LOCUS       NM_145125               8547 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus bromodomain and WD repeat domain containing 1 (Brwd1),
            transcript variant 1, mRNA.
ACCESSION   NM_145125
VERSION     NM_145125.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8547)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8547)
  AUTHORS   Fulton,S.L., Wenderski,W., Lepack,A.E., Eagle,A.L., Fanutza,T.,
            Bastle,R.M., Ramakrishnan,A., Hays,E.C., Neal,A., Bendl,J.,
            Farrelly,L.A., Al-Kachak,A., Lyu,Y., Cetin,B., Chan,J.C.,
            Tran,T.N., Neve,R.L., Roper,R.J., Brennand,K.J., Roussos,P.,
            Schimenti,J.C., Friedman,A.K., Shen,L., Blitzer,R.D., Robison,A.J.,
            Crabtree,G.R. and Maze,I.
  TITLE     Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn
            mouse model of Down syndrome
  JOURNAL   Nat Commun 13 (1), 6384 (2022)
   PUBMED   36289231
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8547)
  AUTHORS   Hildebrandt,M.R., Wang,Y., Li,L., Yasmin,L., Glubrecht,D.D. and
            Godbout,R.
  TITLE     Cytoplasmic aggregation of DDX1 in developing embryos: Early
            embryonic lethality associated with Ddx1 knockout
  JOURNAL   Dev Biol 455 (2), 420-433 (2019)
   PUBMED   31330130
REFERENCE   4  (bases 1 to 8547)
  AUTHORS   Schimenti,J.C. and Handel,M.A.
  TITLE     Unpackaging the genetics of mammalian fertility: strategies to
            identify the 'reproductive genome'
  JOURNAL   Biol Reprod 99 (6), 1119-1128 (2018)
   PUBMED   29878059
  REMARK    Review article
REFERENCE   5  (bases 1 to 8547)
  AUTHORS   Mandal,M., Maienschein-Cline,M., Maffucci,P., Veselits,M.,
            Kennedy,D.E., McLean,K.C., Okoreeh,M.K., Karki,S.,
            Cunningham-Rundles,C. and Clark,M.R.
  TITLE     BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis
  JOURNAL   Nat Commun 9 (1), 3888 (2018)
   PUBMED   30250168
  REMARK    GeneRIF: Study data indicate that, in both mice and humans, BRWD1
            is a master orchestrator of enhancer accessibility that cooperates
            with transcription factor networks to drive late B-cell
            development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8547)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   7  (bases 1 to 8547)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   8  (bases 1 to 8547)
  AUTHORS   Ramos,V.C., Vidal-Taboada,J., Bergonon,S., Egeo,A., Fisher,E.M.,
            Scartezzini,P. and Oliva,R.
  TITLE     Characterisation and expression analysis of the WDR9 gene, located
            in the Down critical region-2 of the human chromosome 21
  JOURNAL   Biochim Biophys Acta 1577 (3), 377-383 (2002)
   PUBMED   12359327
REFERENCE   9  (bases 1 to 8547)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 8547)
  AUTHORS   Pletcher,M.T., Wiltshire,T., Cabin,D.E., Villanueva,M. and
            Reeves,R.H.
  TITLE     Use of comparative physical and sequence mapping to annotate mouse
            chromosome 16 and human chromosome 21
  JOURNAL   Genomics 74 (1), 45-54 (2001)
   PUBMED   11374901
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK051870.1, AK030493.1, AJ292467.1, CF162350.1, CV558558.1,
            AK027961.1 and AW542089.1.
