LOCUS       NM_001081477           12788 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus bromodomain and WD repeat domain containing 3 (Brwd3),
            mRNA.
ACCESSION   NM_001081477 XM_897923
VERSION     NM_001081477.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12788)
  AUTHORS   Gendrel,A.V., Tang,Y.A., Suzuki,M., Godwin,J., Nesterova,T.B.,
            Greally,J.M., Heard,E. and Brockdorff,N.
  TITLE     Epigenetic functions of smchd1 repress gene clusters on the
            inactive X chromosome and on autosomes
  JOURNAL   Mol Cell Biol 33 (16), 3150-3165 (2013)
   PUBMED   23754746
REFERENCE   2  (bases 1 to 12788)
  AUTHORS   Cox,B.J., Vollmer,M., Tamplin,O., Lu,M., Biechele,S.,
            Gertsenstein,M., van Campenhout,C., Floss,T., Kuhn,R., Wurst,W.,
            Lickert,H. and Rossant,J.
  TITLE     Phenotypic annotation of the mouse X chromosome
  JOURNAL   Genome Res 20 (8), 1154-1164 (2010)
   PUBMED   20548051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731764.11 and BX000698.11.
            
            On Jul 28, 2018 this sequence version replaced NM_001081477.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.10075084.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AL731764.11        57094-57341         c
            249-307             AL731764.11        56903-56961         c
            308-337             AL731764.11        56672-56701         c
            338-397             AL731764.11        56209-56268         c
            398-548             AL731764.11        48340-48490         c
            549-647             AL731764.11        47801-47899         c
            648-808             AL731764.11        28432-28592         c
            809-1030            AL731764.11        26977-27198         c
            1031-1131           AL731764.11        21750-21850         c
            1132-1202           AL731764.11        21024-21094         c
            1203-1303           AL731764.11        19741-19841         c
            1304-1344           AL731764.11        17297-17337         c
            1345-1449           AL731764.11        14140-14244         c
            1450-1603           AL731764.11        12728-12881         c
            1604-1738           AL731764.11        8642-8776           c
            1739-1867           AL731764.11        7107-7235           c
            1868-2093           AL731764.11        2891-3116           c
            2094-2261           BX000698.11        76183-76350         c
            2262-2445           BX000698.11        72763-72946         c
            2446-2539           BX000698.11        71247-71340         c
            2540-2689           BX000698.11        69457-69606         c
            2690-2766           BX000698.11        67675-67751         c
            2767-2932           BX000698.11        66822-66987         c
            2933-3046           BX000698.11        65885-65998         c
            3047-3154           BX000698.11        63066-63173         c
            3155-3279           BX000698.11        60009-60133         c
            3280-3362           BX000698.11        59172-59254         c
            3363-3474           BX000698.11        58235-58346         c
            3475-3536           BX000698.11        57807-57868         c
            3537-3692           BX000698.11        57542-57697         c
            3693-3813           BX000698.11        56785-56905         c
