LOCUS       NM_134155               1374 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus breast cancer metastasis-suppressor 1 (Brms1),
            transcript variant 1, mRNA.
ACCESSION   NM_134155
VERSION     NM_134155.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1374)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1374)
  AUTHORS   Streubel,G., Fitzpatrick,D.J., Oliviero,G., Scelfo,A., Moran,B.,
            Das,S., Munawar,N., Watson,A., Wynne,K., Negri,G.L., Dillon,E.T.,
            Jammula,S., Hokamp,K., O'Connor,D.P., Pasini,D., Cagney,G. and
            Bracken,A.P.
  TITLE     Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells
            required for self-renewal
  JOURNAL   EMBO J 36 (15), 2216-2232 (2017)
   PUBMED   28554894
REFERENCE   3  (bases 1 to 1374)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1374)
  AUTHORS   Smith,K.T., Sardiu,M.E., Martin-Brown,S.A., Seidel,C.,
            Mushegian,A., Egidy,R., Florens,L., Washburn,M.P. and Workman,J.L.
  TITLE     Human family with sequence similarity 60 member A (FAM60A) protein:
            a new subunit of the Sin3 deacetylase complex
  JOURNAL   Mol Cell Proteomics 11 (12), 1815-1828 (2012)
   PUBMED   22984288
REFERENCE   5  (bases 1 to 1374)
  AUTHORS   Munoz,I.M., MacArtney,T., Sanchez-Pulido,L., Ponting,C.P., Rocha,S.
            and Rouse,J.
  TITLE     Family with sequence similarity 60A (FAM60A) protein is a cell
            cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase
            complex
  JOURNAL   J Biol Chem 287 (39), 32346-32353 (2012)
   PUBMED   22865885
REFERENCE   6  (bases 1 to 1374)
  AUTHORS   Danial,N.N., Gramm,C.F., Scorrano,L., Zhang,C.Y., Krauss,S.,
            Ranger,A.M., Datta,S.R., Greenberg,M.E., Licklider,L.J.,
            Lowell,B.B., Gygi,S.P. and Korsmeyer,S.J.
  TITLE     BAD and glucokinase reside in a mitochondrial complex that
            integrates glycolysis and apoptosis
  JOURNAL   Nature 424 (6951), 952-956 (2003)
   PUBMED   12931191
REFERENCE   7  (bases 1 to 1374)
  AUTHORS   Park,Y.G., Lukes,L., Yang,H., Debies,M.T., Samant,R.S., Welch,D.R.,
            Lee,M. and Hunter,K.W.
  TITLE     Comparative sequence analysis in eight inbred strains of the
            metastasis modifier QTL candidate gene Brms1
  JOURNAL   Mamm Genome 13 (6), 289-292 (2002)
   PUBMED   12115030
  REMARK    GeneRIF: Comparative sequence analysis in eight inbred strains
REFERENCE   8  (bases 1 to 1374)
  AUTHORS   Samant,R.S., Debies,M.T., Shevde,L.A., Verderame,M.F. and
            Welch,D.R.
  TITLE     Identification and characterization of the murine ortholog (brms1)
            of breast-cancer metastasis suppressor 1 (BRMS1)
  JOURNAL   Int J Cancer 97 (1), 15-20 (2002)
   PUBMED   11774238
REFERENCE   9  (bases 1 to 1374)
  AUTHORS   Hunter,K.W., Broman,K.W., Voyer,T.L., Lukes,L., Cozma,D.,
            Debies,M.T., Rouse,J. and Welch,D.R.
  TITLE     Predisposition to efficient mammary tumor metastatic progression is
            linked to the breast cancer metastasis suppressor gene Brms1
  JOURNAL   Cancer Res 61 (24), 8866-8872 (2001)
   PUBMED   11751410
REFERENCE   10 (bases 1 to 1374)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124502.4.
