LOCUS       NM_001081315            5973 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus bromodomain and PHD finger containing, 3 (Brpf3),
            mRNA.
ACCESSION   NM_001081315 XM_892549
VERSION     NM_001081315.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5973)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5973)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5973)
  AUTHORS   Yan,K., You,L., Degerny,C., Ghorbani,M., Liu,X., Chen,L., Li,L.,
            Miao,D. and Yang,X.J.
  TITLE     The Chromatin Regulator BRPF3 Preferentially Activates the HBO1
            Acetyltransferase but Is Dispensable for Mouse Development and
            Survival
  JOURNAL   J Biol Chem 291 (6), 2647-2663 (2016)
   PUBMED   26677226
  REMARK    GeneRIF: These results indicate that BRPF3 forms a functional
            tetrameric complex with HBO1 but is not required for mouse
            development and survival
REFERENCE   4  (bases 1 to 5973)
  AUTHORS   You,L., Yan,K., Zou,J., Zhao,H., Bertos,N.R., Park,M., Wang,E. and
            Yang,X.J.
  TITLE     The chromatin regulator Brpf1 regulates embryo development and cell
            proliferation
  JOURNAL   J Biol Chem 290 (18), 11349-11364 (2015)
   PUBMED   25773539
REFERENCE   5  (bases 1 to 5973)
  AUTHORS   Doyon,Y., Cayrou,C., Ullah,M., Landry,A.J., Cote,V., Selleck,W.,
            Lane,W.S., Tan,S., Yang,X.J. and Cote,J.
  TITLE     ING tumor suppressor proteins are critical regulators of chromatin
            acetylation required for genome expression and perpetuation
  JOURNAL   Mol Cell 21 (1), 51-64 (2006)
   PUBMED   16387653
REFERENCE   6  (bases 1 to 5973)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 5973)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC140278.2.
            
            On Feb 6, 2007 this sequence version replaced XM_892549.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147555.1, SRR11927934.4947539.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               AC140278.2         111492-111727       c
            237-1707            AC140278.2         105454-106924       c
            1708-1864           AC140278.2         102184-102340       c
            1865-1996           AC140278.2         98136-98267         c
            1997-2125           AC140278.2         95660-95788         c
            2126-2438           AC140278.2         95055-95367         c
            2439-2741           AC140278.2         94215-94517         c
            2742-3248           AC140278.2         91261-91767         c
            3249-3342           AC140278.2         88787-88880         c
            3343-3440           AC140278.2         84412-84509         c
            3441-3538           AC140278.2         81442-81539         c
            3539-3693           AC140278.2         76937-77091         c
            3694-5973           AC140278.2         74064-76343         c
FEATURES             Location/Qualifiers
     source          1..5973
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 15.03 cM"
     gene            1..5973
                     /gene="Brpf3"
                     /gene_synonym="mKIAA1286"
                     /note="bromodomain and PHD finger containing, 3"
                     /db_xref="GeneID:268936"
                     /db_xref="MGI:MGI:2146836"
     exon            1..236
                     /gene="Brpf3"
                     /gene_synonym="mKIAA1286"
                     /inference="alignment:Splign:2.1.0"
     exon            237..1707
                     /gene="Brpf3"
                     /gene_synonym="mKIAA1286"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..3877
                     /gene="Brpf3"
                     /gene_synonym="mKIAA1286"
                     /codon_start=1
                     /product="bromodomain and PHD finger-containing protein 3"
                     /protein_id="NP_001074784.1"