            3814-3939           BX000698.11        55620-55745         c
            3940-4018           BX000698.11        55456-55534         c
            4019-4075           BX000698.11        54282-54338         c
            4076-4216           BX000698.11        53352-53492         c
            4217-4288           BX000698.11        52176-52247         c
            4289-4441           BX000698.11        50754-50906         c
            4442-4605           BX000698.11        48625-48788         c
            4606-4703           BX000698.11        48167-48264         c
            4704-4862           BX000698.11        47219-47377         c
            4863-12788          BX000698.11        33781-41706         c
FEATURES             Location/Qualifiers
     source          1..12788
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X"
     gene            1..12788
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /note="bromodomain and WD repeat domain containing 3"
                     /db_xref="GeneID:382236"
                     /db_xref="MGI:MGI:3029414"
     exon            1..248
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..5617
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /note="bromo domain-containing protein disrupted in
                     leukemia"
                     /codon_start=1
                     /product="bromodomain and WD repeat-containing protein 3"
                     /protein_id="NP_001074946.1"
                     /db_xref="CCDS:CCDS41100.1"
                     /db_xref="GeneID:382236"
                     /db_xref="MGI:MGI:3029414"
                     /translation="MAAAPTQIEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPR
                     RLDWEGKEHRRSFEDLVAANAHIPPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGR
                     QSLLRDAKDCKSTLWNGSAFAALHRGRPPELPVNYVKPPNVVNITSARQLTGCSRFSH
                     VFPSSAYQHIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATL
                     RGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPST
                     KGTTRYLTSTGADGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFIT
                     TGSTDHVIRIYYLGSEIPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQ
                     YQQQEWKSIVLDMATKMSGNNLTSAEDKVTKLKVTMVAWDRYDTTVITAVNNFLLKVW
                     NSVTGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMI
                     EGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPLIR
                     DANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGYVA
                     NGDGEVVEQVIGQQTNDQEESILDGIIRELQREQDLRLINEGDVPHFPINRSYSVNGA
                     LSSPNMDIPSSPNIGLRRSGQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNELNSG
                     VSRVQEECRNAKGDLEVSLYTVEKKKKPSYPIQRNDYQPSCGRSLRRTQRKRQHTYLT
                     RSNIEHNSQASSQTSGVQEDSDSSSEEDETVGTSDASVEDPVVEWQSESSSSDSSSEY
                     SDWIADAGINLQPPKRQTRQATQKIYSSSEDENLKLEDRQKKPKQTKKKKGGLVSMAG
                     EPNEEWLAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKIYSVNLQKQP
                     WNKMDLREQEFVKIVGIKYEIGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMPDVID
                     FLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYSVHWD
                     NNEREKMSPWDMEPIPDGTAFPDEVGAGIPVSQEELTALLYKPQEGEWGAHSRDEECE
                     RVIQGINNLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIKQRLENRFYRRISAL
