LOCUS       NM_153539               3118 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus bone morphogenetic protein/retinoic acid inducible
            neural specific 3 (Brinp3), transcript variant 1, mRNA.
ACCESSION   NM_153539
VERSION     NM_153539.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3118)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3118)
  AUTHORS   Berkowicz,S.R., Featherby,T.J., Whisstock,J.C. and Bird,P.I.
  TITLE     Mice Lacking Brinp2 or Brinp3, or Both, Exhibit Behaviors
            Consistent with Neurodevelopmental Disorders
  JOURNAL   Front Behav Neurosci 10, 196 (2016)
   PUBMED   27826231
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3118)
  AUTHORS   Tanaka,K., Matsumoto,E., Higashimaki,Y., Sugimoto,T., Seino,S. and
            Kaji,H.
  TITLE     FAM5C is a soluble osteoblast differentiation factor linking muscle
            to bone
  JOURNAL   Biochem Biophys Res Commun 418 (1), 134-139 (2012)
   PUBMED   22245424
  REMARK    GeneRIF: FAM5C might be an important humoral bone anabolic factor
            produced from muscle cells.
REFERENCE   4  (bases 1 to 3118)
  AUTHORS   Terashima,M., Kobayashi,M., Motomiya,M., Inoue,N., Yoshida,T.,
            Okano,H., Iwasaki,N., Minami,A. and Matsuoka,I.
  TITLE     Analysis of the expression and function of BRINP family genes
            during neuronal differentiation in mouse embryonic stem
            cell-derived neural stem cells
  JOURNAL   J Neurosci Res 88 (7), 1387-1393 (2010)
   PUBMED   20025061
REFERENCE   5  (bases 1 to 3118)
  AUTHORS   Jones,B.C., Beard,J.L., Gibson,J.N., Unger,E.L., Allen,R.P.,
            McCarthy,K.A. and Earley,C.J.
  TITLE     Systems genetic analysis of peripheral iron parameters in the mouse
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 293 (1), R116-R124 (2007)
   PUBMED   17475678
REFERENCE   6  (bases 1 to 3118)
  AUTHORS   Yalcin,B., Willis-Owen,S.A., Fullerton,J., Meesaq,A., Deacon,R.M.,
            Rawlins,J.N., Copley,R.R., Morris,A.P., Flint,J. and Mott,R.
  TITLE     Genetic dissection of a behavioral quantitative trait locus shows
            that Rgs2 modulates anxiety in mice
  JOURNAL   Nat Genet 36 (11), 1197-1202 (2004)
   PUBMED   15489855
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK046878.1, BC030498.1 and CJ323385.1.
            
            On Mar 11, 2009 this sequence version replaced NM_153539.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046878.1, SRR1660815.212022.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2277              AK046878.1         2-2278
            2278-3024           BC030498.1         1896-2642
            3025-3118           CJ323385.1         348-441
FEATURES             Location/Qualifiers
     source          1..3118
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 63.24 cM"
     gene            1..3118
                     /gene="Brinp3"
                     /gene_synonym="B830045N13Rik; Fam5c"
                     /note="bone morphogenetic protein/retinoic acid inducible
                     neural specific 3"
                     /db_xref="GeneID:215378"
                     /db_xref="MGI:MGI:2443035"
     exon            1..412
                     /gene="Brinp3"
                     /gene_synonym="B830045N13Rik; Fam5c"
                     /inference="alignment:Splign:2.1.0"
     exon            413..698
                     /gene="Brinp3"
                     /gene_synonym="B830045N13Rik; Fam5c"
                     /inference="alignment:Splign:2.1.0"
     exon            699..889
                     /gene="Brinp3"
                     /gene_synonym="B830045N13Rik; Fam5c"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1080
                     /gene="Brinp3"
                     /gene_synonym="B830045N13Rik; Fam5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1186
                     /gene="Brinp3"
                     /gene_synonym="B830045N13Rik; Fam5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1423
                     /gene="Brinp3"
                     /gene_synonym="B830045N13Rik; Fam5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1646
                     /gene="Brinp3"
                     /gene_synonym="B830045N13Rik; Fam5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..3118
                     /gene="Brinp3"
                     /gene_synonym="B830045N13Rik; Fam5c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2838..2843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brinp3"
                     /gene_synonym="B830045N13Rik; Fam5c"