            
            On Sep 7, 2007 this sequence version replaced NM_145125.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ292467.1, BC145265.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164131,
                                           SAMN01164132 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-475               AK051870.1         23-497
            476-1310            AK030493.1         477-1311
            1311-3026           AJ292467.1         1316-3031
            3027-3518           CF162350.1         112-603
            3519-4009           CV558558.1         279-769
            4010-7634           AJ292467.1         4015-7639
            7635-8191           AK027961.1         527-1083
            8192-8547           AW542089.1         1-356               c
FEATURES             Location/Qualifiers
     source          1..8547
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 56.77 cM"
     gene            1..8547
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /note="bromodomain and WD repeat domain containing 1"
                     /db_xref="GeneID:93871"
                     /db_xref="MGI:MGI:1890651"
     exon            1..175
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..7041
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /note="isoform A is encoded by transcript variant 1; WD
                     repeat domain 9; bromodomain and WD repeat-containing
                     protein 1; WD repeat-containing protein 9"
                     /codon_start=1
                     /product="bromodomain and WD repeat-containing protein 1
                     isoform A"
                     /protein_id="NP_660107.2"
                     /db_xref="CCDS:CCDS49923.1"
                     /db_xref="GeneID:93871"
                     /db_xref="MGI:MGI:1890651"
                     /translation="MAEPSPARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQ
                     YQLLPKRLDWEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEVPPSISRVTS
                     LLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGPPPSLVEIHRGRQLTG
                     CSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNG
                     RLLSTLRGHSAEISDMAVNYENTLIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSL
                     QFSPMAKGPQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSV
                     GGMFLATGSTDHVIRMYFLGFDAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTA
                     RIWRFEQLEWRSILLDMSARISGDTSSEEERFMKPKVTMIAWNQDDSTVVTAVNDHVL
                     KVWSSYTGQLLHNLLGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGIKMKHYF
                     NMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKPYEKIPDQMFFHTDYRP
                     LIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENSADEHLVPQLG
                     YVATSDGEVIEQIISLHTNDSGDASPESSVLDGMIRQLQQQQDQRLGVDQDGTANGLP
                     SGEGTPRRGSFRRLSLDIQSPPNIGLRRSGQVEGVRQMHQNAPRSQIATERDLQAWKR
                     RVVVPEAPPGMFRRLEDIRIERGEEERNLYVIGRKKKTFQVPQKSNSMVLVSQSRQRT
                     CRRKYANYSRRNADQCELSSGNESSGSVRHETSYDQSEGSCSSEDDEWRNDRRSGSDS
                     DSSSDSSSQYSDWTADTGINLQPPLRMSCRRRVTRFCSTSEDEMSMENISPPKRRRKR
                     RKESKPKRESLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQMGDEVMYFRQG
                     HEAYIEAVRRNNIYELNPHKEPWRKMDLRDQELVKIVGLRYEVGPPTLCCLKLAFIDP
                     ATGRLTDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQPCDRFRSIIDDAWWFGTVL
                     SQEPYQPQYPDSHFQCYIVRWDNTETEKLSPWDMEPIPDNVDPPEELGASISVTSDEL
                     EKLLYKPQEGEWGQRSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTVVAY
                     PTDLYTIRMRLVNRFYRRLSALIWEVRYIEHNARTFNEPESVIARSAKKITDQLLKFI
