LOCUS       NM_009766               2772 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus bombesin-like receptor 3 (Brs3), mRNA.
ACCESSION   NM_009766
VERSION     NM_009766.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2772)
  AUTHORS   Pauli,J.L., Chen,J.Y., Basiri,M.L., Park,S., Carter,M.E., Sanz,E.,
            McKnight,G.S., Stuber,G.D. and Palmiter,R.D.
  TITLE     Molecular and anatomical characterization of parabrachial neurons
            and their axonal projections
  JOURNAL   Elife 11, e81868 (2022)
   PUBMED   36317965
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2772)
  AUTHORS   Skop,V., Xiao,C., Liu,N., Gavrilova,O. and Reitman,M.L.
  TITLE     The effects of housing density on mouse thermal physiology depend
            on sex and ambient temperature
  JOURNAL   Mol Metab 53, 101332 (2021)
   PUBMED   34478905
  REMARK    GeneRIF: The effects of housing density on mouse thermal physiology
            depend on sex and ambient temperature.
REFERENCE   3  (bases 1 to 2772)
  AUTHORS   Mogul,A.S., Hadley,C.K., Province,H.S., Pauli,J., Gavrilova,O.,
            Xiao,C., Palmiter,R.D., Pinol,R.A. and Reitman,M.L.
  TITLE     Cre Recombinase Driver Mice Reveal Lineage-Dependent and
            -Independent Expression of Brs3 in the Mouse Brain
  JOURNAL   eNeuro 8 (4) (2021)
   PUBMED   34326065
  REMARK    GeneRIF: Cre Recombinase Driver Mice Reveal Lineage-Dependent and
            -Independent Expression of Brs3 in the Mouse Brain.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2772)
  AUTHORS   Pinol,R.A., Mogul,A.S., Hadley,C.K., Saha,A., Li,C., Skop,V.,
            Province,H.S., Xiao,C., Gavrilova,O., Krashes,M.J. and Reitman,M.L.
  TITLE     Preoptic BRS3 neurons increase body temperature and heart rate via
            multiple pathways
  JOURNAL   Cell Metab 33 (7), 1389-1403 (2021)
   PUBMED   34038711
  REMARK    GeneRIF: Preoptic BRS3 neurons increase body temperature and heart
            rate via multiple pathways.
REFERENCE   5  (bases 1 to 2772)
  AUTHORS   Xiao,C., Liu,N., Province,H., Pinol,R.A., Gavrilova,O. and
            Reitman,M.L.
  TITLE     BRS3 in both MC4R- and SIM1-expressing neurons regulates energy
            homeostasis in mice
  JOURNAL   Mol Metab 36, 100969 (2020)
   PUBMED   32229422
  REMARK    GeneRIF: BRS3 in both MC4R- and SIM1-expressing neurons regulates
            energy homeostasis in mice.
REFERENCE   6  (bases 1 to 2772)
  AUTHORS   Yamada,K., Wada,E., Imaki,J., Ohki-Hamazaki,H. and Wada,K.
  TITLE     Hyperresponsiveness to palatable and aversive taste stimuli in
            genetically obese (bombesin receptor subtype-3-deficient) mice
  JOURNAL   Physiol Behav 66 (5), 863-867 (1999)
   PUBMED   10405115
REFERENCE   7  (bases 1 to 2772)
  AUTHORS   Ohki-Hamazaki,H., Sakai,Y., Kamata,K., Ogura,H., Okuyama,S.,
            Watase,K., Yamada,K. and Wada,K.
  TITLE     Functional properties of two bombesin-like peptide receptors
            revealed by the analysis of mice lacking neuromedin B receptor
  JOURNAL   J Neurosci 19 (3), 948-954 (1999)
   PUBMED   9920658
REFERENCE   8  (bases 1 to 2772)
  AUTHORS   Weber,H.C., Hampton,L.L., Jensen,R.T. and Battey,J.F.
