LOCUS       NM_001037756            2592 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus breast cancer metastasis-suppressor 1-like (Brms1l),
            transcript variant 1, mRNA.
ACCESSION   NM_001037756 XM_001473780
VERSION     NM_001037756.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2592)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2592)
  AUTHORS   Streubel,G., Fitzpatrick,D.J., Oliviero,G., Scelfo,A., Moran,B.,
            Das,S., Munawar,N., Watson,A., Wynne,K., Negri,G.L., Dillon,E.T.,
            Jammula,S., Hokamp,K., O'Connor,D.P., Pasini,D., Cagney,G. and
            Bracken,A.P.
  TITLE     Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells
            required for self-renewal
  JOURNAL   EMBO J 36 (15), 2216-2232 (2017)
   PUBMED   28554894
REFERENCE   3  (bases 1 to 2592)
  AUTHORS   Wang,Q., Chikina,M., Zaslavsky,E., Pincas,H. and Sealfon,S.C.
  TITLE     beta-catenin regulates GnRH-induced FSHbeta gene expression
  JOURNAL   Mol Endocrinol 27 (2), 224-237 (2013)
   PUBMED   23211523
  REMARK    GeneRIF: findings indicate the expression of Brms1L depends on
            beta-catenin activity and contributes to follicle stimulating
            hormone beta induction by Gonadotropin-Releasing Hormone.
REFERENCE   4  (bases 1 to 2592)
  AUTHORS   Smith,K.T., Sardiu,M.E., Martin-Brown,S.A., Seidel,C.,
            Mushegian,A., Egidy,R., Florens,L., Washburn,M.P. and Workman,J.L.
  TITLE     Human family with sequence similarity 60 member A (FAM60A) protein:
            a new subunit of the Sin3 deacetylase complex
  JOURNAL   Mol Cell Proteomics 11 (12), 1815-1828 (2012)
   PUBMED   22984288
REFERENCE   5  (bases 1 to 2592)
  AUTHORS   Munoz,I.M., MacArtney,T., Sanchez-Pulido,L., Ponting,C.P., Rocha,S.
            and Rouse,J.
  TITLE     Family with sequence similarity 60A (FAM60A) protein is a cell
            cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase
            complex
  JOURNAL   J Biol Chem 287 (39), 32346-32353 (2012)
   PUBMED   22865885
REFERENCE   6  (bases 1 to 2592)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK155742.1 and BC034885.1.
            
            On Mar 29, 2018 this sequence version replaced NM_001037756.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.228488.1, AK154678.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2566              AK155742.1         2-2567
            2567-2592           BC034885.1         1514-1539
FEATURES             Location/Qualifiers
     source          1..2592
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 24.18 cM"
     gene            1..2592
                     /gene="Brms1l"
                     /gene_synonym="0710008O11Rik; BRMS1; D12Ertd407e"
                     /note="breast cancer metastasis-suppressor 1-like"
                     /db_xref="GeneID:52592"
                     /db_xref="MGI:MGI:1196337"
     exon            1..280
                     /gene="Brms1l"
                     /gene_synonym="0710008O11Rik; BRMS1; D12Ertd407e"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1110
                     /gene="Brms1l"
                     /gene_synonym="0710008O11Rik; BRMS1; D12Ertd407e"
                     /codon_start=1
                     /product="breast cancer metastasis-suppressor 1-like
                     protein"
                     /protein_id="NP_001032845.1"
                     /db_xref="CCDS:CCDS36453.1"
                     /db_xref="GeneID:52592"
                     /db_xref="MGI:MGI:1196337"
                     /translation="MPVHSRGDKKETNHHDEMEVDYAENEGSSSEDEDTESSSVSEDG
                     DSSEMDDEDCERRRMECLDEMSNLEKQFTDLKDQLYKERLSQVDAKLQEVIAGKAPEY
                     LEPLATLQENMQIRTKVAGIYRELCLESVKNKYECEIQASRQHCESEKLLLYDTVQSE
                     LEEKIRRLEEDRHSIDITSELWNDELQSRKKRKDPFSPDKKKPVVVSGPYIVYMLQDL
                     DILEDWTTIRKAMATLGPHRVKTEPPVKLEKHLHSARSEEGRLYYDGEWYIRGQTICI
                     DRKDECPTSAVITTINHDEVWFKRPDGSKSKLYISQLQKGKYSIKHS"
     exon            281..371
                     /gene="Brms1l"
                     /gene_synonym="0710008O11Rik; BRMS1; D12Ertd407e"
                     /inference="alignment:Splign:2.1.0"
     exon            372..499
                     /gene="Brms1l"
                     /gene_synonym="0710008O11Rik; BRMS1; D12Ertd407e"
                     /inference="alignment:Splign:2.1.0"
     exon            500..579
                     /gene="Brms1l"
                     /gene_synonym="0710008O11Rik; BRMS1; D12Ertd407e"
                     /inference="alignment:Splign:2.1.0"
     exon            580..676
                     /gene="Brms1l"
                     /gene_synonym="0710008O11Rik; BRMS1; D12Ertd407e"
