LOCUS       NM_001003920            3014 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus BR serine/threonine kinase 1 (Brsk1), transcript
            variant 1, mRNA.
ACCESSION   NM_001003920 XM_356021
VERSION     NM_001003920.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3014)
  AUTHORS   Dugan,M.P., Maiya,R., Fleischer,C., Bajo,M., Snyder,A.E.,
            Koduri,A., Srinivasan,S., Roberto,M. and Messing,R.O.
  TITLE     Brain-specific serine/threonine-protein kinase 1 is a substrate of
            protein kinase C epsilon involved in sex-specific ethanol and
            anxiety phenotypes
  JOURNAL   Addict Biol 29 (3), e13388 (2024)
   PUBMED   38497285
  REMARK    GeneRIF: Brain-specific serine/threonine-protein kinase 1 is a
            substrate of protein kinase C epsilon involved in sex-specific
            ethanol and anxiety phenotypes.
REFERENCE   2  (bases 1 to 3014)
  AUTHORS   Nakanishi,K., Niida,H., Tabata,H., Ito,T., Hori,Y., Hattori,M.,
            Johmura,Y., Yamada,C., Ueda,T., Takeuchi,K., Yamada,K.,
            Nagata,K.I., Wakamatsu,N., Kishi,M., Pan,Y.A., Ugawa,S.,
            Shimada,S., Sanes,J.R., Higashi,Y. and Nakanishi,M.
  TITLE     Isozyme-Specific Role of SAD-A in Neuronal Migration During
            Development of Cerebral Cortex
  JOURNAL   Cereb Cortex 29 (9), 3738-3751 (2019)
   PUBMED   30307479
  REMARK    GeneRIF: Isozyme-Specific Role of SAD-A in Neuronal Migration
            During Development of Cerebral Cortex.
REFERENCE   3  (bases 1 to 3014)
  AUTHORS   Chu,Q., Yao,C., Qi,X., Stripp,B.R. and Tang,N.
  TITLE     STK11 is required for the normal program of ciliated cell
            differentiation in airways
  JOURNAL   Cell Discov 5, 36 (2019)
   PUBMED   31636950
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3014)
  AUTHORS   Dhumale,P., Menon,S., Chiang,J. and Puschel,A.W.
  TITLE     The loss of the kinases SadA and SadB results in early neuronal
            apoptosis and a reduced number of progenitors
  JOURNAL   PLoS One 13 (4), e0196698 (2018)
   PUBMED   29698519
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3014)
  AUTHORS   Mochida,S., Hida,Y., Tanifuji,S., Hagiwara,A., Hamada,S., Abe,M.,
            Ma,H., Yasumura,M., Kitajima,I., Sakimura,K. and Ohtsuka,T.
  TITLE     SAD-B Phosphorylation of CAST Controls Active Zone Vesicle
            Recycling for Synaptic Depression
  JOURNAL   Cell Rep 16 (11), 2901-2913 (2016)
   PUBMED   27626661
  REMARK    GeneRIF: CAST/SAD-B reaction serves as a brake on synaptic
            transmission
REFERENCE   6  (bases 1 to 3014)
  AUTHORS   Choi,Y.J., Di Nardo,A., Kramvis,I., Meikle,L., Kwiatkowski,D.J.,
            Sahin,M. and He,X.
  TITLE     Tuberous sclerosis complex proteins control axon formation
  JOURNAL   Genes Dev 22 (18), 2485-2495 (2008)
   PUBMED   18794346
REFERENCE   7  (bases 1 to 3014)
  AUTHORS   Hezel,A.F., Gurumurthy,S., Granot,Z., Swisa,A., Chu,G.C.,
            Bailey,G., Dor,Y., Bardeesy,N. and Depinho,R.A.
  TITLE     Pancreatic LKB1 deletion leads to acinar polarity defects and
            cystic neoplasms
  JOURNAL   Mol Cell Biol 28 (7), 2414-2425 (2008)
   PUBMED   18227155
REFERENCE   8  (bases 1 to 3014)
  AUTHORS   Witte,H., Neukirchen,D. and Bradke,F.
  TITLE     Microtubule stabilization specifies initial neuronal polarization
  JOURNAL   J Cell Biol 180 (3), 619-632 (2008)
   PUBMED   18268107
REFERENCE   9  (bases 1 to 3014)
  AUTHORS   Barnes,A.P., Lilley,B.N., Pan,Y.A., Plummer,L.J., Powell,A.W.,
            Raines,A.N., Sanes,J.R. and Polleux,F.