                     KNQDCTNISELCNTSDNDEDDSADDLDDSDLPKTSSGRRKVHNWKRRSRASGCIESDW
                     RRQCKALLILIFQCEDSEPFRQPVDLDEYPDYRDIIDTPMDFGTVRETLEAGNYDSPV
                     EFCKDIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISFDFKIGQKFKEKLRR
                     SQRFKQRQNCNGAVPGDRRRRNVKQKQFKSQTKVIPQLMCPPSQSTSSKVPLSATRKT
                     SAGVSSGFTSGDSSDSAGSLERVRRQRPEVLRSGSVLFGSEMEDFLATSSSSSASNSS
                     EESKASPGARESSLRSGVLRGSNLGVTRTRAARRKAGSVSLENGCGRKATRKRVYLSD
                     SDNNSVETDENLKNRKCGSSRKVLRKCAAVAASKIKLMSDAEDSSSESPCSGRKLPHR
                     NASAVARKKLLHNSDDQSLKSETEELKDQNQSLLISGPHSVHNSISDSESDSDLRATR
                     KTWNANGCTSHTAATCKTKSRPIESSEEDSRCHGSDHGPSSTGDPSTSGQKLRADSIS
                     EEADSEPESSVLCKNTHLCKKAKILSDSEDCEEKCGERRGPEVEGSPVSEALREAILA
                     PQCLSHRGSETDVDSDGGAVREKSYSNENGSVSLENGQRRKVSRKSSSDKESNLQVTQ
                     KSPKDRSSPSRITQRASVATDKMKLTSDAEDLSLESVCTRSKRRRKKPARFACTPAKT
                     ALSSEEKHAHCEVPEAQPACRNKLPEPEHQDSAENPSQAASADLNSGGGSSFEQRKSI
                     QSRQMGAVCVRPPPKTQSSSAGLSQENARSQTLDSETSLPSESVLTQKATVESNFEEE
                     LNYGLRRWNGRRLRTYGKAPLSRTAQVTPSLQASAEVGVKRRRMHPEVDGEDVPGQMG
                     SSGCGPDTSPKASDLGSVTDSDVDCTDNTQTQRKKKRKGKARVLSKESVRKDREPHTK
                     MRPCMLNEKDAVQMHSDTLKAKTVPEKVPRRCATVAANKIKMMCNLKEVVSGPENVGI
                     RTISRKLPYRQASAAAKKKLLSVYKEDDAPIHSENEKELYLRRFRSRKEKAQPTPR"
     exon            176..234
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            235..264
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            265..324
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            325..475
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            476..574
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            575..735
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            736..957
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1058
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1129
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1230
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1271
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1370
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1521
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1656
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1785
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..2011
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2200
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2384
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2478
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2610
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2705
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2895
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3021
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3129
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3254
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3337
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3449
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            3450..3511
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3667
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            3668..3788
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            3789..3914
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            3915..3990
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            3991..4032
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            4033..4176
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            4177..4329
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            4330..4496
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            4497..4723