                     /inference="alignment:Splign:2.1.0"
     exon            677..760
                     /gene="Brms1l"
                     /gene_synonym="0710008O11Rik; BRMS1; D12Ertd407e"
                     /inference="alignment:Splign:2.1.0"
     exon            761..825
                     /gene="Brms1l"
                     /gene_synonym="0710008O11Rik; BRMS1; D12Ertd407e"
                     /inference="alignment:Splign:2.1.0"
     exon            826..865
                     /gene="Brms1l"
                     /gene_synonym="0710008O11Rik; BRMS1; D12Ertd407e"
                     /inference="alignment:Splign:2.1.0"
     exon            866..992
                     /gene="Brms1l"
                     /gene_synonym="0710008O11Rik; BRMS1; D12Ertd407e"
                     /inference="alignment:Splign:2.1.0"
     exon            993..2567
                     /gene="Brms1l"
                     /gene_synonym="0710008O11Rik; BRMS1; D12Ertd407e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2543..2548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brms1l"
                     /gene_synonym="0710008O11Rik; BRMS1; D12Ertd407e"
                     /note="hexamer: AATAAA"
     polyA_site      2567
                     /gene="Brms1l"
                     /gene_synonym="0710008O11Rik; BRMS1; D12Ertd407e"
                     /note="major polyA site"
ORIGIN      
        1 ggccgggggt ggggaggagt cgagggtttc ggatccagct cggtggccgg gtgggtcggg
       61 gcgttcggcg cgcccttcac cgaagcggca gtggccgggc tgggagcagg aagtgggaag
      121 cgacggcgag gttggaaaat gccggtccat tctcgagggg ataagaagga gacgaatcat
      181 cacgatgaga tggaggtgga ctacgcggag aacgagggga gcagttccga agacgaggac
      241 accgagagct cgtcggtctc ggaggatggg gacagttcag aaatggatga tgaagattgt
      301 gaaaggagaa ggatggagtg tttagatgag atgtccaacc tggagaagca gtttacagac
      361 ctcaaagatc aactttataa agagcggttg agtcaggtgg atgcaaaact ccaagaagtc
      421 atagctggaa aagcaccaga gtatttggaa ccactggcca ccttacaaga aaacatgcag
      481 attcgcacaa aggtagcagg aatctataga gaactctgct tagagtctgt gaagaacaag
      541 tacgaatgtg aaatccaggc ttctcgacag cattgtgaga gtgaaaagct tttgttatat
      601 gatacagtcc agagtgagct tgaggagaag ataagaaggc ttgaggagga caggcacagc
      661 atcgacatta cctcagagct gtggaacgac gagcttcagt cacggaaaaa gaggaaggat
      721 ccgttcagcc ccgacaagaa gaagccggtc gttgtctcag gtccatatat agtttatatg
      781 ctgcaggatc tcgacattct tgaggactgg acgacaatta ggaaggcaat ggctacactg
      841 ggtccacacc gagttaaaac agaaccacct gtgaaactgg agaaacatct gcacagtgcc
      901 agatcggaag agggaagact gtattacgat ggtgaatggt atatacgtgg acagacgata
      961 tgtattgata gaaaagatga gtgtcccaca agtgctgtaa ttacaacaat taaccatgat
     1021 gaagtttggt ttaagaggcc tgatggaagc aaatctaagc tttacatttc acagctacag
     1081 aaaggaaaat actcaattaa acattcgtaa tcacgctcta agtgttcccc acatctacct
     1141 tgttagtgtt accaagtgta atgtgccatg gaagccaaga gaatgcactc agcagcttaa
     1201 taatttcatc cagtcatgag agactgtgtc ttctaggtag tactccaagt agaccccaca
     1261 ttagtaagtc attaagagaa atagtgataa actctaatca tgaccatcgc gtttatttgc
     1321 ctcgcaggtc ccgtgccaac aggtctgttt ggtatgtatt tctttctcag tgttgcttca
     1381 ttctgtgtct tactcacgtg agtgtgtctc acctctaatg gactaccgtg cagtcgcctg
     1441 cagttttaaa tccccgcctc cgctgccact cttgtgtttg tacagatgga agacttccta
     1501 tgaatgattt ctattagtgc attcgtttca atcagaactg aaatttatac atacatgtgt
     1561 gagtgcgtct atacagtgtc cccagcaggc ttagaactga tggcctacct gtacaacctc
     1621 cttttacccc aaattcaact gctgggtttt cgaagaaaag ggagcacttt tctagactgc
     1681 ttttccttct cttcttcctg gatggcggtg acctcttttg cagatcatat ttggtgttta
     1741 ttagtagcag tgtgtcaagt gtgaccatgt tgctgcctgt gtttcttctg agcttttaga
     1801 ggggcaggta tcctgcctgg tgtttatgat gcgcagtgcc agagtgacaa gtggctggca
     1861 gtattgtcgt gctttctgca catctgaact tttgaagatt ttactaagca ttatctagag
     1921 gcaaaactag atccttattc taattttatt gctagagtgg aatacatata gatacttccc
     1981 ttaactctac catcccccaa attagctttt ttttttaagt gtttttaaca ctttaaggcc
     2041 atttggtgca atttagaaaa tgttggcctc ccttccctta gccatattca gaatgaactt
     2101 ggaagcctct ggaactgtgc aggaaaccgg agccctcagc ccggaggcac agtgggctac
     2161 agtgtgtacg cagggtacag ccaaatgaag tgctctgctg gtctcatgca ctttaatttc
     2221 tgttacagtg tatttaagag gatgaggaag actcactcaa cactcctcaa aggagtctct
     2281 gcatgattcc gttagttcct tatgacttca cctctgcaga cattccctgc aggtatactc
     2341 cacagttgcc aaattgtaac catctgactt tcgaagttca gtatcagcaa cattgtgctg
     2401 ctctgttctg tttctgatca cccttagcgg ctgtgcagac tgtcccaatc cagtagcatt
     2461 tggcagtgct tataaatata tatatatata tgatgtttga taagcatttt taatgagatt
     2521 tgtattttta aatttagtat gtaataaaaa gaagtgtttg agcgtcaaaa aaaaaaaaaa
     2581 aaaaaaaaaa aa
//