  TITLE     LKB1 and SAD kinases define a pathway required for the polarization
            of cortical neurons
  JOURNAL   Cell 129 (3), 549-563 (2007)
   PUBMED   17482548
  REMARK    GeneRIF: Once activated, LKB1 phosphorylates and thereby activates
            SAD-A and SAD-B kinases, which are also required for neuronal
            polarization in the cerebral cortex.
REFERENCE   10 (bases 1 to 3014)
  AUTHORS   Kishi,M., Pan,Y.A., Crump,J.G. and Sanes,J.R.
  TITLE     Mammalian SAD kinases are required for neuronal polarization
  JOURNAL   Science 307 (5711), 929-932 (2005)
   PUBMED   15705853
  REMARK    GeneRIF: results show that SAD-A and SAD-B, mammalian orthologs of
            a kinase needed for presynaptic differentiation in Caenorhabditis
            elegans, are required for neuronal polarization.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC086636.1 and AC161197.9.
            
            On Dec 10, 2009 this sequence version replaced NM_001003920.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086636.1, AY533671.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                BC086636.1         1-45
            46-46               AC161197.9         76877-76877         c
            47-3014             BC086636.1         46-3013
FEATURES             Location/Qualifiers
     source          1..3014
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.71 cM"
     gene            1..3014
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /note="BR serine/threonine kinase 1"
                     /db_xref="GeneID:381979"
                     /db_xref="MGI:MGI:2685946"
     exon            1..288
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..2489
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /note="isoform 1 is encoded by transcript variant 1; BR
                     serine/threonine-protein kinase 1; serine/threonine kinase
                     SADB; serine/threonine kinase SAD-B;
                     serine/threonine-protein kinase SAD-B; brain-specific
                     serine/threonine-protein kinase 1;
                     serine/threonine-protein kinase BRSK1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase BRSK1 isoform 1"
                     /protein_id="NP_001003920.2"
                     /db_xref="CCDS:CCDS20741.1"
                     /db_xref="GeneID:381979"
                     /db_xref="MGI:MGI:2685946"
                     /translation="MSSGSKEGGGGSPAYHLPHPHPHPPQHAQYVGPYRLEKTLGKGQ
                     TGLVKLGVHCITGQKVAVKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYEN
                     KKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPE
                     NLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCG
                     VILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSL
                     EQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRER
                     LHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGK
                     RRPERKSMEVLSITDAGSGGSPVPTRRALEMAQHSQRSRSVSGASTGLSSSPLSSPRS
                     PVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARSTPLPGPPGS
                     PRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRSRLNSIRNSFLGSPRF
                     HRRKMQVPTAEEMSSLTPESSPELAKRSWFGNFISLDKEEQIFLVLKDKPLSSIKADI
                     VHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKPVRFQVDISSSEGPEPSPRRDGS
                     SGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQALADEKNGAQTRPAGTP
                     PRSLQPPPGRSDPDLSSSPRRGPPKDKKLLATNGTPLP"
     exon            289..383
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /inference="alignment:Splign:2.1.0"
     exon            384..469
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /inference="alignment:Splign:2.1.0"
     exon            470..610
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /inference="alignment:Splign:2.1.0"
     exon            611..727
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /inference="alignment:Splign:2.1.0"
     exon            728..761
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /inference="alignment:Splign:2.1.0"
     exon            762..830
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /inference="alignment:Splign:2.1.0"
     exon            831..977
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1009
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1180
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1278
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1438
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1499