                     MWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCSDILDTYNKIKAEDPDS
                     SDLEEDSEMVDLDSDGPGTSSGRRAKCRGRRQSLKCNPDAWKKQCEELLSLIYEREDS
                     EPFRQPADPQSYPVQQQQEGESSQSVPPDRQDPSLSEDYQDGIDTPMDFSTVKETLES
                     GNYDSPLEFYKDVRQIFSNSKAYTSNKKSRIYSMTLRLSALFENHIKNIISDYKSAIQ
                     SQKRRRPRYRKRLRSSSSSLSSSRAPSPKGKQKQMKLQPKNDQNTSVAYARTSSPFSS
                     PVSDAAEGVSLYLLDDEGDGPFSPSSFSGYSRSGNSHDPGKAKSFRNRVLPAKQDHSL
                     DGPLTNVDGREPRTGAKRKLLSASEEDESMGGEEKEMKETKEQVHLSSSESGELGSSL
                     SSESTSGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQHTNGKRNWKTRGTG
                     GRGRWGRWGRWSRGGRGRGGRGRGGRGRGGGGGRGRGRGRGGRGASRGSSRAKRARVA
                     DDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRSGRVRK
                     MTEKARVSHLMGWNY"
     exon            249..307
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            308..337
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            338..397
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            398..548
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            549..647
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            648..808
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1030
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1131
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1202
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1303
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1344
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1449
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1603
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1738
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1867
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2093
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2261
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2445
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2539
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2689
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2766
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2932
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            2933..3046
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3154
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3279
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3362
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            3363..3474
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3536
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            3537..3692
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            3693..3813
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            3814..3939
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            3940..4018
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            4019..4075
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            4076..4216
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            4217..4288
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            4289..4441
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            4442..4605
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            4606..4703
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            4704..4862
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     exon            4863..12788