                     /db_xref="CCDS:CCDS37532.1"
                     /db_xref="GeneID:268936"
                     /db_xref="MGI:MGI:2146836"
                     /translation="MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVD
                     IDGRLHRISIYDPLKIITEDELTAQDITECNSNKENSEQPQFPAKSKKPSSKGKRKES
                     CSKHASGTSFHLPQPSFRVVDTGSQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEED
                     IAWLDMVNEKRRADGHSSVSADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVC
                     LDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCVLCPNKG
                     GAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGLG
                     AAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTTFTVRKTAYCEAHSPSVAV
                     ARRKGDSPRSLSEVGDEDGPKEGGGEEEQEEAEEEGQEGQGGVGSPLKGVSKKGKMSL
                     KQKIKKEPEEAGREAPSITLPMVTVPQIPSYRLNKICSGLSFQRKTQFMQRLHNYWLL
                     KRQARNGVPLIRRLHSHLQSQRNAEQREQDEKTSAVKEELKYWQKLRHDLERARLLIE
                     LIRKREKLKREQVKVQQAAMELELMPFTVLLRTTLDLLQEKDSAHIFAEPVSLSEVPD
                     YLEFISKPMDFSTMRRKLESHLYHTLEEFEEDFNLIVTNCMKYNAKDTIFHRAAVRLR
                     DLGGAILRHARRQAENIGYDPERGTHLPESPRLEDFYRFSWEDVDNILIPENRAHLSP
                     EAQLKELLEKLDLVSTMRSSGARTRRVRMLRREINALRQKLAQPPPPQLLSLNKTVPN
                     GELPAGSRGDTAVLEQAQQEEPEEEGDRDDSKLPAPPTLEPTGPAPSLSEQESPPDPP
                     TLKPISDSKPSSRFLKSRKVEDEELLEKSALQLGSEPLQCLLSDNGIDRLSLTNPDSH
                     PDTPLGTVGRRTSVLFKKAKNGVKLQRGPDGTLENGEDHGPEDDPASPASTEDEHYSR
                     KRPRSRSCSDSEGERSPQQEEETGVTNGFGKHTESGSDSECSLGLSGGLAFEAGSGLT
                     PPKRSRGKPALSRVPFLEGVNGDSDHSGSGRSLLMPFEDHGDLEPLELVWAKCRGYPS
                     YPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGERLFLVLFFDNKRTWQW
                     LPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGSHAFVTSSYL
                     "
     exon            1708..1864
                     /gene="Brpf3"
                     /gene_synonym="mKIAA1286"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1996
                     /gene="Brpf3"
                     /gene_synonym="mKIAA1286"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2125
                     /gene="Brpf3"
                     /gene_synonym="mKIAA1286"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2438
                     /gene="Brpf3"
                     /gene_synonym="mKIAA1286"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2741
                     /gene="Brpf3"
                     /gene_synonym="mKIAA1286"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..3248
                     /gene="Brpf3"
                     /gene_synonym="mKIAA1286"
                     /inference="alignment:Splign:2.1.0"
     exon            3249..3342
                     /gene="Brpf3"
                     /gene_synonym="mKIAA1286"
                     /inference="alignment:Splign:2.1.0"
     exon            3343..3440
                     /gene="Brpf3"
                     /gene_synonym="mKIAA1286"
                     /inference="alignment:Splign:2.1.0"
     exon            3441..3538
                     /gene="Brpf3"
                     /gene_synonym="mKIAA1286"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3693
                     /gene="Brpf3"
                     /gene_synonym="mKIAA1286"
                     /inference="alignment:Splign:2.1.0"
     exon            3694..5973
                     /gene="Brpf3"
                     /gene_synonym="mKIAA1286"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5624..5629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brpf3"
                     /gene_synonym="mKIAA1286"
                     /note="hexamer: AATAAA"
     polyA_site      5678
                     /gene="Brpf3"
                     /gene_synonym="mKIAA1286"
     regulatory      5708..5713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brpf3"
