ttttcctcct atcccaggcc tgagccaaaa gaaactggtc acatcttccc
    14041 agtggggtac tgctcaaggg caaagcttgg ggcacatctg tggagaggca gaagccaagg
    14101 gatcctggct gtgccctatg attcccagat cttgactgac tctgctctat gtctctcctt
    14161 tgtgatgaag aagcttaaag gattgtgagc caagagatct atctggagtg gagccagggg
    14221 tcataaggta cccagaagga gctggctatg gctgaaaata tcattcagga aaaaactgtt
    14281 cacataaata acagcttcaa actgagccca gaaggtctct caagagcaaa acttactgaa
    14341 gggttggtgt aaccctctcc acatctgccc caggacttgc ctcctctgag gcataagtat
    14401 cacactgttg tcagcatctc cctcactggc ccaggagtag ggcagacagt acctgcctga
    14461 cccctaaagt ctggcctgcc tccagagagc tttggtgtat accatgcatt tctcaggggt
    14521 tcacgtttct catgcatttt tacaaggctt ataaatcctt tagtgtggga tcctgtccca
    14581 ccatcggcag ctgtggttgg gacacttcaa gctgtgttgg acttaagagc ccgagttccc
    14641 gggatttagc tttcttcaca ctatggaata tctcagagat caaacttggg ctatatgggg
    14701 ccatcgctaa aagggctgaa gaaggccctc tttgaggaac tcccaggccc aggtgtgtac
    14761 aggatgtgcc cagggtctag atacctggga ccatgactgt attcctttcc tctcagagtc
    14821 aaggggctag actaggggat gagggcaggc agggtgtcca cgggtcagtc tctggctgac
    14881 ccctaggctc taaagtatta actttacagc acatttcttt tctgacattt ctgatatctg
    14941 ctactctatc cctggctgtg cccacaggac agatctttgc ccttctgtga atatgactgc
    15001 aggagtcttc taggccatag gtatccctgg cccttatgtt gactctgtgt agagcccaga
    15061 cctccatttt ctcccctctt agtgtcataa gcaagggcac cctcctctgc ccacgcaagg
    15121 cctcaacaca ctcacttcat agggatggtc ctcgcaccat cttcttcctg ttctttgggc
    15181 agggtgaaca gtctcagggc ccacactgaa agaacagcca gggcagcaat tctggtctgt
    15241 atgctggagc ctctggggag ttttccaggc aggtccttgt ccgtgagagt acagtcctgc
    15301 ccaatagccc ttctcctccc ttgctgtaaa taatgtgtca tcatggactc catcagggcc
    15361 ggagggacat atataatcaa atgaaactct ctggagatgc catctctgtc tccctgggtg
    15421 ccagcaccct gctaccatgt gcaccgggtg gcactggaga gccatagaag tcatgagata
    15481 ctgtatgtgt aagcacatgt acatgagtgt gtgtgtgtgt gtgtgtgtgt gtgtatgtat
    15541 gtatgtatgt gtgagtgtgt gtgtgtgttt gtgcgtgtgt gcacgagtct cattcagcct
    15601 ctggggtcaa atcaattcct ctcaagtgtg gtaccctaga gagtggtggc catctacatt
    15661 ttctccctct agcttctatg tcttgttttt gctttccctc ccctcctcct cccctctctc
    15721 tccttctctc tgtgaggggg gagagtgctg tacaaagtca aacaaacaag tttacattgt
    15781 aagtgcaatg acccgagtcc tccacatgac cttgtgaatt gtgtgccgtc ctcctgtgct
    15841 ctgtgagaac tcgtggtact tcagtgtccc tcccctgtac tgtgacaagg tatttctgtg
    15901 gtatcagaat aaaaggactt gatataaaca accttcaaaa aaaaaaaaaa aaa
//