  TITLE     Structure and chromosomal localization of the mouse bombesin
            receptor subtype 3 gene
  JOURNAL   Gene 211 (1), 125-131 (1998)
   PUBMED   9573346
REFERENCE   9  (bases 1 to 2772)
  AUTHORS   Ohki-Hamazaki,H., Watase,K., Yamamoto,K., Ogura,H., Yamano,M.,
            Yamada,K., Maeno,H., Imaki,J., Kikuyama,S., Wada,E. and Wada,K.
  TITLE     Mice lacking bombesin receptor subtype-3 develop metabolic defects
            and obesity
  JOURNAL   Nature 390 (6656), 165-169 (1997)
   PUBMED   9367152
REFERENCE   10 (bases 1 to 2772)
  AUTHORS   Ohki-Hamazaki,H., Wada,E., Matsui,K. and Wada,K.
  TITLE     Cloning and expression of the neuromedin B receptor and the third
            subtype of bombesin receptor genes in the mouse
  JOURNAL   Brain Res 762 (1-2), 165-172 (1997)
   PUBMED   9262170
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK038616.1.
            
            On Apr 6, 2007 this sequence version replaced NM_009766.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK038616.1, BC106961.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2772              AK038616.1         2-2773
FEATURES             Location/Qualifiers
     source          1..2772
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 30.78 cM"
     gene            1..2772
                     /gene="Brs3"
                     /gene_synonym="BRS-3"
                     /note="bombesin-like receptor 3"
                     /db_xref="GeneID:12209"
                     /db_xref="MGI:MGI:1100501"
     exon            1..605
                     /gene="Brs3"
                     /gene_synonym="BRS-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1371
                     /gene="Brs3"
                     /gene_synonym="BRS-3"
                     /codon_start=1
                     /product="bombesin receptor subtype-3"
                     /protein_id="NP_033896.2"
                     /db_xref="CCDS:CCDS30150.1"
                     /db_xref="GeneID:12209"
                     /db_xref="MGI:MGI:1100501"
                     /translation="MSQRQSQSPNQTLISITNDTETSSSVVSNDTTHKGWTGDNSPGI
                     EALCAIYITYAGIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVP
                     VDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPPNA
                     ILKTCAKAGGIWIVSMIFALPEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHS
                     LLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVL
                     VALFALCWLPNHLLYLYHSFTYESYANHSDVPFVIIIFSRVLAFSNSCVNPFALYWLS
                     KTFQQHFKAQLCCLKAEQPEPPLGDIPLNNLTVMGRVPATGSAHVSEISVTLFSGSSA
                     KKGEDKV"
     exon            606..957
                     /gene="Brs3"
                     /gene_synonym="BRS-3"
                     /inference="alignment:Splign:2.1.0"
     exon            958..2772
                     /gene="Brs3"
                     /gene_synonym="BRS-3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2772
                     /gene="Brs3"
                     /gene_synonym="BRS-3"
                     /note="putative"
ORIGIN      
        1 acagaaccac taaagggaag gagtagccgg atgtcttggg ttttcttccc attccgttct
       61 gttctgttct cctgacacca cctcattact agacgtaggc actagacgtg acagtcaact
      121 acatttgaac tgagcagagg agaggtagtg aaggcagagt gtgcaggaga catgtctcaa