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6395..6400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /note="hexamer: ATTAAA"
     polyA_site      6427
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /note="major polyA site"
     polyA_site      6446
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /note="major polyA site"
     regulatory      10523..10528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /note="hexamer: AATAAA"
     polyA_site      10546
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /note="major polyA site"
     regulatory      11386..11391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /note="hexamer: ATTAAA"
     polyA_site      11406
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
     regulatory      11752..11757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /note="hexamer: AATAAA"
     polyA_site      11786
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
     regulatory      12763..12768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
                     /note="hexamer: AATATA"
     polyA_site      12785
                     /gene="Brwd3"
                     /gene_synonym="Brodl; D030064D06Rik; Gm10452; Gm596"
ORIGIN      
        1 gctctccttc ctcctccgcc tcctcagctc ttgggctaga atatctatgg gtcgaaacgt
       61 gatgcgatga atccgagaga gaccgaaact gggacgaaga gtgcggcgga agcggcggga
      121 ctcccaagca tgggggcttc accacaatag aggcagcgcc cccacccgcc cccgccagcc
      181 ctcctgagcg aagcccccaa accccctcgg gaaaaggatg gcggcggcac ctacccagat
      241 cgaagccgag ctgtattacc tgatcgcaag gttcttgcag tccggaccct gtaacaaatc
      301 cgctcaggtg ctagtgcaag agctcgaaga gcatcagctg attccgcgcc gcttagactg
      361 ggaagggaaa gagcaccgaa gaagcttcga ggatctggtg gcagccaatg cacacattcc
      421 tccagactac ctccttaaaa tttgtgagag gattggccct ttattagata aggaaatccc
      481 tcagagtgtt cctggggtac agacattact aggtgtcggt cggcagtctc tgttacggga
      541 tgccaaagac tgtaagagta cactatggaa tgggtctgct tttgcagccc tccacagagg
      601 cagaccccca gaactacctg taaattatgt gaaacctcca aacgtggtga atatcacctc
      661 agccaggcaa ttaaccggat gtagtcgctt cagccatgtt ttcccctcat ctgcttacca
      721 gcacattaag atgcataaga gaattctggg acacttatct tctgtctact gtgtagcctt
      781 tgatcgaagc gggaggcgaa tttttacagg ttcagatgac tgtttggtga aaatctgggc
      841 aacagatgat ggacgcctcc ttgccacact gcgagggcac tctgctgaaa tctccgacat
      901 ggctgttaat tatgaaaata ctctcattgc tgcaggcagc tgtgataaag ttgtgagagt
      961 atggtgtctt cgtacttgtg caccagttgc tgtccttcag ggacattcag cttctattac
     1021 ttccatacag ttttgtccat caactaaagg cacaactaga tacctcactt ctactggtgc
     1081 tgatggaaca atttgtttct ggcaatggca tgtaaaaaca atgaagttta gagatcgccc
     1141 agtaaaattt actgagagat ccagacctgg agttcagata tcttgttcat ctttcagttc
     1201 tggtggtatg ttcattacaa cagggagcac tgatcatgta attaggatat actatttggg
     1261 ttctgagata cctgagaaaa ttgctgaatt agaatcacat acggacaaag ttgttgctgt
     1321 tcagttctgt aacaacggag acagcttaag gtttgttagt ggaagtagag acggaacagc
     1381 aagaatatgg caatatcaac aacaagagtg gaagagcata gtgctagata tggctactaa
     1441 aatgagtggg aataatttga catcagctga agacaaagtc actaaactaa aggtgactat
     1501 ggtggcttgg gatcggtatg ataccactgt tattactgca gtgaacaatt tccttttgaa
     1561 agtttggaat tctgtcacag ggcagcttct tcatacttta tctgggcatg atgatgaagt
     1621 atttgttcta gaagcacatc catttgatca aaggatcata ctttcagcag gtcatgatgg
     1681 gaacattttt atttgggacc ttgaccgggg gaccaaaata cgaaattact ttaatatgat
     1741 cgaaggccaa ggtcatggtg cagtatttga ttgtaaattt tcaccagatg gaaaccattt
