LOCUS       NM_133937               1110 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus BRICK1, SCAR/WAVE actin-nucleating complex subunit
            (Brk1), mRNA.
ACCESSION   NM_133937
VERSION     NM_133937.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1110)
  AUTHORS   Escobar,B., de Carcer,G., Fernandez-Miranda,G., Cascon,A.,
            Bravo-Cordero,J.J., Montoya,M.C., Robledo,M., Canamero,M. and
            Malumbres,M.
  TITLE     Brick1 is an essential regulator of actin cytoskeleton required for
            embryonic development and cell transformation
  JOURNAL   Cancer Res 70 (22), 9349-9359 (2010)
   PUBMED   20861187
  REMARK    GeneRIF: Data show that genetic ablation of Brk1 results in
            dramatic defects in embryo compaction and development, suggesting
            an essential role for this protein in actin dynamics.
REFERENCE   2  (bases 1 to 1110)
  AUTHORS   Derivery,E., Fink,J., Martin,D., Houdusse,A., Piel,M.,
            Stradal,T.E., Louvard,D. and Gautreau,A.
  TITLE     Free Brick1 is a trimeric precursor in the assembly of a functional
            wave complex
  JOURNAL   PLoS One 3 (6), e2462 (2008)
   PUBMED   18560548
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1110)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC010582.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010582.1, AK020128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1110
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.81 cM"
     gene            1..1110
                     /gene="Brk1"
                     /gene_synonym="6720456B07Rik"
                     /note="BRICK1, SCAR/WAVE actin-nucleating complex subunit"
                     /db_xref="GeneID:101314"
                     /db_xref="MGI:MGI:1915406"
     exon            1..125
                     /gene="Brk1"
                     /gene_synonym="6720456B07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..235
                     /gene="Brk1"
                     /gene_synonym="6720456B07Rik"
                     /note="probable protein BRICK1"
                     /codon_start=1
                     /product="protein BRICK1"
                     /protein_id="NP_598698.1"
                     /db_xref="CCDS:CCDS39595.1"
                     /db_xref="GeneID:101314"
                     /db_xref="MGI:MGI:1915406"
                     /translation="MAGQEDPVQREIHQDWANREYIEIITSSIKKISDFLNSFDMSCR
                     SRLATLNEKLTALERRIEYIEARVTKGETLT"
     exon            126..208
                     /gene="Brk1"
                     /gene_synonym="6720456B07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            209..1095
                     /gene="Brk1"
                     /gene_synonym="6720456B07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      819..824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brk1"
                     /gene_synonym="6720456B07Rik"
                     /note="hexamer: AATAAA"
     polyA_site      839
                     /gene="Brk1"
                     /gene_synonym="6720456B07Rik"
                     /note="major polyA site"
     regulatory      1070..1075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brk1"
                     /gene_synonym="6720456B07Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1095
                     /gene="Brk1"
                     /gene_synonym="6720456B07Rik"
ORIGIN      
        1 ggccgccatg gcgggacaag aggatccggt gcagcgggag attcaccagg actgggcgaa
       61 ccgggagtac attgagatca tcaccagcag catcaagaaa atctcagact ttctcaactc
      121 tttcgatatg tcttgtcgtt caagactcgc aacactaaat gagaaattga cagcccttga
      181 acggagaata gagtacattg aagcgagggt gacaaagggt gagactctga cctagaagtg
      241 cgccgccgcg ttgctgctgg gaagttgctg tacagaacac tgccgtgtgg gaaaggccca
      301 gcagcctcct gctcctcctc tctccttaca gagcaacagg gctttttctt gtttttcttt
      361 tttcaaaagt ggcctttggg ctctgctgtg tgccctgggg tatgacgtgg catgggggag
      421 caagcagtcc aggggacctc ttggaaacag cattaggctt tttccctttt cagtaacatt
      481 gttcggaact acttgtcaat gtgtttgagg tgttgagagg caaaggctgg gactctaagg
      541 tcctccccac ctctcaaact ctttctctca gactttccct acagctccca tggcctctac
      601 actgatttct gtcaacagtc ggccttctct ccacctgtga gaggtggagg cagtcctggc
      661 tgagacttgt gccctgcagt gtggttgcca gaaaatgttg ttgctaaccc accagtttct
      721 tgttctggga gctcaaagcc aggcccccag ttggcttgaa gggacatttt cagttttctt
      781 tgtgtcactt ggggtatcag tagctctcat gcttccctaa taaactcaac tttgtctgac
      841 tgctgtgact gtggtggcaa gagtggctgg agagggtctc cttgttgaga gtctggtggg
      901 caagagtgct ctccagcaga agaaacctgc agccctagct ggttcaaagc ctaggcggct
      961 ctccagtcag tgttcctgtc tggacacttg aactagttca gtctggaatt acttggtctt
     1021 tcagcagata actaccaagg acttttacta tataggtgtg ttagactcca ataaaagata
     1081 cagtattgaa tcagaaaaaa aaaaaaaaaa
//