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            4724..4891
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            4892..5740
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            5741..6661
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            6662..8547
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8168..8173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /note="hexamer: AACAAA"
     polyA_site      8193
                     /gene="Brwd1"
                     /gene_synonym="5330419I02Rik; D530019K20Rik; G1-403-16;
                     repro5; Wdr9"
                     /note="major polyA site"
ORIGIN      
        1 gcgcacggca tggcggcggc ggcgcgcgcc tgaggagctg ggggtacgcc ggcccggtca
       61 ggcctcggcg cggcctacgc gctccacttg ttcgctggtc cgctcgctcc cgcccggcgc
      121 cccgccatgg cggagccttc gccggcccga cgtccggtgc ctctcatcga gtcggagctg
      181 tactttctca tcgcccgcta cctctcagct ggcccgtgtc gccgagcggc gcaggtgctg
      241 gtgcaggagc tggagcagta ccagctgttg ccgaagaggt tggactggga gggcaacgag
      301 cacaacagga gctacgagga attggtcttg tccaataaac atgtggctcc tgaccaccta
      361 ctacagatat gccagcgcat cggtccgatg ctggataagg aggtcccgcc cagtatctca
      421 agagtcactt ctttgcttgg tgcaggaagg cagtctttgc tacgaacagc aaaagactgc
      481 aggcacacag tgtggaaggg ctctgccttt gctgctcttc acagaggaag acctcctgaa
      541 atgcccgtca attatggccc cccaccgagt cttgtggaga tacaccgagg aaggcagctc
      601 acagggtgtt ccacttttag cacagcgttc ccaggaacta tgtaccagca tataaagatg
      661 cacaggagga ttcttggaca cctgtctgca gtgtactgtg tagcatttga taggacagga
      721 catagaatct ttacaggttc agatgattgc ttggtaaaga tttggtcaac acataatggc
      781 cgcttgttgt ctacgttaag aggccattct gcagagattt cagacatggc tgtgaactac
      841 gagaacacgc tgattgctgc aggaagctgt gataagatca ttagggtgtg gtgcttgagg
      901 acctgcgccc cagttgctgt gctgcaagga cacacggggt caatcacatc tctgcagttt
      961 agcccgatgg ccaaaggacc tcagcggtac atggtttcta cgggcgctga tggcactgtt
     1021 tgcttctggc agtgggattt agagtccttg aagttcagtc cacgacccct gaagttcacg
     1081 gaaaagccaa ggcctggtgt tcagatgctg tgttcttcat ttagcgttgg tggtatgttt
     1141 ttagctacag gtagtactga tcatgtaatc agaatgtatt ttttgggatt cgacgcacct
     1201 gaaaaaatcg ccgagcttga aagccacact gacaaagttg atagtatcca gttttgtaac
     1261 aatggtgacc ggttcttaag tggtagccga gatggaacag cacggatctg gaggtttgag
     1321 cagttggaat ggagaagcat tttactggac atgtctgcca ggatctcggg agacacatct
     1381 tcagaagaag agaggtttat gaaacccaaa gttacaatga ttgcttggaa ccaggatgat
     1441 agcaccgtgg tcacagccgt gaatgatcat gtcctcaagg tgtggagttc ctacactgga
     1501 cagctgcttc ataacttact gggacatgct gatgaagtgt ttgttttgga gacacatccc
     1561 tttgattcca gaattatgtt atctgcagga cacgatggca gcatatttat atgggatatt
     1621 acaaagggca tcaagatgaa gcattacttt aatatgatcg aaggacaagg acatggagct
     1681 gtgtttgact gcaagttttc acaggatgga caacattttg cctgtacaga ttctcacggg
     1741 catcttctga tatttggctt tggatgcagc aagccatatg aaaagattcc tgatcagatg
     1801 ttttttcata ctgactaccg accactgata agagattcca ataactatgt cttggatgag
     1861 cagacacagc aggcacctca tcttatgcct ccaccattct tggtggatgt ggacggaaac
     1921 cctcatccaa ccaagttcca gagattagta ccaggtcgag aaaactcagc agatgaacat
     1981 ttggttccac agctaggcta tgtggccaca agtgatgggg aggtgattga acagattata
     2041 agcctgcata ccaacgacag tggagatgca agcccagagt ccagcgtctt ggatggcatg
     2101 attaggcagc tgcagcagca gcaagaccag agactgggag tggatcagga tgggactgca
     2161 aatggacttc ccagtgggga agggacaccc cgaagaggga gttttagaag actgagttta
     2221 gacattcagt ctcctccaaa catcggtctc cgtcggagtg ggcaggttga aggtgttcgt
     2281 cagatgcatc agaacgctcc tcggagtcag attgctacag agcgtgacct ccaggcttgg
     2341 aagcggagag tagttgttcc agaggcaccg cctggcatgt tcaggcggtt ggaagacatt
     2401 cgcatagaga gaggcgagga ggagaggaac ctgtatgtaa tagggagaaa gaagaagact
     2461 ttccaggtcc cacaaaagtc caattcgatg gttttggtgt cccagtctag acaacggacg