     1801 tgcctgtaca gactctcatg ggcatttgtt gctatttggc tttggatgca gtaaatacta
     1861 tgaaaagatt ccagatcaga tgttcttcca taccgattat cggcccctca tcagagatgc
     1921 caataactat gtattagatg aacaaactca acaagctcct cacctcatgc ctcccccatt
     1981 cttggtggat gtcgatggaa atcctcatcc tacaaaattt caacggctgg taccaggacg
     2041 ggaaaactgt aaagatgaac aacttattcc acagttagga tatgtggcta atggtgacgg
     2101 tgaggtggta gaacaggtaa ttgggcagca aaccaatgac caagaagaaa gcattcttga
     2161 tggaataatc agggagttac agagagaaca agatctcaga ttaattaatg aaggagatgt
     2221 tccacatttt ccaattaata gatcatattc tgttaatggt gctctgagta gtccaaatat
     2281 ggacatacct tcttccccaa atattggcct tcggcgtagt ggccaaattg aaggtgttcg
     2341 gcagatgcac aacaatgctc cccggagcca gatggccact gaaagagatc tcatggcctg
     2401 gagccgaaga gtggtggtga atgagctaaa tagtggcgtt agtagggtac aagaagaatg
     2461 tcgaaatgca aaaggtgacc tagaagttag tctttatact gttgaaaaga agaaaaagcc
     2521 atcttatcct atccaaagaa atgattatca gcccagctgt ggaaggtctt tacgaaggac
     2581 acaacgcaag cgacagcata cttacctaac aaggtcgaac atagagcata attcacaggc
     2641 atcatctcaa acttccggtg tacaagaaga ttcagacagc tcttcagagg aagatgaaac
     2701 tgttggcaca agtgatgctt ccgtagaaga ccctgttgtt gagtggcaaa gtgagagttc
     2761 ttccagcgat tcatcaagtg aatattctga ctggatagca gatgctggga taaatttgca
     2821 gcctcccaaa agacaaacaa gacaggcaac acagaaaata tacagcagtt ctgaagatga
     2881 aaatttgaaa ttagaagata ggcagaagaa acctaaacag actaaaaaga agaaaggggg
     2941 acttgtttct atggcaggcg aacccaatga agaatggctt gcccctcagt ggatcttgga
     3001 taccatacca cgacgttctc cttttgttcc acagatggga gatgagctta tttactttcg
     3061 acaaggacat gaagcttatg tgcgagctgt aaggaaatca aaaatctata gtgttaattt
     3121 acaaaaacag ccatggaaca aaatggatct cagggagcaa gaatttgtga agattgtagg
     3181 aatcaaatat gagattggac cacctacgct atgctgcttg aaacttgcat ttttggatcc
     3241 aatttcaggc aaaatgactg gagagtcttt ttccattaag tatcatgaca tgccagatgt
     3301 cattgatttc cttgtgttac atcagtttta taatgaagcc aaagaaagaa actggcagat
     3361 tggtgataga ttccgcagta taatagatga tgcctggtgg tttgggactg tggaaagtca
     3421 gcagcctttt cagccagaat atcctgatag ctccttccag tgttacagtg ttcactggga
     3481 caataatgaa agagaaaaaa tgagcccctg ggatatggag ccgattccag atggaactgc
     3541 ttttccagat gaagttggtg ctggtattcc tgtgtcccag gaagaactaa ctgcattgct
     3601 ctacaaaccc caggaaggag agtggggtgc tcattccaga gatgaggagt gtgaacgagt
     3661 tattcagggc atcaacaacc ttctttccct ggattttgcc agcccttttg ctgttccagt
     3721 ggatctcagt gcctacccct tgtattgtac tgtagttgct tatccaactg acctcaatac
     3781 catcaaacaa agacttgaaa atcgctttta caggagaata tcagcattaa tgtgggaggt
     3841 acgctatatt gaacacaatg ctaggacttt caatgagcca gatagtccca tagttaaagc
     3901 agccaagatt gtgactgatg tcctacttcg gtttattggg gatcaaagct gttctgatat
     3961 tttggatact tacaataaaa tcaaagcaga agatccagac agcagcgatc tggaggagga
     4021 ttcagaaatg gttgacttag attcagatgg tcctggcact tcatctggaa ggagggctaa
     4081 atgtcgaggc agacgacagt ctctcaagtg taatcctgat gcttggaaaa agcaatgcga
     4141 agagctactg agcctcattt atgaacggga agactcagag ccatttcgtc agccagcaga
     4201 tcctcaatct tacccagttc aacagcaaca agaaggggaa tcctcacaat cagttcctcc
     4261 agataggcaa gacccatctc tttctgagga ttatcaagat ggtatagaca cacctatgga
     4321 cttcagcact gtgaaagaaa ctttggaatc aggaaattat gatagtcctc tggaatttta
     4381 taaagatgtt cgccaaatat tcagcaactc caaagcttat acttctaata aaaagtcaag
     4441 gatctatagc atgacgctga gattgtcagc cttatttgaa aatcacatta aaaacatcat
     4501 ctctgactat aagtcagcaa tccagagtca gaagaggaga agaccacggt acagaaagcg