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1869
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1918
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2042
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2241
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2331
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2996
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2975..2980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /note="hexamer: AATAAA"
     polyA_site      2980
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
     polyA_site      2996
                     /gene="Brsk1"
                     /gene_synonym="Gm1100; SAD-B; SADB"
                     /note="major polyA site"
ORIGIN      
        1 ggggccagcc cagccccctg gggacccccg gagaagtggg gagcaaccgg gggggccggg
       61 acggaggtgt cgccggcccc caccggagga acggggcgac gggccgcagg gggggcggcc
      121 gggggaccgg tcgggccggg accaagggca ccatgtcgtc cgggtccaag gaaggtggcg
      181 ggggctcccc cgcctaccac ctcccacacc cacacccaca cccaccccag cacgcccaat
      241 atgtgggccc ctatcgcctg gagaagacgc tgggcaaagg acagacaggt ctagttaaac
      301 ttggagtcca ctgcatcacg ggtcagaagg tcgctgtcaa gatcgtgaac agggagaagc
      361 tgtcggaatc ggtgctgatg aaggtggaga gggaaatcgc catcctgaag ctcattgaac
      421 acccgcacgt gctcaagctc cacgacgtct acgagaacaa gaaatattta tacttggttc
      481 ttgagcacgt ttctggtggt gagctgttcg actacctggt aaaaaaaggg agactgacac
      541 ccaaggaggc ccggaagttc ttccgccaga tcgtgtcagc actggacttc tgccatagct
      601 actccatctg tcacagagac ttgaagccag agaacctgct gttggatgag aaaaacaaca
      661 tccgcatcgc agactttggt atggcgtccc tgcaagtggg ggacagcctc ctggagacca
      721 gctgcgggtc cccccattac gcatgtccag aggtgatcaa gggggaaaag tatgatggcc
      781 gccgggcaga catgtggagc tgtggagtca tcctatttgc cctgcttgtg ggggcactgc
      841 ccttcgatga cgacaacctg cgccagctac tggagaaggt gaaacgtggg gtcttccaca
      901 tgcctcactt catccctcca gactgccaga gcctcctgag agggatgatt gaagtggagc
      961 ccgagaaaag gctcagtctg gagcaaattc agaaacatcc ttggtatctg ggcgggaaac
     1021 acgaaccaga cccttgcctg gagccagccc caggccgcag agtagccatg cgtagcctgc
     1081 cttccaatgg cgagctggac cctgacgttc tggaaagcat ggcgtctctg ggctgcttca
     1141 gagaccgcga gcggctgcac agagaactgc gaagcgagga ggaaaaccaa gaaaagatga
     1201 tctattattt gcttttggat cggaaagagc ggtatcctag ctgtgaagac caggacctgc
     1261 ctcctcggaa tgatgttgac ccacctcgta agcgtgtgga ttcccccatg ctgagcagac
     1321 acgggaaacg gaggccagag cggaagtcca tggaagtcct cagtatcaca gatgctggga
     1381 gtggtggctc cccagtgcct accagacggg ccttggagat ggcccagcac agtcagagat
     1441 cccgcagcgt cagtggagcc tccactggtc tgtcctccag ccctctgagc agcccaagga
     1501 gtccggtctt ttccttctca ccggagccag gcgctggaga tgaggctaga ggcggaggct
     1561 ccccaacttc caaaacacag acgctgcctt ctcggggccc cagaggtggg ggcgctggag
     1621 agcagccacc accccccagt gcccgttcca cgcccttgcc tggaccacca ggctccccgc
     1681 gctcctccgg cggaaccccc ttgcactcac ctctgcacac gcctcgagcc agccctacgg
     1741 ggaccccagg aacgacgcca cctcccagcc caggcggtgg cgtcggggga gccgcctgga
     1801 gaagtcggct caactccatc cgcaacagct tcctgggctc ccctcgcttc caccggcgca
     1861 agatgcaggt ccctaccgcc gaggagatgt ccagtttgac accagaatcc tctcctgagc
     1921 tggcaaaacg ctcctggttc gggaatttca tctccttgga caaagaagaa caaatattcc
     1981 tcgtgctaaa ggacaaacct ctcagcagca tcaaagcgga cattgtccat gcctttctgt
     2041 cgatccccag cctgagtcac agtgtactgt cacagaccag cttcagggcc gaatacaagg
     2101 ccagcggcgg cccctccgtc ttccagaagc ctgtccgctt tcaggtggac atcagctcct
     2161 ctgagggtcc agaaccctca ccccgaagag atggcagcag tggaggtggc atctactcag
     2221 tcacctttac tctcatctcc ggtcccagcc gtcggttcaa acgtgtggta gagaccatcc
     2281 aggcacagtt gctgagtact cacgaccagc cctccgtgca ggccttggca gatgagaaga
     2341 acggagccca gacccggcct gctgggaccc caccccgaag cctgcagccc ccaccaggcc
     2401 gctctgaccc tgatctgagt agctctcccc gccgaggacc ccctaaggac aagaagctcc
     2461 tggccaccaa tggaacccct ctaccctgac cccagggggc cagggaagga ggggagcccc
     2521 ctccaccccc cttccctgcc cccctactgt gaatctgtat ataaggccca aggagtatgt
     2581 tgggaggggg gacacaaaac taggccttgc cctgcaggga tagggctcca ggggccatac
     2641 ccaatggggg gggaggttct agggcaaaaa gggggtggga gctgttttta tttatttatt
     2701 aattaattta ttattttatt tattgatcaa tctctgcggg tggggtaggg gagggatggg
     2761 ggtggcttag cagatccgga cagggccctc tgtctctgtg tcatccccaa cccccagccc
     2821 cttcctggcc ccctgctccc ccccaggtcc tgccccctcc cctgtgacct tctgtacgga
     2881 tttgccctcc cggaaggaat tctggtttcg cgtgatcctg cctgcgtctg tgtctgattc
     2941 cgccggcggc agcaacaaca acaacaacaa caaaaataaa tagccttgat cagggaaaaa
     3001 aaaaaaaaaa aaaa
//
