LOCUS       NM_026396               2654 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus BRX1, biogenesis of ribosomes (Brix1), mRNA.
ACCESSION   NM_026396
VERSION     NM_026396.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2654)
  AUTHORS   Pritsker,M., Doniger,T.T., Kramer,L.C., Westcot,S.E. and
            Lemischka,I.R.
  TITLE     Diversification of stem cell molecular repertoire by alternative
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14290-14295 (2005)
   PUBMED   16183747
REFERENCE   2  (bases 1 to 2654)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DT927497.1, AK002985.1, CF749026.1 and AK010171.1.
            
            On Apr 5, 2007 this sequence version replaced NM_026396.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088313.1, AK168325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                DT927497.1         1-43
            44-113              DT927497.1         45-114
            114-767             AK002985.1         1-654
            768-1303            CF749026.1         170-705
            1304-2654           AK010171.1         522-1872
FEATURES             Location/Qualifiers
     source          1..2654
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 5.35 cM"
     gene            1..2654
                     /gene="Brix1"
                     /gene_synonym="1110064N10Rik; Bxdc2"
                     /note="BRX1, biogenesis of ribosomes"
                     /db_xref="GeneID:67832"
                     /db_xref="MGI:MGI:1915082"
     exon            1..203
                     /gene="Brix1"
                     /gene_synonym="1110064N10Rik; Bxdc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1106
                     /gene="Brix1"
                     /gene_synonym="1110064N10Rik; Bxdc2"
                     /note="brix domain containing 2; BRX1, biogenesis of
                     ribosomes, homolog; brix domain-containing protein 2;
                     ribosome biogenesis protein Brix"
                     /codon_start=1
                     /product="ribosome biogenesis protein BRX1 homolog"
                     /protein_id="NP_080672.3"
                     /db_xref="CCDS:CCDS37042.1"
                     /db_xref="GeneID:67832"
                     /db_xref="MGI:MGI:1915082"
                     /translation="MAATKRKRRGGLEVQAKKPKRSSKDAGQPAKQADVAKEAEEENR
                     DRIPGPVCKGKWKNKERILIFSSRGINFRTRHLMQDLRMLMPHSKADTKMDRKDKLFV
                     INEVCEMKNCNKCIYFEAKKKQDLYMWLSNSPHGPSAKFLVQNIHTLAELKMTGNCLK
                     GSRPLLSFDPAFDDLPHYALLKEFLIQIFSTPRYHPKSQPFVDHVFTFTILDNRIWFR
                     NFQIIEEDAALVEIGPRFVLNLIKIFQGSFGGPTLYENPHYQSPNMHRRVIRSITAAK
                     YRERQQVKDVQKLRKKEPKTILPHDPTADVFVIPAEEKPVEIQWVKPEPKVDLKARKR
                     RIYKRHRKLQQKMSRGSAK"
     exon            204..315
                     /gene="Brix1"
                     /gene_synonym="1110064N10Rik; Bxdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            316..359
                     /gene="Brix1"
                     /gene_synonym="1110064N10Rik; Bxdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            360..430
                     /gene="Brix1"
                     /gene_synonym="1110064N10Rik; Bxdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            431..480
                     /gene="Brix1"
                     /gene_synonym="1110064N10Rik; Bxdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            481..554
                     /gene="Brix1"
                     /gene_synonym="1110064N10Rik; Bxdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..605
                     /gene="Brix1"
                     /gene_synonym="1110064N10Rik; Bxdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            606..707
                     /gene="Brix1"
                     /gene_synonym="1110064N10Rik; Bxdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..836
                     /gene="Brix1"