     4561 tctgagaagc agcagcagct cgttatctag cagcagagct cccagtccaa aaggcaaaca
     4621 gaagcaaatg aagttacagc ctaaaaatga ccagaatacc tcagtggctt atgccaggac
     4681 tagctctcct ttttcttctc ctgtttcaga tgctgctgaa ggtgtttcac tgtatctact
     4741 tgatgatgaa ggggatgggc ctttttctcc atcaagtttc agtggatata gtagaagtgg
     4801 aaatagccat gacccaggga aagccaaatc atttcgtaat agagttttac cagctaaaca
     4861 agatcactcc cttgatggac ctcttacaaa tgttgatggc agagagcccc ggacaggagc
     4921 caaaagaaaa ctgctcagtg cttcagaaga agatgaaagc atgggaggag aagagaaaga
     4981 aatgaaagaa acaaaggagc aagtacattt atcctcctct gagagtggag agttaggctc
     5041 cagtttaagt tcagaaagta cctctggctc tgactctgac tctgaatcca cttccagaac
     5101 cgatcaagat tatgttgatg gagaccatga ctatagcaaa ttcatacaaa ccagacctaa
     5161 aaggaaactc agaaaacaac acaccaatgg aaaaagaaac tggaagacga gaggcacagg
     5221 aggaagaggc agatggggaa gatggggaag atggagcaga ggaggcagag gaagaggtgg
     5281 caggggtcga gggggtcgag ggcgaggtgg aggtgggggg agagggagag gacgagggag
     5341 aggaggaaga ggtgcctcta gaggatcaag ccgagccaaa cgagcccgag ttgcagatga
     5401 tgaatttgat acgatgtttt caggacgttt cagtcgactt ccacggatta aaacaagaaa
     5461 ccaaggcagg agaactgttt tatataatga tgattcagat aatgacaact ttgtgtccac
     5521 tgaggatcct ctgaatcttg gtacatccag atcaggcaga gtacgtaaaa tgaccgaaaa
     5581 agccagggtt agccatctca tgggatggaa ttattaacag ttaaagattt taaaataatt
     5641 tttaaaaata aaatcactgg ccttctactg cagggaattt atcagaaaat ctacaaagca
     5701 agttgtgtgg ggacttctgc ttcctttcac attggtgctt ttccattatg ccagtataca
     5761 tttgtttcaa gacttttaat ctccacactt catttgttca aacaagcctt actcattagg
     5821 ccttaaatta aaacaaattc tgcccacaca tatatgtgtg tgcacataca catgcacgga
     5881 catgcgctca ctcgcgcaca cacatacaca caacatacac acacacacat acacaccaca
     5941 gacacactac agatttacta cattaaagga gcattctgct tcttaagagt agcatgacat
     6001 ttttatctca ataagatatc cctctttgct tttgtatcac agaagtatag caccttctta
     6061 cagagtttta tatagtttgt ttttgccatt ttgattccta tgcccagtaa taataacttt
     6121 tgcacaatac accaatccta aaggcagcta ttaaatgttt acagtttcta tattgtaaga
     6181 acgatctgga ttattttact cttcccaggc caaactttca tgaactgtac tgaactgaag
     6241 tatatattta tactgcagtt ttggggtggg gtggggggta tcttgatatg cttttcattg
     6301 atttgcttaa ttcacgttta aggtgagaaa gggttggtgc cttgtaaata tgtagcaaat
     6361 cattgtggtg tgtcctgatg tgtgcattaa ctttattaaa agagtatact tgaggtatcg
     6421 atctagacaa ggtgccaaat gcaaaagttt cttgcatcca tttttctttt cctgttatat
     6481 tttattgcat taatagaact tgtgtagctt aaacgtaact taaacatttg aaaaaaaaat
     6541 cctcatccac aaagaataac ttctttgaaa cagtagctca gctacctcta ttaactacaa
     6601 ctactggaaa tgctaaggaa aatagatgct gttactcatt actaaggaga aatagaacaa
     6661 gctttgtagg gatgaatact cctaagttat aagctgagac ttctcaataa tcatattggc
     6721 tctcaaatta atagttgtaa ttaaccagct ttcctaagtg ttatatgctc taggctttta
     6781 tagaacatat ttgtgtaagt agacttgctc tactgcatag atttctctgc taccacttat
     6841 ctaacagctg tgagttactg gttttcattt gaatcttaaa tagtatcaaa gtacctaact
     6901 tgagctggaa tattttggct agctaatact tggaagcaac tttaataggt tcttctgttc
     6961 tcattccaaa gggttcttct gttctagact tccagaaaag agcctcattg cactgcaaac
     7021 agatattttg aatcgttatt ttatagttga aaaacaaaac aaaaaaaaac gtttaaaatc
     7081 atgtatggtc ttgtttacag caatagagtg cacgtgattc cacaagcgag cttcagttcc
     7141 aagatcaatt ttattcctca aatttgagat agcagatgtg ctacgttgtt acataaattc
     7201 ttgaagttgg agggggataa tagttgatct ctgcttttgt aacagcagtt ttgttacacg
     7261 tagatcagac agacttgtgt gataaaacat tttcttaatg tatgcctggt aatccaggac
