LOCUS       NM_029045               2445 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus break repair meiotic recombinase recruitment factor 1
            (Brme1), transcript variant 1, mRNA.
ACCESSION   NM_029045 XM_134324
VERSION     NM_029045.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2445)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2445)
  AUTHORS   Feng,S., Li,J., Wen,H., Liu,K., Gui,Y., Wen,Y., Wang,X. and Yuan,S.
  TITLE     hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing
            in germ cells
  JOURNAL   Nat Commun 13 (1), 3588 (2022)
   PUBMED   35739118
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2445)
  AUTHORS   Shang,Y., Huang,J., Li,W., Zhang,Y., Zhou,X., Shao,Q., Tan,T.,
            Yin,S., Zhang,L. and Wang,S.
  TITLE     MEIOK21 regulates oocyte quantity and quality via modulating
            meiotic recombination
  JOURNAL   FASEB J 36 (6), e22357 (2022)
   PUBMED   35593531
REFERENCE   4  (bases 1 to 2445)
  AUTHORS   Guan,Y., Lin,H., Leu,N.A., Ruthel,G., Fuchs,S.Y., Busino,L., Luo,M.
            and Wang,P.J.
  TITLE     SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early
            meiotic recombination
  JOURNAL   Nucleic Acids Res 50 (9), 5129-5144 (2022)
   PUBMED   35489071
REFERENCE   5  (bases 1 to 2445)
  AUTHORS   Felipe-Medina,N., Caburet,S., Sanchez-Saez,F., Condezo,Y.B., de
            Rooij,D.G., Gomez-H,L., Garcia-Valiente,R., Todeschini,A.L.,
            Duque,P., Sanchez-Martin,M.A., Shalev,S.A., Llano,E., Veitia,R.A.
            and Pendas,A.M.
  TITLE     A missense in HSF2BP causing primary ovarian insufficiency affects
            meiotic recombination by its novel interactor C19ORF57/BRME1
  JOURNAL   Elife 9, e56996 (2020)
   PUBMED   32845237
  REMARK    GeneRIF: A missense in HSF2BP causing primary ovarian insufficiency
            affects meiotic recombination by its novel interactor
            C19ORF57/BRME1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2445)
  AUTHORS   Li,M., Feng,H., Lin,Z., Zheng,J., Liu,D., Guo,R., Li,J., Li,R.H.W.,
            Ng,E.H.Y., Huen,M.S.Y., Wang,P.J., Yeung,W.S.B. and Liu,K.
  TITLE     The novel male meiosis recombination regulator coordinates the
            progression of meiosis prophase I
  JOURNAL   J Genet Genomics 47 (8), 451-465 (2020)
   PUBMED   33250349
  REMARK    GeneRIF: The novel male meiosis recombination regulator coordinates
            the progression of meiosis prophase I.
REFERENCE   7  (bases 1 to 2445)
  AUTHORS   Shang,Y., Huang,T., Liu,H., Liu,Y., Liang,H., Yu,X., Li,M.,
            Zhai,B., Yang,X., Wei,Y., Wang,G., Chen,Z., Wang,S. and Zhang,L.
  TITLE     MEIOK21: a new component of meiotic recombination bridges required
            for spermatogenesis
  JOURNAL   Nucleic Acids Res 48 (12), 6624-6639 (2020)
   PUBMED   32463460
REFERENCE   8  (bases 1 to 2445)
  AUTHORS   Takemoto,K., Tani,N., Takada-Horisawa,Y., Fujimura,S., Tanno,N.,
            Yamane,M., Okamura,K., Sugimoto,M., Araki,K. and Ishiguro,K.I.
  TITLE     Meiosis-Specific C19orf57/4930432K21Rik/BRME1 Modulates
            Localization of RAD51 and DMC1 to DSBs in Mouse Meiotic
            Recombination
  JOURNAL   Cell Rep 31 (8), 107686 (2020)
   PUBMED   32460033
REFERENCE   9  (bases 1 to 2445)
  AUTHORS   Zhang,J., Gurusaran,M., Fujiwara,Y., Zhang,K., Echbarthi,M.,
            Vorontsov,E., Guo,R., Pendlebury,D.F., Alam,I., Livera,G.,
            Emmanuelle,M., Wang,P.J., Nandakumar,J., Davies,O.R. and Shibuya,H.
  TITLE     The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and
            impairs the mitotic BRCA2-RAD51 function in cancer cells
  JOURNAL   Nat Commun 11 (1), 2055 (2020)
   PUBMED   32345962
  REMARK    GeneRIF: BRCA2 binds to the C-terminus of MEILB2, resulting in the
            formation of the BRCA2-MEILB2-BRME1 ternary complex.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2445)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159266.3.