     2521 tgtaggcgta aatatgcaaa ttatagtaga agaaacgctg accagtgtga attatcttct
     2581 ggaaatgaat cttcaggctc tgttagacat gagacatctt atgatcagag tgaaggttct
     2641 tgttcttcag aagatgacga gtggagaaat gacagaagaa gtggtagtga cagcgacagc
     2701 tcaagtgact cttcatctca gtattctgat tggacagctg acacggggat caacttgcag
     2761 cctcctctca ggatgtcatg tcgtcgtcga gtaactcgat tctgcagtac ttcagaggac
     2821 gaaatgtcca tggagaacat atcacctcct aaacgaaggc ggaaaagaag gaaagaaagc
     2881 aagcctaaga gggagagttt acgaaggatg actccagcag aacttgcaaa tatggaacac
     2941 ctatatgagt ttcaccctcc tgtgtggata acggacacca cacttcggaa gtctcccttt
     3001 gttcctcaga tgggtgatga ggtgatgtac ttccgtcagg gtcatgaagc ttatattgaa
     3061 gctgtcagaa gaaataacat ttatgaacta aatcctcaca aggagccatg gaggaaaatg
     3121 gatcttaggg atcaagaact ggtcaaaatt gttggactaa ggtatgaggt tggaccacct
     3181 acactttgtt gcctcaaact agcatttata gatccagcga ctggcagact gacggataaa
     3241 tctttctcta ttagatatca tgacatgcca gatgttattg attttcttgt gttgcgccaa
     3301 ttttatgatg aagcaagaca gagaaactgg cagccttgtg acagatttcg atctataatt
     3361 gatgatgctt ggtggtttgg aaccgtgttg agtcaagaac cgtatcaacc ccagtatcct
     3421 gacagtcact tccagtgtta cattgttagg tgggacaaca ccgagactga aaagcttagc
     3481 ccttgggaca tggaaccgat tcctgacaat gttgatcctc cagaagaatt gggagcaagt
     3541 atctctgtca cttcagatga gctagagaaa ttgctctaca aaccacaaga aggagaatgg
     3601 ggccagaggt caagagatga ggagtgtgat cggatcatca gtggcataga ccagctttta
     3661 aacctcgata tagcagcagc gtttgcaggc ccggtggatc tgtgcacata tcccaagtac
     3721 tgcacagtag tggcttatcc aactgatctc tacacaattc gaatgaggct tgttaatcga
     3781 ttttacaggc ggttatctgc attaatttgg gaagtccgat atatagagca taatgcaaga
     3841 acgtttaatg aaccggaaag tgtaattgca agatcagcta aaaaaataac tgaccagctt
     3901 ctgaagttta tcaagaatca agattgtaca aatatatcgg aactatgtaa cacttctgac
     3961 aatgatgagg acgacagtgc tgatgatttg gatgatagtg atcttcctaa aacgtcttct
     4021 ggaagaagga aggtccacaa ctggaaaagg aggagtagag ccagtggctg tattgagagt
     4081 gactggagga ggcagtgcaa ggccctgctt atcctcatct tccagtgtga ggactcggag
     4141 ccctttagac agcccgtgga cttggatgag tacccagatt accgagatat tatagatacg
     4201 ccaatggatt ttggaacagt aagggaaact ctagaagctg ggaattacga tagccctgtg
     4261 gagttttgca aagacattcg attgatattt agcaatgcaa aggcatatac accgaacaaa
     4321 agatcaaaga tttatagtat gaccttgaga ttgtctgctt tgtttgaaga aaaaatgaag
     4381 aaaatctcct ttgattttaa aattggtcaa aaattcaagg agaaacttcg tagaagccaa
     4441 agattcaagc aacgacaaaa ctgtaacggt gctgtccctg gtgacaggcg caggagaaat
     4501 gtcaagcaga agcagttcaa atctcagaca aaagtaattc cacagttgat gtgtcctcct
     4561 tctcagtcta cctcaagtaa ggtacctttg tctgcaaccc gcaagacaag tgctggtgtc
     4621 tcttcaggct ttacttctgg ggactcttca gactctgcag gatctttaga aagagtcaga
     4681 agacagaggc ctgaagtact caggagtggt tctgtgctgt ttggaagtga aatggaagat
     4741 ttcttagcta cctcttcatc ttcttcagct tcaaacagtt cagaggaaag caaagcgagt
     4801 cctggagctc gagaatcttc cttgcgcagt ggtgtgttga gaggcagcaa cctcggggtg
     4861 accagaacaa gagctgctcg gaggaaagct ggttctgttt ctttagaaaa tgggtgtggt
     4921 agaaaagcca ctcggaagag agtctattta agtgattctg ataacaattc agtggaaaca
     4981 gatgaaaatc tgaaaaatag aaaatgtgga agtagccgga aagttctgcg gaagtgtgct
     5041 gctgttgctg ccagcaagat aaagctgatg agtgatgcag aggattcgag ctcagagagc
     5101 ccctgctctg ggcggaagct gccacatcga aacgcttcag ctgtggccag gaagaagttg
     5161 ctacacaact ctgatgatca gagccttaag tcagagacag aagaactgaa agaccagaac
     5221 caatcactgt tgatatccgg tccccattct gtccacaaca gcatcagtga ctcagagtca
     5281 gacagtgact tgcgagcaac ccggaagacc tggaatgcta acggctgcac atcccacact
     5341 gcagcaacat gcaaaaccaa gtcacgtcca atagagtctt ctgaggaaga ttccagatgt
     5401 catggatctg atcatgggcc cagcagcact ggggaccctt caacatctgg gcagaaactc
     5461 agggcagata gcatctctga ggaagctgac tctgaaccag aaagcagtgt actatgcaag