     7321 atttcttaag ctgatgtgtt tgtctcatgc ttttaatcat ttcatgcatc tgaaaatctg
     7381 ttaagtgcag aggaaggagt acacacataa ctttgcttat tggtggggtt gggggtttat
     7441 tcttgaatta atacccttaa gcaattttca cttgcagtag aaatgatgtt caggctttaa
     7501 gaaaatataa tgaactgtta atggcactaa tgtctgttgc tagagagcag accaagctga
     7561 tatttttgtt gtttttcttc actataccaa aactatttct ggttataaac tcaactgcca
     7621 ttttagccat agtatagagt caaactgttc ccatttgaga gtctacattt gattttttta
     7681 ttaaaatata ctatttcagt tattcatctc ttgggcattt agactaaatt gtgcctgtgt
     7741 tttcctggag tcagtaacat tttgtcctat aacaatcaac atactatagt tgcttaaatt
     7801 cctggttata cccaaatgta tatcatgtgt accattttag tatgaaattt tggttgacat
     7861 tcttctatga agagctgatt cttgagatgt agaagaattg tcatttgtgt gatattagca
     7921 gtctggagct ttatttataa tttattttga aaaataaaaa tgccacattt attccccaaa
     7981 tgtcaagatt ttctaggctt acataattag aataataagg ctaaagacat ttttaagcat
     8041 attttatatg tagtgaaata ctgtgaaata ctagtgaaca gcattttgct gtgatgttga
     8101 tttcagtcat tagaatttaa agagttagtc accagggtat ggtaggtgag catagttatc
     8161 atttattata aatcaaacag atacttttct gtttgcatgc aaactatttt cataagtgtg
     8221 aaaaaggtct ggaaaataat atttttactt ttttaatctg gacttccctt tccccaattt
     8281 atattttagt ttttttaata ccacttccta caaatgtgtc ataatttgta tcatattgaa
     8341 tacttttatc atttcagttt tctagagagc ttttaaacct aaataagatc tgggttcagc
     8401 catagcaaag aaagtaggaa atgagttaag aattctgcac atgaagacca ctgttaggcc
     8461 catgaaaaca cacacatgta gagctttaat cctgtgctat atctgaatag tcagtaagct
     8521 ataatatttc atgaatgcta gtgttcagat tccaagcttc atgaccttag catgtgtaga
     8581 tgtttataaa attgaatcat gtgtttcttc tctggcttgc tgtacatatc tcagctagca
     8641 ataggaggct ctccaaaaca tgcacaaacc cactagccta atgactaaat ttgtttttgt
     8701 aaaagtcttt gtgtgcttgt atgtatgtag cttttttcta gtttgacata ccttatccca
     8761 gacattaaaa agagagacta ttttcgatgg aggacactgt ctaccaatta tttgcctctt
     8821 tagagctcag cctgtgcatt tcttagcgct taatcatcca tgtcattatg tcttctagat
     8881 gacaattttg gttttgtcac gtgtgtccct cttttctttt catttaattt tggtctttca
     8941 tttgtttgta ttttctcttt ccctccccag aaatcaggct tattctagaa attgttccta
     9001 aggtgcttcc tttgctccag aggcaaagga actgagtaaa atgctgaagt ttccctctac
     9061 acactttagt tctcctatac ctaaattagc tttcagatgt tgtaaattcg agtgatttat
     9121 catttggttt tgttttaatc atgtagattg tcatcagaca atacagtgat taaaagagaa
     9181 agatgtgaat gccacttcta acttttgaat aaaacttttg gagcattttt taaaatgtgc
     9241 aagtttgtgg taatgataca caccttacta tatatggaat cattttatgc acagttgcca
     9301 actggtactt ctttaaagct gcattttcat gccctcaaaa aggaatctta aaacatgcta
     9361 ttttcactac attttggtgt tcagcctttt aagcatgtac aataacattt gaaagtccaa
     9421 aattaatagt tctgggggaa ggaatagggc ttttgatatt taaagtcttt tattttaaat
     9481 gctaaccaca ttcaccaaca tcttggtggc agccgaggct ttatgaatgt tactgaaaat
     9541 attctaagat cattttttaa ggcttgtttt taaaattcat ggtgaaatat tgcatgctgt
     9601 tttttttttt ctttacatct cttaacaccc aaatgttaat ttaccacatt tacaaagttt
     9661 gagttaagat ccaattaaag tgaaaggttt ttatggtgct gtattttatg gaacatggag
     9721 agcactcagg tttcttgata tttattcctt gctatggtct tataatcctt aaatatttct
     9781 tttgtagtct ttcttcttgg gcttgctctt atatctacgt cttttcatta ggaagactgt
     9841 acttaaccag catacttcaa tcagactgga aatttcacat tcattccaga gagaaaaaaa
     9901 aataggccct ccagtttaga gttaaggtgt gtttatttat atgtatgccc atttcttatt
     9961 cttatatcta tcttaattaa atctagaata tgggacttag acatataaaa gcatggtaat
