LOCUS       NM_001282127            4546 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus bromodomain and PHD finger containing, 1 (Brpf1),
            transcript variant 3, mRNA.
ACCESSION   NM_001282127
VERSION     NM_001282127.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4546)
  AUTHORS   Zhao,B., Zhang,H., Liu,Y., Zu,G., Zhang,Y., Hu,J., Liu,S. and
            You,L.
  TITLE     Forebrain excitatory neuron-specific loss of Brpf1 attenuates
            excitatory synaptic transmission and impairs spatial and fear
            memory
  JOURNAL   Neural Regen Res 19 (5), 1133-1141 (2024)
   PUBMED   37862219
REFERENCE   2  (bases 1 to 4546)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4546)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4546)
  AUTHORS   He,Q., Hong,M., He,J., Chen,W., Zhao,M. and Zhao,W.
  TITLE     Isoform-specific involvement of Brpf1 in expansion of adult
            hematopoietic stem and progenitor cells
  JOURNAL   J Mol Cell Biol 12 (5), 359-371 (2020)
   PUBMED   31565729
  REMARK    GeneRIF: Isoform-specific involvement of Brpf1 in expansion of
            adult hematopoietic stem and progenitor cells.
REFERENCE   5  (bases 1 to 4546)
  AUTHORS   Aiello,G., Ballabio,C., Ruggeri,R., Fagnocchi,L., Anderle,M.,
            Morassut,I., Caron,D., Garilli,F., Gianno,F., Giangaspero,F.,
            Piazza,S., Romanel,A., Zippo,A. and Tiberi,L.
  TITLE     Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh
            Medulloblastoma
  JOURNAL   Cell Rep 29 (12), 4036-4052 (2019)
   PUBMED   31851932
REFERENCE   6  (bases 1 to 4546)
  AUTHORS   Zhou,Q., Law,A.C., Rajagopal,J., Anderson,W.J., Gray,P.A. and
            Melton,D.A.
  TITLE     A multipotent progenitor domain guides pancreatic organogenesis
  JOURNAL   Dev Cell 13 (1), 103-114 (2007)
   PUBMED   17609113
REFERENCE   7  (bases 1 to 4546)
  AUTHORS   Doyon,Y., Cayrou,C., Ullah,M., Landry,A.J., Cote,V., Selleck,W.,
            Lane,W.S., Tan,S., Yang,X.J. and Cote,J.
  TITLE     ING tumor suppressor proteins are critical regulators of chromatin
            acetylation required for genome expression and perpetuation
  JOURNAL   Mol Cell 21 (1), 51-64 (2006)
   PUBMED   16387653
REFERENCE   8  (bases 1 to 4546)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4546)
  AUTHORS   Pfisterer,P., Ehlermann,J., Hegen,M. and Schorle,H.
  TITLE     A subtractive gene expression screen suggests a role of
            transcription factor AP-2 alpha in control of proliferation and
            differentiation
  JOURNAL   J Biol Chem 277 (8), 6637-6644 (2002)
   PUBMED   11741941
REFERENCE   10 (bases 1 to 4546)
  AUTHORS   Wertz,K. and Herrmann,B.G.