                     /gene_synonym="1110064N10Rik; Bxdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            837..2654
                     /gene="Brix1"
                     /gene_synonym="1110064N10Rik; Bxdc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1234..1239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brix1"
                     /gene_synonym="1110064N10Rik; Bxdc2"
                     /note="hexamer: AATAAA"
     polyA_site      1255
                     /gene="Brix1"
                     /gene_synonym="1110064N10Rik; Bxdc2"
                     /note="major polyA site"
ORIGIN      
        1 ggcagaaccg gaagtgcagg cagcgaccga cgcggcgagg cgagatggcg gcgaccaaga
       61 gaaagcggcg tggaggcttg gaggttcaag cgaagaagcc aaaaaggagc tcgaaagatg
      121 ccgggcagcc agctaagcag gccgatgtgg ccaaagaggc ggaggaggaa aatagagatc
      181 gtattccagg tccggtttgc aagggcaaat ggaaaaataa ggaacggatc ctcatctttt
      241 cttccagagg aataaatttc agaacaagac acttaatgca ggacttgaga atgttgatgc
      301 ctcattctaa agcagatact aaaatggatc gtaaagataa attatttgtg ataaatgagg
      361 tctgtgaaat gaaaaattgc aacaaatgca tctactttga agctaagaaa aaacaggatc
      421 tctatatgtg gctttcaaat tcacctcatg gtccatctgc caaattcttg gttcaaaata
      481 ttcataccct ggctgaatta aagatgactg gaaactgttt gaaaggttct cggccccttt
      541 tgtcttttga ccctgctttt gatgacttgc cacattatgc tttgttaaag gaattcttaa
      601 ttcagatctt cagtacgcca cgataccatc ccaagagtca gccgtttgtg gaccacgtgt
      661 ttacgttcac cattctggat aacaggatat ggttccggaa cttccagatt atagaagaag
      721 acgctgctct agtggaaata ggacctcgtt ttgttttaaa tctcataaag atttttcagg
      781 gaagctttgg aggaccaacc ttatatgaaa atcctcatta ccagtctcca aacatgcatc
      841 ggcgtgtcat aagatccatc acagctgcca agtatagaga gagacagcaa gtcaaagatg
      901 ttcagaaact gaggaagaaa gaaccaaaga ctatccttcc acatgacccc actgcagacg
      961 tgtttgttat accagcggag gagaagccag tagaaataca gtgggtgaaa ccagagccta
     1021 aagtagatct gaaagcaagg aagagacgga tttacaaaag gcatcggaaa ctgcaacaga
     1081 agatgagcag agggagtgca aagtgaatca gaggataact gtatttattt tgtattccat
     1141 gtgtaaatac ttttagtata cagaacgagc tatgcctaat tagggcacca ttttaaaaaa
     1201 ctgaaatctt taagtcggtg ttggtctttt tctaataaag catcttaact caccagctac
     1261 tttattcttt tcagagcctc acttagcaca cttacgagtt ggcttgccct gtttgcttag
     1321 aattgcagtg tggttaagct gatattcaag cagactagtt gggtctgtaa ttacttacca
     1381 agacgttagg gactttagag tggatttttt ttgtgggtgg cagagtggag gagatggtca
     1441 tttactgagt tttctctgct gaagtcacga attcatgaag ccttgagaag ccgacttgtg
     1501 attgttaacg gatatttgat ctcactgaac caccaaattg tggtgtttac tgaaaaaaac
     1561 ctgttctagt tgtggctcag cctttgcaca cacctttaat cccgagggct gaaatactga
     1621 cacaccatta atcccaaaca aggtaacatc agtttgtaga aggaaacacc cttgtttgaa
     1681 ggtgatatat aattacgtgg cagacaaagt gacgagtcag aaaaagatgg gagagaatag
     1741 gatatgcccg atgcgggagg agagaggctc ttgagagcag cagagaaggc agcttcactg
     1801 gcacagttgc acagagacgt gctgaagaaa gaatgagcca gaagattaga acagatagcc
     1861 agagttcatt tgaggtcaag cacagcaaag aggccaagag agaagtcaga ttgaatccgt
     1921 cagcttggag aggagtttga gccagaacac ctgagttgaa tcagctagct ggagatcaga
     1981 aaactagaaa gggtgagctt aattcagtct gttgaggctg aaggcactct aggcctggaa
     2041 tacattgtac agaggctaga agcttccagg actagaccta ggttagactg agtatgcctc
     2101 ggagacaacg atgacatcag gagaatacaa gttactttga catctgatca tttcagtgcc
     2161 tctacctctg gtgcatccaa gtcttaggtt ttgaaaaaca agacctgttt gtaagcagtt
     2221 ttaaatttat cttagacaac ttcagattct agagagcagt agcaacaggg aaaacagcaa
     2281 cctgagccac cagtgatgat ggggatagct gactagggag atgcatgaac atagatgata
     2341 tatatatata tatatatata tatatatata tatatattat acacacacac acacccatat
     2401 atacatatat gtatgtgtat atatatatgt gcgtatatgt gttgtatcag atggttttgt
     2461 cacatctttt cacctaacag tgtatgtttt ttcacatctg cagcatgttt attaactaga
     2521 catatatgtg ttacccattc agagatagtt cagtttttgt gtttctagta tggtgcctgt
     2581 ggtaaatatt tctgtacaga aatccctttg tacagtactt gttaaataaa actctggtca
     2641 aggttttttt ctag
//