                     /gene_synonym="mKIAA1286"
                     /note="hexamer: AATAAA"
     polyA_site      5725
                     /gene="Brpf3"
                     /gene_synonym="mKIAA1286"
                     /note="major polyA site"
ORIGIN      
        1 gtggcgggcg gcagcggtgg tggcggcggt ggctccattc cccctcctcc cccgggagag
       61 gcggccgggc ccggggagac ggagcggagg gccggagcgg gaggaggccg cgctccctca
      121 gccgggccgc gcacggagct gctcgctcgc ccggcccgct cgcccggccg ctcacccggc
      181 cggccgcgct cgcgctcagg gggcccccga agctaggggc ccggccggcg gctgaggttt
      241 gccttcgtgg tttccagttg ccatgaggaa gcctcgccga aagtcacggc agaatgccga
      301 gggccggaga tccccatccc catacagtct taagtgctca cccacacggg agaccctgac
      361 ttacgcccaa gcccagagga ttgttgaggt cgacatcgat ggccgcctac atcggatcag
      421 catttatgac ccacttaaga tcatcactga agatgagctg actgctcagg atattaccga
      481 atgcaatagc aacaaggaaa acagtgagca gccccaattc cctgccaagt ccaagaaacc
      541 ctcatcaaag ggcaagagga aggagtcctg ttccaagcat gcgtccggta cctccttcca
      601 cctcccccag cccagctttc gtgtggtgga tacggggagc cagccagaag cgcccccatt
      661 gcctgctgct tactaccgat acattgagaa gcctccggaa gacctggatg cggaggtaga
      721 gtacgacatg gacgaggagg acattgcctg gctagacatg gtcaacgaga agcgccgagc
      781 agacggccac agctcggtgt cggcagacac cttcgagctg ctggtggacc ggcttgagaa
      841 ggaatcctac ctggagagcc gcagcagtgg ggcccagcag tccctaatcg acgaagacgc
      901 cttctgttgc gtgtgcctgg acgatgagtg ccacaatagc aatgtcatcc tgttctgcga
      961 catctgcaac ttagctgtgc accaggagtg ctacggcgtt ccctatatcc cagagggcca
     1021 gtggctatgt cgctgctgcc tgcagtctcc ctctcgtccc gtggattgcg tcctgtgccc
     1081 caataaaggt ggggccttca aacagaccag tgatggccac tgggcccacg tagtctgcgc
     1141 catctggatc cctgaggtct gcttcgctaa taccgtgttc ctggagccta ttgagggcat
     1201 cgacaacatt ccacccgccc gctggaagct aacctgctat atctgcaagc agaaagggct
     1261 gggcgcggcc attcagtgcc ataaagtgaa ctgctacacc gctttccacg tgacatgcgc
     1321 gcagcgggct gggctcttca tgaagattga acccatgaga gaaaccagcc tcaacggcac
     1381 cacctttact gttcgcaaga ctgcgtattg tgaggcccac tctccaagtg tggccgttgc
     1441 caggagaaag ggcgactccc caaggagcct cagtgaagtc ggggatgagg atgggccgaa
     1501 agagggtgga ggggaggagg agcaggaaga agctgaggag gagggccagg aaggccaagg
     1561 tggggtgggc agccccctca agggcgtgtc caagaagggt aagatgagtt tgaagcagaa
     1621 gatcaagaag gagccagagg aagctggccg agaggcaccc tccatcactc tccccatggt
     1681 cactgtccca cagataccct cttacaggtt gaacaagatc tgtagtggtc tctcctttca
     1741 gaggaagacc cagttcatgc agcggcttca caactactgg ctgctgaagc ggcaggctcg
     1801 gaacggtgtc cccctcatca ggcgcctgca ctcccactta cagtcccaga gaaatgctga
     1861 gcagcgggag caggacgaga agactagtgc agtgaaggag gagctcaaat actggcagaa
     1921 acttcgccat gacctggagc gagcgcggct gctgatcgag ctcatccgca aaagggagaa
     1981 gctcaagcgg gagcaggtca aagtacagca ggctgccatg gagctggagc tgatgccgtt
     2041 tacggtcctg ttgaggacga ctctggacct gctgcaggag aaagactctg cacacatctt
     2101 tgctgaacct gtcagcctga gtgaggttcc agattacctg gaattcatat ccaagccaat
     2161 ggatttttct actatgaggc ggaagctgga atctcacctg taccacacct tggaggagtt
     2221 tgaggaggac tttaacctta tagttaccaa ctgcatgaag tataatgcta aagacacaat
     2281 tttccaccga gcagctgtcc gcctccggga cctgggaggg gccatcctgc ggcacgcccg
     2341 gcggcaggca gagaacatcg gctatgatcc tgagaggggc acccacttgc ccgaatcacc
     2401 cagattggaa gacttttacc gattctcctg ggaggatgtg gacaacatcc ttatcccaga
     2461 gaaccgggcc catctgtccc cagaggcaca gctgaaggaa ctgctggaga aactggatct
     2521 ggtgagcacc atgcggtcca gcggggcccg cacccgtcgt gtccgcatgc tgcgcaggga
     2581 gatcaatgcc cttcggcaaa agctagcaca gccaccgcca ccacagctcc tgtcactgaa
     2641 caagactgtg cccaacgggg agctgccagc aggatctcgg ggggatacag ctgtcctgga
     2701 gcaggctcag caggaggagc cagaagagga aggggacaga gatgattcaa aattgcctgc
     2761 cccaccaacc ctggagccta ccgggcctgc gccttccttg tcagaacagg aatcccctcc
     2821 agatccccca accctgaaac ccatcagcga cagcaaacct tcaagccggt tcctaaagtc