    10021 tattttctaa aaatataaaa ttattgatac accttcagat cgccattgat acttttaaaa
    10081 tcccatattg aaatatccag aaacccagtt ggaaaatgtg tttttgcata tgtcaccaaa
    10141 tatacattag gcagtactac aaatgttaac tttttaaaca ataccatggt gatggcaatc
    10201 agtaatttat ttctttgttc tgtaacttat catccatgtt ttttgtaatc ctttatacag
    10261 tattaacaaa actgtacttt atgtttgttc ttagtgtcca taaattttta agtggaaaac
    10321 attcagttaa tagttgatgt gctgttgtgt atgggcagaa tgtccattaa actaaaaaat
    10381 tcagtggaga agaaaggtaa acaaaactgg cttggtttat aaaagatgtt ttgtttggca
    10441 gttgtgggtc attataagca attactttca aagacaaaaa atactggact aaatttgttg
    10501 ccattcttta tgggatgttt acaataaaat tccaagttgt ttggaatcag ttgcactctc
    10561 gctgctttat gccttaattc atactagaga taaattaaca agacgaaaga attataagaa
    10621 ctacgaagtt aacctttcga actatccagc tttagagatt gtatcatgta atctgtgggt
    10681 cttcttgtca taagatattt tattatcatt ttttttttaa ttcttagaaa ctgagttgct
    10741 tcctatgaaa gaaaagatgt ttccttttct tgctgatatt ctttggatca cctttaggta
    10801 atcaatatga tggtaacact ttaaaatttg ggctgcttgg tgccttaaat agcagcccca
    10861 agcactcgta agttctttat tcggcagagc ttcttgagtt ggttagattt cgaatatact
    10921 tgctgttaaa ttttaacagc tgagctatgg atacccagtg ttttttattt gaggttaaat
    10981 tgcctgttga ctatgaattt attataaatg gtgctttaac ttgatgtaaa tctaggaggg
    11041 agagaaatga attgagctgg ggtctgaatg ttttactagg aacactcatc cttggcctta
    11101 aatctatacc ctcaagtttt ctcccaatgt caaggattct actgagttca agataaataa
    11161 gcttccaaaa gactggtccg catcttttat atgtagcttg tctgttttgt gtttttagaa
    11221 ttgagaagag tttttgaata gttcacctct cttctggcat tagatcagct gactgacagc
    11281 ccaattttca caatacccag attgaggtca gggtatattt gtgttatttt tgtttagctg
    11341 tttgactgct ttaaaataac ctcttttatt atgtgaatat gttacattaa aaattctttg
    11401 ttagaaggct ttcgtatttt atttacccgc tagatttctt aaatggaaaa attaaagaat
    11461 tcttatgaca aaactttatt gaagtattca gaagattgtt tgcctcattg agaagatcaa
    11521 gggggaagag tgccctttgc tttctatatt atttatcact tactccttaa agctactttc
    11581 caaaaatgca caaaataaat tgaaactaat acgttgagct tgtgagttaa tttttaaatg
    11641 ggatttttgg tgctatattt aaactcattt cctgtcttaa gatttttata taagtactta
    11701 aagcattttt atgatgcata ttgctggtag accaaatata acattaaata aaataaatat
    11761 tttatggtat tatttttccc caaaaatttg gagtgacttt tctcgttttg taacttttta
    11821 gttacctctc cttttccatc tgtagtacct gacttaataa agttccttct cacctgcaga
    11881 atataaacat ctcgtagcta attttagcaa aagtgttagc atactaatct ttcggcatat
    11941 attaaggact ttcaaaactc tgtcatgcta ttatgctttc actaatttgt aaaattctac
    12001 ttaatgcctg ctcagtgccc ttagaatttc caattttata aaatttctca caaacatttt
    12061 aagtaataaa agcatttcaa atcatttaat acaagctact aatattgata agtattttat
    12121 tcattcttag tggtgttttg tggatcattt ttgtcctgtt taaattccaa ctagaatttg
    12181 tacggtagta cgtaatttgt actaggaatt ttgtgtactc tgtcaagtac ttcgtggaga
    12241 gaaaacttgt cataagttgt ttctagtttt ttttttttgt tttgttttac aaaatgtcag
    12301 tttcaatgaa atatgcctcc caaattgtgt actacccatt ttaacaggag attttgttat
    12361 ccttgggtac tgttcattta aaatgtcaat aactaagtgc tgatagttct ggattgtttc
    12421 catatgttaa gttttaattt atgaacgaga gccacccttg tatgcaaaaa cataactgtt
    12481 atttgttcta gtctgacctc ataacatatc tcctccttga cagttttagt tactaaatct
    12541 tttatcacat tatttctaat tgttcaactc aaaattgtca gggactgaat cacattcttg
    12601 ctctgcagtt gtatgatgat gttcttccta tataatatct accagctggt gtttgtagcc
    12661 tgtattggac tgtacctccc tgggattgtt catctgtacc ttctgtgttt taagcactgt
    12721 aatttttaaa agagctttag agtttacgaa atttattcct caaatatagt cttaatcacc
    12781 agaaagac
//