            
            On Jan 31, 2022 this sequence version replaced NM_029045.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075658.1, ERR3363660.1962922.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-319               AC159266.3         140329-140647
            320-367             AC159266.3         141087-141134
            368-530             AC159266.3         151694-151856
            531-609             AC159266.3         153462-153540
            610-714             AC159266.3         154549-154653
            715-1824            AC159266.3         158830-159939
            1825-1922           AC159266.3         162604-162701
            1923-2015           AC159266.3         164067-164159
            2016-2445           AC159266.3         164410-164839
FEATURES             Location/Qualifiers
     source          1..2445
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 40.35 cM"
     gene            1..2445
                     /gene="Brme1"
                     /gene_synonym="4930432K21Rik; Mamerr; Meiok21; MRM"
                     /note="break repair meiotic recombinase recruitment factor
                     1"
                     /db_xref="GeneID:74666"
                     /db_xref="MGI:MGI:1921916"
     exon            1..319
                     /gene="Brme1"
                     /gene_synonym="4930432K21Rik; Mamerr; Meiok21; MRM"
                     /inference="alignment:Splign:2.1.0"
     exon            320..367
                     /gene="Brme1"
                     /gene_synonym="4930432K21Rik; Mamerr; Meiok21; MRM"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..2142
                     /gene="Brme1"
                     /gene_synonym="4930432K21Rik; Mamerr; Meiok21; MRM"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C19orf57 homolog; BRCA2 and
                     MEILB2-associating protein 1; meiotic recombination
                     modulator"
                     /codon_start=1
                     /product="break repair meiotic recombinase recruitment
                     factor 1 isoform 1"
                     /protein_id="NP_083321.2"
                     /db_xref="CCDS:CCDS52616.1"
                     /db_xref="GeneID:74666"
                     /db_xref="MGI:MGI:1921916"
                     /translation="MNKKKQRNSGVGLHPSKPSKNPRLRDSQSSMMVHSHYSRESEDS
                     SEPAPSVELGGEEPLHEAFSCPVEDTGAASDLAGSPKELVPLPPSQNSVGKFVPQFAK
                     PRKTVTRKAKAWEEDLEGCTTSQETRPELGALKAASQPQRESLRFPPHDIRPEVQTQP
                     DGTLSKERTISLDNRSLGNNGFEMATVQDSSSPLSDAAAEGREADSRDPQERDAQGGE
                     AGAQHSGEPQEGEDILYTSALAPASEPTWSVAQDLSVPTYTLSSTAAAPSSTSPADAS
                     LMDTVITEVSLDPSVLQQSAPQVAKLLGSLDEQIPDGGCIGTLLSSTPLAEETTAGRE
                     EARWEERCHGDTLASFTETEPEKQEPVTEAGDSGHIAQEMDPVVKTKDSGSDEQSPGD
                     IGMLPLPAQSMNQMLVELRGLTCDQDLEGLSTPHTSSQLEHTCAASDPPQSTKDCHSS
                     PGIPVHLAAPCPRDQAAWQESSAMELDFLPDSQIQDALDATNMEQGFPSGSMPDLGWP
                     VPSSQSIGGSPKAVTKPQSRSHVETWAQETYRMQDATDTVRGLVVELSGLNRLIMSTH
                     RDLEAFKRRKTKSLPYLTKGLGSLPRGDQSWRDL"
     exon            368..530
                     /gene="Brme1"
                     /gene_synonym="4930432K21Rik; Mamerr; Meiok21; MRM"
                     /inference="alignment:Splign:2.1.0"
     exon            531..609
                     /gene="Brme1"
                     /gene_synonym="4930432K21Rik; Mamerr; Meiok21; MRM"
                     /inference="alignment:Splign:2.1.0"
     exon            610..714
                     /gene="Brme1"
                     /gene_synonym="4930432K21Rik; Mamerr; Meiok21; MRM"
                     /inference="alignment:Splign:2.1.0"
     exon            715..1824
                     /gene="Brme1"
                     /gene_synonym="4930432K21Rik; Mamerr; Meiok21; MRM"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1922