      181 aggcagtctc agtcacctaa tcagacttta atttccatta caaatgacac agaaacatca
      241 agctctgtcg tctccaacga tactacacat aaaggatgga ccggagacaa ctctccagga
      301 atagaagcac tgtgtgccat ctatatcact tatgctggga tcatttcagt gggcatcctc
      361 ggaaatgcta tcctcatcaa agtctttttc aagactaaat ccatgcaaac agttccaaat
      421 attttcatca ccagcctggc tttcggagac ctgttacttc tgctgacttg tgtgcctgtg
      481 gatgcaaccc actacctggc agaaggatgg ctgtttggaa aggtcggttg taaagtgctt
      541 tccttcatcc ggctcacttc tgtcggtgtg tcagtgttca cgctaacaat tctcagcgct
      601 gacagataca aagcagtcgt gaagccactt gagcgacagc cccccaatgc cattctgaag
      661 acctgtgcaa aagctggtgg catctggatc gtgtctatga tatttgctct gccagaggct
      721 atattctcaa atgtatacac tttccaagat cctaacagaa atgtgacatt tgaatcatgt
      781 aactcctacc ctatctctga gaggcttttg caagaaatac attctctgtt gtgtttcttg
      841 gtattctaca ttatcccgct ctcgattatc tctgtctatt attctttgat tgccaggact
      901 ctttacaaaa gcaccctgaa cataccgact gaggaacaaa gccatgcccg aaagcagatt
      961 gaatcccgga agagaattgc caaaacagtt ttggtgctgg tggctctgtt cgcactctgc
     1021 tggttgccga atcatctcct gtatctctac cactccttca cttatgaaag ctatgcaaac
     1081 cactctgatg tcccttttgt tatcatcatt ttctctcggg tgctggcttt cagtaattcc
     1141 tgcgtgaacc cctttgctct ctattggctg agcaagacct tccagcagca ttttaaagct
     1201 cagctctgct gcctcaaggc agagcagcct gagcctcctc ttggtgacat cccccttaac
     1261 aacctcactg tgatggggcg ggtcccagct actgggagtg cacatgtctc tgaaattagt
     1321 gtgaccctgt tcagtggcag tagtgccaag aagggagagg acaaagttta gatgttacat
     1381 taaaaatgat gatttttagt cccactgtgt gtatccagct ttaagctgtg catagtacag
     1441 tgtctgggtt ttctgttgtt catgaattgt gttgaagttt tcagaaagaa ttatccttgt
     1501 aagtaataga caaaccatca ttttcttcaa ggtgcaaaca gtaatgccat ttgggctttc
     1561 taaatacaac aaagcccacc aagtagagaa gaagaggttt ggaaatacca gtcaactgtg
     1621 aagaaggctg tatagaaggg atggtaaaga aaccagataa aggtttaaat atcgaattgg
     1681 atcccatctc tctgatattc ctcatctctt gtgcactcat gtggttatct taaaatagtg
     1741 cttctgttta cttgtgcagt aaatctagag attctactcc gcaaactagg agatcaaaaa
     1801 gagagaaaac atctcttgca gtgttttgta aaatatctct ctatatatgc tttcacagag
     1861 tgattgccct tttccttcaa tcgccattcc attataagaa atcttgcaat tgaaatgaaa
     1921 atgtttaaga gttggaaggt gttaaacact gattctgggg cagggtgctt cccttactgg
     1981 gtcaacacgt cctgaattta tgtaattcta ttgccatttg gttaataact aggcaaaacc
     2041 atgtctcacg agcattgtga ggaatttgtc ttattcacag gacaaccagg ggccccagag
     2101 gaaggattct tgtccaagtt tctaagctgt cactgttgga aactctttct tctaagggaa
     2161 ctcatttcat ttcagtgagc agtgccctct ttctaaagcc cagaggaact gccacttgga
     2221 attgtcatct ggctgttcac gtgtcatcag atcatctact tgcttgattt tcctcaactc
     2281 gatgggtgcc taagtcctag agttcacctc tgttaccaga agtcagacag aaggctctga
     2341 cttgctatcc tcgtctccaa cttgctaaca caaataagca tgttaataaa tgtaattggg
     2401 aaaacaaaat ccttgtagtc aatagatttg tcagacttca atttgtgctt tcagaaatgt
     2461 attcttgaag caaatagcag cttacctttg gcactatagt tacatttgta tttgtaaaaa
     2521 cctggtttgt tttttgtttt ttgtttttag aatgcttttg ctatttttga cctttaaatg
     2581 gcttgtgctg ttgtgaactt ctaattatgt ggctcaaaag gggcggggca tataataaca
     2641 ctgggcttta aatgtccgta aaattagctt acttaaagtg ggggtgctaa tattgtatta
     2701 acattgctta aaagtgagca aagttgttgt aaaaaatctg gaggtgagca aataaatatt
     2761 aaataaagtt tg
//