            
            On Sep 10, 2019 this sequence version replaced NM_134155.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF233580.1, BC016108.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AC124502.4         82098-82225         c
            129-274             AC124502.4         77550-77695         c
            275-365             AC124502.4         77362-77452         c
            366-493             AC124502.4         77067-77194         c
            494-573             AC124502.4         76859-76938         c
            574-670             AC124502.4         76677-76773         c
            671-763             AC124502.4         76104-76196         c
            764-828             AC124502.4         75015-75079         c
            829-868             AC124502.4         74556-74595         c
            869-1374            AC124502.4         73676-74181         c
FEATURES             Location/Qualifiers
     source          1..1374
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.23 cM"
     gene            1..1374
                     /gene="Brms1"
                     /note="breast cancer metastasis-suppressor 1"
                     /db_xref="GeneID:107392"
                     /db_xref="MGI:MGI:2388804"
     exon            1..128
                     /gene="Brms1"
                     /inference="alignment:Splign:2.1.0"
     exon            129..274
                     /gene="Brms1"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..876
                     /gene="Brms1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     breast cancer metastasis-suppressor 1 homolog"
                     /codon_start=1
                     /product="breast cancer metastasis-suppressor 1 homolog
                     isoform 1"
                     /protein_id="NP_598916.1"
                     /db_xref="CCDS:CCDS50355.1"
                     /db_xref="GeneID:107392"
                     /db_xref="MGI:MGI:2388804"
                     /translation="MPIQPSGKETEEMEAEGDSAAEMNGEADESEEERSGSQTESEEE
                     SSEMDDEDYERRRSECVSEMLDLEKQFSELKEKLFRERLSQLRLRLEEVGAERAPEYT
                     EPLGGLQQSLKIRIQVAGIYKGFCLDVIRNKYECELQGAKQHLESEKMLLYDTLLGEL
                     QERIQRLEEDRQSLDISSEWWDDKLHSRSSSKAGDAMPPSKRKKAPLVSGPYIVYMLQ
                     EIDILEDWTAIKKARAAVSPQKRKADGP"
     exon            275..365
                     /gene="Brms1"
                     /inference="alignment:Splign:2.1.0"
     exon            366..493
                     /gene="Brms1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..573
                     /gene="Brms1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..670
                     /gene="Brms1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..763
                     /gene="Brms1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..828
                     /gene="Brms1"
                     /inference="alignment:Splign:2.1.0"
     exon            829..868
                     /gene="Brms1"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1374
                     /gene="Brms1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1356..1361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brms1"
                     /note="hexamer: AATAAA"
     polyA_site      1374
                     /gene="Brms1"
                     /note="major polyA site"
ORIGIN      
        1 gacacctcct ggagaaagag aatcctgcgc agcactgttc cggagatcaa cggcggcggc
       61 gttcacaccc tgggtcggac agctctccgg gagtcctgga cgtgaggccg gaggccccag
      121 tgtctgcgag cccagatgcc catccagcct tcaggcaaag aaacagaaga gatggaggca
      181 gaaggggatt cagcagctga gatgaacggg gaggcagatg agagcgagga ggagcggagt
      241 ggcagccaaa ctgagtcaga ggaggagagc tcagagatgg atgatgaaga ctatgagcgg
      301 cgccgcagtg agtgtgtcag tgagatgctg gacctggaaa agcagttctc agagctgaag
      361 gagaagttgt tcagggaacg gctcagccag ctacgtttac gactggagga agtgggggct
      421 gagagagccc cagaatatac ggaacctctt ggcgggctgc agcagagcct gaagatccgc
      481 attcaggtgg cagggatcta caagggcttc tgtctggatg tgatcaggaa taagtatgag
      541 tgtgaactcc agggagccaa acaacacctg gagagtgaga agatgctgct gtatgacaca
      601 ctgcttgggg agctgcagga gcggatccag aggctggagg aggaccggca gagccttgac
      661 atcagctctg agtggtggga cgacaaacta catagcagaa gcagctccaa ggccggggac
      721 gccatgccac ccagcaagag gaagaaggca ccgctcgttt ctggtccata cattgtgtac
      781 atgctgcaag agatcgacat cctggaagac tggacagcca tcaaaaaggc cagggcagca
      841 gtgtcccctc agaagagaaa agcagacgga ccctgaccct gcatttactc tcgctcggag
      901 ggtcctggga gcagctggta cctcacgcag gattaacatt tctctgcaaa ggcagggggt
      961 tgcctagtag ctcttcagtg ttgctgctgg cccctgaccc tctgccacca ctggcctgga
     1021 ctcctctgct ctccttggga tctgcacaac tgtggccctg aagccgacct ggccaagcaa
     1081 gactgtggtc tccatccctg accagcccac tccctcccaa agaataactt cttcagcgtc
     1141 cccccacaga gagaccaggc ctcatccaga gtcacagcag cagtcctcct gaccttgaac
     1201 cctggccctc agccactgag ccaggcccaa ctgtaggagg aactctcaag cagacatgtt
     1261 gggccttgtc caccctgact gccgctggag aggacggctt cccaggcttt ctcagggcta
     1321 ttcctggtgt ctgcctctca gattccaaag actggaataa aatttaacct ggga
//