     2881 ccggaaggtg gaagatgagg agctcttaga aaaatcagcc ctgcaactgg ggagcgagcc
     2941 cttgcaatgc ttgcttagtg acaatggcat tgacagactg tccctcacaa accccgacag
     3001 ccatcctgac acccctctcg gcaccgtggg ccgccgaacc tccgtcctct tcaagaaggc
     3061 caagaatgga gttaagctac agaggggtcc cgatgggacc cttgagaatg gcgaggacca
     3121 tggcccagag gacgatcctg cttctccagc cagcacagag gatgaacact attcccggaa
     3181 gcggccaagg agccggagct gtagtgacag tgaaggggag aggtcccctc agcaggagga
     3241 agagacaggc gtgactaacg gctttggaaa acacacggaa agcgggtctg actcggaatg
     3301 tagtttgggt ctcagtggag gactggcgtt tgaagctggc agtggcctga cgcctcccaa
     3361 acgcagccgt gggaagccag ccctgtctcg tgtgcccttc ctggaaggtg tgaatggaga
     3421 ctctgaccac agtggctcag gcagaagcct cctgatgccc tttgaagacc acggagacct
     3481 ggagcccctg gagctggtgt gggccaagtg ccgaggctac ccctcctacc ctgccttgat
     3541 catcgatccc aagatgcccc gggagggcct cctgcacaac ggtgtcccca tccctgtccc
     3601 tccactggac gtgctgaagc tgggcgagca gaagcaggca gaggctggag agaggctctt
     3661 tcttgtcctc ttctttgaca acaagaggac ctggcagtgg cttccaaggg acaaagtcct
     3721 gcccctgggt gtggaggaca ctgtggacaa gctcaagatg ctagaaggcc gcaagaccag
     3781 catccggaag tcagtacaag tggcctatga ccgcgccatg atccacctga gccgagtgcg
     3841 tggctcccat gcctttgtca cttccagcta cctgtgagag ccgagctggg cctgtgtctg
     3901 ccttctttgc ctctcctctg tccctgaggc atgagaacct ctgctgcccc tgccacgtgt
     3961 atggccggca gcttctttct aatggcaggc cctgactgga ctgggtctcc gagggcaaga
     4021 cccaatattg accaatcatg tggttcccct ggagggctgc tgtgtgccaa aaaactccca
     4081 cccgaggtcc ctggggatat tccactgaag aaccacttag aagtagaaac agctgagagt
     4141 cttagccagc cagggagata gacctggccc acaaggcaag agggcctagg ctgcttttct
     4201 ggggccagcc ggctctctcc atgtctctcc cacctaacca tacctcaggg caggcaaggt
     4261 tctgacattg atcccagaga tgtgccaggg tccctcggga accctcagag cttcccttcc
     4321 cccacaccgc ccgtgcttgc acccccctgt ctcatctccc acacccaacc caggttctcc
     4381 cttccctcat tgctctctgc tctcccttgt gccaaactga cagcaacatc accaaattga
     4441 tctttttctt tgatgtccca tttccttcct ggccagctgc tacattagat ggatgtctgc
     4501 caggcgcttg agtcccaggt agaagctacc ccacctgtaa ggaccctccc ccactcacag
     4561 ccctccagca ggcatgctgc tgccctcccc tcctgcagca gccataagcc tcactgcatc
     4621 agcatgatca ccgcggcacg ggcggcgggt ggcgggtggc gggtggcggg tggcgtgcgg
     4681 catggcactg ccctccagca cccgccctct gggattgctg cccctgcctc ccagaacagg
     4741 gctcttttct ttcatctcct gccttcaacc tcttctccac catcacctcc tcaatcccta
     4801 ccctcaaaaa ggaaggaaaa ccaaactgtg aatgaggaaa gctgactgac aagccaacgc
     4861 agctctcaga ggcttctgct cttgacattt cttttcactt ctttaagcac caaagccgca
     4921 ggcgggtttg cagaccgcca attgccatgt tgacttctac cttgatgtta tttttaattg
     4981 ttttcaattt tttcataggg gagttttggg caaaaaacga agtccctggg gagatcactg
     5041 ccatttttac atactcaaac tttttaaaga aatacaacca accaaccacc aacttcttac
     5101 acttttggga ctcgagccag agtttaaaag ggaaccaaca aaactcacca agagggccag
     5161 gttctgtcca gcaaacagca cagccacgcg ggacagggcg tggtgtacat aactgtaaga
     5221 tagcaggcac acactctcca ttaccggaac cctcccttgt gcatccatgc tgcacagcct
     5281 aatcaaggag ccgacacgtc cccctatccc caggtagctg gtcagctgtg gactctgtga
     5341 cccttgtcta aacctgtgtc aagatcttgg ggcttctccc tttctgtctc cttcccccaa
     5401 cactatctcc tctgtctcta tttttcagtc tcggaatcct tccctctctc cgagtcccac
     5461 tttaaaaact gctcttttag gacaggatgc ggctcggatc tgctgtggca cagggcctct
     5521 tctctgtctg gtctgctgtg aagcacatga tgctctattt attgtagaaa gtgactttat
     5581 ttgccttcta gaattgttta taacagatgg ttataagaga ggtaataaac agaaaaacct
     5641 atgcctgtaa agaatacaag agttaatttt acctaccata atatgatgtc ttattttctc
     5701 tccgagaaat aaatgttcta tgggctgtgg tgtgcggtgc tgtttgctgt ccgtgacggg
     5761 gcctcctgtc ctaacaccac ccgcttctct gaaggcagaa ccattaagaa cggacctgtc
     5821 tgtcctttag atctcatgga tggcctgagg agggtcctgc caggttgccg caggttgcag
     5881 agaagtcatt gttcaagtca ctgtgtgctg tatgaggccg ctagaggctg atggtgggtg
     5941 ctctccttac agaagcagag ctcactgatg gag
//