                     /note="hexamer: AGTAAA"
     polyA_site      2861
                     /gene="Brinp3"
                     /gene_synonym="B830045N13Rik; Fam5c"
                     /note="major polyA site"
     regulatory      3002..3007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brinp3"
                     /gene_synonym="B830045N13Rik; Fam5c"
                     /note="hexamer: AATAAA"
     polyA_site      3024
                     /gene="Brinp3"
                     /gene_synonym="B830045N13Rik; Fam5c"
                     /note="major polyA site"
ORIGIN      
        1 cactagttgt ctactcctgt ttacaacaca tcctttcact tctctttgga gatctgtttg
       61 tcttattcat cctgttctct tgggttaccc agcttcctca ctttgtgggt acttccagtt
      121 tggtacattt gtttgcctga ggattatcat aagaaaggtt cccactgtta accattctca
      181 gaaaagaaaa aaaaaagaaa gaaagaaagc acttctttaa catttttggg ttcttggccc
      241 ctggaataag tgactttcac ctgattagat gccaccagga actactgagt gtttccaact
      301 cctactttcc tgcagctcac cactctacac tgctttggaa gatcatggga tgtctccttg
      361 aatcgtggat atgtttctct cacactcatc ttgcttcatt aactttcctc tggtgttgag
      421 ggaaagctga gaggatgacg gctctaagtc cccagtggaa gcatgatatg gcggcgcaga
      481 gctggtgctg aactgtcctc tctgatggct ctatgggagt ggatagtact gagtcttcat
      541 tgctgggttt tagcggttgc tgctgtctct gaccagcatg ccacaagccc cttcgactgg
      601 ctcctctctg ataagggacc cttccatcgc tcacaggagt acacagattt tgtggacaga
      661 agccgacagg gatttagcac aagatacaag atatacaggg agtttggtcg ttggaaggta
      721 aataaccttg cagttgagag aagaaatttc cttggttctc ctctgcctct tgcccctgag
      781 ttcttccgca acataagact tttgggacga cgacctactc tacagcaaat cacagaaaat
      841 cttatcaaga aatatgggac tcatttcttg ctatcagcta ctctgggagg agaggagtca
      901 ctcacaattt ttgtggacaa gcggaagctg agcaaaagat ctgaaggaag tgaaaccagc
      961 accaatagtt cgtctgttac cctggagacc ttacatcaat tggctgcttc ctattttatt
     1021 gacagggaca gcacccttcg cagacttcac catatccaaa ttgcatccac tgccatcaag
     1081 gtgacagaaa cacggacagg tcctcttggc tgcagtaact atgacaacct agattctgtc
     1141 agctctgttc tggttcagag tcctgagaat aaaattcagt tgcaagggct tcaagttctc
     1201 cttcccgact accttcagga acgttttgta caggcagcac tgagctacat tgcttgcaat
     1261 tctgagggcg agtttatctg caaggataat gactgctggt gccactgtgg tccaaaattc
     1321 ccagaatgta attgcccttc catggatatt caagccatgg aagagaatct tcttcgaata
     1381 acagaaacat ggaaagccta caacagtgac tttgaagatt cagatgaatt caagttcttt
     1441 atgaaaagac tacccatgaa ttattttctc aacacttcaa ctataatgca tttgtggaca
     1501 atggattcta attttcagcg ccgctacgaa caactggaga acagcatgaa acagcttttc
     1561 ctgaaggcac acagaattgt acacaagctc tttagcctta gcaaacggtg ccacaagcag
     1621 cctctcatca gcctgccgag acagagaaca tcaacctact ggctcactcg catccagtct
     1681 tttctctact gcaatgagaa tggccttctg ggaagcttct ccgaggaaac ccactcctgc
     1741 acatgcccca acgaccaggt agtgtgcaca gcctttctgc cctgtactgt gggcgatgcc
     1801 tctgcctgcc ttacctgtgc acctgacaac cgtacccggt gtggcacctg caacacaggc
     1861 tacatgctga gccagggact ctgcaagcct gaagtcgctg agtcaaccga tcactacatt
     1921 ggctttgaga ccgacctaca agacctagag atgaaatacc tgttgcagaa aacagataga
     1981 cgaatagaag tacatgccat ctttatcagc aatgacatgc gcctcaacag ctggtttgat
     2041 ccttcctgga gaaagcggat gctcctgacc ttgaagagta acaaatacaa gtccagtctg
     2101 gtccacatga tcttgggtct ctctttacag atttgcttaa ctaaaaacag cacgttggag
     2161 ccagtgctgg ctgtttatgt caatcccttt ggaggcagcc actccgagag ctggtttatg
     2221 cctgtgagtg agagcagctt tccagactgg gagcggacta agctggacct ccctctacag
     2281 tgctataact ggacactgac tctgggaaac aaatggaaga cattttttga gacagtacac
     2341 atctacctga ggagtcgcat caaggcaaat ggccccaaca gcaatgagag catttattat
     2401 gagcctttgg agtttattga cccatcccgg aacctgggct acatgaaaat caacaacatc
     2461 caagtgtttg gctacagcat gcactttgac cctgaagcca ttcgggacct gattttgcag
     2521 ctggactacc cttatactca gggatcccag gactcggcac ttttgcagct actagagata
     2581 agagaccgtg taaataaact ctccccaccc ggtcagcgcc gcctggatct gttttcttgc
     2641 ttgcttcgtc atagactcaa gctgtctact agtgaggtgg tgagaattca gtctgctctt
     2701 caggcattta atgccaagtt gccaaacaca gtggattatg acacaaccaa attatgtagt
     2761 taaccataaa tgtcaagcac aacccaaaat cttgaaggag tttttacagt gcttttgtgg
     2821 aagtttatgt ttggaaaagt aaatttaaat tgtcttttca atatctgtct tatatcagtc
     2881 aataacgttg gatggcaatt tacacacatg aacttgctga caatgaatat attatactac
     2941 agttttggtt tatgaatgaa ataaatactg acaccagtct agaagacatt ctacttttta
     3001 caataaattt catttgtaat tttatatgtt ccgtggcaat gcttttgtgc attacatcct
     3061 ctagagggaa cataaaaaga taccaataaa attttgtagc tgaacagtta ttaacaag
//