     5521 aatacacatc tgtgtaagaa agccaagatc ttgagtgact cagaagactg tgaggaaaag
     5581 tgtggagaaa ggagaggtcc tgaagtggaa ggaagcccag tttctgaagc cttgagggaa
     5641 gccattcttg ccccccagtg tctctcacat cgtggatctg agactgatgt ggattctgac
     5701 ggcggtgcag tgagagagaa atcatacagc aatgaaaacg gatctgtatc actagagaat
     5761 ggacaaagaa gaaaagtttc ccgaaaaagt tccagtgaca aggaaagtaa tctacaggta
     5821 acccagaagt cacccaaaga cagaagcagc ccctcgagga ttactcagcg tgctagtgtg
     5881 gctactgata aaatgaagct cacaagtgat gcagaagacc tcagcctaga gagcgtgtgt
     5941 actcgaagca aaaggagaag gaaaaagcct gctcgatttg cttgtacccc agcaaagact
     6001 gcattgagta gtgaggagaa acacgcacat tgtgaagtgc ctgaggcaca gcctgcctgc
     6061 aggaacaagc tccctgagcc tgaacaccaa gatagtgcag agaatcccag tcaggctgca
     6121 agtgcagact tgaattctgg agggggttcc agttttgaac aaagaaaaag catacagagc
     6181 aggcaaatgg gcgctgtctg cgtaaggcca cctcctaaaa cccaaagctc ctctgctggg
     6241 ctttctcagg aaaacgccag aagccaaacc ctagatagtg agactagctt gccttctgag
     6301 tcggttttga cccagaaagc tactgtagag agtaactttg aagaagaact gaactatgga
     6361 ttaagaaggt ggaatggcag aaggctcagg acatacggga aggccccact cagtaggaca
     6421 gcacaagtta ctcccagttt acaggcctca gcagaggtcg gggtgaagag gaggagaatg
     6481 catcctgagg tagatggtga ggacgtgccc ggacaaatgg ggagttcagg atgcggacct
     6541 gacaccagtc ccaaggcatc agacttgggg tcagtaactg actctgatgt tgactgtacc
     6601 gataacacac aaacccaaag gaagaagaaa aggaaaggga aagcaagagt gcttagcaaa
     6661 gaatctgttc gtaaagacag agaaccccat acaaaaatga gaccatgtat gcttaatgag
     6721 aaggatgcag tacagatgca tagtgacacc ctgaaagcaa aaacggtgcc tgagaaagtc
     6781 ccccgcagat gtgctaccgt tgctgcaaat aaaataaaga tgatgtgtaa tctaaaagaa
     6841 gtggtctcag gaccagagaa tgtcggcatt aggacgatca gcagaaaact gccctatcga
     6901 caagcctctg ctgcagctaa gaaaaagtta ctgagtgttt ataaagagga tgatgcaccc
     6961 atacattcag agaacgaaaa ggagctatat cttaggcggt tcagatcccg gaaggaaaaa
     7021 gcccagccta ctccgaggta gaaaggttac cgggaattgt cagcagctcc aatgcctgcc
     7081 ctgaagtccg ctcccaacca taagccgtcc cagcaccttt tgaacaattt tgtgaaagcc
     7141 attactctgg gtcaaagtgg gatgatggct tccagttagc tctacacagc acagcatagg
     7201 gtgttccaag gaggtaggag atgtggattg tgttgtcagg tgagaaagca gaaggaccca
     7261 ctgaatgtaa agcaaaggct tgacgcagct tggtcctcta gagaaataaa agcatgtggg
     7321 atatatgggg aaacaatgct aatttcaatg gtttgccctc acagactgaa aactaggcca
     7381 tttccaaagg agggagcagt aagcccatgt gactgctgaa ttttaactgg gtctgattta
     7441 tgtagtgcac atccctggga actgagagag taaatcctgg ggtgttactg acttctgaag
     7501 aggagtgtgg gaaagactgt cattaatgtc ttatttataa cattggaatt catactgaat
     7561 gatagctacc tggtatgagt aattcaggga atgtatcttt ctaagaaagt tctcaatgtg
     7621 actattacac tttatttctt ctatgtagca gcaaagatgt aaaggccaga cttgtggtca
     7681 gaaattagaa caagatgcac tcatcgctta aggtgatgca gttggatcct atttcttacg
     7741 tttctctgct gttccttaga agttagaatg tgacactgca ggttcatttc aggctcacta
     7801 acaagccaag tgtcggggag tctggcctct ggtcgttgtg ctacaaatgt tttgcctaca
     7861 gaggatgtgg actttagttc gttgttcatg gctatttgtt gacattaagg tcaccagatg
     7921 tgacctgtga atgtactgtc aagtcttttt atcatgttac tggagaaact tgtcttcaac
     7981 agtttgtttt tccaattaaa aatagctgtg actattaggc ataacttgca tgtataaatc
     8041 aaaaaaacaa tggaacctag gggtgtgtat ttttcattaa cagtaatgca catttttttc
     8101 agttatatgt atggccaaag tgtccagatt acttgagaaa cttgtttgtg gttgcatgcc
     8161 tgcttaaaac aaaaacacaa ctcagaattc taacatagtg tgtgtctttt tgtaactcac
     8221 tctgaaatct tcagcatctt gctacaagca caggaagagt tcccttcctc ctctttggtg
     8281 catgggtttg gtttatttat ttatttattt tgagctttaa tgaaaaattt aaatgtccaa
     8341 tcccaaatgt catagaatta cttattgagc aattatatcc tcaagaaatg ccatgaaatg
     8401 aaaatatatc agtctaatga agacctgtga attttggcag tgtgaattga agatctgaag
     8461 ttacatcttg ctgtctgatc ctgtccagcc ttttataatg gaatcccttt ctggccttta
     8521 attggaacat atttttattt acccttt
//