  TITLE     Large-scale screen for genes involved in gonad development
  JOURNAL   Mech Dev 98 (1-2), 51-70 (2000)
   PUBMED   11044607
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK043372.1, BC046521.1, AK019522.1 and BY469507.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and has
            multiple differences in the central coding region, compared to
            variant 1. The encoded isoform (3) is shorter, compared to isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138361.1, SRR9219383.37807.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AK043372.1         3-62
            61-3392             BC046521.1         1-3332
            3393-4393           BC046521.1         3435-4435
            4394-4544           AK019522.1         2021-2171
            4545-4546           BY469507.1         466-467
FEATURES             Location/Qualifiers
     source          1..4546
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.75 cM"
     gene            1..4546
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
                     /note="bromodomain and PHD finger containing, 1"
                     /db_xref="GeneID:78783"
                     /db_xref="MGI:MGI:1926033"
     exon            1..201
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
                     /inference="alignment:Splign:2.1.0"
     exon            202..807
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..3850
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     peregrin; bromodomain and PHD finger-containing protein 1"
                     /codon_start=1
                     /product="peregrin isoform 3"
                     /protein_id="NP_001269056.1"
                     /db_xref="CCDS:CCDS71810.1"
                     /db_xref="GeneID:78783"
                     /db_xref="MGI:MGI:1926033"
                     /translation="MGVDFDVKTFCHNLRATKPPYECPVETCRKVYKSYSGIEYHLYH
                     YDHDSPPPPQQTPLRKHKKKGRQSRPANKQSPSPSEVSQSPGREVMSYAQAQRMVEVD
                     LHGRVHRISIFDNLDVVSEDEEAPEEAPENGSNKENTETPAATPKSGKHKNKEKRKDS
                     NHHHHSAPASAAPKLPEVVYRELEQDTPDAPPRPTSYYRYIEKSAEELDEEVEYDMDE
                     EDYIWLDIMNERRKTEGVSPIPQEIFEYLMDRLEKESYFESHNKGDPNALVDEDAVCC
                     ICNDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRRCLQSPSRAVDCALCPN
                     KGGAFKQTDDGRWAHVVCALWIPEVCFANTVFLEPIDSIEHIPPARWKLTCYICKQRG
                     SGACIQCHKANCYTAFHVTCAQQAGLYMKMEPVRETGANGTSFSVRKTAYCDIHTPPG
                     SARRLPALSHSEGEEEEDEEEDEGKSWSSEKVKKAKAKSRIKMKKARKILAEKRAAAP
                     VVSVPCIPPHRLSKITNRLTIQRKSQFMQRLHSYWTLKRQSRNGVPLLRRLQTHLQSQ
                     RNCEQVGRDSDDKNWALKEQLKSWQRLRHDLERARLLVELIRKREKLKRETIKIQQIA
                     MEMQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDHIKKPMDFFTMKQNLE
                     AYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGGAVLRQARRQAEKMGI
                     DFETGMHIPHNLAGDEVSHHTEDVEEERLVLLENQKHLPVEEQLKLLLERLDEVNASK
                     QSVGRSRRAKMIKKEMTALRRKLAHQRETGRDGPERHGPSGRGNLTPHPAACDKDGQT
                     DSAAEESSSQETSKGLGPNMSSTPAHEVGRRTSVLFSKKNPKTAGPPKRPGRPPKNRE
                     SQMTPSHGGSPVGPPQLPIMGSLRQRKRGRSPRPSSSSDSDSDKSTEDPPMDLPANGF
                     SSGNQPVKKSFLVYRNDCNLPRSSSDSESSSSSSSSAASDRTSTTPSKQGRGKPSFSR
                     GTFPEDSSEDTSGTENEAYSVGTGRGVGHSMVRKSLGRGAGWLSEDEDSPLDALDLVW
                     AKCRGYPSYPALIIDPKMPREGMFHHGVPIPVPPLEVLKLGEQMTQEAREHLYLVLFF
                     DNKRTWQWLPRTKLVPLGVNQDLDKEKMLEGRKSNIRKSVQIAYHRALQHRSKVQGEQ
                     SSETSDSD"