                     /gene="Brme1"
                     /gene_synonym="4930432K21Rik; Mamerr; Meiok21; MRM"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2015
                     /gene="Brme1"
                     /gene_synonym="4930432K21Rik; Mamerr; Meiok21; MRM"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2445
                     /gene="Brme1"
                     /gene_synonym="4930432K21Rik; Mamerr; Meiok21; MRM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2426..2431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brme1"
                     /gene_synonym="4930432K21Rik; Mamerr; Meiok21; MRM"
                     /note="hexamer: AATAAA"
     polyA_site      2445
                     /gene="Brme1"
                     /gene_synonym="4930432K21Rik; Mamerr; Meiok21; MRM"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgacgt ctgtggctcc acaccgccgc acatcgttct gttaggcttt gtggtggagt
       61 gggtgcgggt gtgggtgtgg gtgtggatgc tcctgctctc ccgtctgtgg cgcaggtctt
      121 caggagccga gtccacagtg tcaggcctca ggccttcctg tctcccaccg ccagtttgcc
      181 acgcggtccc cgtgactgcc tatgtgggta ttttctcaga acgttacgcc agtgacctag
      241 gcgacctatt ccccatcaga tccaggttga cctcgtcccg actaaggaca gagcaacttc
      301 cattactgct gtggcccaga tttctcaggg aaagataaaa tgaataagaa gaaacagcgg
      361 aactcagggg tcggcctcca tccctcaaag ccttctaaga acccacggct gagagactcc
      421 cagagctcca tgatggtcca ttcacactac tccagagagt cggaagacag ctcagaacct
      481 gctccttctg tagagctagg cggggaggaa ccactacacg aagctttcag ctgcccagtg
      541 gaggacacag gagctgcctc tgacctcgca ggatcaccca aagagctggt ccccctgcct
      601 ccttcccaga actcagttgg gaagtttgtc cctcagtttg ccaaaccaag aaagacagta
      661 actagaaaag ccaaggcatg ggaagaggat ctagagggct gcaccacaag ccaggaaaca
      721 aggccagagc tgggagccct caaagcagcc agccagccac agagagagtc cctgaggttc
      781 cctccccatg acatcagacc agaagtccag acacagccag atggaaccct ttcaaaggag
      841 aggacaatct cactagataa tagaagcctg gggaacaatg gttttgagat ggccacagtt
      901 caagacagta gtagccccct gtcagatgct gctgctgaag gcagggaggc agacagcaga
      961 gacccacagg aaagagatgc ccaaggaggg gaagcagggg cccagcattc tggggaaccc
     1021 caggaaggag aggacatcct ctacacatca gcattagctc ctgcctcaga gcccacctgg
     1081 tctgtggctc aagacctctc tgtccccaca tatactctca gcagcacagc tgcagcaccc
     1141 agctccacca gcccagcaga tgcctctctt atggacactg tcattacaga agtgagctta
     1201 gatccctctg tgctgcaaca gagtgctcca caggtggcca agctgctggg ctctctggat
     1261 gagcagatcc ctgatggagg ctgcattgga actctgctga gctccacacc tcttgctgag
     1321 gagaccacag caggcagaga ggaggccaga tgggaagaga ggtgtcatgg tgataccctg
     1381 gcaagcttca ctgagacaga gcctgagaaa caagagcccg tgacggaagc tggagattcc
     1441 ggccatatag cccaagaaat ggatccagtg gtcaagacca aggactctgg ctctgatgag
     1501 cagtcgccag gagatatagg aatgctgcct ttaccagcac agtccatgaa tcagatgttg
     1561 gtagagttac gtggcctaac ttgtgatcaa gacttagagg gcctcagtac ccctcatacc
     1621 tcctctcagc tagagcacac ttgtgcagct agtgaccctc cccagagcac caaggactgt
     1681 cacagcagcc caggcattcc tgtacacctg gcagctccct gtcccagaga ccaggctgca
     1741 tggcaggagt cctcagcaat ggaactagac ttcctgcctg acagccagat acaggatgcc
     1801 ctggatgcca ctaacatgga gcagggtttt ccttcaggga gtatgccaga ccttggctgg
     1861 cctgtcccta gctcacagtc catcggagga tccccaaagg cagtcaccaa acctcaatcc
     1921 agatcccatg tggaaacctg ggcccaggag acctacagga tgcaggatgc aacagacaca
     1981 gtgcgaggcc tcgtggtgga gctctccggt ctgaaccggc tgattatgag tacccaccgg
     2041 gacctggagg ccttcaagcg caggaagacc aagtctctgc cttacctgac aaaggggttg
     2101 gggagccttc ctagagggga tcagagctgg agggacttgt aatctgctgc agcctgtagg
     2161 ggtcggctta ccatggctcc agatgcagga ggctgagggt ggccacttgg ccaggatcac
     2221 tattgctccc atgcaacagg gttgcctgag ctttaaggaa gtcacctgac agagcatggc
     2281 cctactcccg atgctcatcc cggtttgagc atgcaggagt ctgagctgag ctgcagttgt
     2341 cgttgagttt gtttctggag gagagaggtg ccctctgtct gcctatcctt cccccatgct
     2401 ctctgttaca tttgggaagg tggggaataa atgatgcagt catga
//