     exon            808..1767
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1930
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2062
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2191
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2501
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2822
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..3107
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3255
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..3392
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3393..3511
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3666
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3667..4546
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4500..4505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
                     /note="hexamer: AAGAAA"
     regulatory      4505..4510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
                     /note="hexamer: AATATA"
     polyA_site      4520
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
     regulatory      4524..4529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
                     /note="hexamer: AATAAA"
     polyA_site      4529
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
                     /note="major polyA site"
     polyA_site      4546
                     /gene="Brpf1"
                     /gene_synonym="4833438B11Rik; 4930540D11Rik; Brpf2"
ORIGIN      
        1 aaagtgcgtc tatacagcgc cacgggacca cgtttaccct ggcggacgcc gtcgccgtcg
       61 ctgctgctgc cgccgctgcc acagcctttg ccgccacggt ctcgccgctg ctgttcctgt
      121 gccgcctcca ggagcccccc cattgtcccg gcggcaccgg gttcccaggc cagaagatcc
      181 aaaagctcgg gaaacgcgaa gatgtgacag catgggggtg gactttgacg tgaagacctt
      241 ctgccacaat ttgcgggcaa ctaagccacc atatgagtgc cctgtggaga cttgccgcaa
      301 ggtttacaag agttacagtg gtatcgagta ccacctgtac cactatgacc acgacagccc
      361 accaccccca cagcagaccc cactgcgcaa gcacaaaaag aaagggcgcc agtcacgacc
      421 agccaacaag cagtcaccca gcccctctga agtctcacag tcaccaggcc gagaggtgat
      481 gagctatgct caggcccagc gcatggtaga agtggacctt catggccgtg tccaccgaat
      541 cagcatcttt gacaacttgg atgtggtgtc agaggatgag gaggcccctg aggaggcccc
      601 tgagaatggc agcaacaagg aaaacactga gacacctgcg gctacaccta agtcaggcaa
      661 gcataagaac aaggagaaac gaaaagactc taaccaccac catcacagcg ctcctgccag
      721 tgctgctccc aaattgcctg aggtggtgta tcgtgagcta gagcaagata cccctgacgc
      781 accaccccgg cccacttcct actaccggta catcgagaaa tctgcagagg agctggatga
      841 ggaggtggag tatgacatgg atgaagagga ctatatctgg ctggatatca tgaatgagcg
      901 gcggaagact gagggtgtaa gtcccatccc acaagagatc tttgagtact taatggaccg
      961 tttggagaag gagtcgtact ttgagagtca caataaaggt gaccccaatg cactagtgga
     1021 tgaagatgcc gtgtgctgta tctgcaatga tggcgagtgc cagaacagca atgttatcct
     1081 cttctgtgac atgtgtaact tggctgtgca ccaggagtgc tacggtgtcc cctatatccc
     1141 tgaaggccag tggctgtgcc gccgttgcct gcagtcacct tctcgtgcag tggattgtgc
     1201 tctgtgcccc aataagggtg gtgccttcaa gcagacagat gatggccgct gggcccacgt
     1261 ggtgtgtgcc ttgtggatcc ctgaggtttg ctttgccaac acagtcttcc tagaacctat
     1321 tgacagcatt gagcacatcc caccagctcg gtggaagctc acctgctaca tttgtaaaca
     1381 gcggggctct ggagcctgca tccagtgcca taaggccaat tgctacacag ccttccatgt
     1441 gacatgtgcc caacaagctg gcctttacat gaagatggaa cctgtgcggg agacaggtgc
     1501 caatggtacc tcctttagcg tccgcaagac agcctactgt gacatccaca cacccccagg
     1561 ttctgctcgt cgcctgcctg ccctatccca cagtgagggt gaggaagaag aggatgaaga
     1621 agaagatgag ggtaaaagct ggagctcaga gaaggtcaag aaggccaagg ccaagtctcg
     1681 gattaagatg aagaaagctc ggaagatctt ggcagagaag agggcagcag cacctgtggt
     1741 gtccgtgccc tgcatcccgc cacacaggct cagtaagatc accaaccgcc tgaccatcca
     1801 gaggaagagc cagttcatgc agaggctgca cagctactgg actctgaaac gacaatcacg
     1861 gaatggggtc ccactactca ggcgcctaca aacacacctt cagtctcaga ggaactgtga
     1921 acaagttggg agagattctg atgataaaaa ctgggccctc aaagaacagc tcaagtcctg
     1981 gcagagactg cggcatgacc tggagcgagc tcggctgctg gtggagctga tccgcaagcg
     2041 agagaaacta aaaagggaga cgatcaagat ccagcagatt gccatggaga tgcagctgac
     2101 ccctttcctc atcctcctcc gaaaaacctt ggagcagctc caagagaagg acacaggcaa
     2161 catcttcagc gagccggtcc ctctgtctga ggtacccgac tacctagacc acatcaaaaa
     2221 gcccatggac tttttcacca tgaagcagaa cttggaggct taccgctact tgaactttga
     2281 tgattttgag gaggacttca acctcattgt cagcaactgc ctaaagtata atgccaagga
     2341 caccatcttc tacagggcag cagtgcgact ccgtgagcag ggtggtgctg tgctccgtca
     2401 agcccggcga caggcagaaa aaatgggcat tgactttgag acgggcatgc atatccctca
     2461 caacctggcc ggagatgagg tctcacacca cactgaagat gtagaggaag aacggctggt
     2521 cctgctggag aaccagaaac acctgccagt agaagaacag ctgaagttgt tgctggagag
     2581 gctggatgaa gtcaatgcca gcaagcagag tgtgggccgc tctcggcgtg caaaaatgat
     2641 caagaaggag atgacagcat tgcggcggaa gcttgctcac cagcgggaga ctggccggga
     2701 tgggcctgag cgtcatggcc cctcaggtcg gggcaatctg acaccccacc cagcagcctg
     2761 tgacaaagat ggacagaccg acagtgctgc agaagagagc agcagccagg aaacaagcaa
     2821 aggcctgggt cccaacatgt cctcaacccc cgcacatgag gtgggcagga gaacctcagt
     2881 tctgttctcc aaaaagaacc cgaagacagc tggaccgccc aagaggccgg gccggccccc
     2941 aaaaaaccgg gagagccaga tgacccccag ccacggaggc agtcctgtgg ggccccctca
     3001 gctccccatc atgggctccc tacgtcagcg caagcggggt aggagccccc ggcccagttc
     3061 aagctcagac agcgacagtg ataagtccac agaagatccc ccaatggact taccagccaa
     3121 tggcttcagc agtgggaacc agccagtgaa gaagagtttc ttggtgtacc gtaatgactg
     3181 caaccttccc cgaagcagct cagactctga gtccagcagc agcagcagca gcagtgcagc
     3241 ctcagaccgg accagcacaa ctccctcaaa acaaggcagg ggcaagccct ctttctctcg
     3301 gggcacattc ccagaagaca gtagtgaaga tacctcaggc actgagaatg aggcctactc
     3361 cgtgggcact ggccgcggcg tgggccacag catggtaaga aagagtctgg gtcgaggagc
     3421 tggctggctg tcagaggatg aggactcccc gttggatgct ctggacctcg tgtgggccaa
     3481 atgccgaggc tatccatcat acccagctct gatcattgat ccaaagatgc cccgagaagg
     3541 tatgttccac catggggttc ctatccctgt accaccactg gaggttctaa aacttgggga
     3601 acaaatgaca caggaagccc gagagcatct ctacctcgtt ctcttctttg acaacaaacg
     3661 aacctggcag tggctgcccc ggactaagct tgttcctctg ggtgtgaacc aggatctaga
     3721 caaagagaag atgctggagg gccgcaagtc caacatccgc aagtcagtgc agattgctta
     3781 ccacagggct ctgcagcacc gaagcaaggt gcagggtgag cagagcagcg agaccagcga
     3841 tagtgactga tactctcaga gcccggtggt gctgtgatgg ctctccttcc ctttgctcat
     3901 tgtcctggag tgatgccgcc ctctgcactg attaattcct ggtcttgggg ccagtctcag
     3961 gggaagttgg gtaggggagg tccctcctgc cctgagtgca gctggactgt acaaaacact
     4021 ccaagggccc atggccactc agtgcaagga gaggagaggt ctcagaggtc taacgagttc
     4081 aaaaactcat ggcattgtag ggcagggtgg tgggccacag taagaatact gtaaaaaaca
     4141 ggccctacca cccttaccta ctcatgccag gggaattcat acctgcctag aggcctgagg
     4201 cccttgcagg tggtaaggta aatcagcatc atcccagcct agccgtggga ttgatgtctg
     4261 tctagcctgg aagaggggca ctaggtgacc cctcccctgc tgttgtaaat actgtaatta
     4321 ttggagaatt taaattattc tcatttgtaa ctgcgtttcc gggtcgcgcc agagtcattt
     4381 ggtactaaaa aaagaaaaag aaaaaaaaaa aagaaaagaa tggagcttgt ctctacttcc
     4441 tttccttttc ccatagaact ccccctacct ttcaaactgg tttgtattta tttcaaagga
     4501 agaaaatata ttgattctta gaaaataaag tctatttaga attctt
//
